• 한국식품영양학회지
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• 제5권2호
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• pp.99-103
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• 1992

Patterns in the outbreaks of senile diseases were investigated on 1, 264 workers by special examination among the 43, 210 industrial workers by the screening test performed in Kwang-ju and Chon-nam Branch of Korean Industrial Health Association from January 4 to December 31 in 1991. The results are summarized as follows : 1) Prevalence rate of senile diseases of industrial workers was 2.9%. And prevalence rate according to the kinds of senile diseases was observed in the order of hepatitis (0.9%), hypertension(0.7%), diabetes mellitus(0.5%), anemia(0.4%). 2) Prevalence rate of complicated senile diseases of industrial workers was 0.5%. And prevalence rate according to kinds of complicated senile diseases was observed in the order of others hypertension and arteriosclerosis (0.1%), HBV and others chronic hepatitis(0.1%), essential hypertension and arteriosclerosis(0.03%), iron deficiency anemia and leukopenia(0.03%).

• 대한의생명과학회지
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• 제29권1호
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• pp.1-10
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• 2023

Since its first identification in 1995, klotho (KL) has become the most promising gene to consider for suppressing aging and aging-related diseases. KL knockout mice exhibited similar phenotypes found in human with premature aging such as short lifespan, osteoporosis, arteriosclerosis and hearing loss. Genetically modified mice overexpressing KL prolonged lifespan more than 20%. Also, clinical reports have indicated decreased concentration of the circulating KL protein in blood, which is called soluble klotho (sKL), is closely related to development of senile diseases. The best way to discover significance of sKL on the development of the diseases might be comparison of sKL concentration between controls and patients. Here we analyzed published clinical reports identified sKL concentration in the cohorts. The sKL concentrations were displayed using heatmap for better comparison. In most of the senile diseases, disease progression was inversely related with sKL concentration. Hypertension was the only disease had no relationship, while schizophrenia was the only disease had direct proportion to the disease progression. Overall, sKL concentration in blood could be a marker to determine current severity of the senile diseases and even to estimate disease progression for the patients at the onset of their senile diseases.

• 한국콘텐츠학회:학술대회논문집
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• 한국콘텐츠학회 2010년도 춘계 종합학술대회 논문집
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• pp.594-600
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• 2010

노인 인구의 급격한 증가와 더불어 노인성질환도 증가함에 따라 일상적인 생활을 하지 못하는 노인에 대한 요양과 치료는 노인장기요양보험제도의 실시로 어느 정도 효과를 거두고 있지만 치매 예방을 통한 유병률 감소는 사회적 비용을 감소시킬 수 있음에도 불구하고 그 중요성이 간과되고 있다. 특히 요양시설이나 복지기관 현장에서는 경증 치매 및 치매 예방에 대한 프로그램은 전무하거나 일시적이고 단편적인 기법만을 활용하고 있는 실정이다. 이에 본 논문에서는 치매에 관심이 있는 노인을 대상으로 복지 전문가가 현장에서 비교적 손쉽게 적용할 수 있는 손운동법(촉각), 회상요법(시각), 치료레크리에이션(미각), 음악요법(청각), 원예치료(후각) 등 오감을 자극하는 기법들을 적절히 조화시켜 체계적으로 적용할 수 있는 치매 예방 프로그램을 제안한다.

• 대한한방내과학회지
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• 제13권2호
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• pp.57-69
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• 1992

The study has been carried out to investigate of the senile dementia by referring to 35 literratures. The results were as follows ; 1. In oriental medical science, senile dementia is belong to the category of dullness(매病), insanity(癲狂證), weak(虛勞), amnesia(健忘), etc. 2. The cause of senile dementia summarize the phlegm preventid-heart hole(痰迷心竅), marrow lack(髓海不足), aged follow weaking of body and disfunction of the internal organs(年老體弱과 臟腑機能 失調), the bad blood with vatal block(氣滯血瘀), feeling inharmony, etc in the view of oriental medical science and make the vanishment of the cerebral atrophy and the cerebral cell but havn't indicated the remarkable cause in that of western medical science. The diseases with cause make a point of Alzheimer's dementia, frequent infarction dementia, etc and psychological and environmental factor too. The marrow lack is related to Alzheimer's dementia, the feeling inharmony, psychologic and environmental factor, the phlegm prevented-heart hole and bad blood with vatal block, frequent infarction dementia. 3. The senile dementia is related cleary to the function of the internal organs in oriental medical sciences respect Especially in relation to kidney and marrow, it is presented new cause view to solve the cure problem of western medical science is studying its cause only the anatomic pathology with cerebrum and is thinking to solve cure possibility. 4. The symptom of senile dementia is as follows. The obstacle of a aspect of the Language, Emotion, Behavior. mute, speech inversion, sometimes a laugh sometimes a cry, behavior strange, failure of memory etc. 5. The treatment of senile dementia is follows. The methodes of cure apply phlegm changed-mud(豁痰化濁), self-kidney and added marrow(補腎益髓), self-energy and nutritive blood(益氣補血), vital blood(祛瘀活血), peace of mind and relief(安神情志). The medicines of cure make the most of (sesimtang, jwagui-hwan, tonggwuhwalhuel tang) add and subtract, daeboweonjeon, guibitang, and so on.

