• Biomolecules & Therapeutics
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• v.1 no.2
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• pp.270-274
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• 1993

The acute toxicity of a recombinant granulocyte-macrophage colony stimulating factor (code name: LBD-005) was evaluated in both sexes of ICR mice, 5~6 weeks old, by the oral, subcutaneous and intravenous routes of administration. Based on the results of the acute toxicity study, LBD-005 was not considered to induce any toxic effect on the mice in mortalities, clinical findings, body weights and gross findings. It is suggested that $LD_50$ values in mice would be >48 mg/kg in the oral route and >24 mg/kg in the subcutaneous or intravenous route.

• Biomolecules & Therapeutics
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• v.1 no.2
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• pp.266-269
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• 1993

The acute toxicity of a recombinant human interferon $\alpha$A (code name: LBD-007) was evaluated in both sexes of ICR mice, 5 weeks old, by the oral, subcutaneous and intravenous routes of administration. Based on the results, LBD-007 was not considered to induce any toxic effect on the mice in mortalities, clinical findigs, body weights and gross findings. It is suggested that LD$_{50}$ values in mice would be $>48{\times}10^8$ IU/kg in the oral, subcutaneous or intravenous routes.s.

• Biomolecules & Therapeutics
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• v.1 no.2
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• pp.226-235
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• 1993

DA-125, a new anthracycline antitumor antibiotic, was administered to Sprague-Dawley rats intravenously for 4 weeks to investigate the repeated dose toxicity Focal alopecia was noted in three female rats receiving 1.0mg/kg/day. In rats receiving 1.0 mg/kg/day, weight gain decreased in both sexes after first or second week. Hematological examination revealed lower counts of total leukocyte and increased numbers of platelet after second week. At terminal necropsy, atrophy of thymus and spleen was observed. Lymphocytic depletion of thymus and atrophy of white pulp in spleen were observed microscopically. A decrease in the number of hematopoietic cells in the bone marrow and degeneration of germinal epithelia in testes were also observed. These treatment-related effects were mainly confined to rats receiving 1.0 mg/kg/day. And toxic effects with microscopic changes were not observed in rats receiving 0.2 mg/kg/day or 0.04 mg/kg/day.

• Biomolecules & Therapeutics
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• v.9 no.1
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• pp.46-50
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• 2001

The current study was performed to determine the acute oral toxicity of a crude extract of sanghwang mushroom (Phellinus linteus), in SD rats. 5 rats of each sex were orally treated with a single dose of extract of sanghwang mushroom at doses of 0, 500, 1,000, 2,000 mg/kg, respectively. After the treatment, clinical signs and body weight change, the food and water consumption were observed for 14 days. All animals survived during the study and did not show any clinical signs. Body weight gain showed no significant difference between the control and treated rats. However, body weight gain delayed in high dose group (2,000 mg/kg) on day 1~3 after administration. Another 5 rats of each sex were orally treated with a single dose of extract of sanghwang mushroom at dosages 4,000, 5,000 mg/kg respectively, but all animals survived during the study and did not show any clinical signs. It is suggested that LD$_{50}$ of extract of sanghwang mushroom by oral administration was estimated to be over 5,000 mg/kg in both sexes of rats.s.

• The korean journal of orthodontics
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• v.13 no.2
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• pp.201-204
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• 1983

To study the calcification of second molars in Class I malocclusion with normal craniofacial structure, the author examined cephalograms, orthopantomograms, periapical films of 538 children from 7 y 0 m to 15y 11m old who had Class I malocclusion with normal craniofacial structure, and observed the calcification stage of upper and lower second molars. The results are as follows. 1. The mean ages of crown completion of upper and lower second molars are $8.82{\pm}1.14,\;8.72{\pm}0.75$ in boys, and $8.60{\pm}1.46,\;8.22{\pm}0.92$ in girls. 2. The mean ages of root completion of upper and lower second molars are $14.25{\pm}1.46,\;14.15{\pm}0.83$ in boys, and $14.12{\pm}0.93,\;14.15{\pm}0.83$ in girls. 3. There are no difference between the calcification stages of upper second molars and those of lower second molars in both sexes.

