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Toxicity studies on Trigonella foenum-graecum L. seeds used in spices and as a traditional remedy for diabetes

  • Al-Ashban, R.M.;Abou-Shaaban, R.R.;Shah, A.H.
    • Advances in Traditional Medicine
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    • v.10 no.2
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    • pp.66-78
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    • 2010
  • Acute (24 h) and chronic (90 days) oral toxicity studies on the ethanol extract of Trigonella foenumgraecum Leguminosae (L.) seeds were carried out. Acute dosages were 0.5, 1.0 and 3 g/kg while chronic dosage was 100 mg/kg per day of the extract. All morphological, biochemical, haematological and spermatogenic changes, in addition to mortality, body weight changes and any change in vital organs were recorded. Histopathological investigations were done on vital organs. Growth arrest in the treated animals was observed. The treated mice gained no significant weight during chronic treatment while there was a significant gain in body weight of the control group mice. Biochemical studies revealed a significant decrease in blood sugar levels of fenugreek treatment groups while haematological parameters remained comparable to the control. In the treatment, male group there was a significant decrease in weight of testes as compared to the control. There was a marginal weight gain in kidney weight of mice after chronic treatment as compared to the control. Fenugreek chronic treatment caused a highly significant spermatotoxic effects in male mice.

A Study of Serum Lipid in Korean (한국인(韓國人)의 혈청지질(血淸脂質) 연구(硏究))

  • Lee, Soo-Young;Kim, Kang-Seuck
    • The Journal of the Korean life insurance medical association
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    • v.2 no.1
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    • pp.101-115
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    • 1985
  • In Med Dept. Daehan Education Insurance, Total 690 cases(male 376 cases, female 314 cases) were inspected to study the change of serum lipid value. The objects of investigation were total cholesterol, HDL cholesterol, triglyceride, phospholipid and total lipid value. The results are as follows: 1) In the normal subjects, with the relation of serum lipid value and the age. triglyceride, phospholipid and total lipid value showed the increasing tendency by 70 age, but total cholesterol value and HDL cholesterol value showed the increasing tendency by 59 age and the decreasing tendency after 59 age. 2) In the normal subject the difference of serum lipid value between sexes did not make the significant difference of level statistically in all items which can be inspected. 3) The weight change and serum lipid value are very significantly related. Total cholesterol, HDL cholesterol and total lipid value are high in female if the weight is light. But they are high in male the weight is heavy phospholipid value is opposite to the above result. Triglyceride value is high in male regardless the weight, but the significant difference happened in the high weight group. 4) As serum lipid value of hypertension patients is compared with that of the normal subjects, HDL cholesterol, triglyceride, phospholipid and total lipid value are significantly high. 5) The doubtful group of the fatty infittration of liver among the hypertension pafients have very significant difference in serum lipid value compared with not only the value of the normal subject but also that of the obesity group. 6) The doubtless group of the fatty infitration of liver among the hypertension patients have the significant difference in all serum lipid value compared with that of the normal subject, but compared with the obesity group males had the significant difference of HDL cholesterol value and both sexes had the significant difference in total lipid value, but had no significant difference in total cholesterol, triglyceride and phosprolipid value. 7) The ratio of total cholesterol per HDL cholesterol had the significant difference in the doubtful hypertension patients of the fatty infittration of liver and the relative weight, but it had no significant difference compared with the normal subject in the doubtless hypertension patients.

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Preventive effects of Saponariae Vaccariae Semen and Melandryi Firmi Herba on hyperlipidemia and liver damage induced by alcohol (왕부류행(王不留行)과 경엽여루채(硬葉女婁菜)가 알콜 투여로 유발된 흰쥐의 고지혈증과 간 손상의 예방에 미치는 영향)

