• Journal of Microbiology and Biotechnology
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• v.33 no.9
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• pp.1111-1118
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• 2023

As a long-term condition that affects the airways and lungs, chronic obstructive pulmonary disease (COPD) is characterized by inflammation, emphysema, breathlessness, chronic cough, and sputum production. Currently, the bronchodilators and anti-inflammatory drugs prescribed for COPD are mostly off-target, warranting new disease management strategies. Accumulating research has revealed the gut-lung axis to be a bidirectional communication system. Cigarette smoke, a major exacerbating factor in COPD and lung inflammation, affects gut microbiota composition and diversity, causing gut microbiota dysbiosis, a condition that has recently been described in COPD patients and animal models. For this review, we focused on the gut-lung axis, which is influenced by gut microbial metabolites, bacterial translocation, and immune cell modulation. Further, we have summarized the findings of preclinical and clinical studies on the association between gut microbiota and COPD to provide a basis for using gut microbiota in therapeutic strategies against COPD. Our review also proposes that further research on probiotics, prebiotics, short-chain fatty acids, and fecal microbiota transplantation could assist therapeutic approaches targeting the gut microbiota to alleviate COPD.

• Journal of Oral Medicine and Pain
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• v.48 no.1
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• pp.16-24
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• 2023

Purpose: To determine the effects of botulinum toxin (BoNT) injection into the human masseter muscle on the morphology of the mandibular condyle bone using cone-beam computed tomography (CBCT). Methods: Twenty volunteers were randomly assigned to one of two groups. Group I received a single BoNT injection; Group II received two injections, with the second being administered 4 months after the first. CBCT scans of both temporomandibular joints (TMJs) were performed before and 6 months after the first injection. Bony changes in the cortical layers of the condyle heads were evaluated and the long and short axes of both mandibular condyles were measured. The thickness at the thinnest part of glenoid fossa was also quantitatively measured. Results: There was no significant difference between pre- and post-injection CBCT images. Furthermore, no changes in the cortical layers of the condyle heads were observed among the subjects who exhibited mild degenerative TMJ changes. The quantitative measurements (long axis, short axis, and the thickness of thinnest part of glenoid fossa roof) did not differ significantly between pre- and post-injection except for the long axis in Group I. Conclusions: Within the limitations of this study, it appears that BoNT injections into human masseter muscles do not alter the morphology of the mandibular condyle bone in healthy adults.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2018.10a
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• pp.477-479
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• 2018

This study was carried out to utilize LSTM(Long Short-Term Memory) technique which is one kind of artificial neural network. Among the 27 types of motion data released by the UTD(University of Texas at Dallas), 3-axis acceleration and angular velocity data were applied to the basic LSTM and Deep Residual Bidir-LSTM techniques to classify the behavior.

• The korean journal of orthodontics
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• v.45 no.4
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• pp.180-189
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• 2015

Objective: To compare the positions of the mandibular premolars in Angle Class I subjects according to vertical facial type. The results will provide a theoretical basis for predicting effective tooth movement in orthodontic treatment. Methods: Cephalometric parameters were determined using cone-beam computed tomography in 120 Angle Class I subjects. Subjects were categorized as short, normal, and long face types according to the Frankfort mandibular angle. Parameters indicating the position of the mandibular right premolars and the mandible were also measured. Results: The angle between the mandibular first premolar axis and buccal cortex, the distance between the root apex and buccal cortex, angle of vestibularization, arc of vestibularization, and root apex maximum movable distance were significantly greater in the short face type than in the long and norm face types. The angle between the mandibular second premolar axis and buccal cortex, the distance from root apex to buccal cortex, and the arc of vestibularization were significantly greater in the short face type than in the normal face type. Conclusions: There are significant differences in the mandibular premolar positions in Class I subjects according to vertical facial type.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.25 no.11
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• pp.1649-1654
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• 2021

In this paper, we introduce a regularization of long short-term memory (LSTM) based fall detection system using TensorFlow that can detect falls that can occur in the elderly. Fall detection uses data from a 3-axis acceleration sensor attached to the body of an elderly person and learns about a total of 7 behavior patterns, each of which is a pattern that occurs in daily life, and the remaining 3 are patterns for falls. During training, a normalization process is performed to effectively reduce the loss function, and the normalization performs a maximum-minimum normalization for data and a L2 regularization for the loss function. The optimal regularization conditions of LSTM using several falling parameters obtained from the 3-axis accelerometer is explained. When normalization and regularization rate λ for sum vector magnitude (SVM) are 127 and 0.00015, respectively, the best sensitivity, specificity, and accuracy are 98.4, 94.8, and 96.9%, respectively.

