• Journal of Chest Surgery
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• v.25 no.3
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• pp.220-231
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• 1992

We have performed 28 single lung transplantation in mongrel dogs transplanting the left lung exclusively from November 1989 to September 1991, in the department of thoracic surgery of Seoul National University Hospital. In the donor dogs, the main pulmonary artery was divided proximal to its bifurcation, and the left atrium was incised freeing the left veins with a generous atrial cuff. We used cold saline in the first 7 transplantations and Euro-Collins or modified Euro-Collins solution in the remaining 17 transplantations as a lung preservatives. The bronchus was divided at two cartilage rings proximal to the upper lobe bronchus take off. In the recipient procedure, we used a Fogarty catheter as a bronchus block. Left atrial anastomosis was performed first using 5-O prolene and the pulmonary artery was anastomosed using 6-O prolene. The bronchus was anastomosed next with 4-O vicryl interruptedly and covered with a greater omentum which had been prepared previously. All dogs received cyclosporin A and azathioprine as immunosuppressants and were divided into two group. In the 10 Group I dogs, they survived within 6 days, mean survival time was 66.8$\pm$53.4 hours. In remainder 14 Group lI dogs, they survived above 6 days, mean survival time was 9. 5$\pm$5.6 days. The cause of death were as follows: 2 cases of sacrifice, 2 cases of respiratory insufficiency during operation, 2 cases of arrhythmia immediate postoperatively, 2 cases of bleeding, others in Group I, and 6 cases of sacrifice, 4 cases of sepsis, 3 cases of bleeding, others in Group lI. Results of bronchoscopic findings were obstruction above 50% in 12 cases of 16 performance cases within 5th day. Early chest radiologic haziness were showed, and total lung perfusion defect was frequently showed in both group within 7th day. Main autopsy findings were left atrial and pulmonary arterial thrombi and bronchial obstruction The major histologic findings of Group I were pleural exudate, hemorrhagic infarct, pulmonary congestion, and interesting histologic findings of Group II were 3 cases of perivascular or peribronchial lymphocyte infiltration, 3 cases of hemorrhage infarct, 2 cases of interstitial pneumonitis. The structual change of bronchioles, suggesting bronchiolitis obliterans was not observed due to improper preparation of proximal pulmonary tissue and short term survival times.

• Journal of Pharmaceutical Investigation
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• v.27 no.1
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• pp.11-14
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• 1997

This laboratory has recently reported the solubility and in vivo absorption enhancement of diclofenac sodium by ${\beta}-cyclodextrin$ complexation. The acute gastroduodenal mucosa injury provoked by administration of 34 mg/kg and 68 mg/kg of a diclofenac sodium (DS) and equivalent dose of new formulation [diclofenac sodium-beta-cyclodextrin complexation$(DS-{\beta}-CD)$] was evaluated and compared. Microscopic examinations, performed after 18-hrs treatment, demonstrated that $DS-{\beta}-CD$ was less gastrolesive than DS. The drop in gastrophy after a single dose of the assigned drug was considerably greater for DS than for $DS-{\beta}-CD$, which registered similar values to control. Since gastrophy is an expression of the anatomy-functional integrity of the gastric barrier, the results indicate that $DS-{\beta}-CD$ exerts less direct acute damage on the gastric mucosa. Therefore, when administered short-term, $DS-{\beta}-CD$ appears to be less gastrolesive than the standard DS formulation.

• Journal of Pharmaceutical Investigation
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• v.37 no.2
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• pp.79-84
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• 2007

This study was aimed to establish analytical method of Bi to develop a guideline of the bioequivalence test of tripotassium dicitrato bismuthate (TDB). For this purpose, a simple, specific and sensitive inductively coupled plasma-mass spectrometry (ICP/MS) method were developed and validated in human plasma. Various concentrations of bismuth standard solution (0-25ng/mL) were prepared with distilled water and human blank plasma. To 10mL of the volumetric flasks, 2mL of blank plasma was added with 8ml of distilled water. Bi standard solution was added to prepare the calibration samples and injected into ICP-MS. The plasma samples obtained from volunteers given 3 tablets of bismuth (total 900mg as TDB) were analyzed as described above. As a result, the coefficients of variation were <20% in quantitation limit (0.2 ng/mL) and <15% at the rest of concentrations. The stability test by repeated freezing-thawing cycles showed that the samples were stable only for 24hr. The stability tested for samples with a short-term period of storage at room temperature and pre-treatment prior to the analysis showed very stable over 24hr. In 8 healthy Korean subjects received Denol tablets at the dose of 900mg bismuth, AUC, $C_{max},\;T_{max}$ and half-life $(t_{1/2})$ were determined to be $198.33{\pm}173.78 ng{\cdot}hr/mL,\;64.48{\pm}27.06 ng/mL,\;0.52{\pm}0.21 hr,\;and\;5.15{\pm}2.67 hr$, respectively, from the plasma bismuth concentration-time curves. In conclusion, the method was suitable for the determination of bismuth in human plasma samples and could be applied to bioequivalence test of bismuth tablet.

