• Women's Health Nursing
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• v.1 no.2
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• pp.222-243
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• 1995

The purpose of this study was to develop concrete and in-depth knowledge about menarche and to raise the need of menstrual education. The data were collected from purposively sample 34 women from twenties to forties from April 27 to October 10, 1994. Semi-structured intensive interviews were done and these qualitative data were analysed with "Ethnograph" computer program. The results of the study were as follows : 1. The experience of menarche could be classified into two main groups, which were positive and negative response to menarche. The negative experiences were to be shameful, tearful, scared of the phenomena and thought as a kind of punishment for guilt or confused menarche with other symptoms of diseases. On the contrary, the positive experiences were to be proud of physical maturity and to think that is was wonderful, miraculous and to perceive it as a warm experience. 2. The experience of menarche was influenced by various factors. They were the knowledge about menstruation, the quality and amount of informations, the time of menarche, the environmental factors, the response of significant others toward menarche. The experience of menarche could be positive or negative according to these factors. 3. The previous information sources about menstruation could be significant others, school education and mass-media. The significant others were mothers, sisters, friends and the person in charge of school sex education such as school nurses, home economics, military drill and athletics of teachers. And mass-media included sex education booklets, nursery tales, TV programs, and publicity activities of sanitary napkin companies. 4. The opinions of the subjects about the proper time of menarcheal education could be grossly classified into two groups. The first was active approach toward children when they were in elementary school. The second was passive approach which postponed the time until the child ask about it, because it would be awkward for them to discuss about the topic. 5. The participants thought that the ideal methods of menarche education would be systematic school education programs, open discussion with daughters, audio-visual teachings, or practical education in everyday life. 6. The contents of the menarche education based on the participants' opinions, would be positive details about meanings and functions of menstruation. And it would be desirable if the attitudes of the person in charge of education could be positive, open-hearted, and favorable toward menstruation.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.30 no.6
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• pp.474-481
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• 2004

Squamous cell carcinoma is the most prevalent oral cancer, which is characterized by its low survival rate, high malignancy, mortality with facial defects, and poor prognosis. Exact cause and pathogenesis of the squamous cell carcinoma is still unknown. Various routes including smoking, radiation, and viral infections predispose its genesis, and recent studies revealed that genetic defects which fail to prevent cancer proliferation play a role. Generally, a cancer develops from the decreased rate of apoptosis which is an active and voluntary cell death, and from the altered cell cycles. Anticancer effect can be obtained by recovering the apoptotic process, and by suppressing the cell cycles. Among the apoptosis related factors, bcl-2, caspase-9, and VDAC (voltage-dependent anion channel)are produced in mitochondria of the cell. Cyclosporin-A is known to induce apoptosis through its activation with VDAC. This study was to reveal the anticancer effect of Cyclosporin A to the oral squamous cell carcinoma. The inverted microscope was used to find alterations in the tissue, and sensitivity test to the anticancer cells was performed with MTT (Tetrazolium-based colorimetric) assay. Following cell line culture of primary and metastastic oral squamous cell carcinoma, electrophoresis was performed with extracted total RNA. Finally, semi-quantitative study was carried out through RT-PCR (Reverse Transcription-Polymerase Chain Reaction). The results of this study are as follows: 1. The inverted microscopic observation revealed a poorly defined cytoplasm at $2000ng{\sim}3000ng/ml$, indistinct nucleus, and apoptosis. 2. The Growth of cancer cells was decreased at 1000ng/ml of cyclosporin-A. No cancer cell growth was observed at over 2000ng/ml concentration of cyclosporin-A, and at one week, growth of cancer cells was ceased. 3. The MTT assays were decreased as cyclosporin-A concentration was increased. This means that the activation of succinyl dehydrogenase in mitochondria was decreased following administration of cyclosporin A. 4. A result of RT-PCR showed that amount of mRNA of VDAC-2 was decreased half times at a cyclosporine-A concentration of 2000ng/ml. In bcl-2, amount of mRNA was significantly decreased 1/5 times at 2000ng/ml. caspase-9, however, showed slight increase compared to the control group. From the results obtained in this study, administration of cyclosporin-A to the cell lines of oral squamous cell carcinoma induced alterations in morphology and growth of the cells as its concentration increased. Since apoptosis related factors such as VDAS-2, bcl-2, and caspase-9 also showed distinct alterations on their mRNAs, further research on cyclosporin A as an anti-cancer agent will be feasible.

