• 한국정보통신학회논문지
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• 제12권8호
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• pp.1401-1407
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• 2008

최근 고령 인구의 증가에 따른 헬스 케어 수요가 증가하고 있고 환자뿐만 아니라 일반인들에게서도 헬스 케어 모니터링에 대한 요구가 급증하고 있다. 또한 의료 서비스를 제공받으려는 대상자의 불편을 최소화하고, 지속적인 모니터링을 통한 헬스 케어가 가능할 수 있는 의료 기술과 의료 정보 서비스에 대한 수요도 늘어나고 있는 추세이다. 본 논문에서는 헬스 케어를 위한 무선 생체신호 모니터링 시스템을 구현하였다. 구현된 시스템은 생체신호 측 정부와 무선 통신부로 구성된 센서 노드(sensor node)와 원격 시스템의 모니터링 프로그램으로 구성된다. 센서 노드에서는 심전도, 혈압, 맥파, 동맥혈산소포화도, 심박수를 측정할 수 있고 블루투스 기술을 이용하여 무선 전송을 하여 모니터링 시스템에서 실시간 무선 모니터링이 가능하도록 구현하였다.

• 대한통합의학회지
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• 제11권2호
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• pp.169-179
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• 2023

Purpose : Although human periodontal ligament stem cells (hPDLSCs) are a supportive factor for tissue engineering, oxidative stress during cell culture and transplantation has been shown to affect stem cell viability and mortality, leading to failed regeneration. The aim of this study was to evaluate the antioxidant and protective effects against cell damage of celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, and the antioxidant signal of hPDLSCs in H₂O₂-induced oxidative stress. Methods : To induce oxidative stress in cultured hPDLSCs, H₂O₂ was used as an exogenous reactive oxygen species (ROS). Dose-dependent celecoxib (.1, 1, 10, or 100 µM) was administered after H₂O₂ treatment. WST-1 assay was used to assess cell damage and western blot was used to observe antioxidant activity of hPDLSCs in oxidative stress. Immunohistochemistry was performed for inverting the localization of the SOD and Nrf2 antibody. Results : We found that progressive cell death was induced in hPDLSCs by H₂O₂ treatment. However, low-dose celecoxib reduced H₂O₂-induced cellular damage and eventually enhanced the SOD activity and Nrf2 signal of hPDLSCs. Oxidative stress-induced morphological change in hPDLSCs included lowered the survival and number of spindle-shaped cells, and shrinkage and shortening of cell fibers. Notably, celecoxib promoted cell survival function and activated antioxidants such as SOD and Nrf2 by positively regulating the cell survival signal pathway, and also reduced the number of morphological changes in hPDLS. Immunohistochemistry results showed a greater number of SOD- and Nrf2-stained cells in the celecoxib-treated group following oxidative stress. Conclusion : By increasing SOD and Nrf2 expression at the antioxidant system, the findings suggest that celecoxib enhanced the antioxidative ability of hPDLSCs and protected cell viability against H₂O₂-induced oxidative stress by increasing SOD and Nrf2 expression in the antioxidant system.

• 한국환경과학회지
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• 제18권6호
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• pp.603-608
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• 2009

Activated sludge sewage treatment processes are difficult to be controlled because of their complex and nonlinear behaviour, however, the control of the dissolved oxygen level in the reactors plays an important role in the operation of the facility. For this reason, this study is designed to present a system which accurately measures DO, MLSS, pH and ORP in the aeration tank to alleviate situations above and provide the automatization of a sewage treatment plant (STP) using new DO control system. The automatic control systems must be guaranteed the accuracy. Therefore, the proposed automatic DO control system in this study could be commercial applications in the aeration tanks by means of operating cost analysis and user-friendly for operation and maintenance. We could get accurate data from the lab tank which has water quality checker because there was no vortex and air bubble during the measurement process. Improvement of confidence in the lab tank enabled effective and automatic operation of sewage treatment plants so that operation costs and manpower could be saved. If this result is put in place in every sewage treatment plant nationwide for practical purposes, it is estimated to cost 18.5 million dollars in installing the lab tank and to save 9.8 million dollars in management cost a year, except for cost saved by automation.