• Proceedings of the Korea Concrete Institute Conference
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• 1993.10a
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• pp.284-289
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• 1993

To analyze the effects of compressive strength of concrete and longitudinal steel ratio on buckling behavior of columns, 36tied reinforced concrete columns with hinged ends were tested. The 100mm square cross section was used and the amount of eccentricity was 10mm. The compressive strengths of column specimens with slenderness ratios of 15, 30 and 50 were 202, 513 and 752 kg/$\textrm{cm}^2$. The longitudinal steel ratio of columns with bending about a section diagonal and about a principal axis were 2.85%(4-D10). The ratio of ultimate load capacity to that of short column with the same eccentricity was much decreased at high slenderness ratio with increasing the compressive strength of concrete. And the lateral displacement of column at the ultimate load was decreased as the strength was increased. These are due to that at high slenderness ratio, the load capacity and behavior of column are affected by flexural rigidity. And, it was also found that for the same quantity of confining steel and level of axis load, there is little difference between the flexural strength for bending about a section diagonal and for bending about principal axis.

• Earthquakes and Structures
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• v.19 no.4
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• pp.287-301
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• 2020

Fragility as one of the most effective methods to evaluate seismic performance, which is greatly affected by damage index. Taking a multi span continuous rigid frame offshore bridge as an example. Based on fragility and reliability theory, considering coupling effect of time-varying durability damage of materials and time-varying attenuation effect of damage index to analyze seismic performance of offshore bridges. Results show that IDA curve considering time-varying damage index is obviously below that without considering; area enclosed by IDA of 1# pier and X-axis under No.1 earthquake considering this effect is 96% of that without considering. Area enclosed by damage index of 1# pier and X-axis under serious damage with considering time-varying damage index is 90% of that without considering in service period. Time-varying damage index has a greater impact on short pier when ground motion intensity is small, while it has a great impact on high pier when the intensity is large. The area enclosed by fragility of bridge system and X-axis under complete destruction considering time-varying damage index is 165% of that without considering when reach designed service life. Therefore, time-varying attenuation effect of damage index has a great impact on seismic performance of bridge in service period.

• Journal of the Korean Magnetics Society
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• v.5 no.5
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• pp.905-909
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• 1995

We constructed the large 3-axis square Helmholtz coil system for the power frequency magnetic field immunity test. We measured the coil factors and magnetic field homogeneities of the fabricated 3-axis square Helmholtz coil. The experimental results for the field homogeneities are in agreement with the theoretical data. From these results, we determined the effective areas for the immunity test. We also confirmed that the low current using the multi-turns coil can be applicable to the immunity test for the high field in short duration.

• Fisheries and Aquatic Sciences
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• v.21 no.11
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• pp.31.1-31.7
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• 2018

Three economic marine algae that have been used as food and carrageenan sources were collected from Korea during a survey of marine algal flora. They share the generic features of Hypnea, and three major clades supported by the sectional features were confirmed in a phylogenetic tree based on rbcL sequences. The first species, which belongs to a species group corresponding to the sect. Spinuligerae, nests in the same clade with Hypnea yamadae in a genetic distance of 0%. It is morphologically characterized by an entangled base, subcompressed or subterete to terete axes, somewhat percurrent main axis, irregularly alternately branching with wide angle, and rarely hooked spinous branchlets. The second one is also referred to the sect. Spinuligerae and formed the same clade as Hypnea cenomyce. The genetic distance between both sequences was calculated as 0.0-0.1%, which is considered to be intraspecific. This species is distinct by somewhat entangled thallus at the basal part, percurrent axis, short spine-like branchlets densely covering the axis, and medullary lenticular thickenings. The third alga, which forms a species group corresponding to the sect. Pulvinatae, nests in the same clade as Hypnea nidulans (no intraspecific divergence). It shows occasionally epiphytic habitat rather than epilithic habitat of low mat-forming growth and percurrent erect main axes with dense lateral branchlets. Based on these morphological and molecular data, the three Korean species are identified as H. yamadae, H. cenomyce, and H. nidulans. This is the first record of the Hypnea species in Korea.

• IMMUNE NETWORK
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• v.21 no.3
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• pp.20.1-20.18
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• 2021

The gut is an important organ with digestive and immune regulatory function which consistently harbors microbiome ecosystem. The gut microbiome cooperates with the host to regulate the development and function of the immune, metabolic, and nervous systems. It can influence disease processes in the gut as well as extra-intestinal organs, including the brain. The gut closely connects with the central nervous system through dynamic bidirectional communication along the gut-brain axis. The connection between gut environment and brain may affect host mood and behaviors. Disruptions in microbial communities have been implicated in several neurological disorders. A link between the gut microbiota and the brain has long been described, but recent studies have started to reveal the underlying mechanism of the impact of the gut microbiota and gut barrier integrity on the brain and behavior. Here, we summarized the gut barrier environment and the 4 main gut-brain axis pathways. We focused on the important function of gut barrier on neurological diseases such as stress responses and ischemic stroke. Finally, we described the impact of representative environmental sensors generated by gut bacteria on acute neurological disease via the gut-brain axis.