• Title/Summary/Keyword: Self-resonance

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Polystyrene-b-poly(oligo(ethylene oxide) Monomethyl Ether Methacrylate)-b-polystyrene Triblock Copolymers as Potential Carriers for Hydrophobic Drugs

  • You, Qianqian;Chang, Haibo;Guo, Qipeng;Zhang, Yudong;Zhang, Puyu
    • Bulletin of the Korean Chemical Society
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    • v.34 no.2
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    • pp.558-564
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    • 2013
  • A simple and effective method is introduced to synthesize a series of polystyrene-b-poly(oligo(ethylene oxide) monomethyl ether methacrylate)-b-polystyrene (PSt-b-POEOMA-b-PSt) triblock copolymers. The structures of PSt-b-POEOMA-b-PSt copolymers were characterized by Fourier-transform infrared spectroscopy (FTIR) and nuclear magnetic resonance ($^1H$ NMR) spectroscopy. The molecular weight and molecular weight distribution of the copolymer were measured by gel permeation chromatography (GPC). Furthermore, the self-assembling and drug-loaded behaviours of three different ratios of PSt-b-POEOMA-b-PSt were studied. These copolymers could readily self-assemble into micelles in aqueous solution. The vitamin E-loaded copolymer micelles were produced by the dialysis method. The micelle size and core-shell structure of the block copolymer micelles and the drug-loaded micelles were confirmed by dynamic light scattering (DLS) and transmission electron microscopy (TEM). The thermal properties of the copolymer micelles before and after drug-loaded were investigated by different scanning calorimetry (DSC). The results show that the micelle size is slightly increased with increasing the content of hydrophobic segments and the micelles are still core-shell spherical structures after drug-loaded. Moreover, the glass transition temperature (Tg) of polystyrene is reduced after the drug loaded. The drug loading content (DLC) of the copolymer micelles is 70%-80% by ultraviolet (UV) photolithography analysis. These properties indicate the micelles self-assembled from PSt-b-POEOMA-b-PSt copolymers would have potential as carriers for the encapsulation of hydrophobic drugs.

A Study on Soft-Mooring Model Test Techniques for the Evaluation of Added Resistance on Ships (선박의 부가저항 평가를 위한 소프트 계류 모형시험 기법 연구)

  • Min-Guk Seo;In Bo Park;Dong-Min Park;Seunghyun Hwang
    • Journal of the Society of Naval Architects of Korea
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    • v.60 no.5
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    • pp.320-331
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    • 2023
  • In this study, a model test was conducted using the soft-mooring technique to evaluate the added resistance of the ship in waves. The study also examined the specific factors that should be considered during the soft-mooring test. The main purpose of soft-mooring is to prevent drifting caused by waves by providing horizontal restoring forces. However, it can also create undesired restoring forces in the vertical direction. Therefore, we examined the restoring force of the ship's 6-DOF motion based on the arrangement of the soft-mooring and the height of the mooring connection point. We also checked the corresponding resonance period and drift distance. The soft-mooring test was conducted twice, once with self-propulsion and once without self-propulsion, allowing us to review the advantages and disadvantages of each test technique. The main parameters measured in these model tests were 6DOF motion and added resistance on the ship. We compared these measurements obtained from two different techniques (with and without self-propulsion). Additionally, we also compared the measurements based on the types of measuring sensors used (2D load cells on FP, AP, and 1D load cells on each mooring line) as well as the height of the mooring connection point.

