• KSII Transactions on Internet and Information Systems (TIIS)
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• v.7 no.12
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• pp.3180-3199
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• 2013

While non-predefined object segmentation (NDOS) distinguishes an arbitrary self-assumed object from its background, predefined object segmentation (DOS) pre-specifies the target object. In this paper, a new and novel method to segment predefined objects is presented, by globally optimizing an orientation-based objective function that measures the fitness of the object boundary, in a discretized parameter space. A specific object is explicitly described by normalized discrete sets of boundary points and corresponding normal vectors with respect to its plane shape. The orientation factor provides robust distinctness for target objects. By considering the order of transformation elements, and their dependency on the derived over-segmentation outcome, the domain of translations and scales is efficiently discretized. A branch and bound algorithm is used to determine the transformation parameters of a shape model corresponding to a target object in an image. The results tested on the PASCAL dataset show a considerable achievement in solving complex backgrounds and unclear boundary images.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.10 no.2
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• pp.542-558
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• 2016

Vehicular Ad Hoc Networks (VANETs) are self-configuring networks where the nodes are vehicles equipped with wireless communication technologies. In such networks, limitation of signal coverage and fast topology changes impose difficulties to the proper functioning of the routing protocols. Traditional Mobile Ad Hoc Networks (MANET) routing protocols lose their performance, when communicating between vehicles, compromising information exchange. Obviously, most applications critically rely on routing protocols. Thus, in this work, we propose a methodology for investigating the performance of well-established protocols for MANETs in the VANET arena and, at the same time, we introduce a routing protocol, called Genetic Network Protocol (G-NET). It is based in part on Dynamic Source Routing Protocol (DSR) and on the use of Genetic Algorithms (GAs) for maintenance and route optimization. As G-NET update routes periodically, this work investigates its performance compared to DSR and Ad Hoc on demand Distance Vector (AODV). For more realistic simulation of vehicle movement in urban environments, an analysis was performed by using the VanetMobiSim mobility generator and the Network Simulator (NS-3). Experiments were conducted with different number of vehicles and the results show that, despite the increased routing overhead with respect to DSR, G-NET is better than AODV and provides comparable data delivery rate to the other protocols in the analyzed scenarios.

• The Korean Journal of Food & Health Convergence
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• v.5 no.4
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• pp.13-17
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• 2019

Amiodarone hydrochloride is an antiarrhythmic agent which has low aqueous solubility and presents bioavailability problem. These properties are a challenge for the pharmaceutical industry. Inclusion of lipophilic compound in the hydrophobic core of micelles, i.e. self-assembled structures based on surfactants in aqueous solution, is one way of increasing the solubility. Intravenous formulation of amiodarone hydrochloride with polysorbate 80 as a detergent and benzyl alcohol as a co-solvent is used in medical practice. This paper aimed to study the effect of polysorbate 80 and benzyl alcohol on the water solubility of amiodarone hydrochloride. Formation of mixed micelles consisting of nonionic surfactant polysorbate 80 and cationic amiodarone with chloride counterion was investigated by fluorescence spectroscopy. Benzyl alcohol was found to decrease the stability of the mixed micelles and lead to crystallization of amiodarone hydrochloride. The greatest amounts of crystals formed at 4℃ for 30 days in the model drug solutions with polysorbate 80 concentrations of 100.1 mg/mL and 97.9 mg/mL. A change of the polysorbate 80 concentration and avoidance the use of benzyl alcohol are recommended to improve the stability of the parenteral dosage form. These results can open new perspectives in the optimization of amiodarone intravenous formulations.

