• Journal of agriculture & life science
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• v.46 no.3
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• pp.109-118
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• 2012

The gene encoding an esterase enzyme was cloned from a metagenomic library of cow rumen bacteria. The esterase gene (est2R) was 2,120 bp in length, encoding a protein of 516 amino acid residues with a calculated molecular weight of 57,286 Da. The molecular weight of the enzyme was estimated to be 57,000 Da by SDS-PAGE. Est2R shared 35.6% amino acid identity with esterase (CAH19079) of uncultured prokaryote. The Est2R was most active at $20-40^{\circ}C$, and showed optimum at $30^{\circ}C$ and pH 8.0. The most activity of Est2R for the different chain length of p-nitrophenyl ester group as substrate was p-nitrophenyl acetate. Moreover, the enzyme was found to be most active without organic solvent, followed by 98% active with ethanol, and the enzyme activity was highly affected by the acetonitrile. The enzyme was significantly inhibited by $Zn^{2+}$ but stimulated by $Ca^{2+}$. So, novel esterase gene est2R is likely to obtain from cow rumen metagenome and supposed to use for industrial purpose.

• Journal of Korea Port Economic Association
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• v.25 no.3
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• pp.385-406
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• 2009

The volume of trade between Korea and China has been growing significantly year by year since the diplomatic relations have been established in 1992. The economic and logistics cooperation between the two countries is crucial not only for the development of their economic relations but for promotion of value-added logistics. However there are still huge and serious impediments to logistics network and management between the two countries including bottlenecks in transport and customs procedures. The purpose of this study is to investigate how to promote value added logistics activities between Korea and Shandong Province of China. It is suggested the ways to increase VAL activities such as enhanced division of international labour within industries, provision of comprehensive logistics service and establishment of strategy for supply chain management between the two countries.

• Journal of Convergence for Information Technology
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• v.8 no.3
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• pp.169-174
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• 2018

Today, the world has reached 'Industry 4.0'. Industry 4.0 has high uncertainty in various aspects because it is based on building a smart chain where the various elements that make up the industry can communicate with each other. Based on the above facts, based on the researches of the previous researchers, we have searched for the countermeasures of small and medium sized manufacturing companies in Korea in order to minimize the negative aspects of establishing the basic concepts and functioning of Industry 4.0. As a result, efforts to accurately identify and address the uncertainties of Industry 4.0 in a variety of ways will help to drive business growth and economic growth in the country through smart factories, which are at the heart of Industry 4.0.

• Journal of the Korea Safety Management & Science
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• v.14 no.4
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• pp.153-168
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• 2012

It has been recognized as an important issue to design optimally a firm's logistics network for minimizing logistics cost and maximizing customer service. It is, however, not easy to get an optimal solution by analyzing trade-off of cost factors, dynamic and interdependent characteristics in the logistics network decision making. Although there has been some developments in a system which helps decision making for logistics analysis, it is true that there is no system for enterprise-wise's on-site support and methodical logistics decision. Specially, E-biz process along with information technology has been made dramatic advance in a various industries, there has been much need for practical education closely resembles on-site work. The software developed by this study materializes efficient algorithm suggested by recent studies in key topics of logistics such as location and allocation problem, traveling salesman problem, and vehicle routing problem and transportation and distribution problem. It also supports executing a variety of experimental design and analysis in a way of the most user friendly based on Java. In the near future, we expect that it can be extended to integrated supply chain solution by adding decision making in production in addition to a decision in logistics.

• Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
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• v.31 no.2
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• pp.61-65
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• 2020

Background and Objectives The overall incidence of laryngeal tuberculosis (LT) has generally decreased over the recent years, yet there is still a discrete population of patients newly diagnosed with the disease. This study is aimed to examine the patients with LT over the recent 10 years and to investigate the changes in clinical pattern with respect to the past period. Materials and Method A retrospective review has been performed on 20 patients who have been initially diagnosed with LT between 2005 and 2015. Results The age of the patients ranged from 25 years to 95 years with an average age of 45.6 years. Seventeen patients (85%) showed hoarseness, which was the most common clinical symptom. Most affected lesion was the true vocal cord. Laryngoscopic examination showed various clinical manifestations: polypoid 30%, granulomatous 25%, nonspecific 25%, ulcerative 20%. A variety of methods were used for diagnostic confirmation of LT [acid-fast bacilli (AFB) smear 45%, AFB culture 40%, polymerase chain reaction 30%, surgical pathology 45%]. Coexisting pulmonary tuberculosis (PT) was detected in 10 patients (50%). Relative to the patients with inactive PT or normal lung status, those with active PT showed higher incidence of laryngeal lesions located in areas other than true vocal cord (p=0.050). Conclusion Based on the analytic results from this study, laryngologists should recognize the changes in the recent clinical patterns of LT and always be ready for clinical suspicion of this disease on such atypical laryngeal findings which can often mimic laryngeal malignancies to provide the pertinent treatment.

