• Title/Summary/Keyword: Sensitivity Factors

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Endometrial histology and predictable clinical factors for endometrial disease in women with polycystic ovary syndrome

  • Park, Joon-Cheol;Lim, Su-Yeon;Jang, Tae-Kyu;Bae, Jin-Gon;Kim, Jong-In;Rhee, Jeong-Ho
    • Clinical and Experimental Reproductive Medicine
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    • v.38 no.1
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    • pp.42-46
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    • 2011
  • Objective: This study was aimed to investigate endometrial histology and to find predictable clinical factors for endometrial disease (hyperplasia or cancer) in women with polycystic ovary syndrome (PCOS). Methods: We investigated the endometrial histology and analyzed the relationship between endometrial histology and clinical parameters, such as LH, FSH, estradiol, testosterone, fasting and 2 hours postprandial glucose and insulin, insulin resistance, body mass index, endometrial thickness, menstrual status from 117 women with PCOS. Statistical analysis was performed with chi square and t-test, p-value<0.05 was considered as statistically significant. And receiver operating characteristic curve was used to find predictable clinical factors for endometrial disease and to decide the cuff off values. Results: In 117 women with PCOS, endometrial histologic profiles are as follows: proliferative phase in 90 women (76.9%), endometrial hyperplasia in 25 women (21.4%), and endometrial cancer in 2 women (1.7%). Of 25 women with endometrial hyperplasia, simple hyperplasia without atypia, complex hyperplasia without atypia and complex hyperplasia with atypia were diagnosed in 15 (12.8%), 6 (5.1%), 4 (3.4%) women, respectively. Age and endometrial thickness were significantly related with endometrial disease, p=0.013 and p=0.001, respectively. At the cut off level of 25.5 years in age, sensitivity and specificity predicting for endometrial disease were 70.4% and 55.6%, respectively (p=0.023). At the cut off level of 8.5 mm in endometrial thickness, sensitivity and specificity were 77.8% and 56.7%, respectively (p=0.000). Conclusion: In women with PCOS, the incidence of endometrial hyperplasia and cancer were 21.4% and 1.7%. The age and endometrial thickness may be used as clinical determining factors for endometrial biopsy.

Cone-Beam CT-Guided Percutaneous Transthoracic Needle Lung Biopsy of Juxtaphrenic Lesions: Diagnostic Accuracy and Complications

  • Wonju Hong;Soon Ho Yoon;Jin Mo Goo;Chang Min Park
    • Korean Journal of Radiology
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    • v.22 no.7
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    • pp.1203-1212
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    • 2021
  • Objective: To investigate the diagnostic accuracy and complications of cone-beam CT-guided percutaneous transthoracic needle biopsy (PTNB) of juxtaphrenic lesions and identify the risk factors for diagnostic failure and complications. Materials and Methods: In total, 336 PTNB procedures for lung lesions (mean size ± standard deviation [SD], 4.3 ± 2.3 cm) abutting the diaphragm in 326 patients (189 male and 137 female; mean age ± SD, 65.2 ± 11.4 years) performed between January 2010 and December 2014 were included. The accuracy, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of the PTNB procedures for the diagnosis of malignancy were measured based on the intention-to-diagnose principle. The risk factors for diagnostic failures and complications were evaluated using logistic regression analysis. Results: The accuracy, sensitivity, specificity, PPV, and NPV were 92.7% (293/316), 91.3% (219/240), 91.4% (74/81), 96.9% (219/226), and 77.9% (74/95), respectively. There were 23 diagnostic failures (7.3%), and lesion sizes ≤ 2 cm (p = 0.045) were the only significant risk factors for diagnostic failure. Complications occurred in 98 cases (29.2%), including 89 cases of pneumothorax (26.5%) and 7 cases of hemoptysis (2.1%). The multivariable analysis showed that old age (> 65 years) (p = 0.002), lesion size of ≤ 2 cm (p = 0.003), emphysema (p = 0.006), and distance from the pleura to the target lesion (> 2 cm) (p = 0.010) were significant risk factors for complications. Conclusion: The diagnostic accuracy of cone-beam CT-guided PTNB of juxtaphrenic lesions for malignancy was fairly high, and the target lesion size was the only significant predictor of diagnostic failure. Complications of cone-beam CT-guided PTNB of juxtaphrenic lesions occurred at a reasonable rate.

