• Nuclear Engineering and Technology
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• 제49권2호
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• pp.434-441
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• 2017

Containment venting is one of several essential measures to protect the integrity of the final barrier of a nuclear reactor during severe accidents, by which the uncontrollable release of fission products can be avoided. The authors seek to develop an optimization approach to venting operations, from a simulation-based perspective, using an integrated severe accident code, THALES2/KICHE. The effectiveness of the containment-venting strategies needs to be verified via numerical simulations based on various settings of the venting conditions. The number of iterations, however, needs to be controlled to avoid cumbersome computational burden of integrated codes. Bayesian optimization is an efficient global optimization approach. By using a Gaussian process regression, a surrogate model of the "black-box" code is constructed. It can be updated simultaneously whenever new simulation results are acquired. With predictions via the surrogate model, upcoming locations of the most probable optimum can be revealed. The sampling procedure is adaptive. Compared with the case of pure random searches, the number of code queries is largely reduced for the optimum finding. One typical severe accident scenario of a boiling water reactor is chosen as an example. The research demonstrates the applicability of the Bayesian optimization approach to the design and establishment of containment-venting strategies during severe accidents.

• The Plant Pathology Journal
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• 제22권2호
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• pp.131-138
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• 2006

Two strains of Cucumber mosaic virus (CMV) isolated in Kuwait were confirmed their infectivity based on symptomatology and host range on different cultivars of tomato (Lycopersicon esculentum), tobacco(Nicotiana tabacum L.) and squash (Cucurbita pepo). The pattern of symptoms differed for the two CMV strains in tomato and tobacco, showing severe stunting and mosaic symptoms with one strain designated KU2, and almost symptomless with the other strain designated KU1. A satellite RNA 5 (sat-RNA) was found to be associated with the KU1 strain and was characterized as a benign viral satellite RNA. Using reverse transcription and polymerase chain reaction (RT-PCR) with sat-RNA specific primers, an amplified PCR product of about 160bp was determined and analyzed by gel electrophoresis. This naturally occurring benign viral satellite RNA was successfully used as a biological control agent to protect tomato plants against the severe KU2 strain. Tomato plants grown in plant-growth chambers, were preinoculated with KU1 containing the benign viral satellite and then challenge inoculated with the severe KU2 strain at different time intervals. All plants challenged three weeks after preinoculation showed nearly complete protection from subsequent infection by the severe strain. This biological control technology using plant viruses was found protective and could be successfully established sooner after the preinoculation.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제8권2호
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• pp.263-268
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• 2005

본 저자들은 심한 간 부전과 함께 복통, 구토, 의식 변화, 사지 마비, 배뇨 장애 및 호흡부전을 동반한 EPP 예를 경험하였기에 보고하는 바이다.

• 성인간호학회지
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• 제28권2호
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• pp.148-155
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• 2016

Purpose: The purpose of this study was to compare symptom severity and the impact of presence of depressive and/or anxiety symptoms among patients with head and neck cancer (HNC). Methods: One hundred and fifteen patients diagnosed with HNC completed two questionnaires: Hospital Anxiety and Depression Scale (HADS) and the M. D. Anderson Symptom Inventory-Head and Neck Cancer (MDASI-HN). Results: Of the total sample, 55.6% reported depressive symptoms and 33% reported anxiety symptoms. Patients who reported either depressive or anxiety symptoms also had significantly more severe symptoms. The most severe symptom was dry mouth. Participants who were depressed reported that interference in the enjoyment of life due to symptoms was the most distressing whereas participants with anxiety reported symptom interference in work was of most concern. Of patients reporting moderate to severe symptoms, more than 60% reported depressive symptoms. Of patients reporting moderate to severe feelings of being distress and feeling sad, more than 70% reported anxiety symptoms. Conclusion: Patients with HNC reporting moderate to severe symptoms also report depressive and/or anxiety symptoms. The results suggest the need to develop an integrated nursing intervention of both physical and emotional symptoms for patients with HNC.

• 한국멀티미디어학회논문지
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• 제20권2호
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• pp.115-125
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• 2017

For many stroke patients undergoing rehabilitation therapy, there is a need for indicator for evaluating the body function in paretic and non-paretic regions of stroke patients quantitatively. In this paper, the function of muscles and cells in paretic and non-paretic regions of severe and mild hemiplegic stroke patients was evaluated using multi-channel bioelectrical impedance spectroscopy. The paretic and non-paretic regions of severe and mild stroke patients were quantitatively assessed by using bioelectrical impedance parameters such as prediction marker (PM), phase angle (${\theta}$), characteristic frequency ($f_c$), and bioelectrical impedance vector analysis (BIVA). The mean values of impedance vector were significantly discriminated in all comparisons (severe-paretic, severe-non-paretic, mild-paretic, and mild-non-paretic). The bioelectrical impedance parameters were proved to be a very valuable tool for quantitatively evaluating the paretic and non-paretic regions of hemiplegic stroke patients.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2001년도 춘계학술대회논문집A
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• pp.782-787
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• 2001

This paper is concerned with the global rupture of a nuclear reactor pressure vessel(RPV) in a severe accident. During the severe reactor accident of molten core, the temperature and the pressure in the nuclear reactor rise to a certain level depending on the initial and subsequent condition of a severe accident. While the rise of the temperature cause the thermal softening of RPV material, the rise of the internal pressure could cause failure of the RPV lower head. The global rupture of an RPV is simulated by finite element limit analysis for the collapse pressure and mode and this analysis results have been compared with a variation of the internal pressure of RPV. The finite element limit method is a systematic tool to secure the safety criteria of a nuclear reactor and to evaluate the in-vessel corium retention.

