• Journal of Physiology & Pathology in Korean Medicine
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• v.18 no.2
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• pp.381-388
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• 2004

After the author of 'Luxinjing' explained the children's characters using the concept of Pure-Yang, the term has been widely exploited in the literature of Oriental pediatrics, Its meaning could be summed up in three general categories, namely: Shengyang(盛陽), Zhiyinzhiyang(稚陰稚陽) and Shaoyang(少陽). The implications of Pure-Yang were different in each dynasties of China. By the early Qing(淸) period, it meant mostly Shengyang(盛陽), but its meaning moved in the direction of Zhiyinzhiyang(稚陰稚陽) after Wu Jutong(吳鞠通). And this movement in the interpretation of this term was largely triggered by the pharmaceutical concerns of doctors as too much medicine of cooling and gastrointestinal effect was used to 'cool off' the over-charged Yang characters(盛陽) of children, causing considerable detrimental side effects to the children's body. The concept of Zhiyinzhiyang(稚陰稚陽) which emphasizes the fragility of children's body thus came in action. The meaning of physiological terms in Oriental Medicine is essentially linked to its clinical applications as we have seen in the case of Pure Yang. In that respect, the recent interpretation of Pure-Yang as Shaoyang(少陽) among physicians in China seems lacking in its crucial counterpart, which is its clinical applications. No theory can prove fruitful in the absence of its practice.

• Journal of Korean Medical classics
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• v.31 no.4
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• pp.1-16
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• 2018

Objectives : The paper studies the epistemology of Wind Herbs, its origin, its drug category and medicinal property, attempted to understand Lidongyuan's framework of mechanism of internal damage and treatment principle, and why he used it from his viewpoint. Methods : His suggestion was based on this treatment of internal damage suing wind herbs. Therefore, it cannot be viewed as a simple herbological concept. It rather displays the characteristics of medication based on clinical pathology. Therefore, wind herb should be comprehensively understood from the understanding of the mechanism of internal damage. That is why the paper studied around Piweilun, where Lidongyuan's concept on internal damage is established with finality. Additionally, the paper also referred to Wanghaogu's Tangyenbencao, a text that comprehensibly assembles the authors of Zhangyuans, Yixuqiyan's and Yishuixuepi's knowledge o herbology. Results : The origin of wind herb is 'herbs that uses the unique nature of wind in treatment of disease.' Medication unfolds yang qi, and this signifies the Shengyang function. This means that it starts from the lower energizer yin aspect, which is the beginning point of yang qi, and unfolds to the whole body through upbearing and effusion. Instead of producing yang qi directly similar to pungent, sweet and warm formula, however, it contributes to the achievement of the final purpose of the way of Shengyang through forming a ascending mechanism in the whole body via yin aspect's yang qi upbearing and effusion. Conclusions : Wind herb is within the scope of clinical herbology selected by Lidongyuan, for the purpose of achieving comprehensive clinical purposes, in order to treat internal damage. In this way, wind herb is distinguished from the application of other medicines that are limited in usage depending on Qiwei.

• Proceedings of the Korean Society for Bioinformatics Conference
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• 2005.09a
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• pp.10-14
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• 2005

In this paper, we highlight the development of a web application system. Its main objective is to provide pathway visualization functionalities for inter-cytokine relationships, as well as for other types of relationships, with a specific cytokine(s) of interest. A natural language processor is first used to extract information from a certain web page that concerns the cytokine(s) of interest. The results obtained are then further processed and then displayed graphically to the user. The system displays how the cytokine(s) of interest interacts with other cytokines and cells. Useful information such as the type of reaction and catalyst involved, if any, are also displayed. In addition, the system also offers functionalities for graphical manipulations of the visualized pathways. The system has been shown to provide better overview, and hence, improved learning to readers who are new to this field by virtue of accurate inputs obtained from the natural language processing module.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.8
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• pp.4907-4911
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• 2013

