• Journal of Integrative Natural Science
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• v.12 no.4
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• pp.133-141
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• 2019

Mesenchymal stem cells (MSCs) are known to differentiate into multiple lineages, making neurogenic differentiation an important target in the clinical field. In the present study, we induced the neurogenic differentiation of cells using histone deacetylase (HDAC) inhibitors and studied their mechanisms for further differentiation in vitro. We treated cells with the HDAC inhibitors, MS-275 and NaB; and found that the cells had neuron-like features such as distinct bipolar or multipolar morphologies with branched processes. The mRNA expressions encoding for NEFL, MAP2, TUJ1, OLIG2, and SYT was significantly increased following HDAC inhibitors treatment compared to without HDAC inhibitors; high protein levels of MAP2 and Tuj1 were detected by immunofluorescence staining. We examined the mechanisms of differentiation and found that the Wnt signaling pathway and downstream mitogen-activate protein kinase were involved in neurogenic differentiation of MSCs. Importantly, Wnt4, Wnt5a/b, and Wnt11 protein levels were highly increased after treatment with NaB; signals were activated through the regulation of Dvl2 and Dvl3. Interestingly, NaB treatment increased the levels of JNK and upregulated JNK phosphorylation. After MS-275 treatment, Wnt protein levels were decreased and GSK-3β was phosphorylated. In this cell, HDAC inhibitors controlled the non-canonical Wnt expression by activating JNK phosphorylation and the canonical Wnt signaling by targeting GSK-3β.

• Journal of Broadcast Engineering
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• v.12 no.5
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• pp.423-434
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• 2007

In this study, we investigated broadcasting industry in Korea and in U.S. to find out what mostly makes the broadcasting industry competitive for the near future. One source multi use(from now on OSMU) marketing strategy is important when discussing profits of broadcasting contents. To develop a theoretical and academic framework of OSMU, 14 experts participated in focus group interview. A new meaning of OSMU is defined and 4 types of OSMU business models are developed in the study. Also, two successful examples of broadcasting contents, each from Korea and U.S., were analyzed with the models that we have developed. Lastly, we discussed how to enhance the competitiveness of broadcasting contents and industry by using the benefit-maximizing-strategies of OSMU.

• Annals of Hepato-Biliary-Pancreatic Surgery
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• v.28 no.2
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• pp.161-202
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• 2024

Backgrounds/Aims: Reported incidence of extrahepatic bile duct cancer is higher in Asians than in Western populations. Korea, in particular, is one of the countries with the highest incidence rates of extrahepatic bile duct cancer in the world. Although research and innovative therapeutic modalities for extrahepatic bile duct cancer are emerging, clinical guidelines are currently unavailable in Korea. The Korean Society of Hepato-Biliary-Pancreatic Surgery in collaboration with related societies (Korean Pancreatic and Biliary Surgery Society, Korean Society of Abdominal Radiology, Korean Society of Medical Oncology, Korean Society of Radiation Oncology, Korean Society of Pathologists, and Korean Society of Nuclear Medicine) decided to establish clinical guideline for extrahepatic bile duct cancer in June 2021. Methods: Contents of the guidelines were developed through subgroup meetings for each key question and a preliminary draft was finalized through a Clinical Guidelines Committee workshop. Results: In November 2021, the finalized draft was presented for public scrutiny during a formal hearing. Conclusions: The extrahepatic guideline committee believed that this guideline could be helpful in the treatment of patients.

• ETRI Journal
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• v.29 no.2
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• pp.249-251
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• 2007

A novel idea is presented to locate intersections in a video sequence captured from a moving vehicle. More specifically, we propose a Bayesian network approach to combine evidence extracted from a video sequence and evidence from a database, maximizing evidence from various sensors in a systematic manner and locating intersections robustly.

• Proceedings of the Korean Fiber Society Conference
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• 2007.11a
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• pp.293-294
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• 2007

• Proceedings of the SAREK Conference
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• 2006.11a
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• pp.43-43
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• 2006

• Proceedings of the KIEE Conference
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• 2011.07a
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• pp.1201-1203
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• 2011

이 논문은 가속기에 사용되는 전자석용 전원장치 개발에 대해서 기술하였다. 이 전원장치는 DSP TMS320F2808과 ADCs, FPGA를 이용한 디지털 신호처리 기술을 적용하여 5ppm 이하의 출력 전류 안정도를 가진다. 여기서는 전원장치의 입력 및 출력 필터, 비례적분 보상기 등에 대한 설계, 전원장치 모의실험 결과 및 제작 후 출력 전류의 안정도, 시스템의 주파수 특성 등 여러 성능의 측정 결과에 대하여 기술하였다.

• Proceedings of the Zoological Society Korea Conference
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• 2005.08a
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• pp.19-19
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• 2005

• Proceedings of the Korea Air Pollution Research Association Conference
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• 2009.10a
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• pp.680-681
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• 2009

• 대한약리학회:학술대회논문집
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• 2006.11a
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• pp.69.1-69.1
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• 2006