• The Journal of Korea CHUNA Manual Medicine
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• v.3 no.1
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• pp.111-123
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• 2002

Objectives : There have been many studies of the effect of Bee Venom therapy about arthritis, but no one study was reported about its whole functional mechanism to musculo-skeletal system. This study was designed to investigate the effect, Indication, and side effect of Bee Venom therapy on musculo-skeletal disease by literature review of articles. Results : The effects of Bee Venom therapy to musculo-skeletal system are divided to Anti_inflammatory effect and Anti-nociceptive effect. Anti_inflammatory effect is achieved through competitive chemotaxis, immuno-regulation, increasing of cortisol secretion by stimulating hypothalamus-pituitary gland-adrenal cortex axis. Anti-nociceptive effect is achieved by Anti-inflammatory mechanism and it works similar to anti-nociceptive effect of the acupuncture acting on central and peripheral nociceptive transduction system. The Bee Venom therapy could cause severe side effect, for example, hypersensitivity and anaphylaxis, injury to central nerve system and cardiovascular system, peripheral blood system, and renal dysfunction. Conclusions : With its Anti-inflammatory and Anti-nociceptive mechanism, Bee Venom therapy is considered that has good effects to autoimmune disease, chronic inflammation of various musculo-skeletal disease and various pain syndrome. But the clinician must be careful for its side effects.

• Journal of computational fluids engineering
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• v.20 no.1
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• pp.1-9
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• 2015

A developed code is applied to simulate relative motion of floating bodies in a side-by-side arrangement, including effects of a fender and a hawser. The developed code is based on the flux-difference splitting scheme for immiscible incompressible fluids and the hybrid Cartesian/immersed boundary method. To validate the developed code for free surface flows around deforming boundaries, the water wave generation is simulated, which is caused by bed movement. The computed wave profile and time histories of wave elevation are compared with other experimental and computational results. The effects of a fender and a hawser are modeled by asymmetric force acting on the floating bodies according to a relative displacement with the bounds, in which the fender and the hawser exert no force on the bodies. It has been observed that the floating body can be accelerated by a gap flow due to a phase difference caused by the free surface. Grid independency is established for the computed time history of the body velocity, based on three different size grids.

• The Korean Society of Law and Medicine
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• v.8 no.1
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• pp.235-277
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• 2007

In Product Liability law, the 'defection' of the manufactured products is its key concept, defined in detail. The concept had been already developed through the precedents and theories for the past years even before the PL law was enacted and the concept was listed. Especially, the medicine products need the different approach, because they might directly harm to the human life and body due to their being injected or taken, unlikely other manufactured articles. Since the medical products have the double contradictory functions such as effects and side effects, the defection decisions become so difficult. However, because there are high concerns that wrong medical products will directly harm the human life and body, the decision standards should be more strengthened. The decision standards should include the risk-effect standard as the considered components and make the customer-expecting standard as the final standard. The decision time for defection should be made considering the science technology level when the medical products were provided, not when the accident occurred. It is the most important for the manufacturers to prevent the damages by making and selling the non-defective medicine products for themselves, rather than by taking the legal remedy means afterwards. Therefore, the non-defective guidelines for the medicine manufacturers will help increase the effects and minimize the side-effects.

• Journal of Ocean Engineering and Technology
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• v.24 no.5
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• pp.16-21
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• 2010

During the loading/offloading operation of a liquefied natural gas carrier (LNGC) that is moored in a side-by-side configuration with an offshore plant, sloshing that occurs due to the partially filled LNG tank and the interactive effect between the two floating bodies are important factors that affect safety and operability. Therefore, a time-domain software program, called CHARM3D, was developed to consider the interactions between sloshing and the motion of a floating body, as well as the interactions between multiple bodies using the potential-viscous hybrid method. For the simulation of a floating body in the time domain, hydrodynamic coefficients and wave forces were calculated in the frequency domain using the 3D radiation/diffraction panel program based on potential theory. The calculated values were used for the simulation of a floating body in the time domain by convolution integrals. The liquid sloshing in the inner tanks is solved by the 3D-FDM Navier-Stokes solver that includes the consideration of free-surface non-linearity through the SURF scheme. The computed sloshing forces and moments were fed into the time integration of the ship's motion, and the updated motion was, in turn, used as the excitation force for liquid sloshing, which is repeated for the ensuing time steps. For comparison, a sloshing motion coupled analysis program based on linear potential theory in the frequency domain was developed. The computer programs that were developed were applied to the side-by-side offloading operation between the offshore plant and the LNGC. The frequency-domain results reproduced the coupling effects qualitatively, but, in general, the peaks were over-predicted compared to experimental and time-domain results. The interactive effects between the sloshing liquid and the motion of the vessel can be intensified further in the case of multiple floating bodies.