• Journal of Nutrition and Health
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• v.54 no.4
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• pp.342-354
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• 2021

Purpose: Obesity is a serious public health issue for the modern society and is considered a chronic health hazard. There are many surgical and pharmacological approaches to treat obesity. However, various potentially hazardous side effects remain the biggest challenge. Therefore, diets based on foods derived from natural products have gained increasing attention compared to anti-obesity drugs. Recently, research on edible insects as a food source has been a topic of considerable interest in the scientific communities. This study examined the anti-obesity effects of ingesting an edible insect by feeding a high-fat diet (HFD)-induced obese mouse models with a diet containing Tenebrio molitor larvae powder (TMLP). Methods: Six-week-old female C57BL/6J mice were divided into 4 groups according to treatment: 100% normal diet (ND), 100% HFD (HFD), HFD 99% + TMLP 1% (TMLP), and HFD 97% + TMLP 3% (TMLP 3%). TMLP was added to the HFD for 6 weeks for the latter two groups. Results: Compared to the HFD group, mice in the TMLP group showed weight loss, and micro-computed tomographic imaging revealed that the volume of the adipose tissue in the abdominal area also showed significant reduction. After an autopsy, the fat weight was found to be significantly reduced in the TMLP group compared to the HFD group. In addition, the degree of fat cell deposition in the liver tissue and the size of the adipocytes significantly decreased in the TMLP group. Reverse transcription polymerase chain reaction analysis for the mRNA expression of adipogenesis-related genes namely CCAAT-enhancer-binding proteins (C/EBP-β, C/EBP-δ), and fatty acid-binding protein 4 (FABP4) showed that the expression levels of these genes were significantly reduced in the TMLP group compared to the HFD group. Serum leptin level also decreased significantly in the TMLP group in the comparison with the HFD group. In addition, total cholesterol, triglyceride, and glucose levels in mouse serum also decreased in the TMLP group. Conclusion: Taken together, our results showed that TMLP effectively inhibited adipocyte growth and reduced body weight in obese mice.

• Journal of Digital Convergence
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• v.20 no.4
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• pp.791-797
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• 2022

Through recent metaverse marketing case studies, success factors and activation methods were analyzed from the perspective of content, platform, network, and device of the metaverse ecosystem in each industry. The importance of contents and platform of metaverse could be found in entertainment, fashion, office space and real estate, education, advertisement and commerce industries. In order to vitalize the metaverse, firstly, it is necessary to strengthen active participation and retention by providing a stable revenue model for market participants. Secondly, the importance of attractive content to expand subscribers is a key trigger for metaverse activation. Thirdly, it is necessary to increase the convenience of using metaverse service by using a light and simple device for the user. Fourthly, a win-win cooperation strategy should be supported in the value chain of the industry through ecosystem scalability. In addition, business opportunities for market participants and additional revenue models should be continuously provided.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.16 no.10
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• pp.3313-3332
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• 2022

This study is an investigation into the factors affecting patient dissatisfaction among Saudi hospitals. The selected factors considered for analysis are security of information sharing, operational practices, disruptive technologies, and the ease of use of EHR patient information management systems. From the literature review section, it was clear that hardly any other studies have embraced these concepts in one as was intended by this study. The theories that the study heavily draws from are the service dominant logic and the feature integration theory. The study surveyed 350 respondents from three large major hospitals in three different metropolitan cities in the Kingdom of Saudi Arabia. This sample came from members of the three hospitals that were willing to participate in the study. The number 350 represents those that successfully completed the online questionnaire or the limited physical questionnaires in time. The study employed the structural equation modelling technique to analyze the associations. Findings suggested that security of information sharing had a significant direct effect on patient satisfaction. Operational practice positively mediated the effect of security of information sharing on patient dissatisfaction. However, ease of use failed to significant impact this association. The study concluded that to improve patient satisfaction, Saudi hospitals must work on their systems to reinforce them against the active threats on the privacy of patients' data by leveraging disruptive technology. They should also improve their operational practices by embracing quality management techniques relevant to the healthcare sector.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.26 no.10
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• pp.1551-1558
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• 2022

We propose a two-tier cooperative computing system comprised of a mobile device and an edge server for partial offloading of multi-branch structures in Fog/Edge Computing environments in this paper. The proposed system includes an algorithm for splitting up application service processing by using reconstructive linearization techniques for multi-branch structures, as well as an optimal collaboration algorithm based on partial offloading between mobile device and edge server. Furthermore, we formulate computation offloading and CNN layer scheduling as latency minimization problems and simulate the effectiveness of the proposed system. As a result of the experiment, the proposed algorithm is suitable for both DAG and chain topology, adapts well to different network conditions, and provides efficient task processing strategies and processing time when compared to local or edge-only executions. Furthermore, the proposed system can be used to conduct research on the optimization of the model for the optimal execution of application services on mobile devices and the efficient distribution of edge resource workloads.

• Industry Promotion Research
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• v.7 no.3
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• pp.17-26
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• 2022

As the well-being mindset to keep our minds and bodies free and healthy more than anything else in the society we live in is spreading, the meaning of health care has become a key part of the 4th industrial revolution such as big data, IoT, AI, and block chain. The advancement of the advanced medical information service industry is being promoted by utilizing convergence technology. In digital healthcare, the development of intelligent information technology such as artificial intelligence, big data, and cloud is being promoted as a digital transformation of the traditional medical and healthcare industry. In addition, due to rapid development in the convergence of science and technology environment, various issues such as health, medical care, welfare, etc., have been gradually expanded due to social change. Therefore, in this study, first, the general meaning and current status of digital health care medical information is examined, and then, developmental tasks to activate digital health care medical information are analyzed and reviewed. The purpose of this article is to improve usability to fully pursue our human freedom.