• Nuclear Engineering and Technology
• /
• 제55권5호
• /
• pp.1718-1733
• /
• 2023

The virtual Frisch-grid method for room-temperature radiation detectors has been widely used because of its simplicity and high performance. Recently, side electrodes were separately attached to each surface of the detectors instead of covering the entire detector surface with a single electrode. The side-electrode structure enables the measurement of the three-dimensional (3D) gamma-ray interaction in the detector. The positional information of the interaction can then be utilized to precisely calibrate the response of the detector for gamma-ray spectroscopy and imaging. In this study, we developed a 3D position-sensitive 5 × 5 × 12 mm³ cadmium-zinc-telluride (CZT) detector and applied a flattening method to correct detector responses. Collimated gamma-rays incident on the surface of the detector were scanned to evaluate the positional accuracy of the detection system. Positional distributions of the radiation interactions with the detector were imaged for quantitative and qualitative evaluation. The energy spectra of various radioisotopes were measured and improved by the detector response calibration according to the calculated positional information. The energy spectra ranged from 59.5 keV (emitted by ²⁴¹Am) to 1332 keV (emitted by ⁶⁰Co). The best energy resolution was 1.06% at 662 keV when the CZT detector was voxelized to 20 × 20 × 10.

• Journal of Radiation Protection and Research
• /
• 제30권1호
• /
• pp.31-34
• /
• 2005

The article is devoted to the study of some hi-and tricyclic derivatives of aziridine as materials lot newindicators of ionizing radiation. To create high sensitive materials some aspects of photo induced ring opening processes in aziridine derivatives in ethanol solutions and in polymeric matrix were studied and two steps character of the processes investigated was established. Two types of radioindicators were suggested and preliminary tested. The new way of synthesis of radiochromic derivatives of aziridine was developed and series of target compounds synthesized.

• Nuclear Engineering and Technology
• /
• 제54권1호
• /
• pp.255-261
• /
• 2022

A reliable and well-characterized dosimetry system which is traceable to the international measurement system, is the key element to quality assurance in radiation processing with cobalt-60 gamma rays, X-rays, and electron beam. This is specifically the case for health-regulated processes, such as the radiation sterilization of single use medical devices and food irradiation for preservation and disinfestation. Polyethylene is considered to possess a lot of interesting dosimetric characteristics. In this work, a detailed study has been performed to determine the dosimetric characteristics of a commercialized high-density polyethylene (HDPE) film using Fourier transformed infrared spectrometry (FTIR). Correlations have been established between the absorbed dose and radiation induced infrared absorption in polyethylene having a maximum at 965 cm^-1 (transvinylene band) and 1716 cm^-1 (ketone-carbonyl band). We have found that polyethylene dose-response is linear with dose for both bands up to1000 kGy. For transvinylene band, the dose-response is more sensitive if irradiations are made in helium. While, for ketone-carbonyl band, the dose-response is more sensitive when irradiations are carried out in air. The dose-rate effect has been found to be negligible when polyethylene samples are irradiated with electron beam high dose rates. The irradiated polyethylene is relatively stable for several weeks after irradiation.

• The Korean Journal of Physiology and Pharmacology
• /
• 제18권6호
• /
• pp.509-516
• /
• 2014

Radiation therapy for variety of human solid tumors utilizes mechanism of cell death after DNA damage caused by radiation. In response to DNA damage, cytochrome c was released from mitochondria by activation of pro-apoptotic Bcl-2 family proteins, and then elicits massive $Ca^{2+}$ release from the ER that lead to cell death. It was also suggested that irradiation may cause the deregulation of $Ca^{2+}$ homeostasis and trigger programmed cell death and regulate death specific enzymes. Thus, in this study, we investigated how cellular $Ca^{2+}$ metabolism in RKO cells, in comparison to radiation-resistant A549 cells, was altered by gamma (${\gamma}$)-irradiation. In irradiated RKO cells, $Ca^{2+}$ influx via activation of NCX reverse mode was enhanced and a decline of $[Ca^{2+}]_i$ via forward mode was accelerated. The amount of $Ca^{2+}$ released from the ER in RKO cells by the activation of $IP_3$ receptor was also enhanced by irradiation. An increase in $[Ca^{2+}]_i$ via SOCI was enhanced in irradiated RKO cells, while that in A549 cells was depressed. These results suggest that ${\gamma}$-irradiation elicits enhancement of cellular $Ca^{2+}$ metabolism in radiation-sensitive RKO cells yielding programmed cell death.

• 한국정보통신학회논문지
• /
• 제18권8호
• /
• pp.2023-2028
• /
• 2014

본 논문에서는 광민감 광섬유와 일반 단일모드 광섬유로 제작된 광섬유 브래그 격자 센서의 감마방사선 영향을 분석하였다. 제작된 광섬유 브래그 격자는 $Co^{60}$ 감마선원을 이용하여 300 Gy/min의 선량률로 총선량 17.8 kGy 감마선을 조사하였다. 실험결과를 통하여 수소로딩을 하지 않은 광민감 광섬유로 제작된 브래그 격자가 가장 낮은 약 18 pm의 브래그 파장 이동을 보였다. 또한 방사선 조사에 의한 브래그 파장변화는 광섬유 코어의 $GeO_2$ 함량보다는 수소로딩 공정에 훨씬 큰 영향을 받는다는 것을 확인하였다.