  • Choi, Jae-Young;Seo, Bu-Il;Oh, Dal-Seok;Park, Ji-Ha;Roh, Seong-Soo
    • The Korea Journal of Herbology
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    • v.27 no.1
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    • pp.27-34
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    • 2012
  • Objectives : This study was performed to compare the preventive effect of water extracts from Saponariae Vaccariae Semen(SVS) and Melandryi Firmi Herba(MFH) on hyperlipidemia and liver damage induced by alcohol. Methods : Except for the normal group, I fed rat on 25% alcohol for 55 days. And each extract was administrated for the same period. I measured the serum component in rat's blood, body weight and weight of liver. Results : At first, I observed effects of SVS and MFH on hyperlipidemia induced by alcohol. SVS and MFH group didn't show the significant decrease of total cholesterol in comparison with those of the control group. SVS and MFH group showed the significant increase of HDL-cholesterol in comparison with those of the control group. SVS group showed the significant decrease of triglyceride in comparison with those of the control group, but MFH group didn't show the significant decrease of triglyceride in comparison with those of the control group. SVS group showed the significant increase of body weight in comparison with those of the control group at 4weeks and 8weeks. But, MFH group didn't show the significant changes of body weight in comparison with those of the control group at 4weeks and 8weeks. By the way, SVS group showed the significant decrease of triglyceride in comparison with those of MFH group. SVS group showed the significant increase of body weight in comparison with those of MFH group at 8weeks. At second, I observed effects of SVS and MFH on liver damage induced by alcohol. SVS and MFH group showed the significant decrease of AST(aspartate aminotransferase), ALT(alanine aminotransferase), ALP(alkaline phosphatase) and LDH(lactate dehydrogenase) in comparison with those of the control group. SVS group showed the significant increase of liver weight in comparison with those of the control group, but MFH group didn't show the significant increase of liver weight in comparison with those of the control group. By the way, SVS group showed the significant increase of liver weight in comparison with those of MFH group. Conclusions : Reviewing these experimental results, it suggests that water extracts from SVS and MFH have pharmaceutical preventive efficacy on hyperlipidemia and liver damage induced by alcohol. Therefore further additional study should be conducted to elucidate the pharmaceutical efficacy of these in depth.

The Relationship among BMI, Perceived Weight and Health Status (체질량지수, 체중지각 및 건강상태의 상관관계 연구)

  • Jo, Hyun-Sook
    • The Korean Journal of Rehabilitation Nursing
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    • v.10 no.2
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    • pp.99-107
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    • 2007
  • Purpose: The purpose of this study was to identify the relationship between BMI, perceived weight and health status of the nursing students by finding the discrepancy between obesity by measuring BMI and students' perception of their weight. Method: The data were obtained by a questionnaire from 211 female nursing students of G college, Inchon, Korea, and by measuring their heights and weights. Result: The BMI of the 1st grade students($20.74kg/m^2$) was higher significantly than that of the 3rd grade students($19.65kg/m^2$). The difference between the obesity by BMI and perceived weight was significant. The concordance rates between obesity by BMI and perceived weight were 22,9%, 59.5%, 90.9% and 50% in underweight, normal, overweight, and obese students respectively. The students perceiving themselves overweight showed higher physical health status significantly than the students perceiving themselves underweight. There was a statistically significant correlation between BMI and physical health of the students. Conclusion: BMI of the nursing students has a significant influence on their physical health. Also there were significant discrepancies between the obesity by BMI and perceived weight.

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Weight Gain of the Psychiatric Female Hospitalized Patients (정신과 여자 입원 환자의 체중 증가)

  • Seo, Dong-Hyang;Park, Ki-Chang;Shin, Jong-Ho
    • Korean Journal of Psychosomatic Medicine
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    • v.6 no.2
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    • pp.120-125
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    • 1998
  • Objectives : The purposes of present study were to identify weight increment in female psychiatric patients during hospitalization and to evaluate the relationship between weight gain and daily calorie intake, daily activity and other variables of disease itself. Methods : 20 patients were studied. Body weight were measured once a week, and daily activity(total amounts of walking/day) and total amount of daily calorie intake were measured twice a week. We examined psychiatric and medical illness history, eating disorders' history and family history of eating disorders and obesity. Results: Mean body weight and Body Mass Index(BMI) at admission are 49.40kg and 19.59kg/$m^2$. Mean weight increment during hospital stays of mean 65 days is 4.90kg. Mean amounts of daily calorie intake and daily activity(daily walks) were increased during hospital stays, but not statistically significant. The degree of weight increment is higher in longer hospital stay group, but not statistically significant. Mean body weight at admission of mood disorder group is higher than that of schizophrenia group, but not statistically significant. Conclusion : This results suggested that weight increment in female psychiatric hospitalized patients is present. However, it is not resulted by amount of calorie intake and daily activity level.

