• 융합정보논문지
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• 제7권3호
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• pp.105-109
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• 2017

본 연구는 기업의 배당공시 이후 애널리스트들의 이익 추정 수정치가 주가에 어떤 영향을 미치는지 살펴보았다. 우선, 배당공시 이후 발표된 애널리스트들의 이익 추정치에 대한 주가 반응을 추정한 결과, 이익 추정이 상향조정된 기업들은 그렇지 못한 기업들에 비해 통계적으로 유의한 양(+)의 누적초과수익률을 기록한 것으로 나타났다. 그리고 배당공시와 이익 추정치 발표의 상호관계에 있어서 '신호효과'와 '확증효과'를 검증하였다. 검증 결과, 확증효과가 우세한 것으로 나타났다. 이는 배당과 이익 수정이 동일한 방향일 때는 시장이 반응을 하지만, 서로 다른 방향일 때는 시장에 중요한 정보가 되지 못함을 의미한다.

• Asian-Australasian Journal of Animal Sciences
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• 제29권4호
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• pp.571-579
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• 2016

In this work, we prepared a panel of monoclonal anti-idiotypic antibodies to ovine prolactin (oPRL) by the hybridoma technique. Among these antibodies, one anti-idotypic antibody (designated B7) was chosen for further characterization by a series of experiments. We first demonstrated that B7 behaved as a typical $Ab2{\beta}$ based on a series of enzyme-linked immunosorbent assays. Subsequently, the results of a competitive receptor-binding assay confirmed that B7 could specifically bind to the prolactin receptor (PRLR) expressed on target cells. Finally, we examined its biological activities in CHO-PRLR and Nb2 cells and observed that B7 could activate Janus kinase 2-signal transducer and activator of transcription signalling in CHO-PRLR and Nb2 cells and induce BaF3 proliferation. The present study suggests that i) B7 can serve as a PRLR agonist or PRL mimic and has potential applications in regulating mammary gland development, milk production and maintenance of lactation in domestic animals and ii) B7 may be a biological reagent that can be used to explore the mechanism of PRLR-mediated intracellular signalling.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1996년도 제4회 추계심포지움
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• pp.135-139
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• 1996

$p70^{s6k}$ lies on a $p21^{ras}$-independent signalling pathway and plays an important role in mitogenesis. Activation is associated with phosphorylation at multiple sites, four of which lie in an autoinhibitory region. The immunosuppressant rapamycin induces $p70^{s6k}$ inactivation through dephosphorylation of a second set of mitogen-induced sites. Here we identify these sites as $T_{229}$, $T_{389}$, and $S_{404}$. $T_{229}$ resides in the "T loop" of the catalytic domain, an essential phosphorylation site in other kinases. However, $p70^{s6k}$ inactivation by rapamycin most closely parallels $T_{389}$ dephosphorylation. Mutation of $T_{389}$ to alanine ablates kinase activity, whereas mutation to glutamic acid confers constitutive kinase activity and rapamycin resistance. indicating an essential role for phosphorylation at this site. $T_{389}$ resides in an unusual hydrophobic motif, not previously noted, between the catalytic and autoinhibitory domains. The importance of this site, and surrounding motif, is emphasized by its conservation in other kinases including homologues of $p70^{s6k}$ derived from such distantly related organisms as yeast and plant.

• 약학회지
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• 제53권3호
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• pp.156-160
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• 2009

The present study was undertaken to determine whether transgelin participates in the regulation of vascular smooth muscle contraction and, if so, to investigate the mechanism. By PCR homology cloning, the cDNA sequence of ferret transgelin was determined and phosphorothioate antisense and random oligonucleotides were synthesized and introduced into strips of ferret aorta by a chemical loading procedure. Treatment of ferret aorta with transgelin antisense oligonucleotides resulted in a significant decrease in protein levels of transgelin to sham- or random sequence-loaded muscles, but no change in the protein levels of actin. Contraction in response to a phorbol ester was significantly decreased in antisense-treated muscles compared to sham- or random sequence-loaded controls. Neither basal intrinsic tone nor the contraction in response to phenylephrine was significantly affected by the antisense treatment. The data indicate that transgelin plays a significant role in the regulation of contraction and suggest that in a tonically active smooth muscle transgelin may function as a signalling protein to facilitate PKC or ERK-dependent signalling rather than thick filament regulation including $Ca^{2+}$ or calmodulin dependent regulation of myosin light chain kinase.

