• Journal of the Institute of Electronics Engineers of Korea SD
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• v.46 no.2
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• pp.24-30
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• 2009

In this paper, the FPGA modem platform complying with 3GPP Release 7 eHSPA specifications and its regularized verification flow are proposed. The FFGA platform consists of modem board supporting physical layer requirements, MCU and DSP core embedded control board to drive the modem board, and peripheral boards for RF interfacing and various equipment interfaces. On the other hand, the proposed verification flow has been regularized into three categories according to the correlation degrees of hardware-software inter-operation, such as simple function test, scenario test call processing and system-level performance test. When it comes to real implementations, the emulation verification strategy for low power mobile SoC is also introduced.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.26 no.7
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• pp.844-850
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• 2016

This study pertains to the extraction of the road noise component of signals from a vehicle's interior noise via the traditional frequency domain and time domain system identification methods. For road noise extraction based on the frequency domain system identification method, the appropriate matrix inversion strategy is investigated and causal and non-causal impulse response filters are compared. Furthermore, appropriate data lengths for the frequency domain system identification method are investigated. In addition to the traditional road noise extraction methods based on frequency domain system identification, a new approach to extract road noise via the time domain system identification method based on a parametric input-output model is proposed and investigated in the present study. In this approach, instead of constructing a higher order model for the full-band road noise, input and output signals are processed in the subband domain and lower order parametric models optimal to each subband are determined. These parametric models are used to extract road noises in each subband; the full band road noise is then reconstructed from the subband road noises. This study shows that both the methods in the frequency domain and the time domain successfully extract the road noise from the vehicle's interior noise.

• Biomolecules & Therapeutics
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• v.24 no.5
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• pp.489-494
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• 2016

Neuropathic pain (NPP) is the main culprit among chronic pains affecting the normal life of patients. Procaine is a frequently-used local anesthesia with multiple efficacies in various diseases. However, its role in modulating NPP has not been reported yet. This study aims at uncovering the role of procaine in NPP. Rats were pretreated with procaine by intrathecal injection. Then NPP rat model was induced by sciatic nerve chronic compression injury (CCI) and behavior tests were performed to analyze the pain behaviors upon mechanical, thermal and cold stimulations. Spinal expression of Janus kinase 2 (JAK2) and signal transducer and activator of transcription 3 (STAT3) was detected by qRT-PCR and western blot. JAK2 was also overexpressed in procaine treated model rats for behavior tests. Results showed that procaine pretreatment improved the pain behaviors of model rats upon mechanical, thermal and cold stimulations, with the best effect occurring on the $15^{th}$ day post model construction (p<0.05). Procaine also inhibited JAK2 and STAT3 expression in both mRNA (p<0.05) and protein levels. Overexpression of JAK2 increased STAT3 level and reversed the improvement effects of procaine in pain behaviors (p<0.01). These findings indicate that procaine is capable of attenuating NPP, suggesting procaine is a potential therapeutic strategy for treating NPP. Its role may be associated with the inhibition on JAK2/STAT3 signaling.

• Journal of Genetic Medicine
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• v.6 no.1
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• pp.25-37
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• 2009

Hereditary peripheral neuropathies can be categorized as hereditary motor and sensory neuropathies (HMSN), hereditary motor neuropathies (HMN), and hereditary sensory neuropathies (HSN). HMSN, HMN, and HSN are further subdivided into several subtypes. Here, we review the most recent findings in the molecular diagnosis and therapeutic strategy for hereditary peripheral neuropathies. The products of genes associated with hereditary peripheral neuropathy phenotypes are important for neuronal structure maintenance, axonal transport, nerve signal transduction, and functions related to the cellular integrity. Identifying the molecular basis of hereditary peripheral neuropathy and studying the relevant genes and their functions is important to understand the pathophysiological mechanisms of these neurodegenerative disorders, as well as the processes involved in the normal development and function of the peripheral nervous system. These advances and the better understanding of the pathogenesis of peripheral neuropathies represent a challenge for the diagnoses and managements of hereditary peripheral neuropathy patients in developing future supportive and curative therapies.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2005.11b
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• pp.134-139
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• 2005

