• Proceedings of the Microbiological Society of Korea Conference
• /
• 2007.05a
• /
• pp.120-122
• /
• 2007

All living organisms use numerous signal-transduction pathways to sense and respond to their environments and thereby survive and proliferate in a range of biological niches. Molecular dissection of these signalling networks has increased our understanding of these communication processes and provides a platform for therapeutic intervention when these pathways malfunction in disease states, including infection. Owing to the expanding availability of sequenced genomes, a wealth of genetic and molecular tools and the conservation of signalling networks, members of the fungal kingdom serve as excellent model systems for more complex, multicellular organisms. Here, we employed Cryptococcus neoformans as a model system to understand how fungal-signalling circuits operate at the molecular level to sense and respond to a plethora of environmental stresses, including osmoticshock, UV, high temperature, oxidative stress and toxic drugs/metabolites. The stress-activated p38/Hog1 MAPK pathway is structurally conserved in many organisms as diverse as yeast and mammals, but its regulation is uniquely specialized in a majority of clinical Cryptococcus neoformans serotype A and D strains to control differentiation and virulence factor regulation. C. neoformans Hog1 MAPK is controlled by Pbs2 MAPK kinase (MAPKK). The Pbs2-Hog1 MAPK cascade is controlled by the fungal "two-component" system that is composed of a response regulator, Ssk1, and multiple sensor kinases, including two-component.like (Tco) 1 and Tco2. Tco1 and Tco2 play shared and distinct roles in stress responses and drug sensitivity through the Hog1 MAPK system. Furthermore, each sensor kinase mediates unique cellular functions for virulence and morphological differentiation. We also identified and characterized the Ssk2 MAPKKK upstream of the MAPKK Pbs2 and the MAPK Hog1 in C. neoformans. The SSK2 gene was identified as a potential component responsible for differential Hog1 regulation between the serotype D sibling f1 strains B3501 and B3502 through comparative analysis of their meiotic map with the meiotic segregation of Hog1-dependent sensitivity to the fungicide fludioxonil. Ssk2 is the only polymorphic component in the Hog1 MAPK module, including two coding sequence changes between the SSK2 alleles in B3501 and B3502 strains. To further support this finding, the SSK2 allele exchange completely swapped Hog1-related phenotypes between B3501 and B3502 strains. In the serotype A strain H99, disruption of the SSK2 gene dramatically enhanced capsule biosynthesis and mating efficiency, similar to pbs2 and hog1 mutations. Furthermore, ssk2, pbs2, and hog1 mutants are all hypersensitive to a variety of stresses and completely resistant to fludioxonil. Taken together, these findings indicate that Ssk2 is the critical interface protein connecting the two-component system and the Pbs2-Hog1 pathway in C. neoformans.

• The Journal of Korean Institute of Communications and Information Sciences
• /
• v.28 no.9B
• /
• pp.774-782
• /
• 2003

Generally, in the Mobile IP technologies, the use of RSVP(Resource ReSerVation Protocol) is recommended in order to provide a mobile node real-time service. However, the handoff of a mobile node increases the registration delay, RSVP reservation delay and signalling overhead in the Mobile IP and RSVP interworking. Specially, the resource reservation on the path between a mobile node and a correspondent node is the duplicated reservation and then causes unnecessary creation of the signalling overhead and waste of the resource, since the majority of the path before handoff and after handoff is same. If the radius of a cell providing a wireless interface to a mobile node is small, the number of handoff will increase and also signalling overhead and duplicated resource reservation will increase. In this paper, we proposed the integration model of Cellular IP and RSVP with RSVP proxy scheme. Here, Cellular IP protocol minimizes registration delay, transfer delay, and loss by handoff in micro cell network, the RS VP proxy that minimizes the duplication of resource reservation prevents the path for RSVP session from change using the address for reservation of a mobile node. Proposed scheme was evaluated in comparison with the existing Mobile IP and RSVP interworking scheme using the probability of resource reservation fail to the radius of a cell and the handoff rate.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.14 no.6
• /
• pp.2985-2991
• /
• 2013