• 전자공학회논문지 IE
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• 제48권3호
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• pp.20-25
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• 2011

본 논문은 와이브로 통신환경에서 SDR(Software Defined Radio) 시스템을 위한 실행속도 증진 방법을 개발하였다. 본 논문에서는 SDR 기능 구현을 위해 GPU(Graphics Processing Unit)라는 새로운 프로세서를 사용하였다. 일반적으로 통신시스템에서는 DSP(Digital Signalling Processor)나 FPGA(Field Programmable Gate Array)를 이용하여 시스템을 구현한다. 그러나 이러한 프로세서는 장단점이 커서 구현 및 디버깅을 하기 어렵다. GPU는 다수의 프로세서로 구성되어 있어 벡터 처리에 적합하며, 각 프로세서는 thread의 셋으로 구성이 되어 있다. 본 논문에서는 GPU만의 자원뿐만 아니라 CPU 자원 까지 사용하기 위한 Framework 또한 구현하였다. 다양한 실험결과, 본 제안 시스템이 와이브로 환경에서 우수한 성능을 제공함을 확인할 수 있었다.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1998년도 하계학술대회 논문집 A
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• pp.384-386
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• 1998

In the emergency case such as a single line operation in a double line section because of a line broken or train's mal-operation, single line equipments that can operate without a line indication are needed. The main purpose of this study is to verify and analyze the availability of the single line operation that is able to operate without the indication of up or down line, and to offer a realizably alternative method to improve this situation. In order to carry out this study, we concentrated on getting related information. And to adopt the single line operation to existing line, the technology survey of other countries signalling system and the technical analysis of the interior signalling equipment were performed. As a result of this study, the required system and effect of the single line operation system were represented.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1998년도 추계학술대회 논문집 학회본부 B
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• pp.630-632
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• 1998

The basic user location strategies proposed in current PCS(Personal Communication Services) Network are two-level Database strategies. These Databases which exist in the Signalling network always maintain user's current location information, and it is used in call setup process to a mobile user. As the number of PCS users are increasing, this strategies yield some problem such as concentrating signalling traffic on the Database, increasing Call setup Delay, and so on. In this paper, we proposed RCP(Reverse Connection setup Protocol) model, which apply RVC(Reverse Virtual Call setup) algorithm to PCS reference model, and CRCP(Cache algorithm in RCP) model, which adopt Caching strategies in the RCP model. When Cache-miss occur, we found that CRCP model require less miss-penalty than PCS model. Also we show that proposed models are always likely to yield better performance in terms of reduced Location Tracking Delay time.

• 한방안이비인후피부과학회지
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• 제22권1호
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• pp.11-32
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• 2009

Objective : This study was designed to investigate anti-cancer and whitening activities (LC). So it was investigated the effects of LC on proliferation rates of melanoma genetic profile by LC. Methods : The genetic profile for the effect of LC on human derived melanoma cell, SK-MEL-2, was measured using microarray technique, and the functional analysis on these genes were conducted. Total 441 genes were up-regulated and 830 genes down-regulated in cells treated with LC. Genes induced or suppressed by LC were all mainly concerned with basic signalling pathways, which are involved in cell growth, differentiation and migration. Especially, many genes, which are related in apoptosis and cell cycle arrest were up-regulated by treatment with LC, and genes related in cell cycle were down-regulated. Result : The network of total protein interactions were identified by using cytoscape program, and some key molecules, such as BCL2L1, SIN3A, SMAD2 and c-myc that can be used for elucidation of therapeutical mechanism of medicine in the future. Conclusion : These results suggest possibility of LC as addition drug and whitening cosmetics. In addition, it was also suggested that related mechanisms are involved in BCL2L1, SIN3A, SMAD2 and c-myc related signalling pathways.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2006년도 추계학술대회 논문집
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• pp.863-869
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• 2006

The existing Europe Standard, EN 50159 with respect of safety of railway signalling communication protocol has been changed into International Standard, IEC 62280. This Standard presents the requirement for safe communication between safety-related devices which connects with transmission system, there are both closed and open transmission system. Regardless of this international Standards, the communication protocol for interface between CTC communication server and external facilities has been standardized several years ago in our country, so this is applied to integrated CTC system in KORAIL. Two Standards are currently standardized as a protocol between CTC and external facilities, these standard protocols are also required high level safety as a communication link which is transmitted vital control information in common with the train control system. For that reason, we have made analysis of requirement for the safe transmission required by international standard. Under this analysis, we have studied safety features of communication protocol applying to our standard. In other words, we have researched that how many the requirement from international standard for safe transmission is reflected in domestic standard protocol, and also whether our standard makes sure of safety enough or not.

• 대한약침학회지
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• 제23권2호
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• pp.54-61
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• 2020

Inflammation is an immune response of the human body but excessive inflammation is taken as a major factor in the development of many diseases including autoimmune disorders, cancer and nerve disorders etc. In this regards the need is to suppress the inflammatory response. Suppression of extra or imperfect inflammatory response is not a big deal provided there is an exact knowledge of particular target in the body. Recent advancements in Pharmacological aspect made the therapy with improved outcomes in number of patients. Anticytokine therapy might be one of the important and novel approaches for inflammation and Arthritis. This can be achieved only when we go through the pathophysiology of expression and identification of mediators. Let's take an example of cytokine like interleukins (IL), chemokines, interferons (INF), tumor necrosis factors (TNF-α), growth factors, and colony stimulating factors) release pathway which is a major signalling protein in inflammatory response. In the present study we have reviewed the recent pharmacological therapeutic advancement, inflammatory mediators, receptors, and major signalling pathways. Such information will not only provide the idea about the mechanism of action of Pharmaceuticals and molecular targets but also it provides a new aspect for drug designing and new corrective approaches in existing clinical medicines. This study will be a source of good information for the researchers working in the area of drug designing and molecular Pharmacology especially in anti-inflammatory and anti arthritic medicines for target based therapy.