This paper presents a robust design of vehicle interior noise using Taguchi method and a substructure synthesis method with a hybrid model. Firstly, the proposed method identifies the critical process of the concerned interior noise through a TPA (Transfer Path Analysis). Secondly, a strategy for a robust design is discussed, in which the major noise factor among uncertainties in the process is quality distribution of rubber bushes connecting a cradle and a trimmed body. Thirdly, a virtual test model fer the process is developed by applying a substructure synthesis method with a hybrid modeling approach. Fourthly, virtual tests are carried out according to the predefined tables of orthogonal array in Taguchi robust design process. The process was performed under 2 sub-steps. The first step is sensitivity analysis of 31 panels, and the other step is weight optimization of mass dampers on sensitive panels. Finally, two vehicles with the proposed countermeasures were validated. The proposed method reduces 87.5% of trials of measurements due to the orthogonal arrays and increases robustness by 8.6dB of S/N ratio and decreases $5\;dB(A){\sim}10\;dB(A)$ of interior noise in the concerned range of RPM.

• Mass Spectrometry Letters
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• v.7 no.4
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• pp.111-115
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• 2016

Glycerol was identified and isolated from endogenous interferences during analysis of human urine using high-resolution mass spectrometry (HRMS) for doping control. Urinary sample preparation was simple; the samples were diluted with an organic solvent and then analyzed using a liquid chromatography-mass spectrometry ("dilute and shoot" method). Although the interfering ion peaks were observed at the similar retention time of glycerol, the inference could be identified by isolation with HRMS and further investigation. Thus, creatinine was identified as the endogenous interference for glycerol analysis and it also caused ion suppression resulting in the decrease of glycerol signal. This study reports the first identification and efficient isolation of endogenous interferences in human urine for "dilute and shoot" method. The information about ion suppression could be novel to prevent overestimation or a false result for antidoping analysis.

• Journal of Institute of Control, Robotics and Systems
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• v.16 no.10
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• pp.939-947
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• 2010

With the rising numbers of elderly and disabled people, the demand for welfare services using a robotic system and not involving human effort is likewise increasing. This study deals with a mobile-robot system combined with a BWS (Body Weight Support) system for gait rehabilitation. The BWS system is designed via the kinematic analysis of the robot's body-lifting characteristics and of the walking guide system that controls the total rehabilitation system integrated in the mobile robot. This mobile platform is operated by utilizing the AGV (Autonomous Guided Vehicle) driving algorithm. Especially, the method that integrates geometric path tracking and obstacle avoidance for a nonholonomic mobile robot is applied so that the system can be operated in an area where the elderly users are expected to be situated, such as in a public hospital or a rehabilitation center. The mobile robot follows the path by moving through the turning radius supplied by the pure-pursuit method which is one of the existing geometric path-tracking methods. The effectiveness of the proposed method is verified through the real experiments those are conducted for path tracking with static- and dynamic-obstacle avoidance. Finally, through the EMG (Electromyography) signal measurement of the subject, the performance of the proposed system in a real operation condition is evaluated.