Preliminary Study on the MR Temperature Mapping using Center Array-Sequencing Phase Unwrapping Algorithm (Center Array-Sequencing 위상펼침 기법의 MR 온도영상 적용에 관한 기초연구)

  • Tan, Kee Chin;Kim, Tae-Hyung;Chun, Song-I;Han, Yong-Hee;Choi, Ki-Seung;Lee, Kwang-Sig;Jun, Jae-Ryang;Eun, Choong-Ki;Mun, Chi-Woong
    • Investigative Magnetic Resonance Imaging
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    • v.12 no.2
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    • pp.131-141
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    • 2008
  • Purpose : To investigate the feasibility and accuracy of Proton Resonance Frequency (PRF) shift based magnetic resonance (MR) temperature mapping utilizing the self-developed center array-sequencing phase unwrapping (PU) method for non-invasive temperature monitoring. Materials and Methods : The computer simulation was done on the PU algorithm for performance evaluation before further application to MR thermometry. The MR experiments were conducted in two approaches namely PU experiment, and temperature mapping experiment based on the PU technique with all the image postprocessing implemented in MATLAB. A 1.5T MR scanner employing a knee coil with $T2^*$ GRE (Gradient Recalled Echo) pulse sequence were used throughout the experiments. Various subjects such as water phantom, orange, and agarose gel phantom were used for the assessment of the self-developed PU algorithm. The MR temperature mapping experiment was initially attempted on the agarose gel phantom only with the application of a custom-made thermoregulating water pump as the heating source. Heat was generated to the phantom via hot water circulation whilst temperature variation was observed with T-type thermocouple. The PU program was implemented on the reconstructed wrapped phase images prior to map the temperature distribution of subjects. As the temperature change is directly proportional to the phase difference map, the absolute temperature could be estimated from the summation of the computed temperature difference with the measured ambient temperature of subjects. Results : The PU technique successfully recovered and removed the phase wrapping artifacts on MR phase images with various subjects by producing a smooth and continuous phase map thus producing a more reliable temperature map. Conclusion : This work presented a rapid, and robust self-developed center array-sequencing PU algorithm feasible for the application of MR temperature mapping according to the PRF phase shift property.

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Effects of hydrogen plasma on the formation of self-organized InAs-quantum dot structure (자기조직화에 의한 InAs 양자점 구조 형성에 미치는 수소플라즈마의 효과)

  • ;;;K. Ozasa;Y. Aoyagi
    • Journal of the Korean Crystal Growth and Crystal Technology
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    • v.6 no.3
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    • pp.351-359
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    • 1996
  • We have investigated the effect of hydrogen plasma on the formation of InAs QDs (quantum dots) structure by using a CBE (chemical beam epitaxy)system equipped with ECR (electron cyclotron resonance) plasma source. It is confirmed that the formation of self-organized InAs-QDs on GaAs is started after the growth of InAs layer up to 2.6 ML (monolayer) with the irradiation of hydrogen plasma while it is started after 1.9 ML without hydrogen gas and hydrogen plasma through the observation of RHEED patterns. Density and size of the QDs formed at $T_{sub}=370^{\circ}C$ are $1.9{\times}10^{11}cm^{-2}$ and 17.7 nm without hydrogen plasma, and $1.3{\times}10^{11}cm^{-2}$ and 19.4 nm with hydrogen plasma, respectively. It is also observed from the PL(photoluminescence) measurement on InAs-QDs that red shift in PL peak energy and broadening in FWHM (full width at half maximum)of PL peak caused by the effects of hydrogen plasma on the increment of size and its distribution. These effects of hydrogen plasma are considered as a act of atomic hydrogen which enhances the layer-growth of InAs on GaAs resulted from the relief of misfit strain between GaAs substrate and InAs.

