• 대한핵의학회지
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• 제17권1호
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• pp.63-69
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• 1983

Fifteen cases of Korean hemorrhagic fever who were admitted Chungnam National University Hospital from October 1981 to December 1981 were analysed on the evaluation of metabolic.changes of the thyroid hormones, and thyroid function status in each clinical phase. 1. Serum $T_3,\;T_4$ concentratron, $FT_4I\;and\;T_4/TBG$ ratio were significantly lower (p<0.001, p<0.005, p<0.005, p<0.001, respectively) than control group in oliguric and early diuretic phase of Korean hemorrhagic fever. With the recovery of illness, abnormal thyroid hormones and thyroid function indices tend to become normal range. But Serum $FT_4$, TSH and TBG concentration were within normal range in all phase of KHF. Thus in Korean hemorrhagic fever, euthyroidism is probably maintained by normal or elevated serum $FT_4$ 2. $T_4/T_3\;and\;rT_3/T_3$ rato (p<0.005, p<0.005) were increased in oliguric and early diuretic phase of KHF. These results might be explained by decreased peripheral conversion of $T_4\;to\;T_3$ in oliguric and early diuretic phase.

• 한국임상수의학회지
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• 제13권2호
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• pp.108-113
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• 1996

The effect of aqua-acupuncture of total saponin on the recovery of liver function in -intoxicated rats was exemined. Rats were divided into normal, control and three experimental groups (As-I group : aqua-acupuncture of saline to Gansu locus and Aa-III group : aqua-a-cupuncture of total saponin to blank locus at the thigh). Changes of some serum biochemical parameters (ALT, AST and ALP, total protein and albumin, and albumin/globulin (A/G) ratio) were determined. Serum ALT activities were increased by $CCI_{4}$T and decreased in all aqua-acupuncture groups compared with the control group. Aa-I group showed significant decrease of ALT activities on the 2nd (P<0.05) and 3rd (P<0.05) day, respectively. Aa-II group showed significant decrease on the 3rd day (P<0.05) day. Serum AST activities were increased by $CCI_{4}$T and decreased in all apua-acupuncture groups compared with the control group. Aa-I group showed significant decrease on the 1st (P<0.05), 2nd (P<0.001) and 3rd (P<0.001) day, respectively. Aa-II group showed significant decrease on the 3rd (P<0.001) day. Aa-III group showed significant decrese on the 1st (P<0.05) and 3rd (P<0.001) day, respectrvely. Serum ALP activities were increased by $CCI_{4}$T and decreased in all aqua-a-cupuncture groups compared with the control group. Aa-I group showed significant decrease on the 3rd (P<0.01) day. Total protein, albumin and A/G ratio were decreased by $CCI_{4}$T and increased in all aqua-acupuncture groups compared with control group. Aa-I group showed significant increase only on the 3rd day in albumin (P<0.01). It was thought that the aqua-acupuncture of total saponin to Gansu locus was effective on the recovery of liver function in $CCI_{4}$T-intoxicated rats.

• Nutrition Research and Practice
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• 제1권4호
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• pp.291-297
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• 2007

This study was conducted to investigate the effect of dietary soluble fiber administration and/or high fat diet on serum and brain neurohormonal profiles, adipose tissue mass and body weight gain in Sprague-Dawley rats. Four groups of rats were respectively fed 10% fat diet (C), 10% fat plus pectin diet (P), 20% fat diet (HFC) and 20% fat plus pectin diet (HFP) for 4 weeks. In HFP group, the food and energy intake, body weight gain, FER including fecal excretion were the smallest (p<0.05). Serum HDL-cholesterol, triglyceride and glucose level were also the lowest in HFP group (p<0.05). The weight of brain, epididymal fat pad and adrenal gland except liver didn't show any significant differences among groups. Interestingly serum norepinephrine concentration of HFP group tended to be higher, but dopamine concentration tended to be lower than those of HFC group. However serum catecholamine concentration didn't show any significant differences among all groups. Norepinephrine and epinephrine contents of right portion of midbrain of P and HFP groups were remarkably lower than those of the C group. These results suggested that soluble fiber pectin consumption might affect neurohormonal profiles in serum and brain according to dietary fat level.