Train radio system has been constructed in the second stage of Kyung-bu high speed railway adopting TETRA(Terrestial trunk radio) standard at 851MHz frequency band. The base stations of the train radio system should be located along railway track to ensure seamless communication between train and wayside taking the path loss of train radio propagation into consideration. This paper provides a quantitative analysis of the path loss characteristics based on the measurement results of the train radio propagation along the high speed railway. The free space propagation model and Okumura-Hata model are generally used for base station design, but they predicted 10dB lower or 20dB higher than the measured path loss. Linear regression of the field measured data by applying the log-distance model shows path loss exponent is in the 2.8-3.2 range, which can be used to predict the path loss of the train radio propagation.

• Journal of the Korean Society for Railway
• /
• v.16 no.6
• /
• pp.460-465
• /
• 2013

Radio propagation in a high-speed railway is affected by ground reflective waves that are due to irregular reflection by the railway track, which consists of rails, sleepers, and gravel. This paper provides a train radio propagation model that simulates an irregular track reflective wave as a random variable. A simulation study using the train radio propagation model shows that the path loss exponent is around 3.0, indicating a reduced path loss compared to the value of 4.0 in the general mobile radio environment. Regressive analysis of the received signal strength indicators measured in the Gyeongbu high-speed railway showed the results identical to those of the simulation. These results confirm the train radio propagation model and can be applied to the coverage estimation and the design of a train radio network.

• Journal of the Korean Institute of Telematics and Electronics S
• /
• v.35S no.2
• /
• pp.31-39
• /
• 1998

In this paper, we have presented a quantitative performance effect of CCP(Call Control Processor) when SAAL(Signalling ATM Adaptation Layer) function is distributed from CCP to SIMs(Subscriber Interface Modules) in an ATM switching system with distributed architecutre. For the performance analysis, SLAM II simulation language is used and subscriber signalling messageand inter-processor communication messages according to Q.2931 based local call processing procedure are taken into consideration in the proposed queuing network model. The results of simulation are compared with in case of processing SAAL function on CCP. It is observed that the processing utilization of CCP reach 24,000 BHCA and 25,700 BHCAwhen SAAL function load amounts to 10% and 20% of the processing time of the total message, respectively. These values shows that the processing utilization of CCP is alleviated about 7% in comparison with 2,000 BHCA in case that SAAL function is carried out on CCP. Consquently, it is shown that we have to consider seriously how to distribute the functions concerning call processing in a large cale ATM switching system architecture accomodating a number of SIMs.

• The Journal of Korean Institute of Communications and Information Sciences
• /
• v.16 no.8
• /
• pp.732-744
• /
• 1991

In this paper, performance evaluation of the common channel signalling module which performs the message transfer part function of the CCITT No.7 in TDX 1 exchange is carried out. Simulation model is developed using SLAM II network nodes according to signalling mode and transrated into SLAM II statement, . The simulation results are compared with experimental results and analyzed in order to get the maximum throughput, processing delay time, bottleneck eiement. Also, in order to get the optimized structure of the CSM, simulation is performed on the vanous case, namely, change of the number of STB, change of STG bus or B bus speed, change of CSIOB, processing speed, change of the number of transfered message per one poll.

• The Journal of Korean Institute of Communications and Information Sciences
• /
• v.21 no.7
• /
• pp.1746-1755
• /
• 1996

In this paper, we propose the protocol stact and the server functions of IWU which interconnects distributed LAN's users by using of B-ISDN. The protocol stact of interconnecting IWU under consideration users TCP/IP in upper layer. TCP/IP is popular communication protocol in interconnecting distributed LANs. The interconnecting IWU has server functions for transfering datagrams to B-ISDN such as address translation, fragment and reassembly, CL server, signalling and traffic control. We analyze the performance ofinterconnecting IWU with M/M/1/K queueing model and obtain the throughput and buffer size of interconnecting IWU.

