• Toxicological Research
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• v.17 no.2
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• pp.115-121
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• 2001

Some of endocrine disruptors with sexual hormone-like effects have been increasingly reported to be immunotoxic in many species in recent several years. Phthalate esters have possible effects on the endocrine system. Prenatal exposure to di(n-butyl) phthalate (DBP) has been reported to impair the androgen-dependent development of the male reproductive tract in rat. Therefore, the immunomodulatory effect of DBP was investigated in the developing immune system of fetal and neonatal Sprague-Dawley rats. Timed-bred pregnant SD rats were given to the doses of 0, 250, 500, and 750 mg DBP/kg$\cdot$ body weight /day by gavage once a day from gestational day (GD) 5 to 18. On GD19 or GD22/postnatal day one (PD1), the dams were euthanized, and the changes in organ weights and thymus phenotypes were examined for their offsprings. At 750 mg DBP/kg$\cdot$b.w./day in maternal exposure group, GD19 fetuses showed decreases in body weight. The spleen/body weight ratios were reduced in GD 19 fetuses from the dams exposed to 500 and 750 mg DBP/kg$\cdot$b.w./day. There were no significant changes in thymus and spleen cellularities though these cellularities showed a tendency to decrease in a dose dependent way. In the DBP-exsposed GD22/PD1 offsprings, the body weights, the relative organ weights and the cellularities did not exhibit alteration. Additionally, the percentages of CD3$^{+}$(CD4$^{+}$CD8$^{+}$, CD4$^{+}$CD8$^{-}$, CD4$^{-}$CD8$^{+}$, and CD4$^{-}$CD8$^{-}$) and CD3$^{-}$(CD4$^{+}$CD8$^{+}$, CD4$^{+}$CD8$^{-}$, CD4$^{-}$CD8$^{+}$, and CD4$^{-}$CD8$^{-}$) thymocyte subsets were not changed in any DBP-treated group. The proliferative responses of splenic T cells to Con A and B cells to LPS were decreased in all DBP-exposed GD22/PD1 offsprings.

• Journal of Korean Library and Information Science Society
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• v.41 no.1
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• pp.51-76
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• 2010

This study discussed the trends and characteristics of mental health services in the public libraries of North America. To accomplish this, this study collected its data through literature surveys, observations and interviews with librarians within the Vancouver public library system. The results show that there were many cases in which patrons asked public libraries for information on their mental health problems and the public libraries helped the patrons cope with their problems. The public libraries' assistance programs for national tragedies and natural disasters were temporary services. On the other hand, public libraries were continuously advising and guiding patrons dealing with emotional and psychological problems through the readers' advisory and information services. Specifically, public libraries were actively assisting various sensitive issues that are generated in the development of children and youths(for example, adoption, divorce and separation, remarriage, family, friendship, disabilities, death, self-esteem, emotions, bulling, violence, abuse, suicide, illness, addiction, sexual health, youth pregnancy and so on). The key role of librarians under these circumstances was to guide and recommend appropriate books and professional institutions that help solve the problems.

• Journal of Yeungnam Medical Science
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• v.30 no.2
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• pp.90-94
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• 2013

Background: This study was conducted to examine if basal luteinizing hormone (LH) levels could be useful for screening central precocious puberty (CPP) in girls. Methods: A total of 90 girls under the age of 8 years were included in this study. They underwent the gonadotropin-releasing hormone (GnRH) stimulation test at Good Gang-An Hospital from March 2008 to December 2012 for evaluation of premature sexual development. Patients were classified into two groups: the pubertal response group of patients who had 5 IU/L peak LH levels in the GnRH stimulation test, and the prepubertal response group of patients who had LH levels <5 IU/L. Chronological and bone ages, height, weight, body mass index, gonadotropin response to GnRH stimulation, and basal levels of LH, follicle-stimulating hormone, and estradiol were studied in both groups. The relationship between basal LH and peak-stimulated LH was evaluated using Spearman's correlation. To determine the optimal cut-off values of basal LH levels for differentiating between two groups, the receiver operating characteristic (ROC) curves were analyzed. Results: When the correlation between basal LH levels and peak LH after GnRH stimulation was analyzed in all subjects (N=90), basal LH levels had a statistically significant positive correlation with peak stimulated LH levels (rs=0.493, p<0.001). The cut-off level of optimal basal LH was 0.1 IU/L, according to the ROC curves. Its sensitivity was 73.3%, and its specificity was 77.8%. Conclusion: The study results showed that serum basal LH levels are useful for screening CPP in girls.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.15 no.11
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• pp.6604-6612
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• 2014