The key signaling networks regulating glioma cell proliferation remain poorly defined. The leucine-rich repeat containing G-protein coupled receptor 4 (Lgr4) has been implicated in intestinal, gastric, and epidermal cell functions. We investigated whether Lgr4 functions in glioma cells and found that Lgr4 expression was significantly increased in glioma tissues. In addition, Lgr4 overexpression promoted while its knockdown using small interfering RNA oligos inhibited glioma cell proliferation. In addition, Wnt/${\beta}$-catenin signaling was activated in cells overexpressing Lgr4. Therefore, our results revealed that Lgr4 activates Wnt/${\beta}$-catenin signaling to regulate glioma cell proliferation.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.18 no.8
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• pp.2082-2102
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• 2024

Accurate segmentation of magnetic resonance (MR) images is crucial for providing doctors with effective quantitative information for diagnosis. However, the presence of weak boundaries, intensity inhomogeneity, and noise in the images poses challenges for segmentation models to achieve optimal results. While deep learning models can offer relatively accurate results, the scarcity of labeled medical imaging data increases the risk of overfitting. To tackle this issue, this paper proposes a novel fuzzy c-means (FCM) model that integrates a deep learning approach. To address the limited accuracy of traditional FCM models, which employ Euclidean distance as a distance measure, we introduce a measurement function based on the skewed normal distribution. This function enables us to capture more precise information about the distribution of the image. Additionally, we construct a regularization term based on the Kullback-Leibler (KL) divergence of high-confidence deep learning results. This regularization term helps enhance the final segmentation accuracy of the model. Moreover, we incorporate orthogonal basis functions to estimate the bias field and integrate it into the improved FCM method. This integration allows our method to simultaneously segment the image and estimate the bias field. The experimental results on both simulated and real brain MR images demonstrate the robustness of our method, highlighting its superiority over other advanced segmentation algorithms.

• Wind and Structures
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• v.37 no.5
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• pp.361-373
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• 2023

Suspended monorail trains (SMTs) are sensitive to crosswinds, and instantaneous aerodynamic characteristics of two SMTs passing each other under crosswinds are particularly complicated. In this study, a pressure measurement test is carried out on stationary train-bridge models arranged in several critical positions. In addition, a validated moving CFD model is developed with the dynamic and sliding mesh method to explore the realistic train movement effects. The time-varying aerodynamic forces and surface pressure distribution on, as well as the flow field around running trains and bridges during trains passing each other, are computed in detail to illustrate the shielding effect of the upstream train. The results reveal that when two trains begin to pass each other, the side force coefficient of the downstream train reduces significantly to negative values due to the wind shielding effect of the upstream train. The moving model successfully captures that airflow is separated on the middle line of the head car for the suspended monorail train, and the surrounding bluff double-beams can significantly affect the flow structures around the train. The wind shielding effect of the upstream train on the downstream train will weaken as the relative yaw angle decreases.

• BMB Reports
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• v.41 no.5
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• pp.369-375
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• 2008

Polygonatum cyrtonema Lectin (PCL), which is classified as a monocot mannose-binding lectin, has received great regards for its uniquely biological activities and potentially medical applications in cancer cells. This paper was initially aimed to study apoptosis of PCL on Hela cells. Thus, 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) method was carried out. Through observation of cell morphologic changes and Lactate dehydrogenase (LDH) activity-based cytotoxicity assays, PCL induced HeLa cell apoptosis in a dose-dependent manner. To further gain structural basis, multiple alignments, homology modeling and docking experiments were performed to analyze the correlation between its biological activities and mannose-binding sites. Eventually, considering docking data, chemical modification properties on the three mannose-binding sites were analyzed by a series of biological experiments (e.g., hemagglutinating and mitogenic activity assays, fluorescence and Circular Dichrosim (CD) spectroscopy) to profoundly identify the role of some key amino acids in the structure-function relationship of PCL.

