• 한국자동차공학회논문집
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• 제14권2호
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• pp.1-8
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• 2006

In this paper, an optimum design technology is developed to find an optimal position of the shock absorber using ADAMS and VisualDOC. A vehicle with a torsion-beam rear suspension is modeled by using ADAMS. Design variables for the optimal positioning of the shock absorber are defined considering the hard points of the chassis structure and design positioning are specified through the sensitivity analysis using a bump-crossing simulation. The objective function is defined as the joint reaction forces of the shock absorber connecting joints of the chassis structure. Sequential Quadratic Programming and Genetic Algorithms are used for this study. To validate the optimized design variables, pothole simulations are performed. GA showed better results than SQP algorithms for this design purpose.

• 천문학회지
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• 제35권4호
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• pp.159-174
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• 2002

Cosmological hydrodynamic simulations of large scale structure in the universe have shown that accretion shocks and merger shocks form due to flow motions associated with the gravitational collapse of nonlinear structures. Estimated speed and curvature radius of these shocks could be as large as a few 1000 km/s and several Mpc, respectively. According to the diffusive shock acceleration theory, populations of cosmic-ray particles can be injected and accelerated to very high energy by astrophysical shocks in tenuous plasmas. In order to explore the cosmic ray acceleration at the cosmic shocks, we have performed nonlinear numerical simulations of cosmic ray (CR) modified shocks with the newly developed CRASH (Cosmic Ray Amr SHock) numerical code. We adopted the Bohm diffusion model for CRs, based on the hypothesis that strong Alfven waves are self-generated by streaming CRs. The shock formation simulation includes a plasma-physics-based 'injection' model that transfers a small proportion of the thermal proton flux through the shock into low energy CRs for acceleration there. We found that, for strong accretion shocks, CRs can absorb most of shock kinetic energy and the accretion shock speed is reduced up to $20\%$, compared to pure gas dynamic shocks. For merger shocks with small Mach numbers, however, the energy transfer to CRs is only about $10-20\%$ with an associated CR particle fraction of $10^{-3}$. Nonlinear feedback due to the CR pressure is insignificant in the latter shocks. Although detailed results depend on models for the particle diffusion and injection, these calculations show that cosmic shocks in large scale structure could provide acceleration sites of extragalactic cosmic rays of the highest energy.

• 한국연소학회:학술대회논문집
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• 한국연소학회 2005년도 제31회 KOSCO SYMPOSIUM 논문집
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• pp.20-27
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• 2005

I consider the structure of steady wave system which is admitted by the continuum equations for materials that undergo phase transformations with exothermic chemical reaction. In particular, the dynamic phase front structures between liquid and gas phases, and solid and liquid phases are computationally investigated. Based on the one-dimensional continuum shock structure analysis, the present approach can estimate the nano-width of waves that are present in combustion. For illustration purpose, n-heptane is used in the evaporation and condensation analysis and HMX is used in the melting and freezing analysis of energetic materials of interest. On-going effort includes extension of this idea to include broad range of liquid and solid fuels, such as rocket propellants.

• Journal of Microbiology
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• 제34권1호
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• pp.40-48
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• 1996

We have examined the chromatin structure of the HMRE/HSP82 and HMRa/HSP82 allels using three complementary approaches : DNase I chromating footprinting, micrococcal nuclease (MNase) nucleosome-protected ladder assay, and an in vivo E. coli dam methylase accessibility assay. The footprinting results indicate that the promoter and silencer sequences are assembled into nucleoprotein complexes which exhibit no detectable change in structure, despite a 70-fold range in expression levels. In addition, the promoter region of the HMRa/HSP82 allele is cleaved randomly by MNase in all cases, indicating the absence of anonical nucleosomes over this region irrespective of SIR4 or heat-shock. Finally, no discernible difference in the accessibility of the HMRE/HSP82 locus to dam methylase in SIR4 vs. sir4 cells was seenm which again suggests that the chromatin structure of HMRE/HSP82 allele is identical regardless of SIR4. Altogether, our results indicate that in contrast to other observations of the silent mating-type loci, no discernible structural alteration is detected at either HMR/HSP82 allele regardless of SIR genetic background or transcriptional state of the gene.

• Bulletin of the Korean Chemical Society
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• 제33권8호
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• pp.2508-2512
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• 2012

Cold shock proteins (CSPs) are a family of proteins induced at low temperatures. CSPs bind to single-stranded nucleic acids through the ribonucleoprotein 1 and 2 (RNP 1 and 2) binding motifs. CSPs play an essential role in cold adaptation by regulating transcription and translation via molecular chaperones. The solution nuclear magnetic resonance (NMR) or X-ray crystal structures of several CSPs from various microorganisms have been determined, but structural characteristics of psychrophilic CSPs have not been studied. Therefore, we optimized the purification process to obtain highly pure Lm-Csp and determined the three-dimensional structure model of Lm-Csp by comparative homology modeling using MODELLER on the basis of the solution NMR structure of Bs-CspB. Lm-Csp consists of a ${\beta}$-barrel structure, which includes antiparallel ${\beta}$ strands (G4-N10, F15-I18, V26-H29, A46-D50, and P58-Q64). The template protein, Bs-CspB, shares a similar ${\beta}$ sheet structure and an identical chain fold to Lm-Csp. However, the sheets in Lm-Csp were much shorter than those of Bs-CspB. The Lm-Csp side chains, E2 and R20 form a salt bridge, thus, stabilizing the Lm-Csp structure. To evaluate the contribution of this ionic interaction as well as that of the hydrophobic patch on protein stability, we investigated the secondary structures of wild type and mutant protein (W8, F15, and R20) of Lm-Csp using circular dichroism (CD) spectroscopy. The results showed that solvent-exposed aromatic side chains as well as residues participating in ionic interactions are very important for structural stability. Further studies on the three-dimensional structure and dynamics of Lm-Csp using NMR spectroscopy are required.

