• Clinical and Experimental Reproductive Medicine
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• 제26권2호
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• pp.287-291
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• 1999

Dopamine agonists are commonly used in the medical treatment of prolactinomas. Bromocriptine has been the most widely used ergot derivative for two decades. Its oral administration, at a daily dose of $2.5{\sim}7.5mg$, restored normal gonadal function and normoprolactinemia in about 80% of patients. Nevertheless, a subset of patients could not achieve normal prolactin levels or resume normal gonadal function despite $15{\sim}30mg$/day bromocriptine for at least 6 months. Subsequently, these prolactinomas were consedered to be resistant to bromocriptine. The percentage of bromocriptine - resistant prolactinoma patients reported in the literature varies between 5 and 17% according to the series. Patients with bromocriptine resistance or bromocriptine intolerance have, however, been treated with other dopamine agonists, such as lysuride, pergolide, cabergoline, or quinagolide. Until cabergoline recently gained a product licence in the UK, there was no alternative dopamine agonist with a licence for this purpose. Quinagolide (CV $205{\sim}502$, Norprolac, Sandoz) is a nonergot dopamine agonist with improved selectivity for the D2 receptor, designed to retain the active pharmacophore of bromocriptine without the ergot moiety that might be responsible for side - effects. We have experienced a case of bromocriptine resistant hyperprolactinemia which was reponsive to pergolide. So we report this case with a brief review of literatures.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 2008년도 춘계 학술발표회 제20권1호
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• pp.865-868
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• 2008

본 연구에서는 최근 사용이 증대되고 있는 고성능 콘크리트의 폭렬현상을 방지하기 위해 일련의 연구 중 메탈라스 횡구속을 병행한 비탈형 거푸집을 사용한 고성능 콘크리트 RC기둥부재의 내화특성을 검토하였는데, 그 결과를 요약하면 다음과 같다. 유동성 및 공기량은 모두 목표 범위를 만족하였고, 압축강도는 재령 28일에서 80 MPa이상으로 고강도범위를 나타내었다. 폭렬 특성으로는 섬유를 혼입하지 않은 플레인의 경우는 심한 폭렬이 발생하였고, 나일론(이하 NY)+폴리프로필렌(이하 PP) 섬유를 0.05%를 혼입한 경우에는 표면부에만 부분적인 박리폭렬이 발생하였다. 비탈형 거푸집 변화에 따라서는 비탈형 25-20, 비탈형 50-20의 경우에는 모두 마 감재부분에 폭렬이 발생하였는데, 비탈형 50-20의 경우가 비탈형 25-20보다 양호한 폭렬방지 성능을 나타내었다. 비탈형 50-40의 경우는 폭렬이 방지되었는데 질량감소율은 10%이하로 나타났고, 온도이력은 모재표면부 최고온도가 $376.1^{\circ}C$로 가장 우수한 내화 성능을 나타내었다.

• 한국콘크리트학회:학술대회논문집
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• 한국콘크리트학회 2008년도 춘계 학술발표회 제20권1호
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• pp.249-252
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• 2008

이 논문에서는 비부착 CFRP 판으로 긴장된 RC(Reinforced Concrete) 보의 비선형 해석방법을 제시하였다. 하중 재하 시 부재의 단면 내에서 변화하는 재료상태를 정확히 예측하기 위해 철근콘크리트 뼈대는 콘크리트와 보강철근 화이버로 구성된 화이버모델요소로 이상화하였다. 또한 CFRP 판의 비부착 거동을 모사하기 위해 CFRP 판을 뼈대요소의 각 절점에 연결되는 여러 개의 요소로 이상화하되, 연결부에서 슬립이 가능한 것으로 가정하여 슬립으로 인한 CFRP 판의 인장력을 반복적으로 보정함으로써 CFRP 판요소들의 응력이 같도록 하였다. 이 논문에서 제시한 해석방법의 정당성을 검토하기 위해 비부착 CFRP 판으로 긴장된 RC 보의 극한해석을 수행하여 해석결과를 타 연구자의 실험결과와 비교해 본 결과, 두 연구결과가 잘 일치함을 확인하였다.