• Journal of Pharmaceutical Investigation
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• v.32 no.2
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• pp.135-140
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• 2002

Cefadroxil is a semi-synthetic cephalosporin active against many Gram-positive and Gram-negative bacteria. The drug has been used for the treatment of the urinary and respiratory tract infections when caused by susceptible strains of the designated microorganism. The purpose of the present study was to evaluate the bioequivalence of two cefadroxil capsules, Duricef (Bo Ryung Pharmaceutical Co. Ltd.) and Hanacef (Korean Pharmaceutical Co. Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). The cefadroxil release from the two cefadroxil capsules in vitro was tested using KP VII Apparatus II method with various different kinds of dissolution media (pH 1.2, 4.0, 6.8 buffer solution and water). Twenty four normal male volunteers, $21.58{\pm}2.43$ years in age and $70.74{\pm}10.29$ kg in body weight, were divided into two groups and a randomized $2{\times}2$ cross-over study was employed. After one capsule containing 500 mg as cefadroxil was orally administered, blood was taken at predetermined time intervals and the concentrations of cefadroxil in serum were determined using HPLC with UV detector. The dissolution profiles of two cefadroxil capsules were very similar at all dissolution media. The pharmacokinetic parameters such as $AUC_t,\;C_{max}\;and\;T_{max}$ were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed $AUC_t\;and\;C_{max}$ and untransformed $T_{max}$. The results showed that the differences in $AUC_t,\;C_{max}\;and\;T_{max}$ between two capsules based on the Duricef were 0.05%, -5.29% and 4.53%. There were no sequence effects between two capsules in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.25) $(e.g.,\;log(0.95){\sim}log(1.05)\;and\;log(0.87){\sim}log(1.02)$ for $AUC_t\;and\;C_{max}$, respectively). The 90% confidence interval using untransformed data was within ${pm}20%$ $(e.g.,\;-6.75{\sim}15.74\;for\;T_{max})$. All parameters met the criteria of KFDA guideline for bioequivalence, indicating that Hanacef capsule is bioequivalent to Duricef capsule.

• Journal of The Korean Association For Science Education
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• v.34 no.7
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• pp.635-645
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• 2014

The purpose of this study is to identify elementary school teachers' perceptions, practices, and background factors related to introducing students' everyday experience in science teaching process. The participants of this study were four elementary school teachers who have different features such as major, teaching period, gender, growth area, and age. The data was collected through semi-constructed and in-depth interviews. The results of the research are as follows: Teachers mostly used students' everyday experience during the introduction phase of science lessons for the purpose of motivation. They hold a positive view of using students' everyday experience during science lessons and thought that science teaching needs to actively use more of students' everyday experience, while in actual practice they disregarded or only passively introduced students' everyday experience. The various background factors found to affect teachers' practice are as follows: positive memory on their science class; educational experience of their own children; their own childhood environment; their learning style; their insufficient knowledge or enthusiasm; perceived educational value of everyday life in science education; teacher's duties; importance of students' achievement; difficulty in guiding experiment; reaction of students on introducing everyday experience; characteristics of science textbook and teacher's guidebook; lack of lesson time; realization of national common basic education; characteristics of their students; demands from parents or students; effect of introducing everyday experience. In addition, we found that the teachers behave not in accordance with what they thought due to external factors related to their profession and that, for a more active use of students' everyday experience in their teaching, teachers need support from textbooks and teachers' guidebooks.

• The Journal of Korean Physical Therapy
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• v.13 no.1
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• pp.83-96
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• 2001

The purpose of this study is to provide the fundamental information fer the rehabilitation of hand injury and to emphasize the point of early treatment of hand injury after operation. The subjects are composed with the physical therapists who care hand injury and are engaged in 76 university hospitals,59 general hospitals and 88 semi and local clinics respectively. Investigator take the research form chart with 41 questionnaire and use the cross tabulation frequencies and one-way ANOVA of SPSS WIN(ver 10.0) for the statistic analysis. The results of this research are as follows :1. The number of physical therapists who care hand injury are 110 men and 113 women. 2. The beginning period of active assistive exorcise on the various type of injuries are as follows: At the case of flexor tendon injury, the most part of physical therapists make response to the period that is above 4 weeks in the rate of 29.1%. At the case of fracture, the most part of physical therapists make response to the period those are from 3 weeks to less than 4 weeks and from 4 weeks to less than 5 weeks in the rate of 28.7% respectively. At the case of crushing injury, the most part of physical therapists response to the period that is above 4 weeks in the rate of 32.2%. At the case of amputation injury, the most part of physical therapists response to the period that is above 4 weeks in the rate of 40.4%. 3. In the physical therapy request, treatment period are mentioned in 22.0%. 4. The most difficult factors in the hand treatment is to contracture soft tissue and joint to physical therapist in the rate of 59.6%. 5. Among the reasons of the intervention between physical therapy request and actual treatment, the case of wrong physical therapy request is examined in 69.4%.

• Journal of Advanced Marine Engineering and Technology
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• v.38 no.6
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• pp.632-638
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• 2014

Nowadays, as part of an effort to increase the efficiency of propulsion shafting system, the revolution of the main diesel engine in CMCR(Contract Maximum Continuous Rating) is reduced whereas the stiffness of hull structure supporting the main diesel engine is relatively flexible. However, vibration problems related with resonant response of main diesel engine are increasing although top bracing is installed between the main diesel engine and the hull structures to increase natural frequency of engine body above CMCR to avoid resonant phenomenon. In this study, the dynamic characteristic of top bracing is reviewed by analyzing measuring results of general cargo ships which apply the hydraulic type instead of the friction type to control the natural frequency and the vibration of the engine body. Moreover, considering the vibration characteristic of the engine body and the hydraulic type of the top bracing by varying the number of top bracing, authors suggest the more effective way to control the vibration of the engine body despite of lower stiffness of the hull structure than in the past when the hydraulic type of top bracing is used.