• 대한본초학회지
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• 제22권4호
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• pp.35-43
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• 2007

Objective : The aim was to study experimentally the effects of Daeyoungjeon(DYJ) on the hypothyroidism of rats induced by thiouracil. Methods : Spargue-Dawley rats were separated into four groups. Except normal group, the other three groups were treated with thiouracil 0.50g/kg/days for 30 days by oral administration. Among the three groups, one group was treated DYJ extract 0.75g/kg/days for 20 days separately. Another group was treated DYJ extract 1.50g/kg/days for 20 days separately. T3-uptake, T3, T4, TSH, hematological values, enzyme activity, total cholesterol, triglyceride and Na+ content change in the Serum of rats were measured after medication of solid extract of DYJ. Results : As a result of this study, in the serum T3-Uptake and T4 level, hematological values and sodium were increased in DYJ group compared to control group. The serum TSH, total cholesterol, triglyceride, enzyme activity and body weight were decreased in DYJ group compared to control group. Conclusion : According to the above results, it is suggested that DYJ is effective to cure hypothyroidism.

• 대한방사선기술학회지:방사선기술과학
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• 제5권1호
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• pp.55-62
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• 1982

Measurement of triiodothyronine($T_3$) concentration is useful for the diagnosic and treatment of thyroid gland diseases. Fundermental studies of measurement of $T_3$ concentration by radioimmunoassay were performed and values determined by commercially available kit, Coat-A-Count, Diagnostic Products Corporation. The optimal utilization of the radioimmunoassay in measuring $T_3$ concentrations is dependant not only on high quality performance of the assay, but also on their appropriate application to the clinical situation. These are several aspects that must be considered in every individual case. These include factors such as accurate pippeting in reagent preparation in the assay and through decanting to remove all visible moisture after incubation steps and so forth. In attempt to assess quality control of the radioimmunoassay of serum $T_3$, serum pools with high, medium, low $T_3$ concentrations were assayed for each of 5 samples. The results obtained with this study were as follow: 1. The coefficient of variation(C. V.) for the standard curve ranged between $0.2{\sim}3.5%$. 2. It was necessary that both incubation time and temperature should correctly be maintained all the in the assay performance. 3. The precison with the $T_3$ RIA procedure was good. 4. The measured values of serially diluted serum $T_3$ concentration with Ong/dl standard solution was proportional to the predicted values. However dilution curve of distilled water was not strait. 5. Calculated $T_3$ values of patient serum in normal group was $107.8{\pm}25.90ng/dl$ in male patient and $127.29{\pm}24.08ng/dl$ in female patient.

• 대한수의학회지
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• 제29권2호
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• pp.25-31
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• 1989

The present study was carried out to investigate the effects of nitrate ($KNO_3$) on the thyroid glands in rabbits which were administrated $KNO_3$ of 1g/kg/day for 6 weeks. Growth rate, and serum levels for $T_4$, $T_3$ and TSH were observed every weeks. The histological changes and the weights of the thyroid glands were observed in 6 weeks. The results obtained were summarized as follows: 1. The mean growth rates of experiments were decreased significantly in the 1st week, but were increased a little from the 5th to 6th week compared with those of controls. 2. The serum levels for $T_4$ of the experimental group manifested significantly decreased values than those of control through the experimental term consistently and the serum levels for $T_3$ were greatly decreased in the 3rd and 4th weeks. 3. TSH contents of the serum were not changed through the experimental term. 4. The mean weight of the thyroid gland in the experiment was decreased significantly after 6 weeks compared with that of control. 5. In the experimental group, the color of colloid in the thyroid follicles revealed deeper eosinophilic and the heights of the follicular epithelial cells were taller than those of controls. The colloid in the thyroid follicles revealed depletion. As summarized above, the observations suggest that nitrate can be an antithyroid substance in rabbits and it leads the thyroid glands to hypofunctional state.

