• Biomolecules & Therapeutics
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• v.22 no.4
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• pp.328-333
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• 2014

Vitiligo is a pigmentary disorder induced by a loss of melanocytes. In addition to replacement of pure melanocytes, cocultures of melanocytes with keratinocytes have been used to improve the repigmentation outcome in vitiligo treatment. We previously identified by in vitro studies, that adipose-derived stem cells (ADSCs) could be a potential substitute for keratinocytes in cocultures with melanocytes. In this study, the efficacy of pigmentation including durability of grafted melanocytes and short-term safety was examined in the nude mouse and Sprague-Dawley rat after grafting of primary cultured human melanocytes, with or without different ratios of primary cultured human ADSCs. Simultaneous grafting of melanocytes and ADSCs, which were separately cultured and mixed on grafting at the ratios of 1:1, 1:2, or 1:3, showed better efficacy than that of pure melanocytes. Grafting of melanocytes cocultured with ADSCs resulted in a similar outcome as the grafting of cell mixtures. Skin pigmentation by melanocytes : ADSCs at the ratios of 1:1 and 1:2 was better than at 1:3. No significant difference was observed between the 1-week and 2-week durations in coculturing. Time-course microscopic examination showed that the grafted melanocytes remained a little longer than 6-week post-grafting. No inflammatory cell infiltration was observed in the grafted skin and no melanocytes were detectable in other organs. Collectively, grafting of melanocytes and ADSCs was equally safe and more effective than grafting of melanocytes alone. Despite the absence of significant differences in efficacy between the group of 1:1 and that of 1:2 ratio, 1:2 ratio for 1-week coculturing may be better for clinical use from the cost-benefit viewpoint.

• Journal of Labour Economics
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• v.23 no.1
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• pp.1-25
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• 2000

This paper investigates why is the unemployment outflow rate into employment so high and why do the precarious workers have short unemployment spell after the economic crisis. Using the matched panel data of the Economically Active Population Survey. This paper points out that, in spite of the fact that most spells of unemployment are quite short, a very substantial portion of the unemployed experiences multiple unemployment spells over a period of time. Also recurrent unemployment leads to very long total durations of unemployment. This evidence implies recurrent unemployment is as important as long-term unemployment under the poor social safety net system.

• Journal of the Korea Safety Management & Science
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• v.13 no.2
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• pp.251-258
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• 2011

The existing evaluation systems based on financial performance summarize the information about past results and focus on short-term performance, and so they have the limits to explain the future value of firms and to make a long-term strategic performance. By this reason, as a way to increase the future value, the development of the integrated performance evaluation system with which we may manages financial performance and knowledge assets together has been required recently. This study puts together various researches for the evaluation of knowledge assets, and analyzes the existing studies for the domestic medical devices industry and the tendency of introduction for business practice. Under this analysis, this study develops the knowledge asset evaluation indexes for medical devices industry by using the Balanced Score Card (BSC) of Kaplan & Norton(1992), and then presents the evaluation model by applying the Analytic Hierarchy Process (AHP) of Saaty(1980) to get the weight for each index. With the final evaluation model, we can calculate the evaluation score combined with both the quantitative indexes and the qualitative indexes at once.

• The Korean Journal of Gastroenterology
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• v.72 no.5
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• pp.245-251
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• 2018

Gastric cancer is the most common cancer in Korea and the fifth most common cancer globally. Helicobacter pylori (H. pylori) infection is considered the main etiologic agent for gastric cancer development. Most regional guidelines for H. pylori treatment recommend treating the organism to prevent gastric cancer in the high-risk group. However, evidence that such a strategy can also be applied to the general population, especially in terms of the preventive effect and safety, has not been adequately presented yet. Although a meta-analysis in the general population suggested effectiveness in decreasing gastric cancer incidence, individual studies should be critically reviewed to evaluate the soundness of the evidence. Recently published, long-term, Korean studies on metachronous gastric cancer prevention ended the controversies from previous short-term studies and confirmed the effectiveness. Currently, further prospective, large, randomized studies are ongoing in the general population and will provide more definitive, high-level evidence on this gastric cancer prevention strategy in the next decade.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.9
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• pp.4327-4333
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• 2016