• Journal of Korean Academy of Oral and Maxillofacial Radiology
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• v.3 no.1
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• pp.29-34
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• 1973

The study was made on the facial profile of the normal Korean adults using the roentgenographic cephalograms. The subjects ccnsisted of 50 males and 50 females with the normal occlusion. The measurements were made of the facial angles in skeletal pattern and depth, height and the length in the soft tissue profile. The mean and standard deviations from the subjects were calculated and compared with the samples of male and female. The authors have drawn the conclusions as follows: 1. Compared with the angulation in skeletal patterns, there were no differences between both sexes. 2. Individual variations of the lower face were larger than the upper face in most measuring points. 3. Generally, facial heights were lesser than facial depth in sexual differences. 4. Most dimensions of the facial depth, height and length of the male were larger than those of female.

• The Journal of Advanced Prosthodontics
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• v.4 no.2
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• pp.72-75
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• 2012

PURPOSE. This study evaluated the existence of golden proportion between the widths of the maxillary and mandibular anterior teeth in Indian population. MATERIALS AND METHODS. The clinical tooth width measurements were recorded with the digital vernier calipers on 576 patients of both sexes in the age group of 21 - 30 years. Flexible ruler was used to determine the width of maxillary and mandibular anterior teeth on the patients by the same operator. The data obtained was statistically analyzed using paired student t-test (${\alpha}$=.05). RESULTS. The golden proportion was not found between the width of the right central and lateral incisors in 53% of women and 47% of men. The results revealed the golden percentage was rather inconstant in terms of relative tooth width. CONCLUSION. The golden proportion is an inappropriate method to relate the successive widths of the maxillary anterior teeth in Indian population.

• Culinary science and hospitality research
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• v.13 no.1 s.32
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• pp.224-234
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• 2007

Consumers' awareness has been changing through the development of information industry and change of life style. To understand the new generation came to be our concern in terms of being able to predict the trend of the future. Companies are trying to go through the market-change by making a marketing strategy that matches their emotion and characteristics. There should be a research on the new generation, specially university students, according to sex. Therefore, this research covers the university students in early twenties to see the differences between sexes. Foodservice industry needs to have consideration on coupon-books. It is reconfirmed that advertisement by word of mouth is still effective in sales promotion.

• Korean Journal of Community Nutrition
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• v.8 no.3
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• pp.340-348
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• 2003

Differences in food and nutrient intake among Korean adults based on different stress levels were investigated using information obtained from 7,370 adults who participated in the 1998 Korean National Health and Nutrition Survey. The twenty-four hour recall method was used for this dietary survey. Data pertaining to indivisual stress levels were collected by means of interviews as part of the National Health Behavior Survey. Following the analysis of variance, Duncan's Multiple Range Test was used to test the differences in food and nutrient intake among groups with different levels of stress. Eighty-three percent of the study subjects were reported to have a certain level of stress. Unlike the observations made in European and American studies, there were no significant differences observed in food and nutrient intake based on the stress levels among Korean adults of either sexes. These results may imply that even though stress was clustered with other health related behavior, the association between food intake and stress among Koreans was very weak. (Korean J Community Nutrition 8(3) : 340∼348, 2003)

• The Mathematical Education
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• v.44 no.4 s.111
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• pp.509-524
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• 2005

The purpose of this study is to investigate the current state of the contents of the mathematics education that are implemented for 3-10 grade students in Korea. To satisfy the purpose of the study, we conducted a nationwide questionnaire to get opinions from students on the relevance of the mathematics curriculum. 4,158 elementary school students, 4,571 middle school students, and 1,653 high school students participated in this survey. Many students feel that the quantity is relevant, so the requirement of reduction in quantity is a little. Also secondary students feel that mathematics is difficult and this condition becomes more serious in proportion as grade. Finally we noticed the difference between sexes, grades, and tracks of studying in every question.