• Tuberculosis and Respiratory Diseases
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• 제59권3호
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• pp.279-285
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• 2005

연구 배경 : 세계적으로 Asian dust로 알려져 있는 황사는 주로 봄철 중국과 몽고의 사막지역에서 발생하는 모래먼지로 수천 킬로미터를 이동하여 낙하하는 자연적으로 발생되는 대표적인 오염 물질이다. 한반도에 영향을 미치는 황사는 주로 $10{\mu}m$이하의 미세먼지($PM_{10}$)로서 $PM_{10}$의 증가는 황사현상의 증가와 매우 밀접한 관련이 있다. $PM_{10}$은 호흡기에 침착이 가능하고 따라서 호흡기 증상 및 폐기능에 영향을 미치는 것으로 알려져있으나 아직 이에 대한 병리기전의 연구는 미미하여 기존에 추정되는 $PM_{10}$의 병리기전 이외에 황사 먼지의 이동에 따르는 미생물의 전파, 특히 바이러스의 전파에 대한 연구는 임상적으로 의미가 있을 것으로 생각되며 황사시 바이러스 감염 질환 자체의 발생을 알아 보기위해 황사시 대기에서 시료를 채취하여 바이러스의 존재 유무에 대해 연구하였다. 방 법 : $PM_{10}$은 인천지역 10군데에서 측정하였으며 고용량 대기 포집기(HA 500F, Sibata, 일본)를 이용하여 하루에 한번씩 포집하였다. 공기포집기의 흡입용량인 500 L/min으로 6시간 시행하였다. 시료를 흡착하기 위하여 $0.25{\mu}m$ pore size의 지름이 110mm 인 Glass microfiber filter( Prefilter AP 15, 124mm)를 이용하였다. nfluenza virus, 구제역에 관계된 Piconaviridae의 Aphthovirus속인 RNA바이러스, Hog cholera virus 돼지콜레라 바이러스) 의 검출을 위해 수집한 membrane filter를 전처리하여 Polymerase chain reaction으로 바이러스를 확인하였다. 결 과 : 연구 기간 중 24시간 평균 $PM_{10}$수치는 황사 발생일에 $148.0{\mu}g/m^3$, 비황사발생일에 $57.0{\mu}g/m^3$ 로 차이를 보였다. 2003년과 2004년 4월부터 8월 사이에 채취한 시료에서 검출 대상 바이러스인 Influenza virus A, B, Hog cholera virus, 구제역에 관련된 Aphthovirus등은 검출되지 않았다. 결 론 : 연구는 연구기간 동안에 황사의 발생이 적어 충분한 연구가 되지 못하였으며, 또한 검출하고자 했던 바이러스질환의 발생도 적어 실제 황사와의 관련성을 규명하기에 적절한 연구가 이루어지질 못했다. 향후 황사 발생과 바이러스질환의 유행이 일치하는 시점에 좀더 광범위한 시료의 채취 방법으로 연구가 필요할 것으로 생각된다.

• Clinical and Experimental Pediatrics
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• 제51권7호
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• pp.704-712
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• 2008

