• Molecules and Cells
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• 제38권7호
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• pp.638-642
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• 2015

Quercetin can suppress osteosarcoma cell growth and metastasis. However, other effects of quercetin on osteosarcoma remain largely unknown. This research aims to evaluate the effects of quercetin in combination with cisplatin as treatment for osteosarcoma and investigate its regulatory mechanism. Cell viability and apoptosis in 143B cell line were determined after treatment with quercetin and/or cisplatin. RT-PCR and Western blot analysis were performed to determine the RNA or protein expression levels. Moreover, transwell assay was used to evaluate metastasis. Furthermore, rescue experiments were performed to investigate the potential regulatory mechanism of the treatment. Results showed that quercetin with concentration that was equal to or greater than $10{\mu}M$ inhibited 143B proliferation, while $5{\mu}M$ quercetin enhanced the cisplatin sensitivity of 143B cells. Expression of miR-217 was upregulated after quercetin and/or cisplatin treatment, while its target KRAS was downregulated both at mRNA and protein levels. MiR-217 knockdown led to the loss of enhanced cisplatin sensitivity while miR-217 overexpression showed the opposite effects, indicating that quercetin regulated cisplatin sensitivity by modulating the miR-217-KRAS axis. In conclusion, $5{\mu}M$ quercetin enhanced the cisplatin sensitivity by modulating the miR-217-KRAS axis. This finding suggests that quercetin may be administered with cisplatin to improve the treatment for osteosarcoma.

• 한국콘텐츠학회논문지
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• 제15권11호
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• pp.10-17
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• 2015

감성을 규칙적인 숫자로 변화하려는 감성컴퓨터 연구가 지속적이다. 감성컴퓨팅 방식으로 감성을 숫자화하고, 감성트리를 통해 실행했다. 감성컴퓨팅의 감성 평가는 James A. Russell의 핵심 효과(Core Affect)의 감성좌표를 활용했다. 감성트리 실행 목적은 감성컴퓨팅과 감성트리의 상관관계를 검증했다. 감성트리 속성실험은 색상, 명도, 채도로 구성했다. 명도 50% 증가했을 때, 쾌정도(X축)는 10.49점 증가했다. 명도 50%, GREEN 50% 증가는 쾌정도(X축) 10.49점, 긴장도(Y축) 15.85점만큼 증가했다. 쾌정도(X축)에 명도 50%, 긴장도(Y축)에 BLUE 50%일 때, 쾌정도(X축) 10.49점, 긴장도(Y축) 14.65점만큼 감성이 변화했다. 대표감성크기 변화는 명도 50%, 색상 RED 50% 증가했을 때, 흥분 감성이 5.4% 증가했고, 우울한 감성이 -4.2% 감소했다. 명도 50%, 색상 GREEN 50%의 증가는 흥분 감성이 8.6%로 증가했고, 우울한 감성이 -5.5%로 감소했다. 감성속성 증감에 따른 감성변화와 대표감성크기를 숫자 방식으로 분석했다. 향후 영상 이미지 감성컴퓨팅의 실행인 감성트리를 통해 사람의 감성과 더 유사하도록 행복한 감성 숫자 연구가 필요하다.

• 대한전기학회논문지:전기물성ㆍ응용부문C
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• 제52권9호
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• pp.418-423
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• 2003

This paper describes an electronic compass using micromachined X- and Y-axis micro fluxgate sensors which were perpendicularly aligned each other to measure X- and Y-axis magnetic fields respectively. The fluxgate sensor was composed of rectangular-ring shaped magnetic core and solenoid excitation(49 turns) and pick-up(46 turns) coils. Excitation and pick-up coil patterns which were formed opposite to each other wound the magnetic core alternatively to improve the sensitivity and to excite the magnetic core in an optimal condition with reduced excitation current. The magnetic core has DC effective permeability of ~1000 and coercive field of ~0.1 Oe. The magnetic core is easily saturated due to the low coercive field and closed magnetic path for the excitation field. To decrease the difference of induced second harmonic voltages from X- and Y-axis, excitation condition of 2.8 $V_{P-P}$ and 1.2 MHz square wave was selected. Excellent linear response over the range of -100 $\mu$T to +100 $\mu$T was obtained with 210 V/T sensitivity. The size of each micro fluxgate sensor excluding pad region was about 2.6${\times}$1.7 $mm^2$ and the power consumption was estimated to be 14 mW.W.

