• Archives of Pharmacal Research
• /
• v.29 no.8
• /
• pp.712-719
• /
• 2006

In this study, we prepared core-shell type nanoparticles of a poly(DL-lactide-co-glycolide) (PLGA) grafted-dextran (DexLG) copolymer with varying graft ratio of PLGA. The synthesis of the DexLG copolymer was confirmed by $^1H$ nuclear magnetic resonance (NMR) spectroscopy. The DexLG copolymer was able to form nanoparticles in water by self-aggregating process, and their particle size was around $50\;nm{\sim}300\;nm$ according to the graft ratio of PLGA. Morphological observations using a transmission electron microscope (TEM) showed that the nanoparticles of the DexLG copolymer have uniformly spherical shapes. From fluorescence probe study using pyrene as a hydrophobic probe, critical association concentration (CAC) values determined from the fluorescence excitation spectra were increased as increase of DS of PLGA. $^1H-NMR$ spectroscopy using $D_2O$ and DMSO approved that DexLG nanoparticles have core-shell structure, i.e. hydrophobic block PLGA consisted inner-core as a drug-incorporating domain and dextran consisted as a hydrated outershell. Drug release rate from DexLG nano-particles became faster in the presence of dextranase in spite of the release rate not being significantly changed at high graft ratio of PLGA. Core-shell type nanoparticles of DexLG copolymer can be used as a colonic drug carrier. In conclusion, size, morphology, and molecular structure of DexLG nanoparticles are available to consider as an oral drug targeting nanoparticles.

• Journal of Korea Foundry Society
• /
• v.13 no.5
• /
• pp.450-461
• /
• 1993

AC4C alloy casts in the metallic mold, zircon sand mold, silica sand mold and shell mold with the pouring temperatures of 680, 710 and $740^{\circ}C$ have been investigated. The tensile strength, elongation and hardness of AC4C alloy castings have been influenced by the kind of molds used. The mechanical properties in zircon sand mold castings were greater than those in other sand mold castings, but were inferior to the properties in metallic mold castings. Eutectic Si particle size and DAS were increased in the order of metallic mold, ziron sand mold, silica sand mold and shell mold. Also, they were increased with the increase of pouring temperatures. DAS, eutectic Si particle size and grain size decreased with the increase of mechanical properties as the cooling rate increased. The eutectic Si particle size and DAS of AC4C alloy castings after T6 treatment were decreased in as-cast. The variation of eutectic Si particle size has been effected on the tensile strength, elongation and fractured surface.

• Ocean and Polar Research
• /
• v.36 no.4
• /
• pp.327-341
• /
• 2014

This study aims to analyze causality among Wando abalone producer prices by size using a vector autoregressive model to expiscate the leading-price of Wando abalone in various price classes by size per kg. This study, using an analytical approach, applies a unit-root test for stability of data, a Granger causality test to learn about interaction among price classes by size for Wando abalone, and a vector autoregressive model to estimate the statistical impact among t-1 variables used in the model. As a result of our leading-price analysis of Wando abalone producer prices by shell size using a VAR model, first, DF, PP, and KPSS tests showed that the Wando abalone monthly price change rate by size differentiated by logarithm were stable. Second, the Granger causality relationship analysis showed that the price change rate for big size abalone weakly led the price change rate for the small and medium sizes of abalone. Third, the vector autoregressive model showed that three price change rates of t-1 period variables statistically, significantly impacted price change rates of own size and other sizes in t period. Fourth, the impulse response analysis indicated that the impulse responses of structural shocks for price change rate for big size abalone was relatively more powerful in its own size and in other sizes than shocks emanating from other sizes. Fifth, the variance decomposition analysis indicated that the price change rate for big size abalone was relatively more influential than the price change rates for medium and small size abalone.

• The Research Journal of the Costume Culture
• /
• v.16 no.5
• /
• pp.852-862
• /
• 2008

The purpose of this paper is to find how to do the width of skirt and the girth of the waist in the adequate pattern making for the obese women's skirt. Appearance test of the five experimental skirts was evaluated by the four experts in clothing construction. At the same time, 3D clothing air volume was observed for the five types of experimental skirt with different size specifications. The results from the appearance test were as follows; when the width of skirt pattern is set for(the shell girth/2), it was suggested w/4+1(front), w/4(back) for girth of the waist. On one hand, in case of (the shell girth of front)/2+(the shell girth of back)/2, it was suggested(the waist girth of front)/2 and(waist girth of back)/2 for obese women's skirt with the best appearance. As results, it was found that the width of skirt pattern for the obese women should be the greatest shell girth instead of hip girth. In the case of the hip girth, the amount of ease on hip was suggested 6cm. It was found that pattern with the wrinkle of ease was full of the gaps between body and skirt in 3D clothing air volume. In spreading out to 2D flat pattern from 3D scan data, when the width of skirt pattern was set for(the shell girth of front)/2+(the shell girth of back)/2, it was suggested(the waist girth of front/2)+(the waist girth of back/2) than the shell girth/2 in girth of the waist for the best appearance. And the conversion of 3D scan data into 2D flat pattern in curve shape of crosswise had to spread out of the plane in straight line. The obese women's clothing should be manufactured with systematical consideration of the diversity and scarcity of the obese women's body shape.

