• Asian Pacific Journal of Cancer Prevention
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• v.13 no.12
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• pp.6017-6022
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• 2012

Background: Resveratrol has been reported to have potential chemopreventive and apoptosis-inducing properties in a variety of tumor cell lines. Objective: In this study, to investigate the effects of resveratrol on protein kinase C (PKC) activity and apoptosis in human colon carcinoma cells, we used HT-29 cells and examined the $PKC{\alpha}$ and ERK1/2 signaling pathways. Methods: To test the effects of resveratrol on the growth of HT-29 cells, the cells were exposed to varying concentrations and assessed with the the MTT cell-viability assay. Fluorescence-activated cell sorter (FACS) analysis was applieded to determine the effects of resveratrol on cell apoptosis. Western blotting was performed to determine the protein levels of $PKC{\alpha}$ and ERK1/2. In inhibition experiments, HT-29 cells were treated with G$\ddot{o}$6976 or PD98059 for 30 min, followed by exposure to $200{\mu}M$ resveratrol for 72 h. Results: Resveratrol had a significant inhibitory effect on HT-29 cell growth. FACS revealed that resveratrol induced apoptosis. Western blotting showed that e phosphorylation of $PKC{\alpha}$ and ERK1/2 was significantly increased in response to resveratrol treatment. Pre-treatment with $PKC{\alpha}$ and ERK1/2 inhibitors (G$\ddot{o}$6976 and PD98059) promoted apoptosis. Conclusion: Resveratrol has significant anti-proliferative effects on the colon cancer cell line HT-29. The PKC-ERK1/2 signaling pathway can partially mediate resveratrol-induced apoptosis of HT-29 cells.

• Journal of Biosystems Engineering
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• v.43 no.4
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• pp.426-439
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• 2018

Purpose: To continuously monitor soil and climatic properties, a data acquisition system (DAQ) was developed and tested in plum farms (Gyewol-ri and Haechang-ri, Suncheon, Korea). Methods: The DAQ consisted of a Raspberry-Pi processor, a modem, and an ADC board with multiple sensors (soil moisture content (SEN0193), soil temperature (DS18B20), climatic temperature and humidity (DHT22), and rainfall gauge (TR-525M)). In the laboratory, various tests were conducted to calibrate SEN0193 at different soil moistures, soil temperatures, depths, and bulk densities. For performance comparison of the SEN0193 sensor, two commercial moisture sensors (SMS-BTA and WT-1000B) were tested in the field. The collected field data in Raspberry-Pi were transmitted and stored on a web server database through a commercial communications wireless network. Results: In laboratory tests, it was found that the SEN0193 sensor voltage reading increased significantly with an increase in soil bulk density. A linear calibration equation was developed between voltage and soil moisture content depending on the farm soil bulk density. In field tests, the SEN0193 sensor showed linearity (R = 0.76 and 0.73) between output voltage and moisture content; however, the other two sensors showed no linearity, indicating that site-specific calibration is important for accurate sensing. In the long-term monitoring results, it was observed that the measured climate temperature was almost the same as website information. Soil temperature information was higher than the values measured by DS18B20 during spring and summer. However, the local rainfall measured using TR 525M was significantly different from the values on the website. Conclusion: Based on the test results obtained using the developed monitoring system, it is thought that the measurement of various parameters using one device would be helpful in monitoring plum growth. Field data from the local farm monitoring system can be coupled with website information from the weather station and used more efficiently.

• Proceedings of the Korea Water Resources Association Conference
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• 2020.06a
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• pp.141-141
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• 2020

강원도는 산림 비중이 크고 급경사지가 많은 지형적 특성과 여름철 비교적 선선하고 강우량이 많은 기후적 특성 때문에 고랭지 농업이 활발히 이루어지고 있다. 하지만, 많은 부분을 차지하는 고랭지밭 면적 탓에 강우시에 토양침식과 비점오염물이 하천으로 유입되고 있다. 강원도 송천 상류에 위치한 도암호는 장기간 탁수를 저류하고 방류로 인한 해체 논란까지 일으키기도 했다. 이에 정부는 흙탕물 저감과 비점오염원 관리를 위한 국고보조사업과 다양한 환경 정책들을 시행중이다. 효율적이고 효과적인 수질 정책을 시행하고 분석하기 위해서는 장기간의 모니터링 자료를 이용한 통계적 분석을 활용하는 것이 중요하다. 수질 자료는 변동이 심하고, 비정규분포를 이루며 결측치와 검출한계 이하의 값들이 많아 비모수 통계 방법을 널리 사용되어 왔다. 그중에서도 계절적 특성을 갖는 수질자료의 장기경향분석에 적합한 Seasonal Mann-Kendall Test을 사용하여 남한강상류 유역의 수질 경향성을 분석하였으며, Sen's Slope를 구하여 수질 자료의 경향 크기를 구하였다. 하지만, Seasonal Mann-Kendall Test는 연구 기간동안의 경향성을 반영할 수 없다는 단점이 있기 때문에 LOWESS Test를 통해 장기간 수질 자료 사이의 경향성을 분석하였다. 이러한 수질자료의 경향 분석 결과는 유역 내 취약 지점을 확인할 수 있으며, 환경 정책의 효과를 평가하고 보완할 수 있는 자료로 이용될 수 있을 것이다.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.34 no.1
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• pp.117-133
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• 2014