• 만화애니메이션 연구
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• 통권39호
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• pp.393-412
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• 2015

사람의 이미지를 보고 느끼는 감성인식은 환경, 개인적 성향에 따라 다양하게 변화한다. 그리하여 이미지 감성인식을 숫자로 제어하려는 감성컴퓨터 연구에 집중되고 있다. 그렇지만 기존의 감성컴퓨팅 모형은 숫자화된 객관적이고, 명확한 측정이 미흡한 상황이다. 따라서 이미지 감성인식을 감성컴퓨팅을 통해 정량화하고, 객관적인 평가 방식의 연구가 필요한 상황이다. 이에 본 논문은 이미지 감성인식을 계산 방식에 따라 숫자화한 정량화로 감성크기를 표현했다. 그리하여 이미지 감성인식의 주요한 속성인 색채를 구성인자로 적용한다. 또한 디지털 색채 감성컴퓨팅을 적용하여 계산하는데 연구의 중점을 두었다. 이미지 색채 감성컴퓨팅 연구방식은 감성속성인 색상, 명도, 채도에 중요도에 따른 가중치를 감성점수에 반영한다. 그리고 감성점수를 이미지 감성계산식에 적용하여 쾌정도(X축), 긴장도(Y축)를 숫자 방식으로 계산한다. 거기에 쾌정도(X축), 긴장도(Y축)의 교차하는 위치점을 이미지 감성좌표의 감성점으로 위치한다. 이미지 색채 감성좌표는 러셀의 핵심 효과(Core Affect)를 적용하여 16가지 주요대표감성을 기반으로 한다. 이미지 감성점은 기준의 위치에서 대표감성크기와 감성상관관계를 숫자화하고, 이미지 감성을 정량화한다. 그리하여 이미지 감성인식은 숫자 크기로 비교한다. 감성점수의 대소에 따라 감성이 변화함을 증명한다. 비교 방식은 이미지 감성인식을 16개 대표감성과 연관된 감성의 상위 5위로 구분하고, 집중된 대표감성크기를 비교 분석한다. 향후 감성컴퓨팅 방식이 사람의 감성인식과 더 유사할 수 있도록 감성계산식의 연구가 필요하다.

• 한국자동차공학회논문집
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• 제5권1호
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• pp.38-48
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• 1997

A method for performing kinematic design sensitivity analysis of vehicle suspension systems is presented. For modeling of vehicle suspensions, the multibody dynamic formulation is adopted, where suspensions are assumed as combination of rigid bodies and ideal frictionless joints. In a relative joint coordinate setting, kinematic constraint equations are obtained by imposing cut-joints that transform closed-loop shape suspension systems into open-loop systems. By directly differentiating the constraint equations with respect to kinematic design variables, such as length of bodies, notion axis, etc., sensitivity equations are derived. By solving the sensitivity equations, sensitivity of static design factors that can be used for design improvement, can be obtained. The validity and usefulness of the method are demonstrated through an example where kinematic sensitivity analysis of a MacPherson strut suspension of performed.

• 분석과학
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• 제28권6호
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• pp.430-435
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• 2015

메틸나이트로이미다졸계 유도체들에 관한 화약 성능과 충격감도 간의 이차원 분석이 이들 물질의 효용성을 판단하기 위해 진행되었다. 화약 성능은 Cheetah 프로그램으로 계산되었으며, 충격감도는 인공신경망 연구로 예측했다. 연속적인 나이트로기의 치환이 분자들을 민감하게 하지만 메틸트라이나이트 이미다졸까지도 비교적 안전한 상태를 유지하는 것으로 예측된다. 최근에 국방과학연구소에서는 성능과 감도를 X, Y축에 도시하고 신규화약물질의 유용성을 전체적으로 분석하는 방안을 개발하였다. 이들 성능-감도 이차원 그래프에 따르면 메틸다이나이트로이미다졸계 유도체들은 둔감화약조성에 사용이 가능할 것으로 판단되고, 반면 메틸트라이나이트로이미다졸은 고폭화약조성에 사용할 수 있을 것으로 판단된다.