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ON THE GALACTIC SPIRAL PATTERNS: STELLAR AND GASEOUS

  • MARTOS MARCO;YANEZ MIGUEL;HERNANDEZ XAVIER;MORENO EDMUNDO;PICHARDO BARBARA
    • Journal of The Korean Astronomical Society
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    • v.37 no.4
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    • pp.199-203
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    • 2004
  • The gas response to a proposed spiral stellar pattern for our Galaxy is presented here as calculated via 2D hydrodynamic calculations utilizing the ZEUS code in the disk plane. The locus is that found by Drimmel (2000) from emission profiles in the K band and at 240 ${\mu}m$. The self-consistency of the stellar spiral pattern was studied in previous work (see Martos et al. 2004). It is a sensitive function of the pattern rotation speed, $\Omega$p, among other parameters which include the mass in the spiral and its pitch angle. Here we further discuss the complex gaseous response found there for plausible values of $\Omega$p in our Galaxy, and argue that its value must be close to $20 km s^{-l}\;kpc^{-1}$ from the strong self-consistency criterion and other recent, independent studies which depend on such parameter. However, other values of $\Omega$p that have been used in the literature are explored to study the gas response to the stellar (K band) 2-armed pattern. For our best fit values, the gaseous response to the 2-armed pattern displayed in the K band is a four-armed pattern with complex features in the interarm regions. This response resembles the optical arms observed in the Milky Way and other galaxies with the smooth underlying two-armed pattern of the old stellar disk populations in our interpretation. The complex gaseous response appears to be related to resonances in stellar orbits. Among them, the 4:1 resonance is paramount for the axisymmetric Galactic model employed, and the set of parameters explored. In the regime seemingly proper to our Galaxy, the spiral forcing appears to be marginally strong in the sense that the 4:1 resonance terminates the stellar pattern, despite its relatively low amplitude. In current work underway, the response for low values of $\Omega$p tends to remove most of the rich structure found for the optimal self-consistent model and the gaseous pattern is ring-like. For higher values than the optimal, more features and a multi-arm structure appears.

An Experimental Study on the Self-excited Instabilities in Model Gas Turbine Combustor (모델 가스터빈 연소기내의 자발 불안정성에 관한 실험적 연구)

  • Lee, Min-Chul;Hong, Jung-Goo;Shin, Hyun-Dong
    • 한국연소학회:학술대회논문집
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    • 2004.11a
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    • pp.197-205
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    • 2004
  • Most of gas turbines is operated by the type of dry premixed combustion to reduce NOx emission and economize fuel consumption. However this type operation, combustion induced instability brought failure problems cause by high pressure and heat release fluctuations. Though there has been lots of studies since Lord Rayleigh to understand this instability mechanism and control the instabilities, none of them made matters clear. In order to understand the instability phenomena, a simple experimental study with dump combustor was conducted at the moderate pressure and ambient temperature conditions. From this model gas turbine combustor self-excited instabilities at the resonance mode(200Hz) and bulk mode(10Hz) were occurred and observed at the three points of view; pressure, heat release and equivalence ratio which are acquired by peizo-electric transducer, HICCD camera and acetone LIF respectively. From this results we could see the instability mechanism clear with the account of time scale analysis which explained by the propagation of pressure wave to the upward of mixture stream and convectional transfer of the equivalence ratio fluctuation by this pressure fluctuation.

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Electrical Characterization of BGA interconnection for RF packaging (Radio Frequency 회로 모듈 BGA 패키지)

  • Kim, Dong-Young;Woo, Sang-Hyun;Choi, Soon-Shin;Jee, Yong
    • Proceedings of the IEEK Conference
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    • 2000.06b
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    • pp.96-99
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    • 2000
  • We presents a BGA(Ball Grid Array) package for RF circuit modules and extracted its electrical parameters. We constructed a BGA package of ITS(Intelligent Transportation System) RF module and examined electrical parameters with a HP5475A TDR(Time Domain Reflectometry) equipment and compared its electrical parasitic parameters with PCB RF circuits. With a BGA substrate of 3 $\times$ 3 input and output terminals, we have found that self capacitance of BGA solder ball is 68.6fF, self inductance 146pH, mutual capacitance 10.9fF and mutual inductance 16.9pH. S parameter measurement with a HP4396B Network Analyzer showed the resonance frequency of 1.55㎓ and the loss of 0.26dB. Thus, we may improve electrical performance when we use BGA package structures in the design of RF circuit modules.

