• Advances in Traditional Medicine
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• v.8 no.4
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• pp.440-447
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• 2008

This study investigated the role of Panax ginseng (PG) on the phorbol myristate acetate (PMA) + calcium ionophore A23187-induced hypoxia-inducible factor-$1{\alpha}$ (HIF-$1{\alpha}$) activation, phosphorylation of the extracellular signal-regulated kinase (ERK), and inflammatory cytokine production from the human mast cell line, HMC-1. HIF-$1{\alpha}$ and phosphorylation of ERK were observed by Western blotting. The inflammatory cytokine production was determined by enzyme-linked immunosorbent assay. PG inhibited the PMA+A23187-induced HIF-$1{\alpha}$ expression and the subsequent production of vascular endothelial growth factor. In addition, PG suppressed PMA + A23187-induced phosphorylation of ERK. We also show that the increased cytokines interleukin (IL)-$1{\beta}$, IL-6, and tumour necrosis factor-${\alpha}$ level was significantly inhibited by treatment of PG. In the present study, we report for the first time that PG is an inhibitor of HIF-$1{\alpha}$ and cytokines on the mast cell-mediated inflammatory responses.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.15 no.4
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• pp.379-386
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• 2004

OFDM(orthogonal frequency division multiplexing) communications system is very attractive for the high data rate transmissionin the frequency selective fading channel. Since OFDM has high PAPR(peak-to-average power ratio), OFDM signal may be distorted by the nonlinear HPA(high power amplifier). In this paper, we propose an improved dummy sequence scheme for reducing the PAPR in OFDM communication system. This method inserts each different dummy sequence at the predefined sub-carriers fur PAPR reduction. After IFFT, the OFDM data signal with the lowest PAPR is selected to transmit. The complementary sequence is used as dummy sequence. So, it can cut down the computation time and quantity because it dose not require the peak value optimization for finding the phase rotation factor and the transmission of the side information about the rotation factor unlike the PTS method.

• Molecules and Cells
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• v.21 no.2
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• pp.237-243
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• 2006

Brain-derived neurotrophic factor (BDNF) is a neuromodulator of nociceptive responses in the dorsal root ganglia (DRG) and spinal cord. BDNF synthesis increases in response to nerve growth factor (NGF) in trkA-expressing small and medium-sized DRG neurons after inflammation. Previously we demonstrated differential activation of multiple BDNF promoters in the DRG following peripheral nerve injury and inflammation. Using reporter constructs containing individual promoter regions, we investigated the effect of NGF on the multiple BDNF promoters, and the signaling pathway by which NGF activates these promoters in PC12 cells. Although all the promoters were activated 2.4-7.1-fold by NGF treatment, promoter IV gave the greatest induction. The p38 mitogen-activated protein kinase (MAPK) inhibitor, SB203580, phosphatidylinositol 3-kinase (PI-3K) inhibitor, LY294003, protein kinase A (PKA) inhibitor, H89, and protein kinase C (PKC) inhibitor, chelerythrine, had no effect on activation of promoter IV by NGF. However, activation was completely abolished by the MAPK kinase (MEK) inhibitors, U0126 and PD98059. In addition, these inhibitors blocked NGF-induced phosphorylation of extracellular signal-regulated protein kinase (ERK) 1/2. Taken together, these results suggest that the ERK1/2 pathway activates BDNF promoter IV in response to NGF independently of NGF-activated signaling pathways involving PKA and PKC.

• International Journal of Oncology
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• v.54 no.6
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• pp.2117-2126
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• 2019

Transforming growth factor-β1 (TGF-β1) is a multifunctional cytokine that functions as a growth suppressor in normal epithelial cells and early stage tumors, but acts as a tumor promoter during malignant progression. However, the molecular basis underlying the conversion of TGF-β1 function remains largely undefined. X-linked inhibitor of apoptosis-associated factor 1 (XAF1) is a pro-apoptotic tumor suppressor that frequently displays epigenetic inactivation in various types of human malignancies, including colorectal cancer. The present study explored whether the anti-apoptotic effect of TGF-β1 is linked to its regulatory effect on XAF1 induction in human colon cancer cells under stressful conditions. The results revealed that TGF-β1 treatment protected tumor cells from various apoptotic stresses, including 5-fluorouracil, etoposide and γ-irradiation. XAF1 expression was activated at the transcriptional level by these apoptotic stresses and TGF-β1 blocked the stress-mediated activation of the XAF1 promoter. The study also demonstrated that mitogen-activated protein kinase kinase inhibition or extracellular signal-activated kinase (Erk)1/2 depletion induced XAF1 induction, while the activation of K-Ras (G12C) led to its reduction. In addition, TGF-β1 blocked the stress-mediated XAF1 promoter activation and induction of apoptosis. This effect was abrogated if Erk1/2 was depleted, indicating that TGF-β1 represses XAF1 transcription through Erk activation, thereby protecting tumor cells from apoptotic stresses. These findings point to a novel molecular mechanism underlying the tumor-promoting function of TGF-β1, which may be utilized in the development of a novel therapeutic strategy for the treatment of colorectal cancer.

