• 정보교육학회논문지
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• 제18권3호
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• pp.433-442
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• 2014

본 논문은 초등학생의 스마트폰 사용 실태가 독서 실태 및 자기조절읽기에 어떠한 영향을 미치는지를 알아보기 위해 초등학교 6학년을 대상으로 스마트폰 중독 자가진단과 독서 실태 및 자기조절읽기 검사를 실시하여 결과를 분석하였다. 분석 결과 스마트폰 보유 여부와 스마트폰 중독 정도에 따라서는 독서량, 독서시간, 자기조절 읽기에 영향을 미쳤으나, 스마트폰 이용기간은 영향을 미치지 않았다. 초등학생들의 올바른 스마트폰 사용 방법과 스마트폰 중독 예방을 위해 학교 및 가정에서 지속적인 교육이 이루어져야 하며, 스마트 시대에 적절한 독서 지도방안 등도 연구되어져야 할 것이다.

• Reproductive and Developmental Biology
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• 제34권3호
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• pp.229-233
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• 2010

Pluripotency and self-renewal capacity of human embryonic stem cells (hESCs) are retained by hESCs related genes as OCT4, SOX2 and NANOG. These genes are shown high expression level in diverse cancer cells and have potential role in the carcinogenesis. On the contrary to this, several genes which are up-regulated in the differentiated hESCs are involved to suppress the carcinogenesis or proliferation of cells. We discovered several genes in immortalized lung fibroblast (WI-38 VA13) by suppression subtractive hybridization. Among them, we focused chromosome 6 open reading frame 62 (C6orf62) which is uncharacterized, mapped to 6p22.3 and generated to Hepatitis B virus X-transactivated proteins (HBVx-transactivated proteins, XTP). Aim of this study was to characterize C6orf62 through analyzing of expression pattern in various cell lines. Expression of C6orf62 was significantly upregulated in diverse normal cell lines than cancer cell lines. And C6orf62 was up-regulated in differentiated hESCs (endothelial cells, neural cells) compared to those of undifferentiated hESCs. Also, C6orf62 in WI-38 cells was highly up-regulated during G1/S transition of the cell cycle. Taken together, C6orf62 is shown expression pattern similar to differentiated hESCs-associated genes which down-regulated in cancer cells. Therefore, we assume that C6orf62 may participate to suppress the proliferation and to induce differentiation through regulating the cell cycle.