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A Study on Weight Control and Dietary Life among Middle School Students: Nutrition Knowledge, Dietary Behavior and Food Frequency (남녀 중학생들의 체중조절과 식생활 비교 연구: 영양지식, 식생활 태도 및 식품 섭취 빈도)

  • Kang, Hee-Won;Lee, Sang-Sun
    • Journal of Nutrition and Health
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    • v.39 no.8
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    • pp.817-831
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    • 2006
  • The purpose of this study is to compare the nutrition knowledge, dietary behavior and food frequency according to the gender and weight control attempt among middle school students in Seoul and Gyunggi-do, Korea. The subjects were divided into three groups, one with experience in attempting to lose their weight, one with experience in attempting to gain their weight and one with no experience in attempting to control their weight. Nutrition knowledge level of girls was higher than that of boys (p<0.01), but there were no significant difference according to weight control attempt. As for the scores of dietary behavior, there were no significant differences by gender but according to weight control attempt, the scores of dietary behavior of the weight loss attempt group were higher than those of the other attempt groups (p<0.01). In the food intake frequency, there were significant differences according to weight control attempt (p<0.05, p<0.01).

Comparison of Temperament in Infancy between the normal Infants and Low-birth-weight (정상체중출생아와 저체중출생아의 영아기 기질 비교)

  • Bang, Kyung-Sook;June, Kyung-Ja
    • Korean Parent-Child Health Journal
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    • v.5 no.1
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    • pp.50-61
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    • 2002
  • The purpose of this study was to compare the temperamental differences between the normal infants and low-birth-weight infants. The subjects of this study were 70 mothers with normal infants and 62 mothers with the low-birth-weight. Convenient sampling was done at three regions. The infant temperament scale developed by Pridham & others (1994) was used. Data were analyzed by SPSS WIN program. The results were as follows; 1) There was a significant difference in total temperament score between the low-birth-weight infants and normal infants. The scores of the low-birth-weight infants were significantly lower than those of normal infants in the subscales of amenability and persistence, activity, and reactivity. In adaptability, there was no significant difference between two groups. 2) In both groups, there were no significant difference by socio-economic status of parents, delivery type, and birth order. But, in the case of low-birth-weight infants, the temperament score of infants over 6 months was significantly higher than that of infants under 6 months. 3) In the correlation analysis among subscales of the temperament, amenability and persistence, activity, and reactivity showed the significant relationship. But adaptability showed significant correlation only with the amenability and persistence. In conclusion, temperament score of low-birth-weight infants were significantly lower than that of normal infants. It was suggested that parenting education for low-birth-weight infants would be needed to understand and impact the positive infant temperament.

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Estimation of the Combining Abilities of Abdominal Eat Deposition of Broiler (육용계의 복강지방축적에 대한 결합능력추정연구)

  • 정선부;정일정
    • Korean Journal of Poultry Science
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    • v.10 no.2
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    • pp.83-89
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    • 1983
  • Sixteen crosses from two strains of White Cornish and White Plymouth Rock were reared seperately on floors and abdominal fat was measured every two weeks interval from two weeks to twelve weeks of age. The abdominal fat weights surgically removed were slightly heavier in female than male. Estimates of general combining ability variances of body weight showed significant at all weeks of age in both sexes but those of abdominal fat weight were significant at 2, 8, 10 and 12 weeks of age in female and 2, 6 and 12 weeks of age in male. In percentage of abdominal fat to body weight, the significant differences were observed at 10 and 12 weeks of age only in female. The specific combining ability variances were significant at 4, 6, 10 and 12 weeks of age in female and 4, 8 and 12 weeks of age in male in body weight. In abdominal fat weight, there were significant differences at 4, 8, 10 and 12 weeks of age in female but no significant differences in male. The specific combining ability variances of percentage of abdominal fat to body weight showed significant differences at 4 and 8 weeks of age in female but no significant difference in male.