• Asian-Australasian Journal of Animal Sciences
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• v.31 no.12
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• pp.1903-1912
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• 2018

Objective: To evaluate the effect of lactic acid bacteria and storage temperature on the microbial, chemical and mycotoxin composition of corn silage. Methods: Corn was harvested at 32.8% dry matter, and chopped to 1 to 2 cm. The chopped material was subjected to three treatments: i) control (distilled water); ii) $1{\times}10^6$ colony forming units (cfu)/g of Lactobacillus plantarum; iii) $1{\times}10^6cfu/g$ of Pediococcus pentosaceus. Treatments in triplicate were ensiled for 55 d at $20^{\circ}C$, $28^{\circ}C$, and $37^{\circ}C$ in 1-L polythene jars following packing to a density of approximately $800kg/m^3$ of fresh matter, respectively. At silo opening, microbial populations, fermentation characteristics, nutritive value and mycotoxins of corn silage were determined. Results: L. plantarum significantly increased yeast number, water soluble carbohydrates, nitrate and deoxynivalenol content, and significantly decreased the ammonia N value in corn silage compared with the control (p<0.05). P. pentosaceus significantly increased lactic acid bacteria and yeast number and content of deoxynivalenol, nivalenol, T-2 toxin and zearalenone, while decreasing mold population and content of nitrate and 3-acetyl-deoxynivalneol in corn silage when stored at $20^{\circ}C$ compared to the control (p<0.05). Storage temperature had a significant effect on deoxynivalenol, nivalenol, ochratoxin A, and zearalenone level in corn silage (p<0.05). Conclusion: Lactobacillus plantarum and Pediococcus pentosaceus did not decrease the contents of mycotoxins or nitrate in corn silage stored at three temperatures.

• Structural Engineering and Mechanics
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• v.82 no.1
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• pp.1-16
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• 2022

This work elaborately investigates the influences of the guideway geometry parameters and track irregularity on the dynamic performances of the suspended monorail vehicle-guideway system (SMVGS). Firstly, a spatial dynamic analysis model of the SMVGS is established by adopting ANSYS parameter design language. Then, the dynamic interaction between a vehicle with maximum design load and guideway is investigated by numerical simulation and field tests, revealing the vehicle-guideway dynamic features. Subsequently, the influences of the guideway geometry parameters and track irregularity on the dynamic performances of the SMVGS are analyzed and discussed in detail, and the reasonable ranges of several key geometry parameters of the guideway are also obtained. Results show that the vehicle-guideway dynamic responses change nonlinearly with an increase of the guideway span, and especially the guideway dynamic performances can be effectively improved by reducing the guideway span; based on a comprehensive consideration of all performance indices of the SMVGS, the deflection-span ratio of the suspended monorail guideway is finally recommended to be 1/1054~1/868. The train load could cause a large bending deformation of the pier, which would intensify the car-body lateral displacement and decrease the vehicle riding comfort; to well limit the bending deformation of the pier, its cross-section dimension is suggested to be more than 0.8 m×0.8 m. The addition of the track irregularity amplitude has small influences on the displacements and stress of the guideway; however, it would significantly increase the vehicle-guideway vibrations and rate of load reduction of the driving tyre.

• The Journal of the Korea Contents Association
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• v.21 no.12
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• pp.337-347
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• 2021

Land is key natural resource that Chinese government actually owns. Real estate and land development have played an important part in China's urban development and economic development. The Chinese local governments' land development policies can mainly be characterized as the establishment of economic development zones and the development of new towns. Given the great importance of these measures, we can expect that these policies can generate noticeable impacts on land development and land price. However, little research has explored these impacts empirically. Using the data collected from land development projects of three districts in Linyi city-old town, new town, economic development zone, this paper attempts to investigate the impact of government development policy on land development and land price. This research chooses investment amount and land price as dependent variables. The multiple regression results demonstrate that the local government's land Development policies can affect land investment size and land price significantly. As we have noticed, the target of government development policy is to make use of urban land resources more scientifically and efficiently. Based on my empirical analysis, some useful insights can be provided for improving our understanding concerning the effects of these government land development policies.