• 대한한방내과학회지
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• 제16권1호
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• pp.40-61
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• 1995

This study was performed to investigate concept, systoms, causes of disease, pathogenic mechanisms, therapies and precriptions about senile constipation through the successive medical literature, recent chinese medical literature and chinese medical joumals. Senile constipation seems to be applicable to dryness syndrom and constipation of insufficiency type, have something to do with kidney(the most), lung, spleen and large intestine. The most principal cause of disease is yin-fluid, the rest deficiency of qi, insufficiency of yang, stagnation of qi and retention of fever etc. There are enriching the blood and moistening dryness in principal therapy, the rest are invigorating qi and loosing the bowel, warming and invigorating the spleen and kidney, regulating the flow of qi and promoting the stagnancy of qi and expelling the pathogenic heat etc. In prescriptions there are Yunjangtang, Jengaektang, Hwanggitang, Jechunjeon, Yukmatang and Majainhwan as the causes of disease, meanwhile are Yungjang-tang, Jechunjeon and Majainhwan in the vulgaris prescriptions. And in medical herbs there are nourishing yin medicines as Rhizoma rehmanniac, Radix ophiopogonis and Radix scrophulariae etc., invigorating qi medicines as Radix astragali, Radix codonopsitis and Radix polygoni multiflori etc, invigorating yang medicines as Caulis cistanchis and Semen psoraleae etc., promoting qi circulating medicines as Radix saussurea, Lignum aquilariae and Radix linderae etc., and reducing fever and therapeutic method to keep the adverse qi flowing downward medicines as Semen cannabis, Rhizoma rhei, Fructus immaturus ponciri, and Cortex magnoliae etc.. Meantime Rhizoma rehmanniae, Radix ophiopogonis, Caulis cistanchis, Radix angelicae gigantis, Semen cannabis, Semen biotae, Semen pruni japonicae and Semen persicae in principal herb-medicines. In clinical reports the process of disease was between 10 to 20 years, the evacuation cycle between 4 to 7 days, generally possessed chronic diseases as hypertension, diabetes, arteriosclerosis and cerebro- vascular disorders etc. and the efficiency rate was more than 90%. The senile constipation is occured in succession or promoted by chronic diseases as obesity, hypertension, diabetes, arteriosclerosis. hrperlipemia, cerebro- vascular disorders etc., so diet-regulating, adequate exercise, proper evacuation-habit and psychologic rest etc. are important more than medicine-treatments.

• 디지털융복합연구
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• 제19권10호
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• pp.535-543
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• 2021

노인성 안질환과 구강질환은 비가역적 손상을 일으키기 때문에 삶의 질에 큰 영향을 미친다. 따라서 나이관련황반변성(AMD) 및 녹내장과 같은 노인성 안질환과 구강건강행태와의 관련성을 확인하고자 하였다. 제7기 2차년도(2017) 국민건강영양조사 자료를 이용하여 AMD 및 녹내장과 구강건강행태를 분석하였다. 녹내장과 AMD 유병자와 녹내장과 AMD 미보유자를 비교하기 위해 교차분석을 실시하였고, 복합로지스틱 회귀분석을 통해 AMD 및 녹내장과 구강건강행태와의 위험비를 확인하였다. 황반변성 및 녹내장의 유무에 따라 연령, 학력, 구강위생용품 사용, 발음불편 호소에서 통계적으로 유의한 차이가 있었다. 또한 녹내장 유무는 성별에서도 차이가 있었다. 구강건강행태와 노인성 안질환과의 일부 변수에서 유의한 연관성이 있었다. 구강건강행태는 AMD 및 녹내장 질환을 예방하는 데 위험 요인으로 작용할 수 있으므로 구강건강행태에 대한 인식도가 더욱 높아져야 할 것이다.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제30권5호
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• pp.414-421
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• 2004