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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• v.11 no.4
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• pp.293-301
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• 2013

Borehole Disposal Concept (BDC) was initiated by the South African Nuclear Energy Corporation (NECSA) with the view to improve the radioactive waste management practices in Africa. At a time when geological disposal of radioactive waste is being considered, the need to protect ground water from possible radioactive contamination and the investigation of radionuclides migration through soil and rocks of zone of aeration into ground water has becomes very imperative. This is why the Borehole Disposal Concept (BDC) is being suggested to address the problem. The concept involves the conditioning and emplacement of disused sealed radioactive sources in an engineered facility of a relatively narrow diameter borehole (260 mm). Tanzania is operating a Radioactive Waste Management Facility where a number of spent sealed radioactive sources with long and short half lives are stored. The activity of spent sealed radioactive sources range from (1E-6 to 8.8E+3 Ci). However, the long term disposal solution is still a problem. This study therefore proposing the country to adopt the BDC, since the repository requires limited land area and has a low probability of human intrusion due to the small footprint of the borehole.

• Smart Structures and Systems
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• v.21 no.1
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• pp.53-64
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• 2018

Nondestructive testing methods are required to assess the condition of civil structures and formulate their maintenance programs. Axial force identification is required for several structural members of truss bridges, pipe racks, and space roof trusses. An accurate evaluation of in situ axial forces supports the safety assessment of the entire truss. A considerable redistribution of internal forces may indicate structural damage. In this paper, a novel compressive force identification method for prismatic members implemented using static deflections is applied to steel beams. The procedure uses the Euler-Bernoulli beam model and estimates the compressive load by using the measured displacement along the beam's length. Knowledge of flexural rigidity of the member under investigation is required. In this study, the deflected shape of a compressed steel beam is subjected to an additional vertical load that was short-term measured in several laboratory tests by using fiber Bragg grating-differential settlement measurement (FBG-DSM) sensors at specific cross sections along the beam's length. The accuracy of midspan deflections offered by the FBG-DSM sensors provided excellent force estimations. Compressive load detection accuracy can be improved if substantial second-order effects are induced in the tests. In conclusion, the proposed method can be successfully applied to steel beams with low slenderness under real conditions.

• Journal of Fisheries and Marine Sciences Education
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• v.29 no.1
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• pp.270-285
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• 2017

This study is about the solution to solve the problem - aging of fisheries worker and exodus of young adult from fisheries. We tried to find out internal improvements which are necessary for overcoming issues. After that, research about inducements and institutional improvements to drive internal improvements has done. and Current policies of Korea for securing workforce in fisheries were examined especially for Gyeongsangnam-do by literature investigation and survey The main purpose of this study is, problems of policy in order to secure Fisheries managers, identify practical obstacle and the activities and management activities performance of training education. and it is to provide evidence to policy improvement. To achieve the purpose of this study, conducted studies are as below. This study is to investigate the educational performance of Fisheries managers and its impact on their business performance using SEM and SEM-Moderate-effect. In terms of the amount of impact on business performance, the level of educational achievement and management activity outcomes had the most impact followed by excellence of educational condition and programs distinction. Therefore, in order to inspire the motivation for learning and communicate the importance of such education to Fisheries communities, there is a need to introduce a variety of methods, professional facilities. The purpose of this research is to define the problems of the Fisheries Census of Korea and to make better policies for improvement. In order to complete the purpose, the research team has firstly conducted a survey in the six regions to reinvestigate the yes or no for accuracy of the primary data related to the Fisheries Census. Moreover, the team has defined the problems of the Fisheries Census through conducting a survey for the experts and users of the fisheries statistics. Also, the team has derived the short/long term improvement of Fisheries Census through out this survey.

