• 수산경영론집
• /
• 제43권2호
• /
• pp.79-94
• /
• 2012

The purpose of this study is to investigate the production efficiencies of the Korean aquaculture fishery with respect to species and methods using a Data Envelopment Analysis. The study extracted the 8 fishes in each of the sea cage culture, aquarium basin, and enclosed aquaculture for the analytical purposes. First, the study estimated the technical, pure technical, and scale efficiencies of the total of 24 aquaculture fishes based on the traditional DEA under the assumptions of both CRS and VRS. 2 fishes were identified as the efficient DMUs under the CCR-model, and 6 fishes under the BCC-model. Second, we tested to see if there was any difference in production efficiencies regarding those three different methods of aquaculture. we could not find any evidence of the differences in efficiency using a rank sum test based on the traditional DEA. However, we could do find that the pure technical efficiency in the sea cage culture was lower than others at 1% level of significance and the pure technical efficiency in enclosed aquaculture was also lower than others at 5% level of significance using Bilateral-DEA, which could explicitly consider the heterogeneity in the 3 production methods of aquaculture. Finally, the study obtained the 95% confidence intervals of the efficiency scores for the 24 fishes under our study using the smoothed bootstraping method in the process of the re-sampling in cooperation with both a kernel density estimation and a reflection method. At the same time, we could estimate the bias-corrected efficiency scores while the traditionally estimated efficiency scores suffered from the biases in the process of solving a linear programming with the deterministic nature of a production frontier. And hence, we could distinguish the differences in production efficiencies of the 8 fishes with respect to those 3 methods of aquaculture.

• Asian Pacific Journal of Cancer Prevention
• /
• 제13권4호
• /
• pp.1491-1494
• /
• 2012

Background: Previous studies have pointed to many different prognostic factors for small cell lung cancer (SCLC) but diabetes mellitus (DM) has not been clearly or consistently identified as of prognostic value. The aim of this study was to investigate the prognostic significance of the characteristics of patients and clinical laboratory tests in SCLC. Specifically, we investigated that the impact of DM for survival in the patients receiving first-line etoposide plus cisplatin (EP) chemotherapy. Methods: We retrospectively reviewed 161 patients with SCLC with a focus on DM and other potential prognostic variables were chosen for univariate and multivariate analyses with respect to survival. Result: Among the sixteen variables of univariate analysis, five were identified to have prognostic significance: performance status (PS) (p<0.001), stage (p=0.001), DM (p=0.005), serum albumin (p<0.001) and hemoglobin levels (p=0.03). Multivariate analysis showed PS, stage and serum albumin level to be independent prognostic factors for survival (p=0.02, p=0.02 and p=0.009 respectively), but DM was not an independnet factor. Conclusion: In conclusion, PS, stage and serum albumin level were identified as important prognostic factors, while DM at the time of diagnosis of SCLC did not have prognostic importance for survival.

• Asian Pacific Journal of Cancer Prevention
• /
• 제13권8호
• /
• pp.3869-3872
• /
• 2012

Background: The majority of patients with gastric cancer in developing countries present with advanced disease. Systemic chemotherapy therefore has limited impact on overall survival. Patients eligible for chemotherapy should be selected carefully. The aim of this study was to analyze prognostic factors for survival in advanced gastric cancer patients undergoing first-line palliative chemotherapy. Methods: We retrospectively reviewed 107 locally advanced or metastatic gastric cancer patients who were treated with docetaxel and cisplatin plus fluorouracil (DCF) as first-line treatment between June 2007 and August 2011. Twenty-eight potential prognostic variables were chosen for univariate and multivariate analyses. Results: Among the 28 variables of univariate analysis, nine variables were identified to have prognostic significance: performance status, histology, location of primary tumor, lung metastasis, peritoneum metastasis, ascites, hemoglobin, albumin, weight loss and bone metastasis. Multivariate analysis by Cox proportional hazard model, including nine prognostic significance factors evident in univariate analysis, revealed weight loss, histology, peritoneum metastasis, ascites and serum hemoglobin level to be independent variables. Conclusion: Performance status, weight loss, histology, peritoneum metastasis, ascites and serum hemoglobin level were identified as important prognostic factors in advanced gastric cancer patients. These findings may facilitate pretreatment prediction of survival and can be used for selecting patients for treatment.