• Journal of Magnetics
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• 제16권3호
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• pp.234-239
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• 2011

Transcranial magnetic stimulation utilizes the method of controlling applied time and changing pulse by output pulse through power density control for diagnosis purposes. Transcranial magnetic stimulation can also be used in cases where diagnosis and treatment are difficult since output pulse shape can be changed. As intensity, pulse range, and pulse shape of the stimulation pulse must be changed according to lesion, the existing sine wave-shaped stimulation treatment pulse poses limitations in achieving various treatments and diagnosis. This study actualized a new method of transcranial magnetic stimulation that applies a 3 Stage 2 Switch( power semiconductor 2EA) for controlling pulse repetition rate by achieving numerous switching control of stimulation coil. Intensity, pulse range, and pulse shape of output can be freely changed to transform various treatment pulses in order to overcome limitations in stimulation treatment presented by the previous sine wave pulse shape. The method of freely changing pulse range by using 3 Stage 2 Switch discharge method is proposed. Pulse shape, composed of various pulse ranges, was created by grafting PFN (Pulsed Forming Network) through AVR AT80S8535 one-chip microprocessor technology, and application in transcranial magnetic stimulation was achieved to study the output characteristics of stimulation treatment pulse according to delaying time of the trigger signal applied in section switch.

• 한국정보통신학회논문지
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• 제14권3호
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• pp.781-793
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• 2010

최근 유비쿼터스 센서네트워크 및 모바일 통신기술의 발달에 힘입어 헬스케어 시스템에 대한 많은 연구가 이루어지고 있다. 본 논문에서는 모바일 센서네트워크 기반의 u-Healthcare 시스템을 설계하고 구현하였다. 구현한 u-Healthcare 시스템은 댁내의 무선 센서네트워크, 원격지에 위치하는 헬스케어센터 및 센싱한 생체선호를 헬스케어 센터로 전송하는 게이트웨이 등 세 부분으로 구성된다. 환자의 생체신호를 측정하기 위하여 3 채널 ECG센서, 맥박산소 농도계, 혈압 센서 등 세 가지의 센서를 이용하였다. 각 센서는 mote에 탑재되어 있으며, mote는 센성된 생체신호를 Zigbee 통신을 이용하여 베이스 노드로 전송한다. 베이스 노드는 수신한 신호를 헬스케어 센터로 보내게 되고 헬스케어센터는 이 선호를 다양한 알고리즘을 이용하여 분석하고 처리한다. 처리된 결과를 표준 데이터베이스와 비교하여 식이요법, 운동요법 등 적절한 처방을 환자에게 SMS 또는 웹으로 전송한다. 이렇게 함으로서 환자는 주기적으로 자선의 건강을 체크하여 관리할 수 있으며, 경증의 건강상의 문제로부터 자신의 건강을 유지할 수 있게 된다.

• 한국ITS학회 논문지
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• 제5권1호
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• pp.31-43
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• 2006

실시간 교통정보 수집과 센터 온라인 신호제어를 기본기능으로 하는 경찰청 교통신호제어기 표준규격서가 개발되어 2005년 3월부터 발효되었다. 발표된 규격은 가로구간의 교통상황을 수집하고, 이를 관제센터에 전송하며, 적절한 교통상황별 신호시간을 부여받아 신호등을 제어하는 지능적인 교통신호기의 표준 사양과 기능을 주요 골자로 하고 있다. 과거의 교통신호기들은 부품이 호환되지 않고 제어기능과 통신방법이 상이하여 도시별로 호환되지 않았으며 유지관리의 시간적 경제적 비용을 증가시켰다. 또한 모순검지방법 등 일부 교통안전에 중요한 기능이 비합리적으로 사용되고 있었다. 본 규격에서는 이런 단점을 극복하기 위해 먼저 하드웨어 호환성을 확보하였다. 그리고 모순검지방법을 보완하였으며, 관제센터와의 통신규약을 규격에 포함하여 모든 도시의 센터에 호환되도록 하였다. 개발된 규격은 시제품 제작과 시험과정을 거쳐 결정되었다. 본 규격으로 제조자에 비 의존적인 유지보수체계가 가능해지며 저렴하고 빠른 고장 대응이 가능하다. 또한 일관된 정보처리 및 제어알고리즘이 적용되어 센터설치 업체의 지역선점효과가 점차 사라질 것이며, 지역별 교차로의 교통통제방법이 일원화되어 표준적이고 안전한 교통제어를 할 수 있을 것으로 기대된다.