• International Journal of Concrete Structures and Materials
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• 제6권2호
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• pp.101-110
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• 2012

This paper focuses on the finite element (FE) response sensitivity and reliability analyses considering smooth constitutive material models. A reinforced concrete frame is modeled for FE sensitivity analysis followed by direct differentiation method under both static and dynamic load cases. Later, the reliability analysis is performed to predict the seismic behavior of the frame. Displacement sensitivity discontinuities are observed along the pseudo-time axis using non-smooth concrete and reinforcing steel model under quasi-static loading. However, the smooth materials show continuity in response sensitivity at elastic to plastic transition points. The normalized sensitivity results are also used to measure the relative importance of the material parameters on the structural responses. In FE reliability analysis, the influence of smoothness behavior of reinforcing steel is carefully noticed. More efficient and reasonable reliability estimation can be achieved by using smooth material model compare with bilinear material constitutive model.

• 조형예술학연구
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• 제8권
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• pp.241-266
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• 2005

Current information-oriented society is expanding rapidly with the huge change to our society from the information revolution emerged in mid '50s. Information technique such as computer, communication satellite and cable technology play their in this information-oriented society, and in 1980s, digital technique was adopted to media, inviting new phenomenon in communication of overall society. Expectations and hope for new trends and changes from digital era flourished when we entered into new Millenium, the 21st century. Since then we have gone through changes in years from analogue to digital. Now the word 'digital' is conceived in unified manner in almost every fields and influences overall society, changing our life pattern rapidly. Modern society had demanded some speedy and bidirectional communication tool in shifting digital era, and resulted from that was a new culture, Now the society changes more and more quickly under the speedy information sharing. From that perspective we need to establish the aspects of sensibility expression, which is one feature of the communication. The sensibility-oriented digital was originated from the human nature, which counts emotion and composure much. To satisfy the human nature a new cultural value which transcend a traditional one is needed. And the sensitivity expression to meet the need is one communication tendency in digital era. Digital era has totally different social qualities from that of analogue era. In digital era, prompt respond to rapid change and creativity combined with sensitivity are needed. Therefore a man with sensitivity would be more outstanding than a man of intelligence. The picture of digital and analogue in our society consists of two axis one is analogue axis like retrospective trend, admiration for nature , oriental thought etc. , and the other is the digital axis of internet and information technology. Sensibility can be widely interpreted as analogue thinking. It is surely different from the plain retrospective trend or nostalgia for past. It is a tendency that digital technology is used and cooperated with the emotion in human nature, In this paper we suggest the sensitivity expressions in detail through the study cases including both sides of digital and sensitivity expressions such as 'Bravo your life' advertising campaign of Samsung Insurance, MP3 advertising campaign, and 'Mini-homepage' of Cyworld. Under the circumstances the main direction of communication is oriented to human. This study's purpose is to think the true meaning of this digital era, to overcoming its weaknesses, such as over-dependency on technique and selfish individualism and to harmonize digital and sensitivity expression. The sensitivity-oriented expression than the reason-oriented one is expected to be put forth in whole media, and this is a more efficient tendency under the shifting digital era.

• 한국정밀공학회지
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• 제14권3호
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• pp.98-106
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• 1997

In this paper, a new method of position synchronizing control is proposed for multi-axes driving system. The proposed position synchronizing control system is constituted with speed and synchronizing controller. The speed controller is aimed at the following to speed reference. Furthermore, it is designed to guarantee low sensitivity under some disturbance as well as robustness against model uncertainties using $H_{\infty}$technique. The synchronizing controller is designed to keep minimizing the position error using PID control law which is considered to reduce the dimension of transfer function in the control system. Especially, the proposed method can be easily conducted by controlling only slave axis speed, because it, has variable structure which is decided to master and slave axis by the sign of synchronizing error. Therfore, the master axis which is smaller influenced than another axes by disturbance can be controlled without reducing or increasing its speed for precise position synchronization. The effectiveness of the proposed method is sucessfully confirmed through many experiments.s.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2022년도 춘계학술대회
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• pp.516-518
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• 2022

본 논문에서는 낙상상태를 감지할 수 있는 장단기 메모리(Long Short-Term Memory)를 이용한 낙상감지 시스템에서 은닉층 노드 수 변경에 따른 영향을 소개한다. 3축 가속도 센서를 이용하여 x, y, z축 데이터를 중력 방향과 이루는 각도를 나타내는 파라미터 theta(θ)를 이용하여 훈련을 진행한다. 학습에서는 validation이 진행되어 8:2의 비율로 훈련 데이터와 테스트 데이터로 나뉘며, 효율성을 높이기 위해 은닉층의 노드 수를 변화하며 훈련을 진행한다. 노드 수가 128일 때 Accuracy 99.82%, Specificity 99.58%, Sensitivity 100%로 가장 좋은 정확도를 나타내었다.