• Asian Pacific Journal of Cancer Prevention
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• 제16권13호
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• pp.5261-5264
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• 2015

Purpose: To examine the effectiveness of serum free-to-total prostate specific antigen ratio (%fPSA) for the detection of prostate cancer (PCa) in men with different serum total PSA (tPSA) categories. Materials and Methods: From January 2010 to December 2013, a total of 225 patients with lower urinary tract symptoms (LUTS) underwent tPSA and %fPSA measurements. Histological examination with calculation of Gleason score and whole body bone scans were performed in identified cases of PCa. Results: PCa was diagnosed in 44 (19.6%) patients and the remaining 181 patients had benign prostate disease. PCa was detected in 5 (23.8%), 13 (8.7%) and 26 (47.3%) cases with tPSA level ranges ${\leq}4ng/ml$, 4 to 10 ng/ml and >10 ng/ml, respectively. The average Gleason score was $7.2{\pm}0.2$. Some 6 (13.6%) out of 44 PCa patients had bone metastases. The sensitivity was 80% and specificity was 81.3% at the cut-off %fPSA of 15% in PCa patients with a tPSA level below 4 ng/mL. A lower %fPSA was associated with PCa patients with Gleason score ${\geq}7$ than those with Gleason score ${\leq}6$ ($11.7{\pm}0.98$ vs. $16.5{\pm}2.25%$, P=0.029). No obvious relation of %fPSA to the incidence of bone metastasis was apparent in this study. Conclusions: The clinical application of %fPSA could help to discriminate PCa from benign prostate disease in men with a tPSA concentration below 4 ng/mL.

• 대한핵의학회지
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• 제30권1호
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• pp.65-76
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• 1996

1993년 2월부터 1994년 8월까지 경북대학교병원 핵의학과에서 진료한 갑상선질환 중 그레이브스병 402예와 하시모토갑상선염 230예를 대상으로 혈청 thyrotropin-binding inhibiting immunoglobulin (TBII)치를 방사면역측정법으로 측정하여 갑상선 기능상태와 그 치료경과에 있어서의 동태를 관찰하고 아울러 혈청 갑상선글로블린치, antithyroglobulin anti-body(ATAb) 및 antimicrosomal antibody(AMAb)의 동태를 동시에 검토하여 다음과 같은 결과를 얻었다. 혈청 TBII치는 갑상선기능항진성 그레이브스병에서 평균 $40.82{\pm}21.651%$, 하시모토갑상선염에서 평균 $8.89{\pm}14.522%$로서 정상 대조군의 평균 $3.21{\pm}2.571%$에 비하여 유의한 상승치를 보였다. 그레이브스병 중에서도 갑상선기능항진증이 있는 387예에서는 TBII치가 비정상적으로 증가한 예가 92.2%(357예)였으며, 갑상선기능이 정상으로 회복된 그레이브스병 15예에서는 TBII치가 비정상적으로 증가된 예는 46.7%(7예)에 불과하였다. 하시모토갑상선염 230예에서는 TBII치가 비정상적으로 상승한 예는 23.9%(55예)였다. 그레이브스병에서 TBII치들은 RAIU 6시간치 및 24시간치, T3, T4, FT4들과 유의한 양의 상관성을 나타내었으며, 혈청 갑상선글로블린 및 AMAb와도 양의 상관성을 나타내었다(p<0.001). 그러나 혈청 TBII치와 TSH와는 음의 상관성을 나타내었고(p<0.001), ATAb와는 상관성이 없었다. 하시모토갑상선염에서는 TBII치는 RAIU 6시간치 및 24시간치, T3, TSH, AMAb와는 유의한 양의 상관성이 있었고(p<0.05), 혈청 T4, FT4, 갑상선글로불린 및 ATAb치와는 상관성이 없었다. 결론적으로, 그레이브스병에서는 혈청 TBII치가 갑상선기능항진증의 정도를 반영하는 소견이 되며 회복기의 TBII치는 예후를 반영하는 자료가 될 수 있다. 그리고 하시모토갑상선염에서는 비록 TBII치가 상승된 예는 많지 알지만 갑상선기능이 항진되거나 저하되는 소견의 정도와 관련이 있고 병변의 중증도를 반영한다고 볼 수가 있다.