• The Journal of Pediatrics of Korean Medicine
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• v.28 no.4
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• pp.96-107
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• 2014

Objectives The purpose of this study is to understand what caregivers think advantageous and disadvantageous regarding Acupoint sticking Dog-days. Also, to know whether Acupoint sticking in Dog-days affect vital signs, and to investigate if occurrence of side effects are related to application duration, sweat, or compliance to precautionary measures. Methods Survey has been handed out to parents of the children who took Acupoint sticking in Dog-days. 10 days after the first dose was administered, survey was performed to examine any side effect occurrences, characteristics of sweat, duration of application, parents' thought about this therapy. Also, vital signs were checked before the first dose, and 10 days after to see any differences in vital signs in regards to this therapy. Results Preferable opinions about Acupoint sticking in Dog-days are 'convenient than herbal medications' (76.5%), 'less reluctance of child' (47.1%), 'reasonable price' (20.6%), 'good effectiveness' (17.6%), 'less side effect' (14.7%), 'no worry about agrochemicals or heavy metals uptake' (11.8%). Downsides were 'difficult to admit to hospital right on the Dog-days' (73.5%), 'no conspicuous effectiveness' (11.8%), 'expensive' (5.9%), 'reluctance of child' (2.9%). Vital sign differences were minimal when examined before and after Acupoint sticking in Dog-days. Side effects occurred 5 times in 34 cases, and they were erythema, itchiness, and hot sensation. There were no scars or blisters reported. All 5 cases were resolved without any interventions within 3 days. Conclusions Acupoint sticking in Dog-days doesn't affect vital signs. Severe side effect is rare, reported side effects were relatively mild, suggesting that it may be safe and well-tolerated. 'Convenience' (76.5%) is biggest advantage of Acupoint sticking in Dog-days and 'less reluctance of child' is also big advantage of Acupoint sticking in Dog-days. 'Difficulty to admit to hospital right on the Dog-days' (73.5%) is biggest disadvantage of Acupoint sticking in Dog-days.

• Journal of Oriental Neuropsychiatry
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• v.24 no.3
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• pp.257-262
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• 2013

Objectives : Aripiprazole is unique drug among the SGA (Second generation antipsychotics) in its pharmacology and pharmacokinetics,but is similar in clinical efficacy. Aripiprazole acts as a partial agonist at dopamine D2 receptors, activating the receptor but eliciting a reduced response compared to the natural neurotransmitter. There are some side effects of aripiprazole, the most common side effects of aripiprazole are headache, nausea, vomiting, insomnia, tremor, constipation and EPS. Difficulty in opening eyes is not defined EPS yet, but it is a rare but important side-effect symptom of aripiprazole. Methods : This article is about a case of side-effect symptom of aripiprazole, 26-year-old single female suffering from schizophrenia had difficulty in opening eyes while she was taking antipsychotics. During the hospitalization, the relaxation therapy is helpful not only to reduce tension in the eyelids but also to headache. Results : It is important that early recognition of aripiprazole-induced oculogyric dystonia can prevent life-threatening complications. Education medical staff to this easily treatable reaction will improve overall quality of health care. Conclusions : This case notifies the need for awareness of the risk of acute oculogyric dystonia in adolescent female patients receiving aripiprazole.

• Wind and Structures
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• v.17 no.4
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• pp.379-397
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• 2013

Large Eddy Simulations (LES) were carried out to investigate the aerodynamic characteristics of a rectangular cylinder with side ratio B/D=5 at Reynolds number Re=22,000 (based on cylinder thickness). Particular attention was devoted to the effects of velocity shear in the oncoming flow. Time-averaged and unsteady flow patterns around the cylinder were studied to enhance understanding of the effects of velocity shear. The simulation results showed that the Strouhal number has no significant variation with oncoming velocity shear, while the peak fluctuation frequency of the drag coefficient becomes identical to that of the lift coefficient with increase in velocity shear. The intermittently-reattached flow that features the aerodynamics of the 5:1 rectangular cylinder in non-shear flow becomes more stably reattached on the high-velocity side, and more stably separated on the low-velocity side. Both the mean and fluctuating drag coefficients increase slightly with increase in velocity shear. The mean and fluctuating lift and moment coefficients increase almost linearly with velocity shear. Lift force acts from the high-velocity side to the low-velocity side, which is similar to that of a circular cylinder but opposite to that of a square cylinder under the same oncoming shear flow.