• 한국추진공학회지
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• 제6권1호
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• pp.71-82
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• 2002

본 연구에서는 2차원의 압축성 Navier-Stokes 코드를 개발하여 mixer-ejector 노즐의 유동장 해석을 다양한 덕트와 노즐 면적비 및 노즐 압력비에 대하여 계산을 수행하였다. 덕트와 노즐 면적비 계산에서는 먼저 효율적인 2차 유동의 유입을 위한 최적의 면적비가 있음을 볼 수 있었다. 높은 면적비에서는 입구 자유유동의 적절한 혼합없이 mixing duct를 그대로 통과하는 것을 볼 수 있었고, 낮은 면적비에서는 제트의 경계가 유입 유동에 장애물로 작용하는 것을 볼 수 있었다. 노즐 압력비의 계산에 있어서는 shroud 벽면과 shock cell structure 간에 상호작용이 작다면 유입유량은 압력비에 따라 증가하는 것을 볼 수 있었다.

• The Korean Journal of Physiology and Pharmacology
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• 제8권6호
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• pp.345-349
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• 2004

Heat shock ($43^{\circ}C$ for 60 minutes) is sufficient to induce apoptosis in a wide number of cell lines. In this study, we asked whether DNA strand breaks are responsible for this phenomenon. Using the highly sensitive comet assay for DNA damage detection, we were unable to demonstrate DNA breaks immediately after heat shock in Raji human Iymphoid cells. It showed that DNA breaks were not necessary for hyperthermic apoptosis, since its activity is indicative of DNA lesions. Here, we present a suggestion that a protein(s) is the major target for heat shock apoptosis. We firstly found glycerol, which reportedly stabilizes protein structure, showed a protective effect in Raji cells against hyperthermic apoptosis. In addition, quercetin, which modulates transcription of the heat shock protein family members, enhanced apoptotic death induced by hyperthermia. Furthermore, Raji cells are protected by a pre-mild heat treatment prior to the killing dose of heat shock.

• 한국정밀공학회지
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• 제23권7호
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• pp.130-137
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• 2006

TFT-LCD(Thin Film Transistor Liquid Crystal Display) module is representative commercial product of FPD(Flat Panel Display). Thickness of TFT-LCD module is very thin. It is adopted for major display unit for IT devices such as Cellular Phone, Camcorder, Digital camera and etc. Due to the harsh user environment of mobile IT devices, it requires complicated structure and tight assembly. And user requirements for the mechanical functionalities of TFT-LCD module become more strict. However, TFT-LCD module is normally weak to high level transient mechanical shock. Since it uses thin crystallized panel. Therefore, anti-shock performance is classified as one of the most important design specifications. Traditionally, the product reliability against mechanical shock is confirmed by empirical method in the design-prototype-drop/impact test-redesign paradigm. The method is time-consuming and expensive process. It lacks scientific insight and quantitative evaluation. In this article, a systematic design evaluation of TFT-LCD module for mobile IT devices is presented with combinations of FEA and testing to support the optimal shock proof display design procedure.

• 한국안전학회지
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• 제29권1호
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• pp.15-20
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• 2014

The silicon as the hyper-elastic material was used to design the shock programmer and dynamic characteristic of the shock programmer was studied. The shock programmer was a structure part that was mounted between the impactor and the test bed. The role of the shock programmer was to generate the acceleration time history by the objective of various impact tests. The effective elastic modulus of the silicon was varied under the velocity of the impactor. The effective elastic modulus of the silicon was estimated by the comparison with results between test and simulation.

• 천문학회지
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• 제35권3호
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• pp.151-157
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• 2002

From the data of solar wind observation by ACE spacecraft orbiting the Earth-Sun Lagrangian point, we selected 48 forward interplanetary shocks(IPSs) occurred in 2000, maximum solar activity period. Examining the profiles of solar wind parameters, the IPSs are classified by their shock drivers. The significant shock drivers are the interplanetary coronal mass ejection(ICME) and the high speed stream(HSS). The IPSs driven by the ICMEs are classified into shocks driven by magnetic clouds and by ejectas based on the existence of magnetic flux rope structure and magnetic field strength. Some IPSs could be formed as the blast wave by the smaller energy and shorter duration of shock drivers such as type II radio burst. Out of selected 48 forward IPSs, $56.2\%$ of the IPSs are driven by ICME, $16.7\%$ by HSS, and $16.7\%$ of the shocks are classified into blast-wave type shocks. However, the shock drivers of remaining $10\%$ of the IPSs are unidentified. The classification of the IPSs by their driver is a first step toward investigating the critical magnitudes of the IPS drivers commencing the magnetic storms in each class.