• KDI Journal of Economic Policy
• /
• v.12 no.2
• /
• pp.95-120
• /
• 1990

The underpricing of new shares of a firm that are offered to the public for the first time (initial offerings) is well known and has puzzled financial economists for a long time since it seems at odds with the optimal behavior of the owners of issuing firms. Past attempts by financial economists to explain this phenomenon have not been successful in the sense that the explanations given by them are either inconsistent with the equilibrium theory or implausible. Approaches by such authors as Welch or Allen and Faulhaber are no exceptions. In this paper, we develop a signalling model of capital investment to explain the underpricing phenomenon and also analyze the efficiency of investment. The model focuses on the information asymmetry between the owners of issuing firms and general investors. We consider a firm that has been owned and operated by a single owner and that has a profitable project but has no capital to develop it. The profit from the project depends on the capital invested in the project as well as a profitability parameter. The model also assumes that the financial market is represented by a single investor who maximizes the expected wealth. The owner has superior information as to the value of the firm to investors in the sense that it knows the true value of the parameter while investors have only a probability distribution about the parameter. The owner offers the representative investor a fraction of the ownership of the firm in return for a certain amount of investment in the firm. This offer condition is equivalent to the usual offer condition consisting of the number of issues to sell and the unit price of a share. Thus, the model is a signalling game. Using Kreps' criterion as the solution concept, we obtained an essentially unique separating equilibrium offer condition. Analysis of this separating equilibrium shows that the owner of the firm with high profitability chooses an offer condition that raises an amount of capital that is short of the amount that maximizes the potential profit from the project. It also reveals that the fraction of the ownership of the firm that the representative investor receives from the owner of the highly profitable firm in return for its investment has a value that exceeds the investment. In other words, the initial offering in the model is underpriced when the profitability of the firm is high. The source of underpricing and underinvestment is the signalling activity by the owner of the highly profitable firm who attempts to convince investors that his firm has a highly profitable project by choosing an offer condition that cannot be imitated by the owner of a firm with low profitability. Thus, we obtained two main results. First, underpricing is a result of a signalling activity by the owner of a firm with high profitability when there exists information asymmetry between the owner of the issuing firm and investors. Second, such information asymmetry also leads to underinvestment in a highly profitable project. Those results clearly show the underpricing entails underinvestment and that information asymmetry leads to a social cost as well as a private cost. The above results are quite general in the sense that they are based upon a neoclassical profit function and full rationality of economic agents. We believe that the results of this paper can be used as a basis for further research on the capital investment process. For instance, one can view the results of this paper as a subgame equilibrium in a larger game in which a firm chooses among diverse ways to raise capital. In addition, the method used in this paper can be used in analyzing a wide range of problems arising from information asymmetry that the Korean financial market faces.

• Journal of the Korean Society for Railway
• /
• v.15 no.6
• /
• pp.609-615
• /
• 2012

TPS (Train Performance Simulation) based on ATO (Automatic Train Operation) is required for driverless LRT (Light Rail Transit) operation plan instead of typical TPS based on driver operation. In this paper, new TPS model using ATO pattern is proposed and compared with the automatic train operation result in a test line of Seoul Metro Line 6 and in a whole line of Busan-Gimhae LRT. The actual ATO pattern can be very accurately simulated by new TPS model with the introduction of 4 parameters such as commercial braking rate, jerk, station stop profile and grade converted distance. The commercial scheduled time for driverless automatic train operation can be proposed to have "Fast" mode TPS trip time plus 3 seconds/km margin recommended by Korean standard LRT specification in this paper.

• The Korean Journal of Financial Management
• /
• v.13 no.1
• /
• pp.285-309
• /
• 1996

Using initial public offerings of 512 UK companies newly admitted to London Stock Exchange between 1985 and 1990, we explored the reason of underpricing of new issues. We particularly examined the underpricing of new issues in terms of signalling hypothesis. We found that there is a positive relationship between the value of the issuing firms and the fraction of equity retained by entrepreneurs. This finding is consistent with Leland and Pyle's model(1977) and the evidence of Downes and Heinkel(1982). We also found a positive association between the firm value and the degree of underpricing. In addition, our empirical evidence revealed that the underpricing of the UK IPOs is positively related to the fraction of equity retained by the original shareholders. Thus, our results support Grinblatt and Hwang's model(1989) which predicts a positive relationship between the value of firm and the degree of underpricing.