• Title/Summary/Keyword: Sensitivity analyses

Search Result 847, Processing Time 0.024 seconds

Factors influencing nursing students' care intentions toward emerging infectious diseases patients: A descriptive-predictive study

  • Park, Seungmi;Jang, Insun;Yu, Soo-Young
    • The Journal of Korean Academic Society of Nursing Education
    • /
    • v.28 no.4
    • /
    • pp.421-432
    • /
    • 2022
  • Purpose: As coronavirus disease 2019 (COVID-19) and other emerging infectious diseases continue to threaten health security, a strategy is required to increase nursing students' care intention for patients with such diseases. This study aimed to identify factors influencing Korean nursing students' care intentions in regard to patients with emerging infectious diseases. Methods: The care intention, COVID-19 knowledge level, ethical sensitivity, beliefs, attitudes toward the care intention, subjective norms, and perceived behavioral control were investigated using the theory of planned behavior. An online survey was completed from December 2020 to January 2021 by 227 nursing students who had complete a clinical practicum. Descriptive statistics, correlation, and hierarchical regression analyses were conducted on the data. Results: The care intention was higher in men than in women nursing students and in junior than in senior students. Behavioral and normative beliefs, attitude toward the behavior, and perceived behavioral control significantly predicted care intention. Ethical sensitivity increased the predictability of nursing students' care intentions for emerging infectious disease patients. Conclusion: The theory of planned behavior predicted nursing students' care intentions for emerging infectious diseases. Therefore, an experience-based response program on emerging infectious diseases is required for nursing students.

McCARD/MIG stochastic sampling calculations for nuclear cross section sensitivity and uncertainty analysis

  • Ho Jin Park
    • Nuclear Engineering and Technology
    • /
    • v.54 no.11
    • /
    • pp.4272-4279
    • /
    • 2022
  • In this study, a cross section stochastic sampling (S.S.) capability is implemented into both the McCARD continuous energy Monte Carlo code and MIG multiple-correlated data sampling code. The ENDF/B-VII.1 covariance data based 30 group cross section sets and the SCALE6 covariance data based 44 group cross section sets are sampled by the MIG code. Through various uncertainty quantification (UQ) benchmark calculations, the McCARD/MIG results are verified to be consistent with the McCARD stand-alone sensitivity/uncertainty (S/U) results and the XSUSA S.S. results. UQ analyses for Three Mile Island Unit 1, Peach Bottom Unit 2, and Kozloduy-6 fuel pin problems are conducted to provide the uncertainties of keff and microscopic and macroscopic cross sections by the McCARD/MIG code system. Moreover, the SNU S/U formulations for uncertainty propagation in a MC depletion analysis are validated through a comparison with the McCARD/MIG S.S. results for the UAM Exercise I-1b burnup benchmark. It is therefore concluded that the SNU formulation based on the S/U method has the capability to accurately estimate the uncertainty propagation in a MC depletion analysis.

Development of a High-performance COVID-19 Diagnostic Kit Employing Improved Antibody-quantum dot Conjugate

  • Seongsoo Kim;Hyunsoo Na;Hong-Geun Ahn;Han-Sam Park;Jaewoong Seol;Il-Hoon Cho
    • Biomedical Science Letters
    • /
    • v.29 no.4
    • /
    • pp.344-354
    • /
    • 2023
  • This study emphasizes the importance of early diagnosis and response to COVID-19, leading to the development of a rapid diagnostic kit using quantum dots. The research focuses on finely tuning bioconjugation with quantum dots to enhance the accuracy and sensitivity of COVID-19 diagnosis. We have developed a COVID-19 rapid diagnostic kit that exhibits a sensitivity more than 50 times higher than existing COVID-19 diagnostic kits. Quantum dots enable the accurate detection of COVID-19 viral antigens even at low concentrations, providing a rapid response in the early stages of infection. The COVID-19 quantum dot diagnostic kit offers quick analysis time, utilizing the quantum properties of particles to swiftly measure COVID-19 infection for immediate response and isolation measures. Additionally, this diagnostic kit allows for multiple analyses with ease, as multiple quantum dots can detect various antigens and antibodies simultaneously in a single experiment. This efficiency enhances testing, reduces sample requirements, and lowers experimental costs. The application of this diagnostic technology is anticipated in the future for early diagnosis and monitoring of other infectious diseases.