• Journal of Nutrition and Health
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• 제36권4호
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• pp.389-396
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• 2003

Maternal nutritional status has been shown to influence pregnancy outcomes. And the elevated maternal plasma homocysteine concentrations have been associated with adverse pregnancy outcomes. We investigated the effects of maternal serum levels of B vitamins and homocysteine, and the C677T MTHFR (5, 10-methylenetetrahydrofolate reductase) polymorphism on pregnancy outcomes. In 177 pregnant women of 24-28 wks of gestation, the MTHFR gene mutation, serum B vitamins and homocysteine concentrations were measured, and their pregnancy outcomes were investigated from medical records. The birth length, and 1- and 5-min Apgar scores of neonates in the T/T mothers were 45.4 $\pm$ 9.3 cm, 7.6 $\pm$ 3.2 and 8.5 $\pm$ 3.8, respectively, which were significantly lower than those in the C/T (48.6 $\pm$ 3.3 cm, 9.0 $\pm$ 0.2, 10.0 $\pm$ 0.2) or the C/C mothers (49.4 $\pm$ 1.9 cm, 9.0 $\pm$ 0.2, 10.0 $\pm$ 0.0). The birth weight, birth length and the gestational age of neonates at delivery from hyperhomocysteinemic mothers whose homocysteine levels higher than 15 $\mu$ mol were 2.5 $\pm$ 1.3 kg, 43.9 $\pm$ 9.0 cm, 35.4 $\pm$ 6.3 wk, respectively, which were significant lower than those from normohomocysteinemic mothers (3.1 $\pm$ 0.6 kg, 48.8 $\pm$ 3.6 cm, 38.5 $\pm$ 2.5 wk). The birth weight and birth length of neonates in mothers whose PLP levels were below the median were significantly lower than those from mothers with the PLP levels above the median. The 1- and 5-min Apgar scores of neonates were lower in mothers with the T/T MTHFR genotype than those with the C/T or C/C only when the serum PLP levels were below the median. The 1-, 5 min Apgar scores and birth length of neonates were lower in mothers with the T/T MTHFR genotype than those with the C/T or C/C only when the serum FMN levels were below the median. In conclusion, maternal B vitamin status, homocysteine and the C677T MTHFR genotype seem to have played an important role on pregnancy outcomes.

• 대한수의학회지
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• 제54권3호
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• pp.165-169
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• 2014

The present study compared leptin, adiponectin, and thyroid hormone concentrations in normal and obese dogs, and evaluated the association between leptin and adiponectin concentrations and thyroid function. The serum leptin, adiponectin, thyroid-stimulating hormone (TSH), total thyroxine (tT4), free thyroxine (fT4), triiodothyronine (T3), and cortisol concentrations were measured in 18 normal dogs (body condition score [BCS]: 4-5/9) and 16 obese dogs (BCS: 8-9/9). Leptin and T3 concentrations were higher in the obese group than the normal weight group (p < 0.01 and p < 0.05, respectively). In both groups, the T3 and leptin concentrations were correlated (r = 0.370, p < 0.05), as were the TSH and fT4 and adiponectin concentrations (r = -0.373, p < 0.05 and r = 0.369, p < 0.05, respectively). In the normal weight group, the TSH and fT4 concentrations were correlated with the adiponectin concentrations (r = -0.528, p < 0.05 and r = 0.482, p < 0.05, respectively). The results of the present study suggest that leptin and T3 concentrations are significantly higher in obese dogs than normal weight dogs, and the serum T3 and leptin concentrations are positively correlated.