In this study, we analysed impacts of the recent increasing trend of exceedance rainfall thresholds for separation of data set and different research periods using Quantile Regression (QR) approach. And also we performed significant test for time series data using linear regression, Mann-Kendall test and Sen test over the Korean major 8-city. Spring and summer precipitation was tend to significant increase, fall and winter precipitation was tend to decrease, and heavy rainy days in last 30 years have increased from 3.1 to 15 percent average. In addition, according to the annual ranking of rainfall occurs Top $10^{th}$ percentile of precipitation for 3IQR (inter quartile range) of the increasing trend, most of the precipitation at the point of increasing trend was confirmed. Quantile 90% percentile of the average rainfall 43.5mm, the increasing trend 0.1412mm/yr, Quantile 99% percentile of the average rainfall 68.0mm, the increasing trend in the 0.1314mm/yr were analyzed. The results can be used to analyze the recent increasing trend for the annual maximum value series information and the threshold extreme hydrologic information. And also can be used as a basis data for hydraulic structures design on reflect recent changes in climate characteristics.

• Korean Journal of Ecology and Environment
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• v.50 no.1
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• pp.169-185
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• 2017

Physicochemical properties of water quality were analyzed to understand the long-term variations in Lake Youngrang from 1998 to 2015. Nonparametric statistical methods were applied to deduct correlation among water quality parameters and water quality trend. In total observations(N=64), the Secchi depth (SD) transparency showed significant positive correlation with salinity (r=0.458) and highly significant negative correlation with chlorophyll-a (r= -0.649) for p<0.0001 in two-tailed test of Spearman's rank correlation. Significant negative correlations of SD were observed with chemical oxygen demand (COD), total phosphorus (TP) and total nitrogen (TN). These correlation patterns were very similar in rainy (N=25) and non-rainy (N=39) periods too. Chlorophyll-a (Chl-a) had significant correlation with COD. Sen's slope test was performed along with Mann-Kendall trend test (significance ${\alpha}=0.05$, two-tailed) to find water quality trend. Positive trends were observed for SD and salinity with Sen's slopes 0.012 and 0.385, respectively (p<0.0001). Negative significant trends were observed for total nitrogen (TN) and Chl-a with Sen's slopes -0.02 (p<0.0001) and -0.346 (p=0.0010), respectively. Temperature, COD and phosphorus components had no trends. Carlson's trophic state index (TSI) for SD, TP and Chl-a were obtained in the ranges of 46~80, 37~82 and 39~82, respectively. Trophic index values suggest that Lake Youngrang was mesoeutrophic to eutrophic and there could be possibility of anoxia during the summer and dominance of blue-green algae. Excess nutrient inputs from external and internal sources were the causes of eutrophication in this lake. The findings of this study would be helpful to recognize water quality variables to manage the water body.

• Journal of Korean Society on Water Environment
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• v.39 no.5
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• pp.377-389
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• 2023

Chungcheongnam-do has been measuring the flow rate and water quality of streams in the province once a month since 2011 in order to water environment policies. Based on the results, after evaluating the coefficient of variation and the tendency of the water quality trend by using the Mann-Kendall test and Sen's Slope for each stream, the streams subject to priority introduction of Total Pollution Load Management at Tributaries were selected through the Stream Grouping Method. The water quality trend analysis results for 125 streams using the Mann-Kendall test and Sen's Slope were evaluated as streams showing a tendency of deteriorating water quality Biochemical oxygen demand (BOD): 13 streams, Total Phosphorus (T-P): 16 streams). Streams with deteriorating water quality were classified into A-D groups using the Stream Grouping Method. Group A, which has a high flow rate and high water quality, is a stream that requires priority management, and was selected as a stream for introduction of Total Pollution Load Management at Tributaries. There are 7 streams that need to be introduced into the BOD category, and there are 7 streams that need to be introduced into the T-P category. In this study, based on flow and water quality monitoring data accumulated over a long period of time (2011-2022), statistical techniques are used to select watersheds in which water quality is deteriorating. Accordingly, it is expected that it will be useful in establishing a water quality improvement plan in the future.