The Relationship between Health Belief and Exercise Compliance among Elderly Adults at Senior Centers (경로당 노인의 건강신념과 운동이행의 관계)

  • Lee, Kyung Im;Eun, Young
    • Research in Community and Public Health Nursing
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    • v.26 no.2
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    • pp.79-88
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    • 2015
  • Purpose: The purposes of this study were to examine the relationship between health belief and exercise compliance among elderly adults at senior centers and to identify factors influencing their exercise compliance. Methods: The subjects of this study were 100 elderly adults who were using senior centers in J City. Data were collected from the 5th of August to the 14th of September in 2014 using a questionnaire about general characteristics, health belief, and exercise compliance. Data analysis included one-way ANOVA, independent t-test, Pearson's correlation, and stepwise multiple regression using the SPSS/WIN 18.0 program. Results: The mean score for exercise compliance was 3.85 (range 1~5), and for perceived health state 3.17 (range 1~5). The mean score for each of the sub-factors of health belief was 3.89 for benefit, 1.94 for barrier, 3.34 for severity, 2.43 for sensitivity, and 3.65 for exercise self-efficacy (range 1~5). There was a significant correlation between exercise compliance and exercise benefit, and 28% of variance in exercise compliance was explained by exercise benefit in health belief, family history of illnesses, and perceived sensitivity in health belief. Conclusion: To promote exercise compliance among elderly adults at senior centers, exercise programs emphasizing exercise benefit should be developed.

Correlation between EGFR Expression and Radiosensitivity in Cervical Adenocarcinoma Cases

  • Hernowo, Bethy S;Suryanti, Sri;Wibisono, Fennisia
    • Asian Pacific Journal of Cancer Prevention
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    • v.17 no.5
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    • pp.2535-2537
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    • 2016
  • Background: Most of the cervical cancer patients, including those with cervical adenocarcinomas, come at advanced stage in the developing world so its mortality is high. Radiotherapy is one of the treatment modality for advanced stage cervical adenocarcinomas, but its efficacy depends on several prognostic factors such as the stage, histopathology, presence of organ dysfunction and expression of cellular biology markers mainly involve in cell proliferation such as the epidermal growth factor receptor (EGFR). Some research indicates that activation of EGFR in malignancy (including cervical cancer) correlates with aggressive behavior, a poor prognosis and decreasing sensitivity of radiotherapy. However, the combination between targeted therapies and radiotherapy are innovative approaches which may provide a good result. This study aimed to assess any correlation between expression of EGFR and response to radiotherapy in cervical adenocarcinoma cases. Materials and Methods: A total of 32 women were registered in a retrospective study period January 2007 and May 2014. Paraffin blocks from these patients were processed by classical histological techniques and for immunohistochemical staining of EGFR, scoring being accomplished according to the immunoreactive scoring (IRS) of Remmele and Stegner. Results: Among the studied molecular factors, there was significant correlation expression of EGFR with poor response to radiotherapy (p=0.0001). Conclusions: The result of this study showed a significant correlation between expression of EGFR and sensitivity of radiation in cervical adenocarcinoma cases. Further research is necessary to obtain information about new therapeutic management.