Purpose: To systematically review efficacyand safety of robotic gastrectomy (RG) compared with conventional laparoscopic gastrectomy (LG) for gastric carcinoma. Materials and Methods: A systematic literature search was carried out using PubMed, Cochrane Library, CBM, CNKI, WanFang, VIP and other sources like relevant references to obtain comparative studies assessing the effectiveness and safety between RG and LG published between 2013 and 2016. Then the literature was screened and the data were extracted by 2 independent reviewers. The quality of the literature was assessed, and the data analyzed using Stata/SE 14 software. Fixed effects or random effects models wereapplied according to heterogeneity. Results: A total of 12 non-randomized observational clinical studies involving 3,580 patients were included, of which 1,096 had undergone RG and 2,484 had received LG. The results of the meta-analysis showed in terms of effectiveness, RG was associated with less blood loss, less time to first flatus and greater number of harvested lymph nodes, but there were no significant differences in proximal and distal resection margins, compared with LG. In terms of efficiency, RG was associated with shorter hospital stay, but longer operative time. In terms of safety, there were no statistically significant differences in complications, mortality and conversions between RG and LG. Conclusions: RG can achieve comparable or better short-term and radical effects than LG, with respect to effectiveness, efficiency and safety in treatment of gastric carcinoma. Future studies involving RG should focus on decreasing operative time and reducing cost. Moreover, there is a need for randomized controlled trials comparing the two techniques with long-term follow-up.

• Nuclear Engineering and Technology
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• v.55 no.2
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• pp.696-706
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• 2023

Consequences of an anticipated Beyond Design Basis Accident (BDBA) Long-Term Station Blackout (LTSBO) event with complete loss of grid power in the VVER-1200 reactor of Rooppur Nuclear Power Plant (NPP) of Unit-1 are assessed using the RASCAL 4.3 code. This study estimated the released radionuclides, received public radiological dose, and ground surface concentration considering 3 accident scenarios of International Nuclear and Radiological Event Scale (INES) level 7 and two meteorological conditions. Atmospheric transport, dispersion, and deposition processes of released radionuclides are simulated using a straight-line trajectory Gaussian plume model for short distances and a Gaussian puff model for long distances. Total Effective Dose Equivalent (TEDE) to the public within 40 km and radionuclides contribution for three-dose pathways of inhalation, cloudshine, and groundshine owing to airborne releases are evaluated considering with and without passive safety Emergency Core Cooling System (ECCS) in dry (winter) and wet (monsoon) seasons. Source term and their release rates are varied with the functional duration of passive safety ECCS. In three accident scenarios, the TEDE of 10 mSv and above are confined to 8 km and 2 km for the wet and dry seasons, respectively in the downwind direction. The groundshine dose is the most dominating in the wet season while the inhalation dose is in the dry season. Total received doses and surface concentration in the wet season near the plant are higher than those in the dry season due to the deposition effect of rain on the radioactive substances.

• Toxicological Research
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• v.26 no.1
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• pp.75-82
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• 2010

