• 한국항공우주학회지
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• 제33권11호
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• pp.80-87
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• 2005

T-50 훈련기에 탑재되어 있는 전기식 비행제어계통 (Digital fly-by-wire flight control system)은 통합 다기능 감지기(IMFP : Integrated Multi-Function Probe)를 이용하여 항공기의 고도/속도/받음각 정보를 획득한다. T-50에는 3개의 IMFP가 장착되어 있으며, 이는 제어법칙에 3중의 소스를 제공한다. IMFP로부터 제공된 3개의 공기 정보는 중간 값을 채택하여 보다 신뢰성 있는 정보를 제어법칙에 제공한다. 고고도 초음속 비행시험 결과, 초음속 영역에서 발생하는 항공기 충격파(Shock wave)의 영향으로 인해 IMFP에서 측정되는 공기정보에 일시적으로 오차가 발생하였다. 이러한 오차정보는 항공기의 안정성에 영향을 미칠 수 있으며, 특히 저고도영역에서 이러한 오차정보가 제어법칙에 제공되어 질 경우, 항공기의 안전성에 영향을 미칠 수 있다. 본 논문에서는 저고도 초음속 영역에서, IMFP 오차정보로 인하여 발생할 수 있는 비행안정성 및 조종성(Controllability)을 해석하기 위해 민감도해석(Sensitivity analysis) 및 HQS(Handling Quality Simulator) 조종사 평가를 수행하였다.

• Molecules and Cells
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• 제41권7호
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• pp.646-652
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• 2018

Neurodegeneration can result in memory loss in the central nervous system (CNS) and impairment of taste and smell in the peripheral nervous system (PNS). The neurodegeneration seen in Parkinson's disease (PD) is characterized by functional loss of dopaminergic neurons. Recent studies have also found a role for dopaminergic neurons in regulating taste memory rewards in insects. To investigate how taste memories and sugar sensitivity can be affected in PD, we utilized the $DJ-1{\beta}$ mutant fruit fly, $DJ-1{\beta}^{ex54}$, as a PD model. We performed binary choice feeding assays, electrophysiology and taste-mediated memory tests to explore the function of the $DJ-1{\beta}$ gene in terms of sugar sensitivity as well as associative taste memory. We found that PD flies exhibited an impaired ability to discriminate sucrose across a range of sugar concentrations, with normal responses at only very high concentrations of sugar. They also showed an impairment in associative taste memory. We highlight that the taste impairment and memory defect in $DJ-1{\beta}^{ex54}$ can be recovered by the expression of wild-type $DJ-1{\beta}$ gene in the dopaminergic neurons. We also emphasized the role of dopaminergic neurons in restoring taste memory function. This impaired memory property of $DJ-1{\beta}^{ex54}$ flies also allows them to be used as a model system for finding supplementary dietary foods that can improve memory function. Here we provide evidence that the associative taste memory of both control and $DJ-1{\beta}^{ex54}$ flies can be enhanced with dietary supplementation of the medicinal plant, omija.

• 한국융합학회논문지
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• 제9권8호
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• pp.33-39
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• 2018

사물인터넷 시대에는 사물들이 유무선 네트워크로 서로 연결되어 필요할 때마다 정보를 주고 받는다. 채널과 네트워크 환경은 시간에 따라 변하고 잡음과 간섭 신호가 채널에 혼재하므로 자신이 수신해야 하는 신호가 언제 채널에 존재하는지 판단하는 케리어 센싱 기능이 매우 중요하다. 무선 통신 시스템의 케리어 센싱 회로는 수신기의 수신감도를 결정짓고, 수신감도는 시스템의 서비스 커버리지와 서비스 품질과 밀접한 연관이 있다. 수신감도가 낮을수록 서비스 커버리지가 증가하지만 노이즈에 민감해지고, 수신감도가 높을수록 서비스 커버리지는 감소하는 반면에 노이즈에 둔감해 진다. 그러므로 수신감도와 노이즈 민감도 관점에서 최적의 케리어 센싱 설계와 최적화가 매우 중요하다. 본 논문에서는 장거리 사물인터넷을 위해 수신감도의 최적화 관점에서 효과적인 케리어 센싱 기법을 제안한다.

• 한국자기학회지
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• 제18권2호
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• pp.71-74
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• 2008

본 논문에서는 4분할 광 검출기 상에 입사된 광점의 크기에 따른 optical beam deflection방식에서의 변위 측정감도의 변화에 대해 살펴보았다. 3mW의 헬륨-네온 레이저를 사용하여 optical beam deflection방식의 광학적 변위 측정 장치를 제작하였으며 광 검출기에 도달하는 광점의 크기를 변화시켜가며 제작된 변위 측정 장비가 나타내는 변위 측정감도를 관찰하였다. 또한 광 검출기에 도달하는 optical beam power를 원형의 균일한 분포를 지닌 광점으로 설정하여 광점 크기의 변화에 따른 변위 측정감도를 계산하였다. 측정된 결과와 계산을 통하여 검출기 상에 입사하는 광점의 크기가 작을수록 변위 측정감도가 증가함을 알 수 있었으며 이는 나노미터 급의 변위측정 장비 개발에 있어 광 검출기에 도달하는 광점의 크기를 최소화함으로써 변위 측정감도를 최적화 할 수 있음을 나타낸다.