Economic Evaluations of Direct/indirect Coal Liquefaction Processes (직.간접석탄액화공정의 경제성 평가)

  • Park, Joo-Won;Bae, Jong-Soo;Kweon, Yeong-Jin;Kim, Hak-Joo;Jung, Heon;Han, Choon
    • 한국신재생에너지학회:학술대회논문집
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    • 2009.06a
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    • pp.857-860
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    • 2009
  • This report examines the economic feasibility of a commercial 50,000 barrel per day direct/indirect coal liquefaction (DCL/ICL) facility to produce commercial-grade diesel and naphtha liquids from medium-sulfur bituminous coal. The scope of the study includes capital and operating cost estimates, sensitivity analysis and a comparative financial analysis. Based on plant capacity of 50,000BPD, employing Illinois #6 bituminous coal as feed coal the total capital cost appeared $3,994,858,000(DCL) and $4,942,976,000(ICL). Also, the internal rate of return of DCL/ICL appeared 13.27% and 12.68% on the base condition. In this case, coal price and sale price of products were the most influence factors. And ICL's payback period(6.8 years) was longer than DCL's (6.6 years). According to sensitivity analyses, the important factors on DCL/ICL processes were product sale price, feed coal price and the capital cost in order.

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Hypertension awareness and the related factors by age (고혈압 인지율의 평가와 연령별 특성)

  • Chun, Heeran;Kim, Il-Ho
    • Korean Journal of Health Education and Promotion
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    • v.33 no.5
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    • pp.37-46
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    • 2016
  • Objectives: This study examines the awareness of hypertension and its age-specific characteristics among Korean adults. Methods: Data were derived from the fourth Korean National Health Examination and Nutrition Survey (KNHANES IV, 2007-2009) of 14,637 subjects aged 30 and older. Self-reported prevalence of hypertension (HTN) was compared with measured arterial systolic/diastolic blood pressure, employing Kappa index, sensitivity, and specificity. Multiple logistic regression analysis was used to determine factors in hypertension awareness by age groups. Results: Kappa agreement between self-reported and measured data in hypertension was high (0.70, 95% CI 0.68-0.71). Awareness by sensitivity was relatively high (65.3%) and specificity was very high (98.8%) for all ages. After age stratification, the results revealed the very lowest level of hypertension awareness among the youngest age group: 29.1% of adults aged 30-49 years, 57.5% of adults aged 45-59 years, and 76.9% of those aged ${\geq}60years$. Predictors for awareness differed by age group. Among adults aged 30-49 years, men exhibited lower awareness to HTN than women. Among middle-aged adults, workers showed lower awareness than non-workers. Among those aged ${\geq}60years$, men and the less educated showed lower awareness to HTN than their counterparts. Conclusions: Age-specific prevention strategies are needed for hypertension management.

Analyzing an Economic Feasibility for Restoration/Creation of Artificial Tidal Flats (인공갯벌 조성에 관한 경제적 타당성 분석)

  • Nam, Kwang-Hyun;Oh, Wee-Yeong
    • Ocean and Polar Research
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    • v.25 no.4
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    • pp.593-601
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    • 2003
  • The purpose of this paper is to investigate economic feasibility of creating artificial tidal flats using cost-benefit analyses. We assumed that the cost factors are associated with designing, construction and monitoring, and the benefit factors are associated with fisheries production, habitation, prevention of disasters, water purification, aesthetic value and existence value. First, for analyzing economic feasibility, the scenario suggests that a design can be made in a year, construction can be completed in three years and monitoring must be made for 20 years. Assuming the discount rate of 7.5%, economic feasibility analyses showed that B/C was 2.26 and IRR was 14.50. This study indicated there is economic validity of implementing creation of artificial tidal flat. In addition, we carried out a sensitivity analysis at the change of discount rate and restoration rate. The result of sensitivity analysis clearly showed that economic validity is low when discount rate is over 15%, and changes in restoration rate did not significantly effect on the economic validity.