This is a reprospective study on the care of odontogenic infections in admission patients with geriatric diseases. The study was based on a series of 480 patients at Dong San Medical Center, Wonju Christian Hospital and Il San Health Insurance Hospital, From Jan. 1, 2000, to Dec. 31, 2002. The Obtained results were as follows: 1. The systemic malignant tumor was the most frequent cause of the geriatric diseases with odontogenic infectious diseases, and refractory lung disease, systemic heart disease, type II diabetes mellitus, cerebrovascular disease, bone & joint disease, senile psychologic disease were next in order of frequency. 2. Male prediction(57.5%) was existed in the odontogenic infectious patients with geriatric diseases. But, there were female prediction in senile psychologic disease, systemic heart disease and cerebrovascular disease. 3. The most common age group of the odontogenic infectious patient with geriatric disease was the sixty decade(47.9%), followed by the seventy & eighty decade in order. 4. In the contents of chief complaints on the odontogenic infectious patients with geriatric disease, peak incidence was occurred as toothache(52.7%), followed by extraction wish, tooth mobility, oral bleeding, oral ulcer, fracture of restoration, gingival swelling in order. 5. In the diagnosis group of odontogenic infectious diseases, periodontitis, pulpitis & periapical abscess were more common. 6. In the treatment group of odontogenic infectious diseases, the most frequent incidence(34.2%) was showed in primary endodontic treatment (pulp extirpation, occlusal reduction and canal opening drainage) and followed by scaling, incision & drainage, only drugs, pulp capping, restoration in order.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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• pp.203.2-204
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• 2003

As medicinal knowledge developed. population system has been migrating into the aged society. These aged society evokes the social problem of senile diseases. One of these. Alzheimer's Disease (AD) has been an issue. and its causative. ${\beta}$-amyloid(A${\beta}$) has also been a key target in drug development. In AD, microglial cell affects neuron cells in any way of positive and negative. (omitted)

• 한국IT서비스학회지
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• 제11권sup호
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• pp.89-101
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• 2012

This paper presents development of a management system for the health and diseases of the elderly. This study aimed to the promotion of the u-healthcare industry and to the increase in its competitive power by developing and expanding a system for managing the health and diseases of the elderly, in cooperation with u-healthcare companies. The study is underway through the following four substudies. In the first substudy titled development of the bio-signal collection and analysis technology using smart media, a technology that supports the collection of bio-signals in the elderly using portable terminals. In the second substudy titled development of the patient-specific healthcare platform expansion and enhancement technology, a technology is being developed for making medical decisions and taking measures based on the results of the processing of the collected bio-signals. In the third substudy titled development of the N-screen based healthcare contents open service technology, a technology is being developed to provide information on health, diseases, and medicine to platforms. In the fourth substudy titled development of the oriental medicine diagnosis and analysis technology for senile diseases. This study is expected to help ensure an excellent workforce and new technologies in the healthcare sector using smart phones, and to help reduce medical expenses by improving the health of citizens.

• Toxicological Research
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• 제17권
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• pp.71-77
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• 2001

The brain of the aged dog possesses senile plaques and amyloid angiopathy, which characterize Alzheimer's disease brains. We have defined the dementia condition of aged dogs and examined which mechanism(s) is responsible for the condition. A series of studies revealed that the dementia condition in aged dogs is significantly related to the number of apoptotic brain cells including both neurons and glial cells, but not to the number of senile plaques. On the other hand, 5-azacytidine (5AzC) is a cytidine analogue, and is thought to induce kinds of cell differentiation possibly through hypomethylation of genomic DNA. We have revealed neuronal apoptosis induced in 5AzC-treated fetal mice and PC12 cells. The ribosomal protein L4 (rpL4) gene is expressed prior to the apoptosis in the PC12 cell system. Therefore, the involvement of the rpL4 gene expression in age-related brain cell apoptosis in dogs may contribute to the investigation of Alzheimer's dementia.