목 적 : 최근 모유수유의 장점이 부각되고 있으나 모유가 미숙아 전용분유에 비해 열량을 포함한 영양소들이 미숙아들의 적절한 성장을 유도하기에는 낮아 이를 극복하기 위한 모유강화제가 개발되었다. 본원에서는 극소저체중출생아들을 대상으로 모유강화제를 첨가한 모유를 수유한 경우와 미숙아 전용분유를 수유한 경우를 비교하여 성장에 어떠한 효과를 미치는지 알아보기로 했다. 방 법 : 2005년 10월부터 2006년 12월까지 동아대학교의료원에서 출생하여 신생아 집중치료실에 입원한 출생체중 1,500 g 이하, 재태주령 33주 미만인 극소저체중출생아들을 대상으로 강화된 모유수유군과 미숙아 전용분유 수유군으로 나누어 전반적인 특징, 영양상태, 성장 추이 및 합병증의 발생 등을 전향적으로 비교 조사하였다. 대상 환자들 중 본원에서 추적관찰이 가능했던 환자들의 경우 외래에서 1, 3, 6개월에 걸쳐 체중, 신장, 두위를 측정하여 비교하였다. 결 과 : 두 군의 평균 재태주령 및 출생체중은 각각 $30^{+1}{\pm}2^{+1}$주과 $29^{+4}{\pm}2^{+1}$주, $1,281.30{\pm}178g$과 $1,234.32{\pm}193g$으로 통계학적으로 차이가 없었으며(P=0.26, P=0.38), 성비, 괴사성 대장염, 패혈증, 신생아호흡곤란증후군, 동맥관개존증, 뇌 내출혈 및 뇌실 내 출혈 등의 합병증의 비율, 평균 재원 기간에서도 유의한 차이는 없었다. 수유 시작 시기는 강화된 모유수유군과 미숙아 전용분유 수유군에서 각각 생후 $8.00{\pm}3.27$일 및 $8.86{\pm}5.37$일(P=0.99), 완전수유 도달 시기는 각각 수유시작 후 $41.78{\pm}20.47$일 및 $36.86{\pm}20.63$일로(P=0.55) 통계적으로 유의한 차이가 없었으며, 총정맥영양 기간 및 수유 곤란증상 횟수에도 유의한 차이는 없었다. 수유시작 시점부터의 체중, 신장, 두위의 성장 속도 및 절대치도 두 군 간에 유의한 차이가 없었으나 각 시점의 평균치를 비교하였을 때 수유 시작 후 7주째 체중은 강화된 모유수유군에서 더 빨리 증가하였다(P=0.03). 환자들의 초기 체중 감소 후 출생체중까지 회복되는데 걸리는 기간도 각각 $22.3{\pm}6.92$일 및 $24.32{\pm}10.68$일로 통계학적 차이는 없었으며(P=0.41), 체중 회복 후부터 퇴원까지의 체중 및 두위, 신장의 증가속도는 두 군에서 유의한 차이는 없었다. 퇴원 후 외래 추적 관찰을 한 각 군의 환자들의 체중, 신장, 두위의 평균치에도 유의한 차이는 없었다. 결 론 : 극소저체중출생아에서 모유강화제를 포함한 모유수유군과 미숙아 전용분유 수유군 간의 전반적인 성장 상태, 생화학적 검사 수치 및 합병증 발생에는 유의한 차이가 없어 모유 강화제는 고열량 수유를 필요로 하는 극소저체중출생아에서 부가적인 선택 사항이라고 하겠다.

• The International Journal of Costume Culture
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• 제7권2호
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• pp.135-150
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• 2004

The purpose of this study is to explicate the contemporary concept of the term 'sportswear' by studying the history of sportswear tradition in America where sportswear was first established and developed. American sportswear originated from some functional clothes made for specific sports during the 19th century. Early in 20th century, there occurred many significant events in America while Americans were undergoing two successive world wars. First of all, due to the wars, women's role in labor force became so significant that their social status was enhanced remarkably. With economy growing every decade, the amount of leisure time for American people substantially increased and, therefore they could develop their leisure activity culture. All these changes made Americans demand the need for comfortable and functional clothes suitable for their changed way of life. In response to this demand, the sportswear tradition became mature due to the contribution by many creative All-American designers, most of whom have made their active contributions since 1970s. Now the sportswear, which used to be designed for specific sports, developed into casual wear in general with its extended definition. The contemporary concept of sportswear is no longer limited to those clothes for specific sports. Sportswear has now become more like a casual activity wear which all classes of people can enjoy in their life. Since the concept and scope of sportswear is extended to a great degree today, we need a new professional term to correctly express the extended nature of these contemporary clothes.

