• Tuberculosis and Respiratory Diseases
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• v.76 no.3
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• pp.114-119
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• 2014

Background: Epigallocatechin-3-gallate (EGCG), a major biologically active component of green tea, has anti-cancer activity in human and animal models. We investigated the schedule-dependent effect of EGCG and paclitaxel on growth of NCI-H460 non-small cell lung cancer cells. Methods: To investigate the combined effect of EGCG (E) and paclitaxel (P), combination indices (CIs) were calculated, and cell cycle analysis was performed. For the effect on cell apoptosis, western blot analysis was also performed. Results: CI analysis demonstrated that both concurrent and sequential E ${\rightarrow}$ P treatments had antagonistic effects (CIs >1.0), but sequential P ${\rightarrow}$ E had synergistic effects (CIs <1.0), on the growth inhibition of NCI-H460 cells. In the cell cycle analysis, although paclitaxel induced $G_2/M$ cell cycle arrest and increased the sub-G1 fraction, concurrent EGCG and paclitaxel treatments did not have any additive or synergistic effects compared with the paclitaxel treatment alone. However, western blot analysis demonstrated that sequential P ${\rightarrow}$ E treatment decreased the expression of Bcl-2 and procaspase-3 and increased poly(ADP-ribose) polymerase (PARP) cleavage; while minimal effects were seen with concurrent or sequential E ${\rightarrow}$ P treatments. Conclusion: Concurrent or sequential E ${\rightarrow}$ P treatment had opposite effects to P ${\rightarrow}$ E treatment, where P ${\rightarrow}$ E treatment showed a synergistic effect on growth inhibition of NCI-H460 cells by inducing apoptosis. Thus, the efficacy of EGCG and paclitaxel combination treatment seems to be schedule-dependent.

• Proceedings of the Korean Institute of Interior Design Conference
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• 2004.05a
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• pp.86-90
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• 2004

The whole image of circulation occupied with user has duplicated inter-relationship. It means many situation exist simultaneously, and the character of space factors are completed by the inter-relationship of the detailed structure. The purpose of this study is on the proper notation for circulation analysis of the sequential space structure which is constructed by the formal constituent and the change of visual circumstance influence on the action of user. This study investigate the possibility of notation by arranging the analysis method of the visual space and focusing on the research for the visual perception behaviour of user being applied various space, and the possibility of application as a method of space design.

• Proceedings of the Korea Committee for Ocean Resources and Engineering Conference
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• 2003.05a
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• pp.163-167
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• 2003

A novel method for 3-dimensional dynamic analysis of marine slender structure gas been developed by using Euler parameters. The Euler parameter rotation, which is being widely used in aerospace vehicle dynamics and multi-body dynamics, has been applied to elastic structure analysis. Large deformation of flexible slender structures is described by means of Euler parameters. Euler parameter method is implemented effectively in incremental-iterative algorithm for 3D dynamic analysis. The normalization constraint of Euler parameters is efficiently satisfied by means of a sequential updating method.

• Journal of the Korea institute for structural maintenance and inspection
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• v.5 no.3
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• pp.213-223
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• 2001

This paper presents an analytical procedure for the time-dependent analysis of the multi-story prestressed concrete structure under the construction stage. To account for the actual structural behavior, the procedure considers the effects due to the construction interval and the time-dependent losses of prestress at every construction step on the entire structural response. A numerical study is performed to demonstrate the general validity of the approach and to quantitatively evaluate the effects resulted from the time-dependent behaviors during construction. Recommendations and conclusions are developed by comparisons with structural responses using the present and conventional methods of analysis. The comparative results show that both effects of sequential construction and time-dependent prestress losses should be considered for the construction stage analysis.

• Journal of Distribution Research
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• v.10 no.3
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• pp.87-101
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• 2005

Market segmentation has been an important issue in marketing for a long time. Many models and statistical methods have been developed by many scholars. The purpose of this research provides one insight for market segmentation based on clustering technique in channel benefit sought. We proposed a sequential approach in market segmentation. A sequential approach means that we do market segmentation by multi-stage method based on the benefits sought in marketing channel. To achieve this approach, we divided the main benefits sought into subcategories. That is to say, after dividing each benefit sought into more detailed concepts, we did market segmentation sequentially.

