• Archives of Reconstructive Microsurgery
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• 제21권1호
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• pp.34-40
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• 2012

Prevention of acute rejection in composite tissue allotransplantation without continuous immunosuppression lacks reports in worldwide literature. Recently dendritic cells (DC) gained considerble attention as antigen presenting cells that are also capable of immunologic tolerance induction. This study assesses the effect of alloantigen-pulsed dendritic cells in induction of survival in a rat hindlimb allograft. We performed hindlimb allotransplantation between donor Sprague-Dawley and recipient Fischer344 rats. Recipient derived dendritic cells were harvested from rat whole blood and cultured with anti-inflammatory cytokine IL-10. Then donor-specific alloantigen pulsed dendritic cells were reinjected into subcutaneous tissue before limb transplantation. Groups: I) untreated (n=6), II) DC injected (n=6), III) Immunosuppressant (FK-506, 2 mg/Kg) injected (n=6), IV) DC and immunouppressant injected (n=6). Graft appearance challenges were assessed postoperatively. Observation of graft appearance, H-E staning, immunohistochemical (IHC) study, and confocal immunofluoreiscece were performed postoperatively. Donor antigen pulsed host dendritic cell combined with short-term immunosuppression showed minimal mononuclear cell infiltration, regulator T cell presence, and could prolong limb allograft survival.

• Architectural research
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• 제12권1호
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• pp.1-8
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• 2010

This research paper explores selected behavioral outcomes of a multi-sensory environment. An experimental study was conducted at a specialized facility for the ageing in Sweden. The objective was to explore the effects of agitated behaviors of ageing residents with dementia and to identify any short-term effects. Appointed nursing staff was instructed to record physically and verbally agitated behaviors on three occasions; pre-session, mid-session, and post-session. Over seven months, nine participants received sixty-one sessions in the multi-sensory room. ANOVA and Post hoc multiple comparisons were performed to identify the differences in mean between each session. Generally irritated/frustrated behavior and eating/drinking non foods revealed statistically significant differences, while there were no significant results in verbally agitated behavior. One short-term effect was observed in one agitated category; a reduction of generally irritated/frustrated behavior. These results suggest that the multi-sensory environment can have positive effects on some manifestations of agitated behavior. This study proposes that a multi-sensory environment may be recommended as an alternative intervention for physically agitated behavior among this category of residents. However, more research is needed to understand the specific effects and the best use of the multi-sensory environment for this population.

• 한국식품과학회지
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• 제31권5호
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• pp.1401-1404
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• 1999

솔잎추출물의 rat에 대한 단기 급성경구독성을 평가하기 위하여 체중 kg당 최고 10g의 솔잎 추출물을 rat의 위에 직접 투입하여 14일간 관찰하였다. 실험 결과 모든 실험군에서 사망예가 관찰되지 않아 $LD_{50}$, 10g/kg B.W. 이상으로 계산되었으며 임상증상이나 체중, 부검에서도 유의할만한 소견이 관찰되지 않았다. 따라서 본 실험의 솔잎 추출물은 rat에 있어서 단기 급성경구독성이나 부작용을 유발하지 않는 소재로 평가되었다.

• 한국환경보건학회지
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• 제24권1호
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• pp.24-31
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• 1998

This study was performed to investigate the difference in species of test fish on the determination of short-term bioconcentration factor in zebrafish(Brachydanio rerio), red sword tail(Xiphophorus hellieri) and goldfish(Carassius auratus). Experimental concentrations of carbamates were 0.05 and 0.10 ppm and chlorothalonil were 0.005 and 0.01 ppm for 3 and 5 days, respectively. This paper reports the measured BCF value on pesticides in various species of test fish, under steady state, and examined correlation between the BCF value and depuration rate constant or LC$_{50}$ or lipid content. Carbamates and chlorothalonil concentration in fish extract and BCF of carbamate and chlorothalonil were increased as incresing test concentration. Carbamates concentration in fish extract and BCF of carbamate were decreased as incresing test period, but chlorothalonil concentration in fish extract and BCF of chlorothalonil were increased as prolonging test period. Determined pesticide concentration in fish extract and BCF were highest in red sword tail, and followed by goldfish, and zebrafish. Determined depuration rate constant were highest in zebrafish, and followed by goldfish, and red sword tail. 96hr-LC$_{50}$ were highest in red sword tail, and followed by zebrafish, and goldfish. Lipid compositions were highest in red sword tail, and followed by goldfish, and zebrafish. Therefore, it is suggested that the difference of BCF between each pesticide due to those of lipid composition of fish and deputation rate constant, while LC$_{50}$ have no effect on BCF.

• 한국지반공학회:학술대회논문집
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• 한국지반공학회 2006년도 춘계 학술발표회 논문집
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• pp.434-444
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• 2006

The stone column method is widely used in Europe as an alternative to conventional pile foundations. Several benefits of using the stone column method include sound performance, low cost, expediency of construction, and liquiefaction resistance, among others. Recently, geosynthetic-encased stone column approach has been developed to improve its' load carrying capacity through increasing confinement effect. Although such a concept has successfully applied in practice, fundamentals of the method have not been fully explored. This Paper Presents the results of an investigation on the loading carriying capacity of geogrid-encased stone column using a series of 2D finite element analyses. The results of the analyses indicated improved short- and long-term carrying capacity of the geogrid-encased stone column method over the conventional strone column method with no encasing.