• Korean Journal of Ecology and Environment
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• v.48 no.2
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• pp.95-107
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• 2015

In order to identify long-term trends of water quality parameters in Lake Kyeongpo, Mann-Kendall test, Sen's slope estimator and linear regression were applied on data, with 15 parameters from three different sites and rainfall, monitored once in every two months from March to November during 1998~2013. Seasonal variation analysis only used Mann-Kendall test and Sen's slope estimator. Analysis result showed that salinity, transparency and nutrient variables (total phosphorus, dissolved inorganic phosphorus, total nitrogen, nitrate nitrogen, ammonia nitrogen) were only parameters having statistically significant trend. In linear regression analysis, salinity (surface and bottom layer of all sites) and transparency (only at site 1), were figured out with statistically significant increasing trend, while in non-parametric statistical method, salinity and transparency in all sites (surface, middle, deep) were figured out with statistically significant increasing trend. Water quality parameters showing statistically significant decreasing trends were dissolved oxygen (surface layer of site 1 and bottom layer of sites 2 and 3), total phosphorus (sites 1 and 2), dissolved inorganic phosphorus, total nitrogen, nitrate nitrogen and ammonia nitrogen in the linear regression analysis and, dissolved oxygen (bottom layer of all sites), total phosphorus, dissolved inorganic phosphorus, total nitrogen, nitrate nitrogen and ammonia nitrogen in the non-parametric method. Seasonal trend analysis result showed that salinity, turbidity, transparency and suspended solids in spring, salinity, transparency, nitrate nitrogen and suspended solids in summer and temperature, salinity, transparency and suspended solids in fall were the variables depending on the season with increasing trends. In general, rainfall during the research period showed decreasing trend. The significant reduction trends of nutrients in Lake Kyeongpo were believed to be related to lagoon restoration and water management project run by Gangneung city and under-water wear removal, but further detailed studies are needed to know the exact causes.

• Smart Structures and Systems
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• v.15 no.6
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• pp.1481-1501
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• 2015

MR-TLCD (Magneto-Rheological Tuned Liquid Column Damper) is a new developed vibration control device, which combines the traditional passive control property with active controllability advantage. Based on traditional TLCD governing equation, this study further considers MR-fluid viscosity in the equation and by transforming the non-linear damping term into an equivalent linear damping, a solution can be obtained. In order to find a countable set of parameters for the design of the MR-TLCD system and also to realize its applicability to structures, a series of experimental test were designed and carried out. The testing programs include the basic material properties of the MR-fluid, the damping ratio of a MR-TLCD and the dynamic responses for a frame structure equipped with the MR-TLCD system subjected to strong ground excitations. In both the analytical and experimental results of this study, it is found that the accurately tuned MR-TLCD system could effectively reduce the dynamic response of a structural system.

• Transactions of the Korean Society of Machine Tool Engineers
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• v.14 no.1
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• pp.30-36
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• 2005

This study is to investigate a damage estimation of single edge notched tensile specimens as a function of acoustic emission(AE) according to the uni-directionally oriented carbon fiber/epoxy composites, CFRP In fiber reinforced composite materials, AE signals due to several types of failure mechanisms are typically observed. These are due to fiber breakage, fiber pull-out matrix cracking, delamination, and splitting or fiber bundle breaking. And these are usually discriminated on the basis of amplitude distribution, event counts, and energy related parameters. In this case, AE signals were analyzed and classified 3 regions by AE event counts, energy and amplitude for corresponding applied load. Bath-tub curve shows 3 distinct periods during the lifetime of a single-edge-notch(SEN) specimen. The characterization of AE generated from CFRP during SEN tensile test is becoming an useful tool f3r the prediction of damage failure or/and failure mode analysis.

• Geomechanics and Engineering
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• v.36 no.2
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• pp.121-130
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• 2024

Many foundation projects are built on red-bed soft rocks, and the damage evolution of this kind of rocks affects the safety of these projects. At present, there is insufficient research on the damage evolution of red-bed soft rocks, especially the progressive process from mesoscopic texture change to macroscopic elastoplastic deformation. Therefore, based on the dual-porosity characteristics of pores and fissures in soft rock, we adopted a cellular automata model to simulate the propagation of these voids in soft rocks under an external load. Further, we established a macro-mesoscopic damage model of red-bed soft rocks, and its reliability was verified by tests. The results indicate that the relationship between the number and voids size conformed to a quartic polynomial, whereas the relationship between the damage variable and damage porosity conformed to a logistic curve. The damage porosity was affected by dual-porosity parameters such as the fractal dimension of pores and fissures. We verified the reliability of the model by comparing the test results with an established damage model. Our research results described the progressive process from mesoscopic texture change to macroscopic elastoplastic deformation and provided a theoretical basis for the damage evolution of these rocks.