• Macromolecular Research
• /
• v.17 no.4
• /
• pp.265-270
• /
• 2009

Noble thermosensitive nanoparticles, based on a PNIPAAm-co-AA core and a chitosan shell structure, were designed and synthesized for the controlled release of the loaded drug. PNIPAAm nanoparticles containing a carboxylic group on their surface were synthesized using emulsion polymerization. The carboxylic groups were conjugated with the amino group of a low molecular weight, water soluble chitosan. The particle size of the synthesized nanoparticles was decreased from 380 to 25 nm as the temperature of the dispersed medium was increased. Chitosan-conjugated nanoparticles with $2{\sim}5$ wt% MBA, a crosslinking monomer, induced a stable aqueous dispersion at a concentration of 1mg/1mL. The chitosan-conjugated nanoparticles showed thermo sensitive behaviors such as LCST and size shrinkage that were affected by the PNIPAAm core and induced some particle aggregation around LCST, which was not shown in the NIPAAm-co-AA nanoparticles. These chitosan-conjugated nanoparticles are also expected to be more biocompatible than the PNIPAAm core itself through the chitosan shell structures.

• Transactions of the Korean Society of Mechanical Engineers A
• /
• v.29 no.12 s.243
• /
• pp.1586-1596
• /
• 2005

In this paper, a structural damage identification method (SDIM) is developed to identify the line crack-like directional damages generated within a cylindrical shell. First, the equations of motion for a damaged cylindrical shell are derived. Based on a theory of continuum damage mechanics, a small material volume containing a directional damage is represented by the effective orthotropic elastic stiffness, which is dependent of the size and the orientation of the damage with respect to the global coordinates. The present SDIM is then derived from the frequency response function (FRF) directly solved from the equations of motion of a damaged shell. In contrast with most existing SDIMs which require the modal parameters measured in both intact and damaged states, the present SDIM may require only the FRF-data measured at damaged state. By virtue of utilizing FRF-data, one may choose as many sets of excitation frequency and FRF measurement point as needed to acquire a sufficient number of equations for damage identification analysis. The numerically simulated damage identification tests are conducted to study the feasibility of the present SDIM.

• Macromolecular Research
• /
• v.17 no.12
• /
• pp.1010-1014
• /
• 2009

Monodispersed microparticles with a poly(D,L-lactide-co-glycolide) (PLGA) core and a poly(ethyl 2-cyanoacrylate) (PE2CA) shell were prepared by Shirasu porous glass (SPG) membrane emulsification to reduce the initial burst release of doxorubicin (DOX). Solution mixtures with different weight ratios of PLGA polymer and E2CA monomer were permeated under pressure through an SPG membrane with $1.9\;{\mu}m$ pore size into a continuous water phase with sodium lauryl sulfate as a surfactant. Core-shell structured microparticles were formed by the mechanism of anionic interfacial polymerization of E2CA and precipitation of both polymers. The average diameter of the resulting microparticles with various PLGA:E2CA ratios ranged from 1.42 to $2.73\;{\mu}m$. The morphology and core-shell structure of the microparticles were observed by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The DOX release profiles revealed that the microparticles with an equivalent PLGA:E2CA weight ratio of 1:1 exhibited the optimal condition to reduce the initial burst of DOX. The initial release rate of DOX was dependent on the PLGA:E2CA ratio, and was minimized at a 1:1 ratio.

• Applied Chemistry for Engineering
• /
• v.18 no.2
• /
• pp.183-187
• /
• 2007

$SiO_2/TiO_2$ core-shell particles with controlled shell thickness were prepared using large silica particles. The thickness of titania coating layer was varied from 8 nm to 38 nm depending on the number of coating steps from 1 to 3 times. After titania coating, the core-shell particles showed textured surface due to the titania coating layer, resulting in 3~25 times increase of specific surface areas. The properties of titania coated silica particles were characterized by FE-SEM, Zeta potential meter, BET, and XRD.

• Transactions of the Korean Society of Mechanical Engineers A
• /
• v.29 no.7 s.238
• /
• pp.998-1004
• /
• 2005

A nano-stereolithography (NSL) process has been developed for fabrication of 3D shell structures which can be applied to various nano/micro-fluidic devices. By the process, a complicated 3D shell structure on a scale of several microns can be fabricated using lamination of layers with a resolution of 150 nm in size, so it does not require the use of my sacrificial layer or any supporting structure. A layer was fabricated by means of solidifying liquid-state monomers using two-photon absorption (TPA) induced using a femtosecond laser processing. When the polymerization process is finished, unsolidified liquid state resins can be removed easily by dropping several droplets of ethanol fur developing the fabricated structure. Through this work, some 3D shell structures, which can be applied to various applications such as nano/micro-fluidic devices and MEMS system, were fabricated using the developed process.

• Asian-Australasian Journal of Animal Sciences
• /
• v.6 no.1
• /
• pp.1-4
• /
• 1993

Least square means for egg weight (EW), average shell thickness (ST), shape index (SI), shell surface area (SA) and shell breaking strength (BS) were determined in the Philippine native (PN) and F2 upgrades with New Hampshire (NH-N) and White Leghorn (WL-N) blood, respectively. Eggs of PN were smaller in size but had higher SI while their egg shells were thinner and weaker than those of the two upgrades. Highest EW, SA and BS means were observed in WL-N. Significant (p<0.01) positive correlations of EW and SI with SA and BS were noted.