• 복식문화연구
• /
• 제15권6호
• /
• pp.1038-1052
• /
• 2007

The purpose of this study is to analyze present the pattern making of the lining fabrics calculating the right ease and rising quantities of arm-hole when the pattern of the lining fabrics of stretchable jacket fabrics is produced. The outcomes of this study are as follows. The right ease of lining fabrics was not room of 0cm as patterns being same the right side of fabrics in the girth of the chest, waist, and the edge of a garment and gets the most excellent valuation, and then the girth of the chest, and waist was applied to 2cm and around the edge of a garment 0cm in regular lining fabrics. In addition to, although the ease of patterns of the lining fabrics was more, it was not necessarily to satisfy. The result of the valuation according to the quantities of rising arm-hole of the pattern of the lining fabrics showed that the making lining fabrics that the quantities of rising arm-hole was 0.8cm in the body and 1.2cm in the sleeve in the both the stretchable fabrics and regular lining fabrics was the most excellent thing, and then 0cm in the body and 2cm in the sleeve, and then 0cm in the body and 0cm in the sleeve. The valuation of external appearance on the quantities of rising arm-hole was recognized similarly because of being rarely significance level, but around the chest and waist was recognized as being significance level in wearing satisfaction.

• 대한안전경영과학회지
• /
• 제16권1호
• /
• pp.169-176
• /
• 2014

This research discusses the characteristics and the implementation strategies for two types of quality metrics to analyze innovation effects in six sigma projects: fixed specification type and moving specification type. $Z_{st}$, $P_{pk}$ are quality metrics of fixed specification type that are influenced by predetermined specification. In contrast, the quality metrics of moving specification type such as Strictly Standardized Mean Difference(SSMD), Z-Score, F-Statistic and t-Statistic are independent from predetermined specification. $Z_{st}$ sigma level obtains defective rates of Parts Per Million(PPM) and Defects Per Million Opportunities(DPMO). However, the defective rates between different industrial sectors are incomparable due to their own technological inherence. In order to explore relative method to compare defective rates between different industrial sectors, the ratio of specification and natural tolerance called, $P_{pk}$, is used. The drawback of this $P_{pk}$ metric is that it is highly dependent on the specification. The metrics of F-Statistic and t-Statistic identify innovation effect by comparing before-and-after of accuracy and precision. These statistics are not affected by specification, but affected by type of statistical distribution models and sample size. Hence, statistical significance determined by above two statistics cannot give a same conclusion as practical significance. In conclusion, SSMD and Z-Score are the best quality metrics that are uninfluenced by fixed specification, theoretical distribution model and arbitrary sample size. Those metrics also identify the innovation effects for before-and-after of accuracy and precision. It is beneficial to use SSMD and Z-Score methods along with popular methods of $Z_{st}$ sigma level and $P_{pk}$ that are commonly employed in six sigma projects. The case studies from national six sigma contest from 2011 to 2012 are proposed and analyzed to provide the guidelines for the usage of quality metrics for quality practitioners.

• Archives of Pharmacal Research
• /
• 제29권12호
• /
• pp.1158-1163
• /
• 2006

More than 95% of lead, a environmental heavy metal, entering into blood accumulates in erythrocytes suggesting erythrocytes as an important target of lead toxicity. Recent studies reported that erythrocytes could contribute to blood coagulation via phosphatidylserine (PS) exposure in erythrocytes. However, in vivo effects of chronic lead exposure especially by drink-ing water on procoagulant activity of erythrocytes have not been studied yet. In the present study, we investigated the effects of chronic exposure of lead by drinking water on erythrocytes in rats. Groups of 40 male rats were provided with drinking water containing various concentrations of lead for 4 weeks and complete blood cell count, procoagulant activities of erythrocytes and platelets were evaluated with basic inspections on body weight and food/water consumption. The administration of lead containing drinking water increased the blood lead level (BLL) in a dose-dependent manner up to $22.39{\pm}2.26\;{\mu}g/dL$. Water consumption was significantly decreased while food consumption or body weight gain was not affected. In contrast to the previous findings with acute lead exposure, chronic lead exposure failed to increase PS exposure in erythrocytes with statistical significance although some trends of enhancement were observed. It implies that a certain adaptation might have happened in body during repeated exposure to lead, resulting in attenuation of PS exposure. With this study, we believe that a valuable information was provided for the study on the toxicological significance and the risk assessment of lead contaminated drinking water.

