• Journal of Radiopharmaceuticals and Molecular Probes
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• v.8 no.2
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• pp.77-85
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• 2022

The Td05 and Sgc8c, DNA-based aptamers, are well-known to target internalized surface markers (IGHM and PTK7) of Burkitt's lymphoma and acute lymphoblastic leukemia (ALL). Thus, Td05 and Sgc8c labeled with metallic radioisotope ⁶⁴Cu can be evaluated as potential diagnostic PET imaging agents. In this study, we modified the carbon chain length of the last adenosine of aptamer (n = 3, 6, 12) to increase tumor cell uptake and select the best candidate among six types of aptamer analogues and one adenosine of aptamer. After labeling of ⁶⁴Cu, [⁶⁴Cu]Cu-DOTA-aptamer analogues were evaluated in vitro studies (serum stability, Log P values, cell uptake, biodistribution). Then, we evaluate in vivo PET imaging study for two candidates (⁶⁴Cu-DOTA-C12-Sgc8c, ⁶⁴Cu-DOTA-C6-Td05). PET images clearly visualize tumors at 24 h post-injection rather than at an early time point and the tumor-to-background ratio also increases at the delay time point. ⁶⁴Cu-DOTA-C12-Sgc8c and ⁶⁴Cu-DOTA-C6-Td05 could be used as potential radiotracers for lymphoma.

• Journal of Biomedical Engineering Research
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• v.17 no.1
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• pp.19-24
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• 1996

The purpose of this paper is to design high-order (or radial) surface gradient coil (SGC), which can provide multi-dimensional spatial selection. Although the spatial Selection with High-Order gradienT (SHOT) can provide a 2-D selection with only one selective RF pulse, the high-order gradient pro- duced by conventional cylindrical-shape coils has not been clinically useful due to the large selection size caused by the limited radial gradient intensity. However, by using the proposed high-order SGCs located near the imaging region, the size of volume selection can be reduced to a clinically useflll size of 1-2 cm in diameter by applying stronger radial gradient field with much less gradient driving power. So far radial SGCs have been designed by using the field component method and may cause distortion in the selection shapes. In this paper, by using the target field approach for the coil design, selected volumes became almost circular. A 40 cm-by-40 cm $z^2$_surface gradient coil has been designed and implemented by using the target field approach. Phantom and volunteer studies have been performed Experimental results using spatially localized MRI show good agreement to the theoretically predicted behavior.

• Proceedings of the KOSOMBE Conference
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• v.1995 no.11
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• pp.250-252
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• 1995

이 논문의 목적은 Target field approach를 사용하여 2차원적인 공간선택을 할 수 있는 방사형 표면 경사 자계코일 (Radial SGC : Radial Surface Gradient Coil)을 설계하는 것이다. 지금까지 쓰이던 원통형의 고차경사자계코일을 이용한 2차원적 원형 선택방법은 한개의 RF Puise로 2차원적인 공간 선택을 할 수 있는 장점이 있었으나 선택되어지는 체적의 지름이 6-8cm로 너무 크다는 단점이 있었다. 이 논문에서는 이와같은 단점을 극복하기 위해 영상을 얻고자하는 부분에 코일을 좀 더 가까이 붙일 수 있으며 선택되어지는 체적의 지름을 1-4cm까지 줄일 수 있는 표면 고차자계코일을 Target field approach 방법을 이용하여 설계하였으며 Phantom과 인체영상을 통해 제작된 코일의 성능을 확인해 보았다. 과거에 사용되었던 Field component method에서는 선택되는 부분이 찌그러지는 경우가 있었으나 Target field approach 방법에 의해 설계된 코일에 의하여 선택되는 부분은 이상적인 원에 가까운 모양이 되었다.