• The Journal of Korean Society for Neurotherapy
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• v.22 no.3
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• pp.31-36
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• 2018

Purpose The purpose of this study was to investigate the effects of contact handorientation response(CHOR) during sit-to-stand(STS) in people with stroke. Methods The subjects of the study were Thirty hemiplegia participated (Rt. hemiplegia/Lt. hemiplegia: 15/15, mean age: $65.82{\pm}8.53$) in this study. The analysis of muscles activation (rectus femoris, biceps femoris, tibialis anterior, gastrocnemius) distribution was conducted by the EMG, and the analysis of foot pressure distribution was conducted by the resistive pressure sensor. Hemiplegic stroke patients were instructed to perform STS three times with the non-affected side hand and affected side hand on the table. Results There was a significant positive correlation between rectus femoris, tibialis anterior muscle activation and affected side hand contact during STS(p<0.05). The STS correlated with the foot pressure in the affected side hand contact(p<0.05). Conclusion AS a result, CHOR during STS is related to muscle activation and the characteristics of foot pressure. This information was observed in the affected side hand contact on the table, suggestion that rehabilitation programs should be implemented.

• Quality Improvement in Health Care
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• v.23 no.2
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• pp.11-20
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• 2017

Purpose: The purpose of this study was to determine the effects of rotation direction during curved walking on gait parameters in stroke patients. Methods: A group of thirty subjects with stroke (Berg Balance Scale score${\geq}41$ were fifteen, Berg Balance Scale score${\leq}40$ were fifteen) were enrolled in this study. Testing indications included two directions for rotation in each subject. These indications were for rotation toward the affected and unaffected side in stroke patients. The gait speed, affected side single support duration, affected side double support duration were recorded. The obtained data were analyzed by using paired t-test and Wilcoxon signed rank test in the group that are below and above 40 points of Berg Balance Scale score. Results: There was significant increase affected side single support duration was turned the affected side in stroke patients that presented a Berg Balance Scale score${\geq}41$ (p<.05). There were significant increase gait speed, affected side single support duration, and significant decrease affected side double support duration while subjects were turned the affected side in stroke patients that presented a Berg Balance Scale score${\leq}40$ (p<.05). Conclusion: This result may be effective to rotate in the paralyzed direction to improve the ability of the paralyzed lower limb to gain weight during gait training for stroke patients with a Berg Balance Scale score<40. Therefore, walking training program for hemiplegic patient needs to be suggested in the direction of turning for suitable balance ability.

• Physical Therapy Rehabilitation Science
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• v.3 no.1
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• pp.49-54
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• 2014

Objective: This study aimed to identify how various applications of weight bearing on the affected side of hemiplegia patients affect the ability of balance keeping of the affected leg and the gait parameters. Design: Cross-sectional study. Methods: Eighteen patients with hemiplegia participated in this study. There were twelve males and six females. This study investigated the effects of the single-leg stance exercise on dynamic balance, weight bearing, and gait ability compared with four conditions. Dynamic balance and weight bearing were measured using the step test (ST) of the affected side in stroke patients. In addition, gait parameters were measured using the optogait system for analysis of the spatial and temporal parameters of walking in stroke patients. Results: This study investigated the effect of the single leg stance exercise on the paralysis side. The ST showed significant findings for all conditions (p<0.05). Therefore, knee extension and flexion exercise on the affected side single-leg stance (condition 4) significantly improved dynamic balance and weight bearing on the affected side (p<0.05). In the condition of moving the knee joint in a single-leg stance was discovered that the stance phase time significantly increased more than in the condition of supporting the maximal voluntary weight on the affected side (p<0.05). Conclusions: Single-leg stance on the paralysis side with knee flexion and extension increased symmetry in weight bearing during stance phase time. This study suggests that single-leg stance exercises augments improved gait function through sufficient weight bearing in the stance phase of the affected side.