• BMB Reports
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• v.41 no.2
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• pp.93-101
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• 2008

The major cell wall components of bacteria are lipopolysaccharide, peptidoglycan, and teichoic acid. These molecules are known to trigger strong innate immune responses in the host. The molecular mechanisms by which the host recognizes the peptidoglycan of Gram-positive bacteria and amplifies this peptidoglycan recognition signals to mount an immune response remain largely unclear. Recent, elegant genetic and biochemical studies are revealing details of the molecular recognition mechanism and the signalling pathways triggered by bacterial peptidoglycan. Here we review recent progress in elucidating the molecular details of peptidoglycan recognition and its signalling pathways in insects. We also attempt to evaluate the importance of this issue for understanding innate immunity.

• Asian-Australasian Journal of Animal Sciences
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• v.14 no.12
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• pp.1785-1793
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• 2001

The interaction of growth hormone with it's receptor results in dimerization of receptor, a feature known in action of certain cytokines. The interaction results in generation of number of signalling molecules. The involvement of Janus kinases, mitogen activated kinases, signal transduction and activator of transcription proteins, insulin like substrate, phosphatidylinositol 3-kinase, phospholipase C, protein kinase C is almost established in growth hormone action. There are still many missing links in explaining diversified activities of growth hormone. Amino acid sequence data for growth hormones and growth hormone receptors from a number of species have proved useful in understanding species specific effects of growth hormone. Complete understanding of growth hormone action can have implications in designing drugs for obtaining desired effects of growth hormone.

• Proceedings of the KSR Conference
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• 2004.10a
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• pp.1297-1302
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• 2004

CBTC(Communication Based Train Control) System has many superior train control performances than conventional track-circuit-based train control system with higher train operation efficiency, and less installation and maintenance cost. It is expected that CBTC will replace the conventional train control systems in near future. As CBTC has different mechanisms from conventional track-circuit-based train control systems in identifying train positions, and communicating information between train and ground facility, we have to pay a earful attention to making the interface between CBTC equipments and other signalling devices. This paper provides the construction of the interface between CBTC equipment and other signalling equipments such as TTC(Total traffic Control) system. ATO. electronic interlocking devices.

• Proceedings of the KIEE Conference
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• 2000.07b
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• pp.1384-1386
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• 2000

To determine operational requirement, the environmental condition for an equipment must be investigated, and to certify equipment's normalized operation, appropriate test must be carried out under the considered environmental condition. The actual environmental conditions to which equipment is likely to be exposed are normally complex and will comprise a number of environmental factors and corresponding parameters, When defining the environmental conditions for a certain application it is, therefore, necessary to list the factors involved and select the appropriate severity. The operational environment is structured in two separate such as requirements, guidance and test specifications. For the preparation to determine operational requirement, operational environment of railway signalling equipment is investigated.

• Proceedings of the KSR Conference
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• 2003.05a
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• pp.511-516
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• 2003

It is very important to ensure system safety during the process of developing a system. Railway system is also devoting a great portion for the safety. Nowadays many countries leading railway industry have their own system assessment principles according to the situation of their train control systems. In this paper, several principles to derive Safety Integrity Level are represented in the railway signalling system. The characteristics of those principles are also considered respectively.

• Proceedings of the KSR Conference
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• 2000.05a
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• pp.157-163
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• 2000

Testing evaluation is a part of process for design, production, evaluation, operation and abolition, and is the process of certifying system performance. The main purpose of testing evaluation is to reduce the risk factor under the determining process. Testing process has the three step such as design qualification, integration and validation test in factory, system integration and commissioning test. Design Qualification is to verify errors on the design process. Integration and validation test in factory is for the H/W and S/W of an equipment and is to verify interface of subsystem, communication protocol and main functions. System integration and commissioning test is a functional test to adjust successful installation of equipment. According to the testing process, briefly consideration for test item, test method and test contents about signalling system is carried out.

• Proceedings of the KSR Conference
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• 2003.10c
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• pp.145-150
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• 2003

The national subway went under construction in 1971, and after three years of endeavor, Seoul subway line number one opened for traffic in 1974. Line number two went under construction in 1978 and it opened for traffic in 1984. With the use of safety operation for more than 20 years, the life cycle nearly came to an end. Therefore the improvements for the safety operation are unavoidable. The total system should not be affected when the new and conventional systems are overlapped, the system operation is in the initial stage, and it confronts the situation of abnormal operation. However, there is a total lack of experience in construction and improvement for the trains that are in the use of large transport and density headway. In this paper, we propose an improvement method of the subway signalling system using ATO (Automatic Train Operation control scheme) to which the latest Digital ATC is applied, and examine the first application model of ATO system.

• YAKHAK HOEJI
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• v.54 no.5
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• pp.323-327
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• 2010

Translationally controlled tumor protein (TCTP) activates basophils to release histamine and causes chronic inflammation. It was also reported that TCTP significantly reduced in brain of Alzheimer's Disease and Down Syndrome as compared to normal person, suggesting that TCTP might be involved in cognitive function. We wondered whether TCTP could act as a general inducer in neurotransmitters release in brain. We, therefore, investigated the role of TCTP in PC12 cell line which expressed neuronal properties. We found that TCTP could activate JNK, and the activity was inhibited by pretreatment of dicoumarol, a JNK inhibitor. However, TCTP could not activate ERK that has known to be involved in neurotransmitter release. These suggest TCTP did not participate in neurotransmitter release from PC12 cells, and TCTP might not be a general inducer in neurotransmitter release.

• Journal of Korean Institute of Industrial Engineers
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• v.22 no.4
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• pp.689-703
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• 1996

In this paper, we evaluate the performance of zone-based registration. First, we propose a mobility function for single zone-based registration. And we establish the circumstances of multiple zone-based registration, which is based on the mobility function for single zone-based registration, and perform simulation programs for the circumstances. Using the simulation results, we obtain optimal N, the number of multiple zones which minimizes signalling traffic in radio channels. Results show that in most cases optimal N is 2. Multiple zone-based registration has less signalling traffic in radio channels than single zone-based registration and zone-based registration must be implemented as multiple zone-based registration.

• Proceedings of the KIEE Conference
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• 2000.11b
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• pp.389-391
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• 2000

A representation technique of a given track topology is required by many software applications in railway technology such as signalling system simulator. To achieve these, the concept of double vertex graph architecture is proposed. These are composed of pairs of vertices and node between the single vertices. Double vertex graph architecture can be understood as a extension of classical graphs. In developed railway signalling simulation software, it is shown that track topology can be represented by proposed algorithm in a efficient way. Especially it makes sure that these are suitable technique for representing and implementing of switch, routes which can be introduced some mistake in classical graph algorithm.