• Journal of Periodontal and Implant Science
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• 제49권4호
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• pp.206-214
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• 2019

Purpose: The purpose of this study was to examine the association between the intake of semi-solid yogurt and periodontitis in Korean adults using a national database. Methods: The data analyzed in this study are a subset of the sixth Korean National Health and Nutrition Examination Survey conducted in 2015 by the Korea Centers for Disease Control and Prevention. The sample size for this study was 4,727. We collected data on sociodemographic characteristics, oral health-related variables, oral and general health status, and intake of semi-solid yogurt. Semi-solid yogurt intake (YI) was calculated by multiplying the frequency of YI over the previous week by the average intake per serving. We assessed periodontal conditions using the Community Periodontal Index (CPI) and defined periodontitis as a CPI score ${\geq}3$. Multivariate logistic regression analyses were performed after adjusting for sociodemographic variables, and oral and general health behaviors and status. Results: The mean weekly YI among those without periodontitis ($1.03{\pm}0.06cups$) was significantly higher than among those with periodontitis ($0.77{\pm}0.08cups$) (P<0.001). Individuals who consumed more than 2 cups of yogurt per day were 76% less likely to have periodontitis than those who consumed less than 1 cup of yogurt per week after adjusting for all covariates (odds ratio, 0.24; 95% confidence interval, 0.10-0.60). Conclusions: We found a significant association between increased intake of semi-solid yogurt and periodontal health. We therefore recommend daily consumption of semi-solid yogurt as a probiotic to improve periodontal health. Further longitudinal studies are required to elucidate plausible mechanisms through which probiotics impact periodontal disease, considering both periodontal pathogens and clinical periodontal parameters.

• Journal of Pharmaceutical Investigation
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• 제29권1호
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• pp.21-27
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• 1999

Semi-solid poly(ortho esters) (POE) were prepared to provide bioerodible carriers for sustained drug delivery systems of naloxone (NLX) in the treatment of narcotic addiction. As the POE have viscous behavior at room temperature, a significant advantage of this polymer is that it can be injected without any surgical intervention. The POE was synthesized by a transesterification reaction between 1,2,6-hexanetriol and trimethyl orthoacetate, and the structure of the polymer was confirmed by IR. The in vitro release of the drug from POE was studied. The release rate of NLX decreased with increasing intrinsic viscosities of the polymer. In vivo biocompatibility studies were carried out in rats with NLX loaded POE. Histopathological analysis showed that NLX implants are well-tolerated by rats when used subcutaneously. Pharmacokinetic studies of POE-NLX implants of two different viscosities were carried out in rabbits. In all cases, plasma concentrations of NLX were maintained over 1 ng/ml for at least 168 hours, but initial burst effect was observed. Mean residence time(MRT) was found to depend on the viscosity of the polymer.

• 한국전자파학회논문지
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• 제23권1호
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• pp.101-107
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• 2012

MICS 및 ISM 대역의 무선기기 설계 시에 인체 팬텀을 이용한 성능검증이 필수적으로 요구되고 있으나, 인체팬텀에 관한 연구 대부분이 휴대폰에 의한 생체 영향에 국한되어 있는 실정이다. 본 논문에서는 FCC에서 제안하고 있는 MICS 대역과 ISM 대역의 인체 팬텀에 대한 전기적 상수를 이용하여 준고체형 팬텀들을 제작하였다. 제작된 준 고체형 팬텀들은 각 대역에서 FCC에서 제시한 전기적 상수(MICS 대역에서 $\varepsilon_r=56.7$, $\sigma=0.94$, ISM 대역에서 $\varepsilon_r=52.7$, $\sigma=1.95$)들을 만족하였다. 또한, 제작된 준 고체형 팬텀의 재료들은 쉽게 구매 가능한 재료들로 구성되었으며, 팬텀 재료의 다양성을 위해서 각 대역에서 polyethylene과 TX-151을 이용한 방법과 글리세린을 이용한 두 가지 방법을 제시하였다. 제작된 준 고체형 팬텀은 평탄한 형태이며, 유전율 측정기로 제작후 1일 (24 시간)이 경과한 후 팬텀의 전기적 특성을 측정하였다.

• Journal of International Society for Simulation Surgery
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• 제2권1호
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• pp.1-6
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• 2015

Purpose Bisphophonate-related osteonecrosis of the jaw (BRONJ) is an emerging problem. Extensive osteonecrosis of the jaw needs free flap reconstruction. Free fibular flap is the most useful flap for maxilla-mandibular hard and soft tissue reconstruction. The advantages of fibular free flap are simultaneous soft and hard tissue reconstruction and placing implant in reconstructed mandible and maxilla. In this study, four consecutive BRONJ patients who underwent fibula free flap reconstruction using simulation surgery were reviewed. Materials and Methods Four BRONJ patients who underwent free fibula reconstruction between May 2006 and September 2014 were included in this study. Male to female ratio was 1:3 and average age was 67.3 years old (62-70). All patients need mandibular bone reconstruction. Three patients suffered from osteoporosis and one male patient had multiple myeloma. Postoperative flap survival, functional reconstruction, esthetic results, food taking were evaluated. Results Three osseous flaps and one osteocutaneous flap were used. All the fibular flaps were survived and patients were recovered without complications. Oro-cutaneous fistula was resolved after operation. All patients were satisfied with the esthetic results. Patients reported improved solid food intake after operation with partial denture. One fully edentulous patient had semi-fluid diet after operation. Conclusion Treatment of the BRONJ is difficult due to lack of standard protocol. Fibular free flap using simulation surgery is the workhorse flap for mandibular hard and soft tissue reconstruction, especially in stage III BRONJ patient. In this study, functional and esthetic results were successful in all patients. Normal diet was possible with partial dentures.