• Journal of Biomedical Engineering Research
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• v.28 no.4
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• pp.494-502
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• 2007

Ubiquitous location based services (u-LBS) will be interested to an important services. They can easily recognize object position at anytime, anywhere. At present, many researchers are making a study of the position recognition and tracking. This paper consists of postion recognition and user identification system. The position recognition is based on location under services (LBS) using a signal strength map, a database is previously made use of empirical measured received signal strength indicator (RSSI). The user identification system automatically controls instruments which is located in home. Moreover users are able to measures body signal freely. We implemented the multi-hop routing method using the Star-Mesh networks. Also, we use the sensor devices which are satisfied with the IEEE 802.15.4 specification. The used devices are the Nano-24 modules in Octacomm Co. Ltd. A RSSI is very important factor in position recognition analysis. It makes use of the way that decides position recognition and user identification in narrow indoor space. In experiments, we can analyze properties of the RSSI, draw the parameter about position recognition. The experimental result is that RSSI value is attenuated according to increasing distances. It also derives property of the radio frequency (RF) signal. Moreover, we express the monitoring program using the Microsoft C#. Finally, the proposed methods are expected to protect a sudden death and an accident in home.

• The Journal of the Korea Contents Association
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• v.11 no.1
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• pp.1-8
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• 2011

With the development of next IT convergence technology and the construction of infrastructure for personalized services, the importance of services based on user's sensibility status and vital signal is being spotlighted. It is the most crucial factor for the strategy of sensibility engineering to investigate student's vital signal according to the sensibility. In this paper, we proposed the vital signal monitoring simulation system by the various visual stimulus. The proposed method obtained the student's vital signal by the various visual stimulus. And the power spectrum analysis using the fast fourier transform is evaluated the activity level between the sympathetic and the parasympathetic. The analyzed result is monitoring the sensibility by displaying the heath signal light. To evaluate the sensibility between the high school's students and the university's students, we conducted SD profile and paired T-tests so as to verify usefulness. This evaluation found that the difference of sensibility activity by positive and negative stimulus was statistically meaningful. Ultimately, this paper suggests empirical application to verify the adequacy and the validity.

• Journal of the Institute of Convergence Signal Processing
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• v.12 no.2
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• pp.107-112
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• 2011

Several developed countries have been developing their own satellite navigation systems, such as Europe's Galileo, China's BEIDOU, and Japan's QZSS, to cope with clock errors and signal vulnerabilities of GPS. In addition, modernization of Loran, eLoran, for GPS backup has been conducted. In Korea, a dependent navigation system has been required and for GPS backup, the need for utilization of time synchronization infrastructure through the modernization of Loran has been raised. Loran signal uses 100Khz groundwave. A significant factor limiting the ranging accuracy of the Loran signal is the ASF arising from the fact that the groundwave signal is likely to propagate over paths of varying conductivity and topography. Thus, an ASF compensation method is very important for Loran and eLoran navigation. This paper introduces the propagation delay model and then compares and analyzes the estimations from the propagation delay model and measured ASFs.

• The Journal of the Acoustical Society of Korea
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• v.41 no.4
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• pp.461-467
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• 2022

Sonobuoy is a disposable device that collects underwater acoustic information and is designed to transmit signals collected in a particular area to nearby aircraft or ships and sink to the seabed upon completion of its mission. In a conventional sonobouy signal transmission and reception system, collected signals are modulated and transmitted using techniques such as frequency division modulation or Gaussian frequency shift keying, and received and demodulated by an aircraft or a ship. However, this method has the disadvantage of the large amount of information to be transmitted and low security due to relatively simple modulation and demodulation methods. Therefore, in this paper, we propose a method that uses an autoencoder to encode a transmission signal into a low-dimensional latent vector to transmit the latent vector to an aircraft or ship and decode the received latent vector to improve signal security and to reduce the amount of transmission information by approximately a factor of a hundred compared to the conventional method. As a result of confirming the sample spectrogram reconstructed by the proposed method through simulation, it was confirmed that the original signal could be restored from a low-dimensional latent vector.

• Proceedings of the Korea Institute of Convergence Signal Processing
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• 2005.11a
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• pp.159-162
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• 2005

Recently, due to rapid developments of wireless communication and digital TV, modern society needs to process of aquisition, storage and transmission of much information. So the importance of signal processing is increasing and various digital filters are used in the two-dimensional signal such as image. And kinds of these digital filters are IIR(infinite impulse response) filter and FIR(finite impulse response) filter. And FIR filter which has the phase linearity, the easiness of creation and stability is applied to many fields. In design of this FIR filter, flatness property is a important factor in pass-band and stop-band. In this paper, we designed a 2-D Circular FIR filter using the Bernstein polynomial, it is presented flatness property in pass-band and stop-band. And we simulated the designed filter with noisy test image and compared the results with existing methods.

• The Journal of the Acoustical Society of Korea
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• v.34 no.5
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• pp.403-409
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• 2015

In this paper, we propose Packet Loss Concealment (PLC) method using adaptive signal scale estimation for performance improvement of G.711 PLC. The conventional method controls a gain using 20 % attenuation factor when continuous loss occurs. However, this method lead to deterioration because that don't consider the change of signal. So, we propose gain control by adaptive signal scale estimation through before and after frame information using Least Mean Square (LMS) predictor. Performance evaluation of proposed algorithm is presented through Perceptual Evaluation of Speech Quality (PESQ) evaulation.