• The Korean Journal of Physiology and Pharmacology
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• 제24권3호
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• pp.233-240
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• 2020

Autophagy regulators are often effective as potential cancer therapeutic agents. Here, we investigated paclitaxel sensitivity in cells with knockout (KO) of ATG5 gene. The ATG5 KO in multidrug resistant v-Ha-ras-transformed NIH 3T3 cells (Ras-NIH 3T3/Mdr) was generated using the CRISPR/Cas9 technology. The qPCR and LC3 immunoblot confirmed knockout of the gene and protein of ATG5, respectively. The ATG5 KO restored the sensitivity of Ras-NIH 3T3/Mdr cells to paclitaxel. Interestingly, ATG5 overexpression restored autophagy function in ATG5 KO cells, but failed to rescue paclitaxel resistance. These results raise the possibility that low level of resistance to paclitaxel in ATG5 KO cells may be related to other roles of ATG5 independent of its function in autophagy. The ATG5 KO significantly induced a G₂/M arrest in cell cycle progression. Additionally, ATG5 KO caused necrosis of a high proportion of cells after paclitaxel treatment. These data suggest that the difference in sensitivity to paclitaxel between ATG5 KO and their parental MDR cells may result from the disparity in the proportions of necrotic cells in both populations. Thus, our results demonstrate that the ATG5 KO in paclitaxel resistant cells leads to a marked G₂/M arrest and sensitizes cells to paclitaxel-induced necrosis.

• 대한기계학회논문집A
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• 제26권9호
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• pp.1931-1942
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• 2002

In this paper a formulation of robust optimization is presented and illustrated by a design example of vibratory micro gyroscopes in order to reduce the effect of variations due to uncertainties in MEMS fabrication processes. For the vibratory micro gyroscope considered it is important to match the resonance frequencies of the vertical (sensing) and lateral (driving) modes as close as possible to attain a high sensing sensitivity. A deterministic optimization in which the difference of both the sensing and driving natural frequencies is minimized as an objective function results in highly enhanced performance but apt to be very sensitive to fabrication errors. The formulation proposed is to attain robustness of the performance by including the sensitivity of the response with respect to uncertain variables as a term of objective function to be minimized. This formulation is simple and practically applicable since no detail statistical information on fabrication errors is required. The geometric variables, beam width, length and thickness of vibratory micro gyroscopes are adopted as design variables and at the same time considered as uncertain variables because here occur the fabrication errors. A robustness test in terms of a percentage yield by using the Monte Carlo simulation has shown that the robust optimum produces twice more acceptable designs than the deterministic optimum. Improvement of robustness becomes bigger as the amount of fabrication errors is assumed larger. Considering that the magnitude of fabrication errors and uncertainties in a MEMS structure are comparatively large, the present method is illustrated to be a viable approach for a robust MEMS design.

• 한국안광학회지
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• 제5권2호
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• pp.157-161
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• 2000

광원의 세기가 다른 조건하에서 눈의 시감효율은 추상체와 간상체에 의해 파장에 따라 2개의 함수로 이루어진다. 광자에 대한 추상체-간상체의 반응확률을 이용하여 $P({\lambda})=A{\cdot}e^{-({\lambda}-{\lambda}_0)^2/2W^2}$의 분포함수 수식을 유도하였다. 이 식은 파장에 따른 CIE의 눈의 시감효율 곡선에 잘 적용되며 상대 시감효율의 경우 photopic의 경우 A=106.4, ${\lambda}_0=559.2$, W=83.5이고 scotopic의 경우 A=99.3, ${\lambda}_0=502.6$, W=79.5의 값을 얻었다. 1m/W의 단위를 사용하는 시감효능 곡선에서는 photopic의 경우 $A=7.2{\times}10^4$, ${\lambda}_0=559.2$, W=86.5이고 scotopic의 경우 $A=1.6{\times}10^5$, ${\lambda}_0=502.6$, W=79.5의 값을 얻었다.

• 한국자동차공학회논문집
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• 제6권4호
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• pp.66-75
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• 1998

In many case of optimal design and sensitivity analysis, obtaining of transfer function between input and output variables is a difficult and time-consuming problem. The bond graph modeling is a method that is used for making it easy to analyze complex systems composed of mechanical and electrical parts. It gives us a simple and systematic tool to get state-space equations easily. And we can obtain the transfer function graphically using bond graph and Mason's rule. This paper shows how bond graphs are converted to block diagram and how Mason's rule is applied. And the simple direct method to obtain transfer function from bond graph is introduced. As a example, induction of transfer function of electric power steering composed of mechanical and electrical parts will be done.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 1997년도 한국자동제어학술회의논문집; 한국전력공사 서울연수원; 17-18 Oct. 1997
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• pp.434-437
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• 1997

In this paper, we present an $H^{\infty}$ controller design of RTP system satisfying robust stability and performance using weighted mixed sensitivity minimization. In industrial fields, RTP system is widely used for improving the oxidation and the annealing in semiconductor manufacturing process. The main control factors are temperature control of wafer and uniformity in the wafer. The control of temperature and uniformity has been solved by PI control method. We improve robust stability and performance of RTP system by the design of $H^{\infty}$ controller using the weighted mixed sensivity function. An example is proposed to show the validity of proposed method.d.

• 한국전산구조공학회:학술대회논문집
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• 한국전산구조공학회 2005년도 춘계 학술발표회 논문집
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• pp.335-342
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• 2005

Using higher order Mindlin plates and piezoelectric materials, eigenvalue problems are considered. Since piezoelectric crystal resonators produce a proper amount of electric signal for a thickness-shear frequency, the objective is to decouple the thickness-shear mode from the others. Design variables are the bulk material densities corresponding to the mass of masking plates for electrodes. The design sensitivity expressions for the thickness-shear frequency and mode shape vector are derived using direct differentiation method(DDM). Using the developed design sensitivity analysis (DSA) method, we formulate a topology optimization problem whose objective function is to maximize the thickness-shear component of strain energy density at the thickness-shear mode. Constraints are the allowable volume and area of masking plate. Numerical examples show that the optimal design yields an improved mode shape and thickness-shear energy.