• Asian Pacific Journal of Cancer Prevention
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• 제16권1호
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• pp.153-155
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• 2015

Background: The aim of this study was to establish the feasibility and efficiency of different pelvic drainage routes after laparoscopic abdominoperineal resection (LAPR) for rectal cancer by assessing short-term outcomes. Materials and Methods: Clinicopathological data of 76 patients undergoing LAPR for very low rectal cancer were reviewed retrospectively between June 2005 and June 2014. Outcomes were evaluated considering short-term results. Results: Of 76 relevant patients at our institution in the period of study, trans-perineal drainage of the pelvic cavity was performed in 17 cases. Compared with the trans-perineal group, the length of hospital stay was shorter in the trans-abdominal group, while the duration of drainage and the infection rates of the perineal wounds between two groups showed no significant differences. Conclusions: The outcomes of this study suggest that trans-abdominal drainage of pelvic cavity is a reliable and feasible procedure, the duration of drainage, infection rates and the healing rates of the perineal wounds being acceptable. Trans-abdominal drainage has a more satisfactory effect after laparoscopic abdominoperineal resection for rectal carcinoma.

• 말소리와 음성과학
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• 제8권1호
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• pp.63-69
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• 2016

The aims of the present study are two-fold: 1) to explore differences on speech perception between younger and older adults according to noise conditions; and 2) to investigate which cognitive domains are correlated with speech perception. Data were acquired from 15 younger adults and 15 older adults. Sentence recognition test was conducted in four noise conditions(i.e., in-quiet, +5 dB SNR, 0 dB SNR, -5 dB SNR). All participants completed auditory and cognitive assessment. Upon controlling for hearing thresholds, the older group revealed significantly poorer performance compared to the younger adults only under the high noise condition at -5 dB SNR. For older group, performance on Seoul Verbal Learning Test(immediate recall) was significantly correlated with speech perception performance, upon controlling for hearing thresholds. In older adults, working memory and verbal short-term memory are the best predictors of speech-in-noise perception. The current study suggests that consideration of cognitive function for older adults in speech perception assessment is necessary due to its adverse effect on speech perception under background noise.

• Environmental Analysis Health and Toxicology
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• 제17권1호
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• pp.81-93
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• 2002

There were no specific effects for test materials on Sprague-Dawiey (S.D.) rats in clinical symptoms, amounts of food intakes, weight changes, laboratory findings, and pathology after whole body 1, 1-Dichloro-1-fluoroethane (used as coolant, metal cleaner and solvents) exposure (0, 1,500, 3,000, and 6,000 ppm) for 13 weeks (6 hour/day, 5 days/week). However, the loss of capillary vessels in eyeball (pupil) was observed in a female rat among 6,000 ppm group. Though there was a tendency for MCHC (Mean Corpuscular Hemoglobin Concentration) in rat to be decreased (p<0.05), it was not regarded as abnormal because the values were within normal limits. In asthma-stimulation related evaluations. there was also a tendency for inflammatory cell counts in bronchoalveolar lavages to be increased. But it had no statistical significance, and also no dependency on sex and the exposed concentration . Based on this result, the non observed effect level (NOEL) induced by 1, 1-Dichloro-1-fluoroethane inhalation was evaluated in groups with 3,000 ppm below (S.D. Rats, 13 weeks). Finally, it was concluded that the short term exposal of 1, 1-Dichloro-1-fluoroethane is not considered as a asthma stimulant by inhalation despite of some study limitations such as test animals use and short-term exposure.

• Journal of Information Processing Systems
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• 제17권5호
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• pp.867-878
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• 2021

In context awareness and user intention tasks, dataset construction is expensive because specific domain data are required. Although pretraining with a large corpus can effectively resolve the issue of lack of data, it ignores domain knowledge. Herein, we concentrate on data domain knowledge while addressing data scarcity and accordingly propose a multi-channel long short-term memory (LSTM). Because multi-channel LSTM integrates pretrained vectors such as task and general knowledge, it effectively prevents catastrophic forgetting between vectors of task and general knowledge to represent the context as a set of features. To evaluate the proposed model with reference to the baseline model, which is a single-channel LSTM, we performed two tasks: voice phishing with context awareness and movie review sentiment classification. The results verified that multi-channel LSTM outperforms single-channel LSTM in both tasks. We further experimented on different multi-channel LSTMs depending on the domain and data size of general knowledge in the model and confirmed that the effect of multi-channel LSTM integrating the two types of knowledge from downstream task data and raw data to overcome the lack of data.

• 한국기계가공학회지
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• 제20권12호
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• pp.85-91
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• 2021

In our daily life, artificial intelligence performs simple and complicated tasks like us, including operating mobile phones and working at homes and workplaces. Artificial intelligence is used in industrial technology for diagnosing various types of equipment using the machine learning technology. This study presents a fault mode effect analysis (FMEA) of start motors using machine learning and big data. Through multiple data collection, we observed that the primary failure of the start motor was caused by the melting of the magnetic switch inside the start motor causing it to fail. Long-short-term memory (LSTM) was used to diagnose the condition of the magnetic locations, and synthetic data were generated using the synthetic minority oversampling technique (SMOTE). This technique has the advantage of increasing the data accuracy. LSTM can also predict a start motor failure.