• Korean Chemical Engineering Research
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• v.58 no.2
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• pp.209-223
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• 2020

Executions of SCM in a chemical company of which divisions produce petrochemicals, compounds, batteries, IT material and medicine directly affect their own profit. Execution level of SCM or optimization is very important. This work presents activities of SCM and optimization of inefficient issues in several industrial divisions using mathematical optimization method. The meaning is not only academic research but also making a useful tool which active partner deals with in his work. It is explained how to do beforehand and afterward optimization problem. The benefits are mentioned in the sections. The first of examples would be cover supply plan optimization, optimal profit business plan, and scheduling of a stretching process of polarizer based on minimizing raw material loss in polarizer production. The second example would be cover the optimization of production/packaging plans to maximize productivity of Poly Olefin processes, and the third example is minimization of transition loss in the production of battery electrodes. The fourth example would be cover scheduling of vessel approaching to berth. Because transportation of large portion of raw material and products of petrochemical industry is dealt with vessel, scheduling of vessel approaching to berth is important at the shore of large difference of tide. The final example would be scheduling problem to minimization of change over time of ABS semi products.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.34 no.3
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• pp.729-737
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• 2014

A study has been carried out that effectively controls the vibration of asymmetric cable-stayed bridges caused by earthquakes with MR dampers. In order to enhance the practical serviceability of MR dampers, an asymmetric cable-stayed bridge structure has been designed and produced, and a MR damper has been produced so as to have this bridge structure controlled appropriately. An experiment that controls vertical and horizontal vibrations has been carried out by exciting the asymmetric cable-stayed bridge in the horizontal direction with the El-centro seismic wave. The control performance of the MR damper has been evaluated under the five control conditions in the experiments of vibration control in each direction. As a result of the experiment, MR dampers were proved to control vibrations more effectively when either Lyapunov control algorithm or Clipped-optimal control algorithm was used to control vibrations of the asymmetric cable-stayed bridge caused by earthquakes. In addition, different controlling effects were found in vibration controls in vertical and horizontal directions due to the asymmetry of the structure and the horizontal excitation. With such controlling effects, semi-active MR dampers are evaluated to effectively control vibrations caused by earthquakes in flexible and asymmetric structures such as asymmetric cable-stayed bridges.

• Journal of the Korean Society for Marine Environment & Energy
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• v.19 no.2
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• pp.144-150
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• 2016

In southwestern East Sea, we investigated the spatio-temporal distribution characteristics of particulate organic carbon (POC) and nitrogen (PON) in September 2011 (summer), January (winter) and May 2012 (spring). Although cold waters known as the origin upwelling in the surface layer of September were not observed, this periods showed high primary productivity because of high concentrations of chlorophyll, low percentage of non-autotrophic particulate fraction among POC calculated by POC/Chl-a ratio (27%) and low POC/PON ratio (6.2), which means active amino acid and protein synthesis, However, May, 2012 showed low primary productivity because of high percentage of non-autotrophic particulate fractions among POC (66%) and high POC/PON ratio (8.1), Although spring bloom and high primary productivity has been reported in the East Sea, high percentage of non-autotrophic particulate fractions in POC, observed in the East sea during the post 2012 spring, is suggested to be due to the increase of phaeo-pigment during post spring bloom. Thus, composition of particulate organic matter may have sensitively changed by marine environmental factors in spite of same season.

• Journal of Broadcast Engineering
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• v.15 no.2
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• pp.163-172
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• 2010

The free viewpoint video delivers an active contents where users can see the images rendered from the viewpoints chosen by them. Its applications are found in broad areas, especially museum tour, entertainment and so forth. As a new free-viewpoint application, this paper presents a stereoscopic free-viewpoint TIP (Tour Into Picture) where users can navigate the inside of a single image controlling a virtual camera and utilizing depth data. Unlike conventional TIP methods providing 2D image or video, our proposed method can provide users with 3D stereoscopic and free-viewpoint contents. Navigating a picture with stereoscopic viewing can deliver more realistic and immersive perception. The method uses semi-automatic processing to make foreground mask, background image, and depth map. The second step is to navigate the single picture and to obtain rendered images by perspective projection. For the free-viewpoint viewing, a virtual camera whose operations include translation, rotation, look-around, and zooming is operated. In experiments, the proposed method was tested eth 'Danopungjun' that is one of famous paintings made in Chosun Dynasty. The free-viewpoint software is developed based on MFC Visual C++ and OpenGL libraries.