• Journal of the Korean Vacuum Society
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• v.22 no.6
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• pp.321-326
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• 2013

The effect of rapid thermal annealing (RTA) on the optical properties of digital-alloy InGaAlAs multiple quantum well (MQW) structures have been investigated by using photoluminescence (PL) and time-resolved PL measurements as a function of RTA temperature. The MQW samples were annealed from $700^{\circ}C$ to $850^{\circ}C$ for 30 s in a nitrogen atmosphere. The MQW sample annealed at $750^{\circ}C$ exhibited the strongest PL intensity and the narrowest FWHM (Full width at half maximum), indicating the reduced nonradiative recombination centers and the improved interfaces between the wells and barriers. The MQW samples annealed at $800^{\circ}C$ and $850^{\circ}C$ showed the decreased PL intensities and blueshifted PL peaks compared to $750^{\circ}C$-annealed sample. The blueshift of PL peak with increasing RTA temperatures are ascribed to the increase of aluminum due to intermixing of gallium (Ga) and aluminum (Al) in the interfaces of InGaAs/InAlAs short-period superlattices. The decrease of PL intensity after annealing at $800^{\circ}C$ and $850^{\circ}C$ are attributed to the interface roughening and lateral composition modulation caused by the interdiffusion of Ga and Al and indium segregation, respectively. With increasing RTA temperature the PL decay becomes slower, indicating the decrease of nonradiative defect centers. The optical properties of digital-alloy InGaAlAs MQW structures can be improved significantly with optimum RTA conditions.

• Journal of Pharmaceutical Investigation
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• v.41 no.4
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• pp.255-262
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• 2011

Method using liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) was developed and validated for the determination of pregabalin in plasma samples. Acquisition was performed by monitoring the transitions: m/z 160.1${\rightarrow}$142.2 for pregabalin and m/z 423.2${\rightarrow}$207.1 for losartan (as an internal standard). After cold acetonitrileinduced protein precipitation of the plasma samples, separation was performed with C18 column by isocratic mobile phase consisted of 10 mM ammonium acetate and acetonitrile (15:85, v/v). Results were linear over the concentration ranged from 0.1 to $10{\mu}g$/mL and the correlation coefficients (r) were $\geq0.99$. Intra- and inter-day precisions were $\leq6.02$ and $\leq11.04%$, respectively, and intra- and inter-day accuracies were 96.60-101.09 and 98.10-102.60%, respectively. This validated method was successfully applied to a bioequivalence study of two formulations of pregabalin, Daewoong pregabalin capsule (Daewoong Pharm. Co., Ltd.) and Lyrica$^{(R)}$ capsule (Pfizer Korea Ltd.) in twenty eight healthy Korean volunteers. The subjects received a single oral dose of each formulation (150 mg as pregabalin) in a randomized $2{\times}2$ crossover study and plasma samples were obtained from each subject at predetermined time intervals. Then, the pharmacokinetic parameters ($AUC_{0-t}$, $C_{max}$ and $T_{max}$) were calculated and statistically analyzed to assess the differences between two formulations. The 90% confidence intervals for the log-transformed data were acceptable range of log 0.8-log 1.25 (e.g., log 1.0048-log 1.0692 for AUC0-t, log 0.9142-log 1.0421 for $C_{max}$). Thus, $AUC_{0-t}$ and $C_{max}$ met the criteria of the Korea Food and Drug Administration (KFDA) for bioequivalence test indicating that Daewoong pregabalin capsule was bioequivalent to Lyrica$^{(R)}$ capsule.

• Journal of Pharmaceutical Investigation
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• v.27 no.4
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• pp.287-293
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• 1997

To make a stable o/w emulsion, the effects of egg lecithin as an emulsifier and polyvinylpyrrolidone (PVP) as an auxiliary emulsifier on the physical stability of emulsion were investigated. The oil-in-water emulsion system was manufactured by microfluidizer and evaluated the physical stability. Average particle size and size distribution of emulsion was measured by dynamic light scattering analyzer and interfacial tension was measured. From the interfacial tension tested, critical micelle concentration of the egg lecithin was 0.1 %w/v and optimal concentration for the preparation of emulsion was 1.0 %w/v. The mean particle size was about $0.2\;{\mu}m$ which was suitable for injections. The short-term accelerated stability studies were conducted by centrifugation, freeze-thaw method and shaking of the emulsion samples. The addition of PVP was caused the reduction in the particle size and improved the physical stability of emulsion. These results suggested that a mixed interfacial film comprising the egg lecithin and PVP was formed at the o/w interface and it was effective in preventing phase separation under thermic or mechanical stress. We used antineoplaston A10 (A10) as a model drug which is peptide and amino acid derivative having a action to the living organism against the development of neoplastic growth by a nonimmunological progress. It has a poor solubility in water and there may be a difficulty in formulation of A10. Emulsion formulation study about A10 was performed. Solubility of A10 in emulsion was about five times as high as that in water. From the results of solubility and partition coefficient, almost A10 molecules in o/w emulsion exist in the interface between oil and water.