• 기본간호학회지
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• 제19권1호
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• pp.35-45
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• 2012

Purpose: This study was done to explore the relationship between perceived patient safety culture and patient safety management activities among health personnel. Methods: This study was a cross-sectional survey. Participants were 342 health personnel working in two tertiary hospitals. Self-administered questionnaires were used to collect data from a convenience sample of 254 nurses and 88 doctors. Results: Scores on participants' perceived patient safety culture and patient safety management activities were just over the mean. There were significant differences in patient safety management activities by type of occupation, nurses' position, length of service, and work week. Doctors scored perceived patient safety culture and patient safety management activities significantly lower than nurses. In addition, perceived patient safety culture was significantly related to patient safety management activities. Factors which influence participants' patient safety management activities were communication, type of occupation, overall evaluation of patient safety, supervisor/manager, frequency with which events were reported, and nurse's position. Conclusion: Findings provide significant evidence that patient safety management activities are associated with perceived patient safety culture. Therefore, to build a positive safety culture, health personnel, especially doctors and general nurses need to visibly commit to patient safety management activities and be role models to ensure patient safety.

• 동의생리병리학회지
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• 제32권4호
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• pp.271-276
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• 2018

The purpose of pilot clinical trial is to evaluate the efficacy and safety of acupuncture therapy on TEWL(Transepidermal Water Loss) and skin hydration. A total of 36 human who visited Dongshin University Oriental Medical Center from October 2nd, 2015 to July 31st, 2016 were included in the pilot clinical trial. Acupuncture therapy was performed at Gokji(LI11) and Daechu(GV14). We observed change of TEWL(Transepidermal Water Loss), skin hydration before and after acupuncture therapy. In the primary endpoint, index of TEWL showed a statistically significant decline($8.01{\pm}2.55{\rightarrow}6.58{\pm}1.97g/h/m2$, $7.40{\pm}2.65{\rightarrow}4.99{\pm}1.89g/h/m2$). Index of skin hydration showed statistical significance($52.83{\pm}6.53{\rightarrow}56.82{\pm}7.24$, $63.50{\pm}8.57{\rightarrow}64.96{\pm}8.48$). To evaluate the safety, vital sign check were conducted and showed no statistically significant result. And there were no severe adverse events during this study. According to the above pilot clinical trial, it is suggested acupuncture therapy were effective for skin moisturizing.

• 동의신경정신과학회지
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• 제29권2호
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• pp.79-97
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• 2018

Objectives: The purpose of this systematic review was to investigate the clinical effects of neurofeedback training on reducing anxiety. Methods: Eight databases were used to extract clinical reports on neurofeedback intervention for anxiety reduction published until 2016. We analyzed the characteristics of selected studies and evaluated biases using the Risk of Bias (RoB) assessment. Results: A total of 22 clinical trials were extracted for the analysis. The risk of bias in most studies was high or unclear. The Chinese Classification of Mental Disorders-3 (CCMD-3) was the most frequently used diagnostic criteria, the Hamilton Rating Scale for Anxiety (HAMA) was the most frequently used assessment tool, and the alpha wave activity increase, sensorimotor rhythm (SMR), and theta wave training were the most frequently used intervention methods. All papers showed a statistically significant decrease of anxiety symptoms; however, significant adverse events were not reported. Conclusions: Neurofeedback intervention might be beneficial for reducing anxiety. However, the quality of the studies used in the analysis was low, and the heterogeneity of the population and interventions was revealed. Therefore, more scientifically designed clinical studies regarding neurofeedback training are required.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2005년도 학술발표회 논문집
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• pp.1184-1188
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• 2005

The impacts of turbidity flow induced by summer rainfall events on water supply, aquatic ecosystems, and socioeconomics are significant and major concerns in most of reservoirs operations. As a decision support tool, the real-time turbidity flow monitoring and modeling system RTMMS is under development using a laterally integrated two-dimensional (2D) hydrodynamic and water quality model. The objectives of this paper is to present the preliminary field observation results on the characteristics of rainfall-induced turbidity flows and their density flow regimes, and the model performance in replicating the fate and transport of turbidity plume in a reservoir. The rainfall-induced turbidity flows caused significant drop of river water temperature by 5 to $10^{\circ}C$ and resulted in density differences of 1.2 to $2.6kg/m^3$ between inflow water and ambient reservoir water, which consequently led development of density flows such as plunge flow and interflow in the reservoir. The 2D model was set up for the reservoir. and applied to simulate the temperature stratification, density flow regimes, and temporal and spatial turbidity distributions during flood season of 2004 After intensive refinements on grid resolutions , the model showed efficient and satisfactory performance in simulating the observed reservoir thermal stratification and turbidity profiles that all are essentially required to enhance the performance of RTMMS.