This study was carried out to investigate the short term toxicity of nine phthalate diesters including di-2(ethylhexyl) phthalate (DEHP), di(n-butyl) phthalate (DBP), di-n-octyl phthalate (DnOP), diethyl phthalate (DEP), butylbenzyl phthalate (BBP), dimethyl phthalate (DMP), di-isodecyl phthalate (DIDP), diundecyl phthalate (DUP), and di-isononyl phthalate (DINP) and five phthalate monoesters including mono- (2-ethylhexyl) phthalate (MEHP), monobutyl phthalate (MBuP), monobenzyl phthalate (MBeP), monoethyl phthalate (MEP), monomethyl phthalate (MMP) and phthalic acid (PA) in Sprague-Dawley male rats. Animals were administered 250 mg/kg/day (monoesters and PA) or 500 mg/kg/day (diesters) of phthalate for two weeks. All animals were examined for body and organ weights, blood hematology, serum biochemistry, and urine analysis. The body weight gain was significantly lower in rats treated with BBP, DBP, DINP, MEHP, MBuP, and PA than that of control. Liver weights were significantly increased in the DEHP, DBP, DnOP, DIDP, and MEHP groups as compared to the control group. Testes weights were significantly decreased only in the DEHP-, DnOP-, and DIDP-treated groups as compared to the control. Significant differences in hematological changes were not observed in any treatment groups. Significant increases in blood glucose levels were observed in the DEHP, MEHP, and MBeP groups. Aspartate aminotransferase (AST) levels were significantly increased in the DBP, DUP, DINP, MBuP, and MBeP groups, whereas alanine aminotransferase (ALT) levels were significantly increased only in the DEHP and MEHP groups. Serum ALP levels were significantly higher in phthalate diester (500 mg/kg/day)-treated rats as compared to control. However, the total cholesterol level was significantly reduced in the DEHP- and DIDP-treated groups, whereas serum triglyceride (TG) levels were higher in the DINP-, MEHP-, and MBuP-treated groups. These results suggest that short term toxicity of phthalate monoesters produces adverse effects as similar to phthalate diesters in Sprague-Dawley rats.

• Journal of the Korean Society of Marine Environment & Safety
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• v.28 no.5
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• pp.780-790
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• 2022

Quantitative risk levels must be presented by analyzing the causes and consequences of accidents and predicting the occurrence patterns of the accidents. For the analysis of marine accidents related to vessel traffic, research on the traffic such as collision risk analysis and navigational path finding has been mainly conducted. The analysis of the occurrence pattern of marine accidents has been presented according to the traditional statistical analysis. This study intends to present a marine accident prediction model using the statistics on marine accidents related to vessel traffic. Statistical data from 1998 to 2021, which can be accumulated by month and hourly data among the Korean domestic marine accidents, were converted into structured time series data. The predictive model was built using a long short-term memory network, which is a representative artificial intelligence model. As a result of verifying the performance of the proposed model through the validation data, the RMSEs were noted to be 52.5471 and 126.5893 in the initial neural network model, and as a result of the updated model with observed datasets, the RMSEs were improved to 31.3680 and 36.3967, respectively. Based on the proposed model, the occurrence pattern of marine accidents could be predicted by learning the features of various marine accidents. In further research, a quantitative presentation of the risk of marine accidents and the development of region-based hazard maps are required.

• Journal of the Korean Society for Precision Engineering
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• v.26 no.12
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• pp.131-137
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• 2009

Recent technological advances made a vehicle more intelligent to increase safety and comfort. An intelligent vehicle provides drivers with safety warning information through audible sounds, visual displays, and tactile devices. However, elderly drivers have been known to decrease the physical and cognitive abilities such as muscular strength, hearing, eyesight, short term memory, and spatial perception. Therefore, possible age-related deficits should be considered to design an effective warning system. This paper aims to evaluate the impact of advancing age on response performance on audible safety warnings which are widely used for alerting driving hazards. In order to understand the effect of age-related hearing loss and movement slowing, three sound characteristics (frequency, intensity, and period) and three age groups (younger, middle, and older) are considered. Data was drawn from 38 drivers who drove a simulated rural road in a driving simulator. Experimental results show that age influences driver's response performance. In conclusion, the appropriate range of a warning sound is suggested.

• Journal of the Korea Safety Management & Science
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• v.15 no.3
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• pp.163-170
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• 2013

There are many pros and cons for whether smart glasses and watch would be further going technology or not beyond smart phone. What have to do domestically is to find acting ways to catch up with technological gap in short term basis through analyses and investigations in technological issues, patents profile, market forecast. In this paper, firstly we investigate and review technological issues and form factors of smart glasses and HMD, and secondly analyze technological tendency and identify their core technology and intension from global key player's patents analyses connected with smart glasses, and conclusively suggest technological prospects and it's countermeasures.