The purpose of this study was to provide basic knowledge and a proper education-training program for hotel enterprises. The results are as follows. First, an education-training program was focused on five factors. Service quality, Job, Organization culture, Self improvement, and Language. Second, the Importance Performance Analysis Result show that Keep the Good Work variables are the Customer reception, Food hygiene, Hygienic management, Cooking, First aid, Self development, and Communication. Possible excesses include Customer satisfaction, Business vision, Brand, Prevention of sexual harassment, Multiple cultures. Finally, an education training program should focus mainly on 'Manner', 'Table manner', 'Personal hygiene' and 'Chinese'.

• Clinical and Experimental Pediatrics
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• v.46 no.4
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• pp.400-403
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• 2003

Congenital adrenal hyperplasia(CAH) is a recognized cause of precocious pseudopuberty. Some children with CAH also develop true precocious puberty with early maturation of the hypothalamic-pituitary-gonadal axis. We review a case of CAH who eventually developed central precocious puberty nine months after initial treatment with corticosteroid. A 3-year-old boy visited complaining of rapid growth, a large penis and frequent penile erections. This patient was diagnosed with CAH with elevated 17-OH progesterone and cortical hypertrophy of adrenal gland on CT scan. His gonadotropin levels were within the normal prepubertal range. Even on treatment with corticosteroid he grew rapidly and had testicular enlargement, pubic hair development and rapid bone maturation. At second admission, his gonadotropin levels were elevated both basally and in response to LHRH stimulation, suggesting that the CAH led to early activation of pubertal gonadotropin secretion(true precocious puberty). He was treated with monthly depot injections of a LHRH analog in addition to the hydrocortisone. His second sexual characteristics regressed gradually and rate of linear growth and bone maturation decreased.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.30 no.1
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• pp.132-138
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• 1997

In order to obtain the basic information for seedling production of surf clam, Spisula sachalinensis, annual reproductive cycle was investigated from March 1994 to May 1995. S. sachalinensis was dioecious. The gonads are located between the digestive diverticula and muscle tissue of the foot. The condition factor was reached its maximum (0.19) in June, and then decreased to 0.16 in July. In November, the value was the lowest and then increased slowly. The age and minimum size for sexual maturation were 2 years old and about 50 mm in shell length, respectively. However, less than $10\%$ of sexually undifferentiated individuals were larger than 80 mm in shell length. On the other hand, the size of mature oocytes was ranged to $50\~60{\mu}m$ in diameter and testis-ova was observed in testis of the mature stage. Annual reproductive cycle could be classified into five successive stages : multiplicative (October to January), growing (February to April), mature (April to June), spawning (June and July) and degenerative and resting (August and September) stages.

• Journal of Korean Library and Information Science Society
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• v.46 no.4
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• pp.21-44
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• 2015

This study is to propose the directions of LGBTQ Friendly Library policies based on LGBTQ's human rights. To accomplish this purpose, this study comparatively analyzed key concepts from UN UDHR, ALA LBR, and IFLA statements up to scholarly library-articles related to LGBTQ with the inductive approach for qualitative data analysis. The result suggests the 7 directions of the library services policy-making for LGBTQ in practice : 1) Recommendations on the enhancement of the LGBTQ's human rights and library obligations, 2) Enforcement of librarians' education and training on LGBTQ subject matters, 3) Convergency on the various LGBTQ's information needs and the enlargement of library collections, 4) Development of search instruments on LGBTQ, 5) Secure library moods and no-distinctive use of its accommodations, 6) Cooperation system with NGO on LGBTQ, 7) Care and support on children and young adults experienced with LGBTQ.

