• Title/Summary/Keyword: Selective reduction and hydroboration

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Thirty Six Years of Research on the Selective Reduction and Hydroboration

  • Cha, Jin-Soon
    • Bulletin of the Korean Chemical Society
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    • v.32 no.6
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    • pp.1808-1846
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    • 2011
  • From 1975 to 2011, for thirty six years, the author and his collaborators have developed a variety of reducing and hydroborating agents, and applied them to organic synthesis, which involves the 1,2-reduction of ${\alpha}$,${\beta}$-unsaturated carbonyl compounds, stereoselective reduction of cycloalkanones, regioselective ring-opening of epoxides, partial reduction of carboxylic acid derivatives to aldehydes, regioselective addition to carbon-carbon multiple bonds, etc. by utilizing metal hydrides and the newly-devised the Meerwein-Ponndorf-Verley (MPV) type reagents. Such developments provide a new synthetic methodology making possible valuable selective reductions and hydroborations, not practical previously.