• 한국지구물리탐사학회:학술대회논문집
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• 2003.11a
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• pp.255-261
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• 2003

Tunnelling in poor and heterogeneous ground is a difficult task. Even with a good geological investigation, uncertainties with respect to the local rock mass structure will remain. Especially for such conditions, a reliable short-term prediction of the conditions ahead and outside the tunnel profile are of paramount importance for the choice of appropriate excavation and support methods. The information contained in the absolute displacement monitoring data allows a comprehensive evaluation of the displacements and the determination of the behaviour and influence of an anisotropic rock mass. Case histories and with numerical simulations show, that changes in the displacement vector orientation can indicate changing rock mass conditions ahead of the tunnel face (Schubert & Budil 1995, Steindorfer & Schubert 1997). Further research has been conducted to quantify the influence of weak zones on stresses and displacements (Grossauer 2001). Sellner (2000) developed software, which allows predicting displacements (GeoFit$\circledR$). The function parameters describe the time and advance dependent deformation of a tunnel. Routinely applying this method at each measuring section allows determining trends of those parameters. It shows, that the trends of parameter sets indicate changes in the stiffness of the rock mass outside the tunnel in a similar way, as the displacement vector orientation does. Three-dimensional Finite Element simulations of different weakness zone properties, thicknesses, and orientations relative to the tunnel axis were carried out and the function parameters evaluated from the results. The results are compared to monitoring results from alpine tunnels in heterogeneous rock. The good qualitative correlation between trends observed on site and numerical results gives hope that by a routine determination of the function parameters during excavation the prediction of rock mass conditions ahead of the tunnel face can be improved. Implementing the rules developed from experience and simulations into the monitoring data evaluation program allows to automatically issuing information on the expected rock mass quality ahead of the tunnel.

• Journal of the Korean Society for Heat Treatment
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• v.26 no.1
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• pp.14-20
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• 2013

Duplex stainless steel, which is a kind of stainless steel with a mixed microstructure of about equal proportions of austenite and ferrite, is generally known as a unique material with excellent corrosion resistance and high strength. However, toughness, strength, and corrosion resistance of the steel could be reduced due to precipitation of topologically closed packed phases such as sigma phase during cooling. In case of large forged products, they have strong possibility that ${\sigma}$-phase precipitates due to difference of cooling rate between surface and inner of the products. Investigation on sigma phase precipitation behavior of duplex stainless steel with change of cooling rate was carried out in this study. Forged SAF 2205 duplex stainless steel was used as specimens to examine the cooling rate effect. Dissolution behavior of sigma phase was also discussed through resolution test of duplex stainless steel containing lots of sigma phase. Experimental results revealed that impact energy was very sensitive to precipitation of small amount sigma phase. However, sigma phase could be removed by short term resolution treatment and impact resistance of the duplex stainless steel was restored.

• Journal of the Korean Geotechnical Society
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• v.29 no.1
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• pp.109-120
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• 2013

This paper presents the results of a laboratory investigation into a study on undrained characteristics of a geogrid-encased stone column (GESC) installed in soft clay under cyclic load. In order to analyze behavior of settlement, pore water pressure, stress concentration ratio and strain of the GESC compared to a stone column, a series of reduced-scale laboratory tests were performed. The model tests show that GESC provides a simple and effective method of deformation resistance and settlement restraint when a short-term cyclic load is applied. The maximum strain of geogrid occurred at 1.2D and 1.5D from the top of the column. This paper highlights the importance of considering overlay effect and replacement ratio on cyclic load supporting GESC.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.13 no.1
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• pp.73-86
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• 2012

This study has the purpose to increase the suitability for the introduction and operation of the curriculum utilizing business simulation games from university education. So we investigated about the usage in management education department of domestic and foreign universities, institutions target for enterprise level education, and giant companies such as Samsung and LG. We surveyed about the demand of it from college students at the management and engineering departments and then designed two basic course models. As research methods, literature research, on-site experts and operators interview on domestic enterprises and institutions of representative companies was conducted. We analysed the course syllabi of some domestic and about 50 foreign universities utilizing it with the literature review. Then we analysed the result of usage investigation and demand survey. According to the results, the relatively small number of universities and corporate institutions compared to U.S. were utilizing it for their training courses in short-term and partial Lab. Results are expected to be used in the training courses of business administration in universities and corporate.