Analyses of International Standard Problem ISP-47 TOSQAN experiment with containmentFOAM

  • Myeong-Seon Chae;Stephan Kelm;Domenico Paladino
    • Nuclear Engineering and Technology
    • /
    • v.56 no.2
    • /
    • pp.611-623
    • /
    • 2024
  • The ISP-47 TOSQAN experiment was analyzed with containmentFOAM which is an open-source CFD code based on OpenFOAM. The containment phenomena taking place during the experiment are gas mixing, stratification and wall condensation in a mixture composed of steam and non-condensable gas. The k-ω SST turbulence model was adopted with buoyancy turbulence models. The wall condensation model used is based on the diffusion layer approach. We have simulated the full TOSQAN experiment which had a duration 20000 s. Sensitivity studies were conducted for the buoyancy turbulence models with SGDH and GGDH and there were not significant differences. All the main features of the experiments namely pressure history, temperature, velocity and gas species evolution were well predicted by containemntFOAM. The simulation results confirmed the formation of two large flow stream circulations and a mixing zone resulting by the combined effects of the condensation flow and natural convection flow. It was found that the natural convection in lower region of the vessel devotes to maintain two large circulations and to be varied the height of the mixing zone as result of sensitivity analysis of non-condensing wall temperature. The computational results obtained with the 2D mesh grid approach were comparable to the experimental results.

Development of Web Credibility Evaluation Model Using AHP (AHP를 이용한 웹 사이트 신뢰성 평가 모델 개발)

  • Kim, Young-Kee
    • Journal of Korean Library and Information Science Society
    • /
    • v.39 no.4
    • /
    • pp.51-69
    • /
    • 2008
  • This study tired to develop the web credibility evaluation model by calculating weighted values and sensitivities of indicators which presented on preceding researches using Analytic Hierarchy Process. "Expert Choice 2000" was used as the tool for analysing AHP. 25 experts are answered for this questionnaire who are selected by judgement sampling method, one of the non-probability sampling method. Also, sensitivity analyses was performed to graphically see how the alternatives change with respect to the importance of the indicators or sub-indicators. The main results are summarized as followings; i) importance analysis in first level factors: trust-worthiness(0,606), expertness(0.222), safety(0.173), ii) importance analysis in second level factors: trustfulness (0.519), reputation(0.087), usefulness (0.102), timeliness(0,093), competency(0.027), security(0.115), reliability(0,058). iii) some of the importance analysis in third level factors: the site provides comprehensive information that is attributed to a specific source(0.252), the site has articles that list citations and references(0.153), the site contains user opinions and reviews(0.072), etc. iv) sensitivity analyses showed that the importance of the indicators or sub-indicators are slightly changed with respect to the alternatives change.

  • PDF

Sensitivity Analysis of Depletion Parameters for Heat Load Evaluation of PWR Spent Fuel Storage Pool (경수로 사용후핵연료 저장조 열부하 평가를 위한 연소조건 인자 민감도 분석)

  • Kim, In-Young;Lee, Un-Chul
    • Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
    • /
    • v.9 no.4
    • /
    • pp.237-245
    • /
    • 2011
  • As necessity of safety re-evaluation for spent fuel storage facility has emphasized after the Fukushima accident, accuracy improvement of heat load evaluation has become more important to acquire reliable thermal-hydraulic evaluation results. As groundwork, parametric and sensitivity analyses of various storage conditions for Kori Unit 4 spent fuel storage pool and spent fuel depletion parameters such as axial burnup effect, operation history, and specific heat are conducted using ORIGEN2 code. According to heat load evaluation and parametric sensitivity analyses, decay heat of last discharged fuel comprises maximum 80.42% of total heat load of storage facility and there is a negative correlation between effect of depletion parameters and cooling period. It is determined that specific heat is most influential parameter and operation history is secondly influential parameter. And decay heat of just discharged fuel is varied from 0.34 to 1.66 times of average value and decay heat of 1 year cooled fuel is varied from 0.55 to 1.37 times of average value in accordance with change of specific power. Namely depletion parameters can cause large variation in decay heat calculation of short-term cooled fuel. Therefore application of real operation data instead of user selection value is needed to improve evaluation accuracy. It is expected that these results could be used to improve accuracy of heat load assessment and evaluate uncertainty of calculated heat load.