• Journal of Communications and Networks
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• v.13 no.3
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• pp.232-239
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• 2011

This paper investigates the user selection problem of successive zero-forcing precoded multiuser multiple-input multiple-output (MU-MIMO) downlink systems, in which the base station and mobile receivers are equipped with multiple antennas. Assuming full knowledge of the channel state information at the transmitter, dirty paper coding (DPC) is an optimal precoding strategy, but practical implementation is difficult because of its excessive complexity. As a suboptimal DPC solution, successive zero-forcing DPC (SZF-DPC) was recently proposed; it employs partial interference cancellation at the transmitter with dirty paper encoding. Because of a dimensionality constraint, the base station may select a subset of users to serve in order to maximize the total throughput. The exhaustive search algorithm is optimal; however, its computational complexity is prohibitive. In this paper, we develop two low-complexity user scheduling algorithms to maximize the sum rate capacity of MU-MIMO systems with SZF-DPC. Both algorithms add one user at a time. The first algorithm selects the user with the maximum product of the maximum column norm and maximum eigenvalue. The second algorithm selects the user with the maximum product of the minimum column norm and minimum eigenvalue. Simulation results demonstrate that the second algorithm achieves a performance similar to that of a previously proposed capacity-based selection algorithm at a high signal-to-noise (SNR), and the first algorithm achieves performance very similar to that of a capacity-based algorithm at a low SNR, but both do so with much lower complexity.

• The Journal of Korean Society of Virology
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• v.29 no.4
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• pp.221-233
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• 1999

Prospect Hill Virus (PHV) is the well known serotype of hantavirus, a newly established genus in family Bunyaviridae. Extensive studies have upheld the original view of PHV genetics with three genes such as nucleocapsid (N) protein, envelope proteins (G1, G2) and RNA dependent RNA polymerase. In this study, we report the existence of additional gene that is encoded in an overlapping reading frame of the N protein gene within S genome segment of PHV. This gene is expected to encode a nonstructural small (NSs) protein and it seems to be only found in PHV infected cell. The presence and synthesis of NSs protein could be demonstrated in the cell infected with PHV using anti-peptide sera specific to the predicted amino acid sequence deduced from the second open reading frame. Ribosomal synthesis of this protein appears to occur at AUG codon at the 83rd base of S genome segment, downstream of N protein initiation codon. This protein is small in size (10.4 KDa) and highly basic in nature. The expression strategy of NSs protein appears that a signal mRNA is used to translate both N and NSs protein in PHV infected cell. 10 KDa protein in virus infected cell lysates can bind to mimic dsRNA. This fact strongly suggests that NSs protein may be involved in virus replication on late phase of viral life cycle.

• Biomolecules & Therapeutics
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• v.20 no.6
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• pp.513-519
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• 2012

Although the immense efforts have been made for cancer prevention, early diagnosis, and treatment, cancer morbidity and mortality has not been decreased during last forty years. Especially, lung cancer is top-ranked in cancer-associated human death. Therefore, effective strategy is strongly required for the management of lung cancer. In the present study, we found that novel daphnane diterpenoids, yuanhualine (YL), yuanhuahine (YH) and yuanhuagine (YG) isolated from the flower of Daphne genkwa (Thymelaeaceae), exhibited potent anti-proliferative activities against human lung A549 cells with the $IC_{50}$ values of 7.0, 15.2 and 24.7 nM, respectively. Flow cytometric analysis revealed that the daphnane diterpenoids induced cell-cycle arrest in the G0/G1 as well as G2/M phase in A549 cells. The cell-cycle arrests were well correlated with the expression of checkpoint proteins including the up-regulation of cyclin-dependent kinase inhibitor p21 and p53 and down-regulation of cyclin A, cyclin B1, cyclin E, cyclin dependent kinase 4, cdc2, phosphorylation of Rb and cMyc expression. In the analysis of signal transduction molecules, the daphnane diterpenoids suppressed the activation of Akt, STAT3 and Src in human lung cancer cells. The daphnane diterpenoids also exerted the potent anti-proliferative activity against anticancer-drug resistant cancer cells including gemcitabine-resistant A549, gefitinib-, erlotinib-resistant H292 cells. Synergistic effects in the growth inhibition were also observed when yuanhualine was combined with gemcitabine, gefitinib or erlotinib in A549 cells. Taken together, these findings suggest that the novel daphnane diterpenoids might provide lead candidates for the development of therapeutic agents for human lung cancers.