• Journal of Pharmaceutical Investigation
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• v.39 no.1
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• pp.73-78
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• 2009

A simple LC-MS/MS method of rabeprazole in human plasma was developed and validated. Rabeprazole and Internal standard (I.S), omeprazole, were extracted from human plasma by liquid liquid extraction, chromatographic separation of rabaprazole in plasma was achieved at $45^{\circ}C$ with a Shiseido UG120 $C_{18}$ column and methanol-10 mM ammonium acetate buffer (pH 9.42 with ammonium water), as mobile phase. Rabeprazole produced a protonated precursor ion [$(M+H)^+$] at m/z 360.10 and corresponding product ion at m/z 242.21. Internal standard produced a protonated precursor ion [$(M+H)^+$] at 346.09 and corresponding product ion at m/z 198.09. This method showed linear response over the concentration range of $1{\sim}500\;ng/mL$ with correalation coefficient greater than 0.99. The lower limit of quantitation (LLOQ) using 0.2 mL plasma was 1 ng/mL, which was sensitive enough for pharmacokinetics studies. The method was specific and validated with a limit of quantitation of 1 ng/mL. The intra-day and inter-day precision and accuracy were acceptable for all samples including the LLOQ. The applicability of the method was demonstrated by analysis of plasma after administration of a single 10 mg dose to 36 healthy subject. From the plasma rabeprazole concentration versus time curves, the mean $AUC_t$ (The area under the plasma concentration-time curve from time 0 to 12 hr ) was $691.36{\pm}321.88\;ng{\cdot}hr/mL$, $C_{max}$ (maximum plasma drug concentration) of $353.21{\pm}131.52\;ng/mL$ reached $3.4{\pm}1.1\;hr$ after adiministration. The mean biological half-life of rabeprazole was $1.37{\pm}0.75\;hr$. Based on the results, this simple method could readily be used in pharmacokinetics studies.

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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• v.5 no.1
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• pp.19-27
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• 2007

Combined method of extraction chromatography and liquid scintillation analysis was established for determinating $^{55}Fe\;and\;^{63}Ni$ radioactivity in solid samples. Activated concrete wastes generated from dismantling KRR-2 were analysed. The sequential separation including precipitation and extraction chromatography resulted in the above 90% chemical recoveries of Fe. Above 62% recoveries of Ni were obtained by this procedure exception to 43.6 and 46.5% recoveries. The seperation and counting procedure was also confirmed with spiked samples of known quantity. The measured and spiked quantity were agreed with the 3.7% and 0.7% variations in the $^{55}Fe\;and\;^{63}Ni$ experiments, respectively. The radioactivities of $^{55}Fe$ in the dismantled concretes are shown from below MDA to maximum 362 Bq/g. The radioactivities of $^{63}Ni$ in all concrete samples are below MDA. The $^{63}Ni$ doesn't exist in dismantled concretes from KRR-2. The radioactivity of $^{55}Fe$ is decreased rapidly as the sampling depth is increased from the concrete surface.

• Analytical Science and Technology
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• v.6 no.5
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• pp.489-499
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• 1993

Some sorption behaviors of U(VI) ion on Arsenazo I-XAD-2 chelating resin were investigated. This chelating resin was synthesized by the diazonium coupling of Amberlite XAD-2 resin with Arsenzo I chelating reagent and characterized by elementary analysis method and IR spectrometry. The optimum conditions for the sorption of U(VI) ion were examined with respect to pH, U(VI) ion concentration and shaking time. Total sorption capacity of this chelating resin on U(VI) ion was 0.39mmol U(VI)/g resin in the pH range of 4.0~4.5. This chelating resin was showed increased sorption capacity on the increased pH value. It was confirmed that sorption mechanism of U(VI) ion on the Arsenazo I-XAD-2 chelating resin was competition reacting between U(VI) ion and $H^+$ ion. Breakthrough volume and overall capacity of U(VI) ion measured by column were was 600 ml and 0.38 mmol U(VI)/g resin, respectively. The desorption of U(VI) ion was showed recovery of 90~96% using 3M $HNO_3$ and 3M $Na_2CO_3$ as a desorption solution. The separation and concentration of U(VI) ion from natural water and sea water was performed successfully by Arsenazo I-XAD-2 chelating resin.