• The Journal of Korean Society for School & Community Health Education
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• v.14 no.2
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• pp.1-14
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• 2013

Objectives: The purpose of this study was to identify the relationship of internet use time and health risk behaviors among adolescents and provide data to set up a strategy for preventing internet addiction. Methods: The data of the 2011 Youth Health Risk Behavior web-based Survey Collected by Korean Center for Disease Control was analyzed using t-test, ANOVA, Chi-square test for this study. Results: There were significant differences between boys and girls in internet use time. Boy's internet use time was different according to city size(F=13.20, p<.001), grade(F=35.85, p<.001), school record(F=298.95, p<.001), economic state(F=326.75, p<.001), living with parents(t=11.60, p<.001), father's education level(F=147.92, p<.001), and mother's education level(F=110.93, p<.001). Girls' internet use time was also different according to school grade(t=-8.68, p<.001), grade(F=61.03, p<.001), school record(F=233.32, p<.001), economic state(F=185.78, p<.001), living with parents(t=10.81, p<.001), father's education level(F=86.54, p<.001), and mother's education level(F=92.64, p<.001). Regarding the health risk behaviors, present smoking, present alcohol drink, drug use skipping breakfast, eating fast food, drinking soda, sexual behavior, suicidal attempt, engagement time in physical education classes, severe exercise, and sleeping satisfaction made differences in the internet use time. Conclusions: The results suggest that health risk behaviors are influenced by internet use time of adolescents. Thus, these results may be contribute to development of programs to prevent internet addiction.

• Journal of the korean academy of Pediatric Dentistry
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• v.43 no.3
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• pp.334-339
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• 2016

Child abuse often interferes with the normal and healthy development of a child, bringing about various complications and problematic behaviors. Furthermore, such physical, mental abuse or neglect, and sexual abuse on a developing child may have serious effects even until after adolescence. The types of injuries caused by physical abuse vary, but some types of injuries are common. A great number of them can be detected during a routine dental examination because many of these injuries are present in the facial and dental region. Accordingly, in the case of abused children, it is important to find the signs of abuse through regular dental checkups, as many suffer injuries to the face, head and neck area including the oral and perioral area. As a pediatric dentist, it is the legal and social obligation to contribute to preventing and assisting the struggle against child abuse. The authors contemplate ways for all pediatric dental related personnel to find some clinical signs and symptoms of child abuse to help early detection, and to manage the situation properly.

• Journal of Periodontal and Implant Science
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• v.31 no.1
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• pp.225-232
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• 2001

The aim of this study was to recommend the optimal age for prevention of periodontal disease and to investigate the trend of treatment modality according to different period. From the chart recordings of the patients who had been treated periodontally from Jan. 1981 to Dec. 1995 in the dept .of periodontics, Chosun University Dental Hospital, those of the periodontally treated patients on more than 4 sixtants were selected for the present study. The distribution of the patients was counted according to the age group and the gender. And they were divided into 3 groups(group 1: 1987-1958, group 2: 1985-1990, group 3: 1991-1995) by 5 year interval according to the treated year. The periodontal treatment modalities were classified into non-surgical therapy, pocket elimination surgery, regenerative periodontal surgery, mucoginigival surgery, clinical crown lengthening, and others. The results were as follows; 1.In the distribution of the periodontally treated patients according to the age group, 40's age group was the highest, and 30's, 40's, and 50's age groups occupied more than two thirds(73%). 2.The sexual distribution of the periodontally treated patients showed that males(53.4%) were a little more than females(46.6%). Within 20's group female was higher, but within 40's male was higher. 3.Regardless of the age group and the gender, pocket elimination surgery was the most frequent treatment modality. 4.In group 1 and 2(1987-1990) the main treatment modality was pocket elimination surgery and non-surgical therapy, but in group 3(1991-1995) it was regenerative periodontal surgery and pocket elimination surgery. The above results suggest that the prevention of periodontal disease should be initiated from early twenties, and the most frequent treatment modality may be closely related with development of new material and method.