• 한국수소및신에너지학회논문집
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• 제20권6호
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• pp.499-504
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• 2009

The effect of gas diffusion layer (GDL) compression caused by different stack clamping pressures on fuel cell performance was experimentally studied in a miniature 5-cell proton exchange membrane fuel cell (PEMFC) stack. Three stacks with different GDL compressions, 15%, 35% and 50%, were prepared using SGL 10BC carbon fiber felt GDL and Gore 57 series MEA. The PEMFC stack performance and the stack stability were enhanced with increasing stack clamping pressure resulting in the best performance and stability for the stack with higher GDL compressions up to 50%. The excellent performance of the stack with high GDL compression was mainly due to the reduced contact resistance between GDL and bipolar plate in the stack, while reduced gas permeability of the excessively compressed GDL in the stack hardly affected the stack performance. The high stack clamping pressure also resulted in excessive GDL compression under the rib areas of bipolar plate and large GDL intrusion into the channels of the plate, which reduced the by-pass flow in the channels and increase gas pressure drop in the stack. It seems that these phenomena in the highly compressed stack enhance the water management in the stack and lead to the high stack stability.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2008년도 하계학술대회 논문집 Vol.9
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• pp.144-144
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• 2008

Blue light emitting diode structures consisting of the InGaN/GaN multiple quantum wells were grown by metalorganic chemical vapor deposition at different growth temperatures for the p-GaN contact layers and the influence of growth temperature on the emission and microstructural properties was investigated. The I-V and electroluminescence measurements showed that the sample with a p-GaN layer grown at $1084^{\circ}C$ had a lower electrical turn-on voltage and series resistance, andenhanced output power despite the low photoluminescence intensity. Transmission electron microscopy (TEM) revealed that the intense electro luminescence was due to the formation of a p-GaN layer with an even distribution of Mg dopants, which was confirmed by TEM image contrast and strain evaluations. These results suggest that the growth temperature should be optimized carefully to ensurethe homogeneous distribution of Mg as well as the total Mg contents in the growth of the p-type layer.

• Steel and Composite Structures
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• 제1권4호
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• pp.427-440
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• 2001

The growing use of unprotected or partially protected steelwork in buildings has caused a lively debate regarding the safety of this form of construction. A good deal of recent research has indicated that steel members have a substantial inherent ability to resist fire so that additional fire protection can be either reduced or eliminated completely. A performance based philosophy also extends the study into the effect of structural continuity and the performance of the whole structural totality. As part of the structural system, thermal expansion during the heating phase or contraction during the cooling phase in most beams is likely to be restrained by adjacent parts of the whole system or sub-frame assembly due to compartmentation. This has not been properly addressed before. This paper describes an experimental programme in which unprotected steel beams were tested under load while it is restrained between two columns and additional horizontal restraints with particular concern on the effect of catenary action in the beams when subjected to large deflection at very high temperature. This paper also presents a three-dimensional mathematical modelling, based on the finite element method, of the series of fire tests on the part-frame. The complete analysis starts with an evaluation of temperature distribution in the structure at various time levels. It is followed by a detail 3-D finite element analysis on its structural response as a result of the changing temperature distribution. The principal part of the analysis makes use of an existing finite element package FEAST. The effect of columns being fire-protected and the beam being axially restrained has been modelled adequately in terms of their thermal and structural responses. The consequence of the beam being restrained is that the axial force in the restrained beam starts as a compression, which increases gradually up to a point when the material has deteriorated to such a level that the beam deflects excessively. The axial compression force drops rapidly and changes into a tension force leading to a catenary action, which slows down the beam deflection from running away. Design engineers will be benefited with the consideration of the catenary action.