• 한국보건간호학회지
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• 제35권1호
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• pp.149-164
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• 2021

Purpose: To identify the factors associated with poor self-rated health in individuals with acquired visual impairment through classification of such individuals into severe and mild visual impairment groups. Methods: This descriptive, cross-sectional, survey-based study analyzed data from 563 individuals with visual impairment due to acquired causes who had been recruited in the 2017 Korean National Survey on Persons with Disabilities. Results: Individuals with severe visual impairment reported poorer self-rated health. Mild depression (p=.003), and low smartphone use (p=.045) were associated with poorer self-rated health in those with severe visual impairment. The factors associated with poor self-rated health in those with mild visual impairment were comorbidities, low smartphone use (p=.006), needed health information (p=.020), unbalanced diet (p<.001), low weight (p=.024), and lack of health checkups (p=.001). Conclusion: Depression was found to be a predictor of poor self-rated health in individuals with severe visual impairment, which highlights the need for nursing and related healthcare intervention to lower depression in this specific population. Further, promoting social network building and providing health information using smartphones may serve to encourage appropriate health behavior in people with severe visual impairment who have reduced mobility and health literacy.

• 가정∙방문간호학회지
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• 제25권3호
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• pp.224-231
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• 2018

Purpose: This study was to analyze the factors affecting ventilator-associated pneumonia with severe trauma patients. Methods: This study conducted from May 1, 2018 to May 31, 2018 based on the medical records of the intensive care unit of a university hospital from May 1, 2017 to April 30, 2018 in Gangwon province. The inclusion criteria were 1) Trauma intensive care unit patient, 2) older than 19 years 3) without pneumonia at the time of admission. The collected data were analyzed using descriptive, correlation analysis, ANOVA, t-tests, $x^2$-tests and regression. Results: The severe trauma patients had a total of 2,877 days receiving ventilator, and nine VAP cases. The overall infection rate was 4.0%, and the VAP incidence rate was 3.13 per 1000 ventilator days. VAP in severe trauma patient affected ICU stay(OR=1.03), mechanical ventilator applied day(OR=1.04). Conclusion: Therefore, the development of an individualized VAP prevention bundle and nursing intervention for patients with trauma will be needed and further studies. In addition, there were no findings regarding the relationship between VAP occurrence and the severity of multiple traumatic injuries, so further studies of these factors should be performed.

• Nuclear Engineering and Technology
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• 제51권3호
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• pp.723-730
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• 2019

Acquiring instrumentation signals generated from nuclear power plants (NPPs) is essential to maintain nuclear reactor integrity or to mitigate an abnormal state under normal operating conditions or severe accident circumstances. However, various safety-critical instrumentation signals from NPPs cannot be accurately measured on account of instrument degradation or failure under severe accident circumstances. Reactor vessel (RV) water level, which is an accident monitoring variable directly related to reactor cooling and prevention of core exposure, was predicted by applying a few signals to deep neural networks (DNNs) during severe accidents in NPPs. Signal data were obtained by simulating the postulated loss-of-coolant accidents at hot- and cold-legs, and steam generator tube rupture using modular accident analysis program code as actual NPP accidents rarely happen. To optimize the DNN model for RV water level prediction, a genetic algorithm was used to select the numbers of hidden layers and nodes. The proposed DNN model had a small root mean square error for RV water level prediction, and performed better than the cascaded fuzzy neural network model of the previous study. Consequently, the DNN model is considered to perform well enough to provide supporting information on the RV water level to operators.

• 대한화상학회지
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• 제24권2호
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• pp.46-49
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• 2021

An anatomically normal first web space is essential for optimal prehensile movements of the thumb and hand. A 28-year-old woman presented with severe scarring and contractures of the first web space of both hands, following a flame burn injury sustained 25 years prior to presentation. First web space contracture may occur secondary to severe injuries, burns (as observed in our patient), or congenital hand anomalies. A significant amount of additional skin is required to release a severe first web space contracture. Reconstruction of wide areas of contractures using only local flaps is challenging. Among other free flaps used in clinical practice, the thinned lateral arm free flap provides flexible vascularized tissue for reconstruction of the skin after severe first web space contracture release. Reconstruction using lateral arm free flaps facilitated thumb abduction and opposition (which were initially difficult) and improved hand function in our patient.