• The Korean Journal of Physiology
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• 제29권2호
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• pp.291-299
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• 1995

Lateral giant (LG)-mediated escape response of crayfish is sensitized by natural traumatic events. Such sensitization has previously been shown to be associated with increased transmission between primary afferents and sensory interneurons at the cholinergic synapse of LG escape reflex circuit. In the present study, it was firstly investigated as to whether transmission is also altered at other synapses of the LG-escape reflex circuit by traumatic shock-induced sensitization. Evidence that traumatic shock also directly affects the excitability of lateral giants is now provided by the finding that traumatic shock produces a significant reduction of the time needed for LG to recruit its contralateral homologue, which is defined as commissural delay. Octopamine, a naturally occurring neuromodulator in the crayfish nerve cord, has also been shown to enhance transmission at the cholinergic synapse between primary afferents and sensory interneurons, and has been conjectured to mediate sensitization. Like traumatic shock, $octopamine\;(10^{-5}-5{\times}10^{-4}\;M)$ also enhanced the efficacy of commissural transmission between lateral giants, as indicated by a significant reduction of commissural delay. This effect was blocked by an octopamine antagonist phentolamine, suggesting a specific action of octopamine on the octopamine receptor present on LGs. These observations suggest that both traumatic shocks and octopamine may cause a rather broad alteration in the excitability of the crayfish nervous system that contributes to the sensitization of the LG escape response.

• The Korean Journal of Pain
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• 제26권4호
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• pp.379-386
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• 2013

Background: Shivering related to spinal anesthesia may interfere with monitoring and is uncomfortable. The aim of the present study was to investigate low-dose intrathecal meperidine for the prevention of shivering after induction of spinal anesthesia in parturients with cesarean section. Methods: This was a prospective randomized, double-blind, placebo-controlled trial including 100 parturients, of American Society of Anesthesiologists (ASA) physical status I or II, scheduled for elective cesarean section under spinal anesthesia who were randomly assigned to a meperidine (0.2 mg/kg) plus hyperbaric lidocaine (5%, 75 mg, n = 50; group M) group or a placebo plus hyperbaric lidocaine (5%, 75 mg, n = 50; group L) group. Demographic and surgical data, adverse events, and the mean intensity for each parturient were assessed during the entire study period by a blinded observer. Results: There were no significant differences between the two study groups regarding the demographic and surgical data (P > 0.05). The incidence of shivering during the entire study period significantly decreased in the group of parturients who received intrathecal meperidine (P = 0.04). There were no significant differences in nausea and vomiting between the two groups. Conclusions: Low-dose intrathecal meperidine (10 mg) is safe and effective in reducing the incidence and severity of shivering associated with spinal anesthesia in parturients with cesarean section.

• Journal of Microbiology and Biotechnology
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• 제27권8호
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• pp.1367-1378
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• 2017

Epigenetic alterations such as DNA methylation, histone acetylation, and chromatin remodeling can control gene expression by regulating gene transcription. DNA methylation is one of the frequent epigenetic events that play important roles in cancer development. Cancer cells can gain significant resistance to anticancer drugs and escape programmed cell death through major epigenetic changes, including DNA methylation. To date, several research groups have identified instances of both (i) hypermethylation of tumor suppressor genes, and (ii) global hypomethylation of oncogenes. These changes in DNA methylation status could be used as biomarkers for the diagnosis and prognosis of cancer patients undergoing chemotherapies or other clinical therapies. Herein, we describe genes for which methylation is dependent upon anticancer drug resistance in patients with gastric cancer; we then suggest a significant epigenetic target to focus on for overcoming anticancer drug resistance.