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Antibody Layer Fabrication for Protein Chip to Detect E. coli O157:H7, Using Microcontact Printing Technique

  • KIM HUN-SOO;BAE YOUNG-MIN;KIM YOUNG-KEE;OH BYUNG-KEUN;CHOI JEONG-WOO
    • Journal of Microbiology and Biotechnology
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    • v.16 no.1
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    • pp.141-144
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    • 2006
  • An antibody layer was fabricated to detect Escherichia coli O157:H7. The micropattern of 16-mercaptohexadecanoic acid (16-MHDA) as alkylthiolate was formed on the gold surface by using the PDMS stamp with microcontact printing $({\mu}CP)$ techniques. In order to form antibody patterns on the template, protein G was chemically bound to the 16-MHDA patterns, and antibody was adsorbed on a self-assembled protein G layer. The formation of the 16-MHDA micropattern, self-assembled protein G layer and antibody pattern on Au substrate was confirmed by surface plasmon resonance (SPR) spectroscopy. Finally, the micropatterning method was applied to fabricate the antibody probe for detection of E. coli O157:H7, and monitoring of antigen by using this probe was successfully achieved.

A Study on Electromagnetic Retarder's Power Recovery System and Regenerating Voltage Control (전자기형 리타더의 전력회수장치 및 회생전압제어에 대한 연구)

  • Jung, Sung-Chul;Ko, Jong-Sun
    • The Transactions of The Korean Institute of Electrical Engineers
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    • v.66 no.8
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    • pp.1207-1214
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    • 2017
  • In the case of frequent braking, when driving downhill or long distance, conventional brakes using friction are problematic in braking safety due to brake rupture and fading phenomenon. Therefore auxiliary brakes is essential for heavy vehicles. And several research has been actively conducted to improve energy efficiency by regenerating mechanical energy into electric energy when the vehicles brake. In this paper, a voltage control method is utilized to recover the electric energy generated in the electromagnetic retarder instead of the eddy current. To regenerate the braking energy into the electrical energy, a resonant L-C circuit is configured in the retarder. The retarder can be modeled as self-excited induction generator due to its operating principle. The driving conditions according to the retarder's parameters are made into 3-D maps. Also, the voltage of the resonant circuit changing depending on the driving pulse applied to the FET was analyzed. For the control of this voltage, we proposed an algorithm using the PI controller. The controlled voltage is converted by a 3-phase AC/DC converter and then charged to a battery inside the heavy vehicles through a DC/DC converter. Electromagnetic retarder and its controller are validated using Matlab Simulink. We also demonstrate the voltage controller through the actual M-G set experiment.

Immunosensor for Detection of Escherichia coli O157:H7 Using Imaging Ellipsometry

  • Bae Young-Min;Park Kwang-Won;Oh Byung-Keun;Choi Jeong-Woo
    • Journal of Microbiology and Biotechnology
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    • v.16 no.8
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    • pp.1169-1173
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    • 2006
  • Imaging ellipsometry (IE) for detection of binding of Escherichia coli O157:H7 (E. coli O157:H7) to an immunosensor is reported. A protein G layer, chemically bound to a self-assembled layer of 11-mercaptoundecanoic acid (11-MUA), was adopted for immobilization of monoclonal antibody against E. coli O157:H7 (Mab). The immobilization of antibody was investigated using surface plasmon resonance. To fabricate antibody spots on a gold surface, protein G solution was spotted onto the gold surface modified with an 11-MUA layer, followed by immobilizing Mab on the protein G spot. Ellipsometric images of the protein G spot, the Mab spot, and Mab spots with binding of E. coli O157:H7 in various concentrations were acquired using the IE system. The change of mean optical intensity of the Mab spots in the ellipsometric images indicated that the lowest detection limit was $10^3$CFU/ml for E. coli O157:H7. Thus, IE can be applied to an immunosensor for detection of E. coli O157:H7 as a detection method with the advantages of allowing label-free detection, high sensitivity, and operational simplicity.