Accuracy of Digital Breast Tomosynthesis for Detecting Breast Cancer in the Diagnostic Setting: A Systematic Review and Meta-Analysis

  • Min Jung Ko;Dong A Park;Sung Hyun Kim;Eun Sook Ko;Kyung Hwan Shin;Woosung Lim;Beom Seok Kwak;Jung Min Chang
    • Korean Journal of Radiology
    • /
    • v.22 no.8
    • /
    • pp.1240-1252
    • /
    • 2021
  • Objective: To compare the accuracy for detecting breast cancer in the diagnostic setting between the use of digital breast tomosynthesis (DBT), defined as DBT alone or combined DBT and digital mammography (DM), and the use of DM alone through a systematic review and meta-analysis. Materials and Methods: Ovid-MEDLINE, Ovid-Embase, Cochrane Library and five Korean local databases were searched for articles published until March 25, 2020. We selected studies that reported diagnostic accuracy in women who were recalled after screening or symptomatic. Study quality was assessed using the Quality Assessment of Diagnostic Accuracy Studies-2 tool. A bivariate random effects model was used to estimate pooled sensitivity and specificity. We compared the diagnostic accuracy between DBT and DM alone using meta-regression and subgroup analyses by modality of intervention, country, existence of calcifications, breast density, Breast Imaging Reporting and Data System category threshold, study design, protocol for participant sampling, sample size, reason for diagnostic examination, and number of readers who interpreted the studies. Results: Twenty studies (n = 44513) that compared DBT and DM alone were included. The pooled sensitivity and specificity were 0.90 (95% confidence interval [CI] 0.86-0.93) and 0.90 (95% CI 0.84-0.94), respectively, for DBT, which were higher than 0.76 (95% CI 0.68-0.83) and 0.83 (95% CI 0.73-0.89), respectively, for DM alone (p < 0.001). The area under the summary receiver operating characteristics curve was 0.95 (95% CI 0.93-0.97) for DBT and 0.86 (95% CI 0.82-0.88) for DM alone. The higher sensitivity and specificity of DBT than DM alone were consistently noted in most subgroup and meta-regression analyses. Conclusion: Use of DBT was more accurate than DM alone for the diagnosis of breast cancer. Women with clinical symptoms or abnormal screening findings could be more effectively evaluated for breast cancer using DBT, which has a superior diagnostic performance compared to DM alone.

Diagnostic Image Feature and Performance of CT and Gadoxetic Acid Disodium-Enhanced MRI in Distinction of Combined Hepatocellular-Cholangiocarcinoma from Hepatocellular Carcinoma

  • Kim, Hyunghu;Kim, Seung-seob;Lee, Sunyoung;Lee, Myeongjee;Kim, Myeong-Jin
    • Investigative Magnetic Resonance Imaging
    • /
    • v.25 no.4
    • /
    • pp.313-322
    • /
    • 2021
  • Purpose: To find diagnostic image features, to compare diagnostic performance of multiphase CT versus gadoxetic acid disodium-enhanced MRI (GAD-MRI), and to evaluate the impact of analyzing Liver Imaging Reporting and Data System (LI-RADS) imaging features, for distinguishing combined hepatocellular-cholangiocarcinoma (CHC) from hepatocellular carcinoma (HCC). Materials and Methods: Ninety-six patients with pathologically proven CHC (n = 48) or HCC (n = 48), diagnosed June 2008 to May 2018 were retrospectively analyzed in random order by three radiologists with different experience levels. In the first analysis, the readers independently determined the probability of CHC based on their own knowledge and experiences. In the second analysis, they evaluated imaging features defined in LI-RADS 2018. Area under the curve (AUC) values for CHC diagnosis were compared between CT and MRI, and between the first and second analyses. Interobserver agreement was assessed using Cohen's weighted κ values. Results: Targetoid LR-M image features showed better specificities and positive predictive values (PPV) than the others. Among them, rim arterial phase hyperenhancement had the highest specificity and PPV. Average sensitivity, specificity, and AUC values were higher for MRI than for CT in both the first (P = 0.008, 0.005, 0.002, respectively) and second (P = 0.017, 0.026, 0.036) analyses. Interobserver agreements were higher for MRI in both analyses (κ = 0.307 for CT, κ = 0.332 for MRI in the first analysis; κ = 0.467 for CT, κ = 0.531 for MRI in the second analysis), with greater agreement in the second analysis for both CT (P = 0.001) and MRI (P < 0.001). Conclusion: Rim arterial phase hyperenhancement on GAD-MRI can be a good indicator suggesting CHC more than HCC. GAD-MRI may provide greater accuracy than CT for distinguishing CHC from HCC. Interobserver agreement can be improved for both CT and MRI by analyzing LI-RADS imaging features.