• Bulletin of the Korean Chemical Society
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• v.29 no.2
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• pp.363-371
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• 2008

As a computational method for the discovery of the effective agonists for PPARd, we address the usefulness of molecular dynamics free energy (MDFE) simulation with explicit solvent in terms of the accuracy and the computing cost. For this purpose, we establish an efficient computational protocol of thermodynamic integration (TI) that is superior to free energy perturbation (FEP) method in parallel computing environment. Using this protocol, the relative binding affinities of GW501516 and its derivatives for PPARd are calculated. The accuracy of our protocol was evaluated in two steps. First, we devise a thermodynamic cycle to calculate the absolute and relative hydration free energies of test molecules. This allows a self-consistent check for the accuracy of the calculation protocol. Second, the calculated relative binding affinities of the selected ligands are compared with experimental IC50 values. The average deviation of the calculated binding free energies from the experimental results amounts at the most to 1 kcal/mol. The computational efficiency of current protocol is also assessed by comparing its execution times with those of the sequential version of the TI protocol. The results show that the calculation can be accelerated by 4 times when compared to the sequential run. Based on the calculations with the parallel computational protocol, a new potential agonist of GW501516 derivative is proposed.

• ETRI Journal
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• v.39 no.6
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• pp.794-802
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• 2017

In this paper, a wireless powered communication network (WPCN) consisting of a hybrid access point (H-AP) and multiple user equipment (UE), all of which operate in full-duplex (FD), is described. We first propose a transceiver structure that enables FD operation of each UE to simultaneously receive energy in the downlink (DL) and transmit information in the uplink (UL). We then provide an energy usage model in the proposed UE transceiver that accounts for the energy leakage from the transmit chain to the receive chain. It is shown that the throughput of an FD WPCN using the proposed FD UE (FD-WPCN-FD) can be maximized by optimal allocation of the UL transmission time to the UE by solving a convex optimization problem. Simulation results reveal that the use of the proposed FD UE efficiently improves the throughput of a WPCN with a practical self-interference cancellation capability at the H-AP. Compared to the WPCN with FD H-AP and half-duplex (HD) UE, FD-WPCN-FD achieved an 18% throughput gain. In addition, the throughput of FD-WPCN-FD was shown to be 25% greater than that of WPCN in which an H-AP and UE operated in HD.

• IEMEK Journal of Embedded Systems and Applications
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• v.9 no.3
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• pp.157-163
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• 2014

This paper demonstrates the benefit of using MOOS-IvP in the development of control system for Unmanned Underwater Vehicles(UUV). The demand for autonomy in UUVs has significantly increased due to the complexity in missions to be performed. Furthermore, the increased number of sensors and actuators that are interconnected through a network has introduced a need for a middleware platform for UUVs. In this context, MOOS-IvP, which is an open source software architecture, has been developed by several researchers from MIT, Oxford University, and NUWC. The MOOS software is a communication middleware based on the publish-subscribe architecture allowing each application to communicate through a MOOS database. The IvP Helm, which is one of the MOOS modules, publishes vehicle commands using multi-objective optimization in order to implement autonomous decision making. This paper explores the benefit of MOOS-IvP in the development of control software for UUVs by using a case study with an auto depth control system based on self-organizing fuzzy logic control. The simulation results show that the design and verification of UUV control software based on MOOS-IvP can be carried out quickly and efficiently thanks to the reuse of source codes, modular-based architecture, and the high level of scalability.

• Proceedings of the KIEE Conference
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• 2006.10a
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• pp.145-146
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• 2006