• Geomechanics and Engineering
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• 제10권5호
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• pp.677-687
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• 2016

Industrialization and urbanization are the two phenomena that are going relentless all over the world. The consequence of this economic success has been a massive increase in waste on one hand and increasing demand for suitable sites for construction on the other. Owing to the surplus raw materials and energy requirement needed for manufacturing synthetic fibers, applications of waste fibers for reinforcing soils evidenced to offer economic and environmental benefits. The main objective of the proposed work is to explore the possibilities of improving the strength of soil using fly ash waste as an admixture and Human Hair Fiber (HHF) as reinforcement such that they can be used for construction of embankments and land reclamation projects. The effect of fiber content on soil - fly ash mixture was observed through a series of laboratory tests such as compaction tests, CBR and unconfined compression tests. From the stress - strain curves, it was observed that the UCC strength for the optimised soil - flyash mixture reinforced with 0.75% human hair fibers is nearly 2.85 times higher than that of the untreated soil. Further, it has been noticed that there is about 7.73 times increase in CBR for the reinforced soil compared to untreated soil. This drastic increase in strength may be due to the fact that HHF offer more pull-out resistance which makes the fibers act like a bridge to prevent further cracking and thereby it improves the toughness which in turn prevent the brittle failure of soil-flyash specimen. Hence, the test results reveal that the inclusion of randomly distributed HHF in soil significantly improves the engineering properties of soil and can be effectively utilized in pavements. SEM analysis explained the change of microstructures and the formation of hydration products that offered increase in strength and it was found to be in accordance with strength tests.

• 한국기계가공학회지
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• 제16권5호
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• pp.85-90
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• 2017

Mica-glass ceramics has features such as micro-sized crystals, high strength, chemical resistance, semitransparent optical properties, etc. Due to its superior material properties, mica glass ceramics have increasing applications in dental and medical components, insulation boards, chemical devices, etc. In many applications, especially for dental and medical components, ultra-precise polishing is required. However, it is known to be a very difficult-to-grind material because of its high hardness and brittle properties. Thus, in this study, a newly developed ultra-precise polishing method is applied to obtain nano-level surface roughness of the mica glass ceramics using magnetorheological (MR) fluids and nano abrasives. Nano-sized ceria particles were used for the polishing of the mica glass ceramics. A series of experiments were performed under various polishing conditions, and the results were analyzed. A very fine surface roughness of Ra=6.127 nm could be obtained.

• 대한전자공학회논문지SD
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• 제49권5호
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• pp.1-9
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• 2012

저항, 콘덴서, 및 인턱터와 함께 4의 회로 소자로 알려진 멤리스터가 개발되었으나, 아직 그 전기적 특성이 충분히 해석되지 않고 있다. 멤리스터들은 연결된 극성에 따라서 저항이 증가 혹은 감소하며, 직렬 혹은 병렬연결 형태에 따라서 그 동작 특성이 다양해진다. 본 연구에서는 HP의 $TiO_2$ 멤리스터를 모델로 하여 다양한 직 병렬회로에 대한 전기적 특성을 분석하였다. 이를 위해서 사인파 입력신호에 대해서 나타나는 전압-전류 간의 히스테르시스 루프의 다양한 모양을 분석하였다. 본 멤리스터 연구결과는 멤리스터 소자에 대한 특성 이해와 논리 회로 및 뉴런 셀에의 응용회로들의 특성을 분석하는데 유용하게 사용될 수 있다.

• 해양환경안전학회지
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• 제20권2호
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• pp.218-227
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• 2014

본 연구에서는 실험 모형을 이용한 탄소성 대변형 시리즈 해석을 수행하여 플레이트 거더의 파손모드와 최종하중을 예측하였다. 수치해석 모형의 붕괴모드는 재하 시 플랜지에서 소성 힌지가 형성되었으며 실험모형의 붕괴모드와 일치하였다. 또한, 웹에서 항복선이 형성되어 크리플링 붕괴모드가 발생하는 것을 관찰할 수 있었으며 각각의 실험모형과 수치모형 최종하중의 평균값 1.07, 표준편차 0.04, 변동계수 0.04로 선형성을 유지하였으며 전체 최종하중 결과도 대략 8 % 오차를 나타내었다. 이는 수치모형 결과가 실험 및 적용 기준에 매우 만족하고 양호한 결과를 도출하였다고 생각한다. 따라서 알루미늄합금 플레이트 거더의 최종하중 예측 시 실험 및 적용 기준과 함께 병행하여 적용을 한다면 이에 대한 합리적 안전수준을 유지한다면 더 효율적이고 경제적 알루미늄 합금 플레이트 거더의 파손모드 및 최종하중에 대해 예측할 수 있을 거라고 생각한다.