• Journal of Astronomy and Space Sciences
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• v.35 no.1
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• pp.39-46
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• 2018

In this study, the performance of ranging techniques for the Korea Pathfinder Lunar Orbiter (KPLO) space communication system is investigated. KPLO is the first lunar mission of Korea, and pseudo-noise (PN) ranging will be used to support the mission along with sequential ranging. We compared the performance of both ranging techniques using the criteria of accuracy, acquisition probability, and measurement time. First, we investigated the end-to-end accuracy error of a ranging technique incorporating all sources of errors such as from ground stations and the spacecraft communication system. This study demonstrates that increasing the clock frequency of the ranging system is not required when the dominant factor of accuracy error is independent of the thermal noise of the ranging technique being used in the system. Based on the understanding of ranging accuracy, the measurement time of PN and sequential ranging are further investigated and compared, while both techniques satisfied the accuracy and acquisition requirements. We demonstrated that PN ranging performed better than sequential ranging in the signal-to-noise ratio (SNR) regime where KPLO will be operating, and we found that the T2B (weighted-voting balanced Tausworthe, voting v = 2) code is the best choice among the PN codes available for the KPLO mission.

• Proceedings of the Korea Water Resources Association Conference
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• 2017.05a
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• pp.350-350
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• 2017

저수지의 설계홍수량 산정 시 인근의 기상관측 자료를 활용하고 있으나 인근에 기상관측 자료가 없거나 저수지 배후 유역이 큰 경우에는 단일 기상관측 자료를 이용하기에는 한계가 있다. 따라서 실무적으로 지점별 기상관측소의 자료를 이용하여 설계홍수량을 산정할 때에는 각 관측소 자료를 이용하여 확률강우량을 산정하고 Thiessen 가중평균을 한 후 면적우량환산계수 (ARF)를 곱하여 사용하고 있는데, Thiessen 방법의 경우 방법이 간단하지만 지형 고도 효과는 무시되고 우량계의 지배면적에 의한 우량계의 분포 상태만을 고려하게 된다. 그러므로 설계홍수량 산정시 사용되는 Thiessen 방법은 공간적 불확실성을 내포하고 있고, 특히 소규모 저수지의 설계홍수량을 산정하는 경우에는 저수지 유역의 국소적인 특징을 나타내기 어렵다. 본 연구에서는 설계홍수량 산정 시 저수지 위치에 해당하는 확률강우량의 공간적 불확실성을 평가하기 위하여 SIS(Sequential Indicator Simulation) 방법을 이용하였다. SIS 방법은 Kriging 기법과 마찬가지로 베리오그램으로부터 얻어지는 공간적 상관관계를 기반으로 하고 있는 방법으로 Kriging 기법과 달리 공간분포의 국소적인 특성을 평가할 수 있다는 장점을 가지고 있다.

• Korean Journal of Childcare and Education
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• v.19 no.6
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• pp.97-113
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• 2023

Objective: The purpose of this study is to investigate the effect of young children's behavioral inhibition on self-determination, examining the sequential mediating effects of mothers' parenting anxiety and autonomy support. Methods: Participants in this study were 225 mothers with children aged 6 years. An online survey was conducted, and SPSS Statistics 23.0 was used for basic analysis. The research model used the Process Macro 4.0 program. Results: The higher the level of behavioral inhibition, the lower the child's self-determination. Furthermore, a mediating effect was confirmed when parenting anxiety was added. However, in the single mediation model and the sequential mediation model in which autonomy support was added, the direct effects of behavioral inhibition temperament and parenting anxiety on self-determination disappeared. As a result, behavioral inhibition characteristics were found to have an indirect effect on self-determination through the sequential mediating effects of mother's parenting anxiety and autonomy support. Conclusion/Implications: If a mother with a child with a behaviorally inhibited temperament properly handles the negative emotions experienced during parenting based on her understanding of the child and supports the child to have a high degree of autonomy, she can enhance the child's right to self-determination.

• Journal of Korean Society for Quality Management
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• v.32 no.3
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• pp.141-152
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• 2004

This study describes process and method to establish concurrent and/or sequential schedule planning for the system design process of the EIA632 standard. For this purpose, the study suggest Process and method that are context analysis of standard process, interface definition from activity decomposition, integration of related activities, and definition of concurrent and/or sequential work flow. The proposed process and method will contribute to minimize time loss that is emerged from activities iteration.

• Journal of applied mathematics & informatics
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• v.8 no.2
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• pp.387-401
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• 2001

If the distance between two vertices becomes longer after the removal of a vertex u, then u is called a hinge vertex. In this paper, a linear time sequential algorithm is presented to find all hinge vertices of an interval graph. Also, a parallel algorithm is presented which takes O(n/P + log n) time using P processors on an EREW PRAM.