Predicting blast-induced ground vibrations at limestone quarry from artificial neural network optimized by randomized and grid search cross-validation, and comparative analyses with blast vibration predictor models

  • Salman Ihsan;Shahab Saqib;Hafiz Muhammad Awais Rashid;Fawad S. Niazi;Mohsin Usman Qureshi
    • Geomechanics and Engineering
    • /
    • v.35 no.2
    • /
    • pp.121-133
    • /
    • 2023
  • The demand for cement and limestone crushed materials has increased many folds due to the tremendous increase in construction activities in Pakistan during the past few decades. The number of cement production industries has increased correspondingly, and so the rock-blasting operations at the limestone quarry sites. However, the safety procedures warranted at these sites for the blast-induced ground vibrations (BIGV) have not been adequately developed and/or implemented. Proper prediction and monitoring of BIGV are necessary to ensure the safety of structures in the vicinity of these quarry sites. In this paper, an attempt has been made to predict BIGV using artificial neural network (ANN) at three selected limestone quarries of Pakistan. The ANN has been developed in Python using Keras with sequential model and dense layers. The hyper parameters and neurons in each of the activation layers has been optimized using randomized and grid search method. The input parameters for the model include distance, a maximum charge per delay (MCPD), depth of hole, burden, spacing, and number of blast holes, whereas, peak particle velocity (PPV) is taken as the only output parameter. A total of 110 blast vibrations datasets were recorded from three different limestone quarries. The dataset has been divided into 85% for neural network training, and 15% for testing of the network. A five-layer ANN is trained with Rectified Linear Unit (ReLU) activation function, Adam optimization algorithm with a learning rate of 0.001, and batch size of 32 with the topology of 6-32-32-256-1. The blast datasets were utilized to compare the performance of ANN, multivariate regression analysis (MVRA), and empirical predictors. The performance was evaluated using the coefficient of determination (R2), mean absolute error (MAE), mean squared error (MSE), mean absolute percentage error (MAPE), and root mean squared error (RMSE)for predicted and measured PPV. To determine the relative influence of each parameter on the PPV, sensitivity analyses were performed for all input parameters. The analyses reveal that ANN performs superior than MVRA and other empirical predictors, andthat83% PPV is affected by distance and MCPD while hole depth, number of blast holes, burden and spacing contribute for the remaining 17%. This research provides valuable insights into improving safety measures and ensuring the structural integrity of buildings near limestone quarry sites.

Influence of infill panels on an irregular RC building designed according to seismic codes

  • Ercolino, Marianna;Ricci, Paolo;Magliulo, Gennaro;Verderame, Gerardo M.
    • Earthquakes and Structures
    • /
    • v.10 no.2
    • /
    • pp.261-291
    • /
    • 2016
  • This paper deals with the seismic assessment of a real RC frame building located in Italy, designed according to the current Italian seismic code. The first part of the paper deals with the calibration of the structural model of the investigated building. The results of an in-situ dynamic identification test are employed in a sensitivity and parametric study in order to find the best fit model in terms of frequencies and modal shapes. In the second part, the safety of the structure is evaluated by means of nonlinear static analyses, taking into account the results of the previous dynamic study. In order to investigate the influence of the infills on the seismic response of the structure, the nonlinear static analyses are performed both neglecting and taking into account the infill panels. The infill panels differently change the behavior of the structure in terms of strength and stiffness at different seismic intensity levels. The assessment study also verifies the absence of brittle failures in structural elements, which could be caused by either the local interaction with infills or the failure of the strength hierarchy.