Capital Structure and Financial Performance: A Case of Saudi Petrochemical Industry

  • ALI, Anis;FAISAL, Shaha
    • The Journal of Asian Finance, Economics and Business
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    • v.7 no.7
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    • pp.105-112
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    • 2020
  • The study investigates and measures the impact of capital structure, profitability and financial performance on the success of the business organization. Capital structure of the business organization refers to the proportion of external funds and internal funds, i.e., debt and equity. In Saudi Arabia, petrochemicals companies are working on equity, but financial performance reflects negative trend for the period 2004 to 2016. The research is based upon secondary data available on the websites of petrochemicals companies of Saudi Arabia. Financial Ratio variability analysis and Trend Indices of financial ratios (TICBI) measure and compare the financial variability and sensitivity of financial ratios of the business organization. Correlation between Trend Indices (TICBI) of independent variable and dependent variables are to be calculated to know the impact of changes in debt equity on other dependent variables. The results reveal the unexpected performance of petrochemicals companies due to under-utilization of the resources caused by low demand and lower prices of the products governed by some internal and external factors. The study finds that size, demand, cost of production, profitable streams of products, and low cost capital in external funds are the factors responsible for overall growth development of the petrochemicals industry of Saudi Arabia.

Factors related to oral health management for child in mothers of multicultural families (다문화가정 모친의 자녀 구강건강관리 관련요인)

  • Kim, Mi;Cho, Young-Sik
    • Journal of Korean society of Dental Hygiene
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    • v.18 no.5
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    • pp.807-819
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    • 2018
  • Objectives: The purpose of this study was to identify the factors affecting the oral health behavior of mothers in multicultural families and the oral health management of children. Methods: The subjects were 303 mothers in multicultural families having children in childhood. To verify the validity of the outcome, a factorial analysis was conducted. To examine differences in the outcome according to socio-demographic characteristics, a one-way ANOVA was used, and the hypothesis was tested through a multiple regression analysis. Results: According to the results, it was found that severity, self-efficacy, sensitivity, and multicultural disability that show attitudes had significant impact on the mother's oral health behavior. Moreover, it was found that self-efficacy, sensitivity, and the mother's oral health behavior that show attitudes had significant impact on the children's oral health management. Conclusions: Based on the results of this study, it would be necessary to increase the interest in mother-and-child oral health, developing a mother-and-child oral health education program targeted toward the oral health of the mothers and children in multicultural families. Moreover, it is essential to educate mothers in multicultural families in order to increase their sense of responsibility toward their children's oral health management, aiming to promote knowledge and to change attitudes and behavior.

An Empirical Study on Individual and Social Commerce Factors Impacting Shopping Value and Intention to Repurchase in Social Commerce and Moderating Effects of Perceived Security (소셜커머스의 쇼핑 가치와 재구매의도에 영향을 미치는 개인 및 소셜커머스 특성과 지각된 보안의 조절효과에 대한 연구)

  • Kim, Sanghyun;Park, HyunSun
    • Journal of Information Technology Services
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    • v.12 no.2
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    • pp.31-53
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    • 2013
  • Web 2.0 has affected existing e-commerce and created a new business model of e-commerce, known as social commerce. Social commerce is a subset of e-commerce using social network services and is emerging as an important platform due to increased popularity of social networking services. This study focuses on analyzing the factors that influence the shopping value and intention to repurchase of social commerce users. Based on prior researches, we develop a research model, including individual characteristics of social commerce users (Collectivism, Price Sensitivity, Impulse Buying) and social commerce characteristics (Cost saving, Product Variety, Shopping Convenience). Furthermore, this study proposed the moderating effect of Perceived Security and the relationship between shopping value and intention to repurchase. To empirically validate, the data were collected from 220 social commerce users. The results indicated that individual characteristics (collectivism, price sensitivity, impulse buying) were positively related to hedonic shopping value. In addition, social commerce characteristics (cost saving, shopping convenience) were positively related to utilitarian value. The shopping value(hedonic and utilitarian) had a significant influence on intention to repurchase. The moderating effects of perceived security also was significant. Lastly, the implications for theory and practice are discussed.