• Analytical Science and Technology
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• v.6 no.5
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• pp.471-477
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• 1993

The novel macrocylic ligand {(4, 5):(13, 14)-dibenzo-6, 9, 12-trioxa-3, 15, 21, -triazabicyclo [15. 3. 1]heneicosa-(1, 17, 19)(18, 20, 21) triene: HDBPDA} was synthesized, and protonable constants of the ligand and the complex stability constants with alkali metals alkaline earth metals were determined. We evaluated the resolution factor(${\Delta}$) from equation that inducing from stability constants(pK). Also, this ligand was grafted on chloromethylated styrene-divinyl benzene(Merrifield resin) for HDBPDA, ion exchanger. Alkali and alkaline earth metal ions were separated using water by the column chromatography with this ion exchanger. Selectivity(${\alpha}$) and resolution(Rs) of alkali and alkaline earth metal ions were measured from the elution curves chromatogram. The selectivity and resolution values of the various ions calculated from the elution curves were compared with those abtained from pK values. The results were in a good agreement between tow methods. Ion exchange capacity of the resin were determined using the alkali and alkaline earth metal ions and pH dependence of capacity was also discussed.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.7
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• pp.419-427
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• 2020

This study was undertaken to address the difficulties and inconveniences of an electric wheelchair. We focused on improving usability of initially completed products by augmenting the prototypes designed in the previous study. For evaluation of usability, 10 elderly women aged over 65 years, capable of movements and physical activities in daily life, were enrolled as subjects. The experimental method included a subjective satisfaction questionnaire evaluation of the elderly women using the target product, and the observation evaluation was achieved using video recording data, etc. Usability evaluation revealed that the elevating sector requires improvement of intuition through separation of the elevating control panel and the driving control panel. Improvements in the driving sector include corrections of the front wheel mechanism or driving control algorithm, UI, and sudden stop system. Transferring section assessment revealed a necessity to secure structures and add structures that support power. We believe that based on the inconveniences and improvements presented in the usability evaluation, appending the existing prototype with complementary products will improve the quality of life of elderly women with limited mobility.

• The Journal of the Korea Contents Association
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• v.11 no.12
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• pp.586-596
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• 2011

In the IT industry, processing units of IT applications are getting smaller and high efficient. Furthermore, the realization of various smart functions is highly feasible now due to advances in sensing technology. The service infrastructures on high efficient and compact mobile devices are applied to various areas. These also could be possessed by users and is built into the devices. Currently, studies on the UX(User Experience) field to attempt an analysis and prediction of user's information are continuing with reference to the UI(User Interface). However, research on the common framework of classification and storing the user-information, and standardization of form has not been attempted yet. In this study, we proposed the AUX(Associative user Experience) model and process structure to store various empirical data by users. The AUX model expressed a diversity of user's empirical data using extended E-TCPN model. And also, we expressed the data structure using XML with reference to the application of AUX model. This expressed model and separation of process structure guarantee its specialty, productivity and flexibility through the humanistic characteristics of users and the independence of technical process structure. The AUX model maps out the AUX information process architecture and expressed the process with the improved MPP algorithm, to analyze of its performance. The simulation of movements applying to MPP traffic allocation of VOD is used to analyze of its performance. The playback deviation of MPP Graphic Allocation Algorism where the AUX model was applied was improved by 10.41% more than the one where it was not applied. As a result of that, playback performance has improved due to the conversion of AUX with accessing media, content of users and dynamic traffic allocation such as MPI and CPI.

• Ocean and Polar Research
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• v.33 no.3
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• pp.309-319
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• 2011

This is a preliminary study of the feasibility of obtaining reliable tidal current harmonic constants, using one month of current observations, to verify the accuracy of a tidal model. An inference method is commonly used to separate out the tidal harmonic constituents when the available data spans less than a synodic period. In contrast to tidal constituents, studies of the separation of tidal-current harmonics are rare, basically due to a dearth of the long-term observation data needed for such experiments. We conducted concurrent and monthly harmonic analyses for tidal current velocities and heights, using 2 years (2006 and 2007) of current and sea-level records obtained from the Tidal Current Signal Station located in the narrow waterway in front of Incheon Lock, Korea. Firstly, the l-year harmonic analyses showed that, with the exception of $M_2$ and $S_2$ semidiurnal constituents, the major constituents were different for the tidal currents and heights. $K_1$, for instance, was found to be the 4th major tidal constituent but not an important tidal current constituent. Secondly, we examined monthly variation in the amplitudes and phase-lags of the $S_2$ and $K_1$ current-velocity and tide constituents over a 23-month period. The resultant patterns of variation in the amplitudes and phase-lags of the $S_2$ tidal currents and tides were similar, exhibiting a sine curve form with a 6-month period. Similarly, variation in the $K_1$ tidal constant and tidal current-velocity phase lags showed a sine curve pattern with a 6-month period. However, that of the $K_1$ tidal current-velocity amplitude showed a somewhat irregular sine curve pattern. Lastly, we investigated and tested the inference methods available for separating the $K_2$ and $S_2$ current-velocity constituents via monthly harmonic analysis. We compared the effects of reduction in monthly variability in tidal harmonic constants of the $S_2$ current-velocity constituent using three different inference methods and that of Schureman (1976). Specifically, to separate out the two constituents ($S_2$ and $K_2$), we used three different inference parameter (i.e. amplitude ratio and phase-lag diggerence) values derived from the 1-year harmonic analyses of current-velocities and tidal heights at (near) the short-term observation station and from tidal potential (TP), together with Schureman's (1976) inference (SI). Results from these four different methods reveal that TP and SI are satisfactorily applicable where results of long-term harmonic analysis are not available. We also discussed how to further reduce the monthly variability in $S_2$ tidal current-velocity constants.