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A Case-Control Study on the Risk Factors of the Low Birth Weight (저체중아(低體重兒) 출산 관련요인에 관한 사례-비교군 연구)

  • Meng, Kwang-Ho;Lee, Sang-Yoon;Lee, Hae-Chun
    • Journal of Preventive Medicine and Public Health
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    • v.17 no.1
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    • pp.251-257
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    • 1984
  • Low birth weight baby, defined as the baby born with less than or equal to 2,500g of body weight by WHO has been a great concern in the fold of maternal and child health since the low birth weight is a major cause of high perinatal mortality. Any measure to prevent the low birth weight baby is most desirable not only for saving the life of a baby but also for levelling up the health of the whole society. The authors attempted to figure out how some known maternal risk factors are related to the low birth weight and to measure their strengh of associations in terms of relative risk using hospital birth records. For this study, hospital birth records of 66 low birth weight cases and sex-parity matched 198 normal controls were chosen from Kangnam St. Mary's Hospital, Catholic Medical Center, and the data were analyzed in regards to several maternal factors. The risk factors studied were mother's age, mother's ABO blood type, previous histories of abortion, low birth weight baby, fetal wastage, and maternal diseases represented by anemia, hypertension, proteinuria, and glucosuria. The results obtained in this study were as follows: 1. The mean body weight of the cases and controls were 1,955g and 3,251g, respectively, and the heights were 41cm for cases and 50cm for controls. Mean gestation periods of cases and controls were 34 weeks and 39 weeks, respectively. 2. Young mother(less than or equal to 20 years of age) or old mother(more than or equal to 30 years of age) experienced more frequently the delivery of low birth weight babies than mothers in between 21 and 29 years of age. But the difference was not statistically significant. 3. Mothers whose blood type was O tended to have slighty higher frequency of low birth weight babies while B mothers have lower frequency. But the difference was not statistically significant too. 4. Those mothers who had experienced low birth weight baby in the past tended to give more births of low birth weight babies. This factor is even statistically significant and the relative risk of the prior experience of low birth weight was 6.7. 5. Mothers with experience of fetal losses and mothers of more than two pregnancies had higher frequency of low birth weight than the mothers with no fatal losses and of first pregnancy, but the difference was not statistically significant. 6. Statistically significant higher frequency of low birth weight were found in mothers with hypertension(odds ratio=4.07), anemia(odds ratio=22,33), and proteinuria(odds ratio=2.79). In summary, these study results strongly suggest that in order to prevent the low birth weight, special care should be made when the mother is too young or too old, and when the mother has experienced deliveries of low birth weight and fetal deaths. Medical control for the maternal diseases such as anemia and hypertension is also needed before or during the pregnency.

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Heritability and Correlation Coefficients in Edible Oil Crops in Korea (우리나라 식용유지 자원식물의 상관 및 유전력)

  • SangRaeLee
    • Korean Journal of Plant Resources
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    • v.1 no.1
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    • pp.1-7
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    • 1988
  • This experiment were carried out to study the heritability, genotypic, pheno-typic and environmental correlation in four edible oil crops. Heritabilities of flowering date, maturing date, plant height and weight of 1, 000 grains in rape were high. A highly significant positive correlation was found between flowering date and maturing date, plant hight and ear length, number of pods per ear and flowering date, maturing date and plant hight, The number of seed per pod showed also significant positive correlation with flowering or maturing date as well as with the relationship between weight of 1, 000 grains and plant height or ear length inrapeseed, respectively. Heritabilities of maturing date, length of stem with eapsule and number of seed per capsule were high, in sesame. Genotypic correlation between plant height and length of stem with capsule, length of stem with capsule and number of capsule per plant, number of capsule per plant and weight of 1, 000 grains, weight of 1, 000 grains and yield were highy positive in sesame. Heritabilities of flowering date, length of main stem, weight of 100 grains and number of shells per square meter in peanut were high, There was positive genotypic correlation between length of main stem and yield, number of shells per quare meter and matured seed ratio, number of shells per square meter and yield, 100 grains weight and yield. On the other hand, a significant negative correlation appeared between flowering date and yield. Heritabilities of days to flowering, stem length, stem diameter and weight of 1, 000 grains in perila were high. There was positive genotypic correlation between stem length and stem diameter, number of pods per plant, stem weight etc, between number of internodes and number of pods per plant, stem weight, number of valid branches and number of pods plant as well, respectively. While, a significant negative correlation was observed between number of valid branches and weight of 1, 000 grains, between number of pods per plant and weight of 1, 000 grains.

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