• 한국산업보건학회지
• /
• 제19권3호
• /
• pp.270-279
• /
• 2009

In order to check a necessity of health control for the laborers who are in use of mixed organic solvents in the printing industries, this study evaluated the use status of mixed organic solvents, health subjective symptoms on the exposure of the solvents, health hazard for each kind of printings for the employees who work for the printing industries located in Seoul and Gyeonggi. The study analyzed 228 sites and 311 people responded of the total 250 sites surveyed from March to September 2007, and obtained the following results; 1) Estimating the exposure of the mixed organic solvents, the study found that estimation of mixture(EM) was different for each kind of printings at a level of significance, excessiveness of EM was 7.5%, the highest, for gravure printing, 5.6% for screen printing, 4.7% for master printing, 2.9% for offset printing. 2) As to the mean scores of health subjective symptoms for each kind of printings, workers in screen printing showed high scores in every subjective symptom, of which symptom of central nervous system was 3.75, the highest, and the difference was statistically at a level of significance(p<0.01). 3) Results of the hazard analysis for carcinogens and non-carcinogens contained in the mixed organic solvents exposed to the workers showed that cancer risk of offset printing workers was $7.8{\times}10^{-9}$ for benzene, the mean cancer risk was $2.02.{\times}10^{-8}$ from Monte-Carlo simulation, and both risks did not exceed the US EPA permissible standard of $1{\times}10^{-6}$. The total hazard indices of the non-carcinogens estimated was 3.523, the highest, for gravure printing, 2.381 for master printing, 1.125 for screen printing, respectively, and all exceeded 1.

• 응용통계연구
• /
• 제21권4호
• /
• pp.615-620
• /
• 2008

공업실험에서는 주효과의 검정력을 높일 목적으로 교호작용효과에 대한 예비검정의 결과가 유의하지 않은 경우에, 이 효과를 오차항으로 풀링한 후에 주효과의 유의성을 검정하는 때때로 풀링 (Sometimes pooling)의 분석 방법을 사용한다. 이 소고에서는 때때로 풀링의 규칙에 관한 참고문헌의 내용을 정리하고, 블록효과가 오차항으로 풀링되었다는 사실이 알려 졌을 때에 독립표본에 의한 모평균의 차이에 대한 95% 신뢰구간의 길이가 쌍체비교에 의한 신뢰구간의 길이보다 짧을 확률을 다양한 예비검정의 유의수준 ${\alpha}_1$값과 충분한 검정력이 보장되지 않은 블록의 크기인 $2{\leq}n{\leq}13$ 범위에서 살펴보았는데, 그 결과는 풀링한 경우에 주효과에 대한 검정력이 높아진다는 사실을 뒷받침하고 있다.

• Genomics & Informatics
• /
• 제8권1호
• /
• pp.28-33
• /
• 2010

Increased exposure of human to RF fields has raised concerns for its potential adverse effects on our health. To address the biological effects of RF radiation, we used genome wide gene expression as the indicator. We exposed normal WI-38 human fibroblast cells to 1763 MHz mobile phone RF radiation at a specific absorption rate (SAR) of 60 W/kg with an operating cooling system for 24 h. There were no alterations in cell numbers or morphology after RF exposure. Through microarray analysis, we identified no differentially expressed genes (DEGs) at the 0.05 significance level after controlling for multiple testing errors with the Benjaminiochberg false discovery rate (BH FDR) method. Meanwhile, 82 genes were differentially expressed between RF-exposed cells and controls when the significance level was set at 0.01 without correction for multiple comparisons. We found that 24 genes (0.08% of the total genes examined) were changed by more than 1.5-fold on RF exposure. However, significant enrichment of any gene set or pathway was not observed from the functional annotation analysis. From these results, we did not find any evidence that non-thermal RF radiation at a 60-W/kg SAR significantly affects cell proliferation or gene expression in WI-38 cells.

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권8호
• /
• pp.3801-3804
• /
• 2014

Background: The prognostic significance of the neutrophil-to-lymphocyte ratio for progression free survival in patients with metastatic renal cell carcinoma is unclear. Materials and Methods: We retrospectively reviewed 45 patients diagnosed with metastatic RCC previously treated with tyrosine kinase inhibitors from two centers, Akdeniz University Hospital and Afyon Kocatepe University. The prognostic value of the pretreatment neutrophil-tolymphocyte ratio, and other clinical and laboratory parameters were assessed by univariate and multivariate analysis. Results: Median progression free survival (PFS) was 13.9 months [95% CI for HR (6.88-20.91)] and overall survival figure of 16.6 months [95% CI for HR (7.23-26.03)] Univariate analysis revealed that PFS was significantly affected by hemoglobin level [p=0.013 (95% CI for HR (0.71-0.96))], eosinophil count [p=0.031 (95% CI for HR (0.20-0.92))], ratio of neutrophil lymphocytes (NLR) [p=0.007 (95% CI for HR (1.47-11.74))] and calcium level [p=0.006 (95% CI for HR (0.15-0.73))]. However, only NLR [p=0.031 (95% CI for HR (1.15-18.1))] and calcium levels [p=0.018 (95% CI for HR (0.20-18.1))] retained significance with multivariate analysis. Median PFS was 23.9 vs 8.6 months in patients with NLR ${\leq}2$ vs NLR >2 (Log rank; p= 0.040). Conclusions: This study showed that increased pretreatment NLR is an independent prognostic factor for patients with metastatic RCC using tyrosine kinase inhibitors.