본 논문은 부분방전(PD: Partial Discharge)의 패턴인식 확률 극대화를 목적으로 신경망(NN: Neural Network) 파라미터 중에서 은닉층 뉴런의 수, 모멘텀(momentum)의 Step size와 Decay rate 를 최적화하기 위하여 유전 알고리즘(GA: Genetic Algonthm)을 적응하였다. 실험적 연구의 대상으로서, GIS(Gas Insulated Switchgear)사고의 주요 원인으로 보고되어있는 결함들을 인위적으로 모의한 16개 Test cell을 이용하여 부분방전을 발생시켰다. 부분방전 신호는 본 연구팀이 개발한 센서를 이용하여 검출되어 데이터베이스가 구축되어 그로부터 추출된 학습 데이터들의 학습에 다음과 같은 5가지 신경망 모델이 적응되었다: Multilayer Perception (MLP), Jordan-Elman Network (JEN), Recurrent Network (RN), Self-Organizing Feature Map (SOFM), Time-Lag Recurrent Network (TLRN). 유전 알고리즘 적용 효율성을 분석하기 위하여 동일한 데이터를 이용하여 다음과 같은 두 가지 방법을 적용한 결과를 상호 비교하였다. 우선 상기 선택된 모델만 적용하였고 다근 하나는 상기 모델과 Genetic Algorithm이 동시에 적용되었다. 모든 모델에 대하여 학습오차와 패턴 분류 확률을 비교한 결과, 유전 알고리즘 적응 시 부분방전 패턴인식 확률이 향상되었음이 확인되어 향후 신뢰성 있는 GIS 부분방전 진단기술에 활용될 수 있을 것으로 사료된다.

• Mycobiology
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• v.37 no.2
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• pp.114-120
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• 2009

Streptomyces albidoflavus C247 was isolated from the soil of the Gyeongsan golf course in Korea. Physiological, biochemical and 16S rDNA gene sequence analysis strongly suggested that the isolate belonged to Streptomyces albidoflavus. Preliminary screening revealed that the isolate was active against fungi and bacteria. Self-directing optimization was employed to determine the best combination of parameters such as carbon and nitrogen source, pH and temperature. Nutritional and culture conditions for the production of antibiotics by this organism under shake-flask conditions were also optimized. Maltose (5%) and soytone (5%) were found to be the best carbon and nitrogen sources for the production of antibiotics by S. albidoflavus C247. Additionally, 62.89% mycelial growth inhibition was achieved when the organism was cultured at $30^{\circ}C$ and pH 6.5. Ethyl acetate (EtOAc) was the best extraction solvent for the isolation of the antibiotics, and 100 ${mu}$/ml of EtOAc extract was found to inhibit 60.27% of the mycelial growth of Rhizoctonia solani AG2-2(IV) when the poison plate diffusion method was conducted.

• Proceedings of the KIEE Conference
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• 2003.07d
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• pp.2627-2629
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• 2003

In this paper, we propose a new architecture of Genetic Algorithms(GAs)-based Self-Organizing Polynomial Neural Networks(SOPNN). The conventional SOPNN is based on the extended Group Method of Data Handling(GMDH) method and utilized the polynomial order (viz. linear, quadratic, and modified quadratic) as well as the number of node inputs fixed (selected in advance by designer) at Polynomial Neurons (or nodes) located in each layer through a growth process of the network. Moreover it does not guarantee that the SOPNN generated through learning has the optimal network architecture. But the proposed GA-based SOPNN enable the architecture to be a structurally more optimized networks, and to be much more flexible and preferable neural network than the conventional SOPNN. An aggregate performance index with a weighting factor is proposed in order to achieve a sound balance between approximation and generalization (predictive) abilities of the model. To evaluate the performance of the GA-based SOPNN, the model is experimented with using nonlinear system data.

• Journal of the Korean Society of Mechanical Technology
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• v.13 no.4
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• pp.109-115
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• 2011

The ice tank is important facility to check the performance of the ship and offshore in ice condition before the construction. MOERI(Maritime & Ocean Engineering Research Institute) constructed ice model basin on the end of 2010. The ice technology to know the phenomena of ice near the ship and to estimate power of the ship in model scale is the main characteristic of the ice model basin. To achieve this goal in one ice sheet, making of test plan and feasibility check of test possibility have to review in the beginning stage of the every test. This paper describes the number of maximum resistance and self propulsion test in a sheet of level ice and proposes the methodology to optimize pack ice, rubble ice, brash ice and ice ridge test in MOERI ice tank. The feasibility of free running test to know maneuvering performance in ice field and some specific idea to measuring ice thickness and ice ridge shape was proposed.