• International Journal of Oral Biology
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• 제35권3호
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• pp.113-119
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• 2010

Porphyromonas (P.) gingivalis lipopolysaccharide (Pg LPS) is the major pathogenic component of periodontal disease. In this study, we have attempted to determine the expression profiles of the signal transduction pathway genes induced by Pg LPS in comparison with Escherichia (E.) coli LPS (Ec LPS). DC2.4 cells were treated for two hours with $1\;{\mu}g/ml$ of Pg LPS or $0.5\;{\mu}g/ml$ of Ec LPS. The total RNA from these cells was then isolated and reverse-transcribed. Gene expression profiles were then analyzed with a signal transduction pathway finder GEArray Q series kit and significant changes in expression were confirmed by real-time PCR. The microarray results indicated that several genes, including Tnfrsf10b, Vcam1, Scyb9, Trim25, Klk6, and Stra6 were upregulated in the DC2.4 cells in response to Pg LPS treatment, but were downregulated or unaffected by Ec LPS. Realtime PCR revealed that the expression of Trim25, Scyb9 and Tnfrsf10b was increased over the untreated control. Notably, Trim25 and Tnfrsf10b were more strongly induced by Pg LPS than by Ec LPS. These results provide greater insight into the signal transduction pathways that are altered by P. gingivalis LPS.

• 한국전자통신학회논문지
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• 제7권3호
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• pp.671-677
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• 2012

수면 중에 부정기적으로 발생하는 인체 이상유형을 모니터링하기 위한 블랙박스 프로그램을 구현하였다. 인체 블랙박스 시스템은 생체 신호를 계측하는 센서와 알람, 전등, 네트워크 카메라와 같은 보조 장치 및 신호를 모니터링 하는 컴퓨터로 구성되어 있다. 신체 이상 증상의 원인을 정확하게 규명하기 위하여 PPG, EOG, EEG, 호흡센서, 온도센서, G-센서 및 마이크로폰과 같은 다양한 센서를 이용하였다. 이상 증상이 발생하면 시스템은 치료에 활용할 수 있는 정보를 제공하기 위해서 환자의 상태를 기록한다. 신체 이상유형을 감지하게 위하여 적절한 센서 위치를 선정한다. 측정 데이터의 유형별 정상 범위에 근거하여, 신체 이상유형을 구별하기 위한 신호 수준을 선정하였다. 이상 신호가 계측되면 전등 및 알람, 네트워크 카메라가 동시에 작동하고, 센서 신호 및 비디오 데이터가 저장된다.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 2003년도 Annual Meeting of KSAP : International Symposium on Pharmaceutical and Biomedical Sciences on Obesity
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• pp.83-83
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• 2003

In our previous study, glucose deprivation was reported to induce the potentiated death and ATP loss in immunostimulated astroglia. And this vulnerability to glucose deprivation was due to overproduction of nitric oxide (NO) and hydrogen peroxide (H$_2$O$_2$). In the present study, the role of extracellular signal-regulated kinase 1/2 (ERK1/2) in the glucose deprivation-induced death of immunostimulated astroglia was examined. We showed that immunostimulation with LPS+IFN-ν activated the ERKl/2 signal pathway and produced a large amount of NO and H$_2$O$_2$. Generation of NO and H$_2$O$_2$ in immunostimulated astroglia was mediated via ERK1/2 signal pathways, since addition of the ERK kinase (MEKl) inhibitor PD98059 reduced NO and H$_2$O$_2$production. ERK1/2 activation-mediated NO and H$_2$O$_2$ production is due to an activation of iNOS and NADPH oxidase, respectively. Finally, we found that glucose deprivation caused ATP depletion and the augmented death in immunostimulated astroglia, which was also prevented by PD98059 treatment. These results demonstrate that the ERK1/2 signal pathways play an important role in glucose deprivation induced the death in immunostimulated astroglia by regulating the generation of NO and H$_2$O$_2$.

• 대한의용생체공학회:의공학회지
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• 제26권6호
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• pp.399-406
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• 2005

In these days, HIS(Hospital Information System) raise the quality of medical services by effective management of medical records. As computing environment was developed, it is possible to search information quickly. But, standard medical data exchange is not completed between medical clinic and another organ so far. In case of patient transfer, past medical record was not efficiently transmitted. It be feasible treatment delay or medical accident. It is trouble that medical records is transferred by a person and communicate with each other. Extensible Markup Language (XML) is a simple, very flexible text format derived from SGML. Originally designed to meet the challenges of large-scale electronic publishing, XML is also playing an increasingly important role in the exchange of a wide variety of data on the Web and elsewhere. Form in system of company product, relative organs that handle bio-signal data is each other dissimilar and integration and to transmit to supplement bottleneck this research uses XML. In this study, it is discussed about sharing of medical data using XML web technology to standard medical record between hospital and relative organization The data structure model was designed to manage bio-signal data and patient record. We experimented about data transmission and all-in-one between different systems (one make use of MS-SQL database system and the other manage existent bio-signal data in itself form in file in this research). In order to search and refer medical record, the web-based system was implemented. The system that can be shared medical data was tested to estimate the merits of XML. Implemented XML schema confirms data transmission between different data system and integration result.