• 대한방사선기술학회지:방사선기술과학
• /
• 제44권2호
• /
• pp.109-115
• /
• 2021

In this study, a physical evaluation of internal radiation exposure in children was conducted using nuclear medicine test(Renal DTPA Dynamic Study) to simulate the distribution and effects of the radiation throughout the tracer kinetics over time. Monte Carlo simulations were performed to determine the internal medical radiation exposure during the tests and to provide basic data for medical radiation exposure management. Specifically, dose variability based on changes in the tracer kinetic was simulated over time. The internal exposure to the target organ (kidney) and other surrounding organs was then quantitatively evaluated and presented. When kidney function was normal, the dose to the target organ(kidney) was approximately 0.433 mGy/mCi, and the dose to the surrounding organs was approximately 0.138-0.266 mGy/mCi. When kidney function was abnormal, the dose to the surrounding organs was 0.228-0.419 mGy/mCi. This study achieved detailed radiation dose measurements in highly sensitive pediatric patients and enabled the prediction of radiation doses according to kidney function values. The proposed method can provide useful insights for medical radiation exposure management, which is particularly important and necessary for pediatric patients.

• Nuclear Engineering and Technology
• /
• 제52권7호
• /
• pp.1503-1510
• /
• 2020

Ultra-low noise charge sensitive amplifiers (CSAs) based on various types of circuit board substrates, such as FR4, Teflon, and ceramics (Al₂O₃) with two different designs, PA1 and PA2, have been developed. They were tested to see the noise effect from the dielectric loss of the substrate capacitance before and after irradiation. If the electronic noise from the CSAs is to be minimized and the energy resolution enhanced, the shaping time has to be optimized for the detector, and a small feedback capacitance of the CSA is favorable for a better SNR. Teflon- and ceramic-based PA1 design CSAs showed better noise performance than the FR4-based one, but the Teflon-based PA1 design showed better sensitivity than ceramic based one at a low detector capacitance (<10 pF). In the PA2 design, the equivalent noise and the sensitivity were 0.52 keV FWHM for a silicon detector and 7.2 mV/fC, respectively, with 2 ㎲ peaking time and 0.1 pF detector capacitance. After 10, 100, 10³, 10⁴, and 10⁵ Gy irradiation the ENC and sensitivity characteristics of the developed CSAs based on three different substrate materials are also discussed.

• 한국환경보건학회지
• /
• 제8권1호
• /
• pp.81-97
• /
• 1982

Ethylene oxide gas has been used as a cold sterilant for heat-sensitive medical equipments and as a fumigant for food for more than 30 years, and it is used more widely than radiation although radiation sterilization has made significant inroads in recent years. But according to recent studies of toxicities such as mutagenicity, haemolytic effect and possible carcinogenicity of Ethylene oxide (ETO) and its two main reaction products, Ethylene chlorohydrin (ETCH) and Ethylene glycol (ETG), Environmental Protection Agency in U.S.A. has suggested some regulations on residual gas in drug products and medical devices for human use. The mutagenic activity of ETO compared with that of X-ray has an equivalency of 1 ppm/hr for ETO as compared to 20 mrad for X-ray, and one could suggest the present maximum allowable concentration for ETO (50 ppm) should be 400 times lower than the radiation standard (2.5 mrad/hr). Although radiation sterilization has advantages of simplicity of operation and complete reliability, changes of physico-chemical properties with possible formation of toxic substances may occur. It is therefore necessary to make some regulations of our own for residual toxicities orginated from each sterilization method.

• 한국원자력학회:학술대회논문집
• /
• 한국원자력학회 2005년도 춘계학술발표회
• /
• pp.1008-1009
• /
• 2005

In order to screen ionizing radiation induced early-response genes, we employed subtractive hybridization method and isolated a metabolism associated gene. The gene expression was very sensitive to ionizing radiation as revealed by a rapid induction of its messenger RNA. We characterized the function of this gene in radiation response. This gene activated p53 and enhanced cell killing effect of ionizing radiation. This effect was attributable to p53 phosphorylation and transcriptional activation.

• 한국주거학회논문집
• /
• 제15권3호
• /
• pp.93-99
• /
• 2004

This study was conducted to estimate the solar energy, as an alternative energy evaluating an effect of solar radiation on indoor space of residential building. The basic data of solar radiation which is useful for architectural design was suggested using theoretical and experimental analysis. Accordingly, this study was carried out measuring the solar energy using Explicit Method. These results were compared with the results using steady state heat transfer method. The results of this study are summarized as follows; Based on the results using Explicit Method and steady state heat transfer on the indoor space of building, it was shown that an analysis on heat transfer using Explicit Method is more sensitive to the outdoor environmental changes. The results using Explicit Method to analysis and evaluate the solar radiation should be used for residential building design.