• Journal of Korean Society of Industrial and Systems Engineering
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• v.45 no.4
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• pp.187-198
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• 2022

This paper addresses the maintenance optimization problem in multi-component systems in which parts are connected in series, carrying out several missions interspersed with scheduled finite breaks. Due to limited time or resources, maintenance actions can be only carried out on a limited set of components. The decision maker then has to decide which components to maintain to ensure a pre-specified performance level during next mission. Most of the existing models in the literature usually assume only one system and enough spare parts. However, there are situations in which maintenance is required for multiple systems of the same type. To overcome this restrictive assumption, this study optimizes the maintenance problem considering the lack of repair parts and cannibalism for many identical systems. This study presents two optimization models with different objectives to solve the problem and analyzes the results so that the decision maker can decide. The results of this study are expected to be used for the maintenance of multiple systems of the same type, such as swarm drones.

• Biomolecules & Therapeutics
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• v.9 no.2
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• pp.69-78
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• 2001

Cyclooxygenase (COX) is an enzyme, which catalyzes the production of prostaglandins from arachi-donic acid and exists in two isoforms (COX-1 and COX-2). COX-1 is involved in the maintenance of physiological functions such as platelet aggregation, cytoprotection in the stomach and maintenance of normal kidney function. COX-2 is induced significantly in vivo under inflammatory conditions. COX-1 and COX-2 serve different physiological and pathological functions. All commercially available nonsteroidal antiinflammatory drugs (NSAIDS) are inhibitors of both COX-1 and COX-2. Therefore, selective inhibitors of COX-2 may be effective antiinflammatory agents without the ulcerogenic effects associated with current NSAms. Since the mid 1990s, a number of reports have been appeared on the preparation and biological activity of selective COX-2 inhibitors. Recently celecoxib, and rofecoxib, the representative COX-2 inhibitors, are introduced in the drug market. In this paper the relationship of structure-activity for selective COX-2 inhibitors is reviewed.

• Molecules and Cells
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• v.41 no.1
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• pp.55-64
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• 2018

Autophagy is an intracellular degradation pathway for large protein aggregates and damaged organelles. Recent studies have indicated that autophagy targets cargoes through a selective degradation pathway called selective autophagy. Peroxisomes are dynamic organelles that are crucial for health and development. Pexophagy is selective autophagy that targets peroxisomes and is essential for the maintenance of homeostasis of peroxisomes, which is necessary in the prevention of various peroxisome-related disorders. However, the mechanisms by which pexophagy is regulated and the key players that induce and modulate pexophagy are largely unknown. In this review, we focus on our current understanding of how pexophagy is induced and regulated, and the selective adaptors involved in mediating pexophagy. Furthermore, we discuss current findings on the roles of pexophagy in physiological and pathological responses, which provide insight into the clinical relevance of pexophagy regulation. Understanding how pexophagy interacts with various biological functions will provide fundamental insights into the function of pexophagy and facilitate the development of novel therapeutics against peroxisomal dysfunction-related diseases.

• The Journal of Korean Academy of Sensory Integration
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• v.21 no.2
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• pp.1-11
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• 2023

Objective : The purpose of this study was to investigate the effects of computerized cognitive rehabilitation on the attention of children with autism spectrum disorder (ASD). Methods : A multiple-baseline design was used in combination with a single-subject experimental research design. A total of 15 sessions were conducted three times a week, each lasting for 30 minutes. The maintenance and selective attention tests in the attention area of the computerized cognitive rehabilitation program were evaluated in random order after each session was completed. To evaluate the participants' selective attention, star cancellation tests was performed as pre- and post-tests. Results : After the computerized cognitive rehabilitation intervention, the accuracy of the participants' attention improved in terms of the maintenance and selective attention tests. In the analysis involving the two standard deviation bands, participants 1 and 2 showed a significant improvement, whereas participant 3 did not show a significant improvement, although the average value improved. Conclusion : The results of this study confirmed that cognitive rehabilitation involving a computerized cognitive rehabilitation program had a positive effect on the attention of three children with ASD.

• International Journal of Stem Cells
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• v.16 no.3
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• pp.293-303
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• 2023

Background and Objectives: The physiological oxygen tension in fetal brains (~3%, physioxia) is beneficial for the maintenance of neural stem cells (NSCs). Sensitivity to oxygen varies between NSCs from different fetal brain regions, with midbrain NSCs showing selective susceptibility. Data on Hif-1𝛼/Notch regulatory interactions as well as our observations that Hif-1𝛼 and oxygen affect midbrain NSCs survival and proliferation prompted our investigations on involvement of Notch signalling in physioxia-dependent midbrain NSCs performance. Methods and Results: Here we found that physioxia (3% O₂) compared to normoxia (21% O₂) increased proliferation, maintained stemness by suppression of spontaneous differentiation and supported cell cycle progression. Microarray and qRT-PCR analyses identified significant changes of Notch related genes in midbrain NSCs after long-term (13 days), but not after short-term physioxia (48 hours). Consistently, inhibition of Notch signalling with DAPT increased, but its stimulation with Dll4 decreased spontaneous differentiation into neurons solely under normoxic but not under physioxic conditions. Conclusions: Notch signalling does not influence the fate decision of midbrain NSCs cultured in vitro in physioxia, where other factors like Hif-1𝛼 might be involved. Our findings on how physioxia effects in midbrain NSCs are transduced by alternative signalling might, at least in part, explain their selective susceptibility to oxygen.

• Food Science and Biotechnology
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• v.15 no.6
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• pp.866-870
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• 2006

The maintenance of physiological activity during dilution is very critical for the accurate enumeration of Vibrio spp. in marine samples. We investigated the effect of various diluents on the recovery of Vibrio parahaemolyticus using the direct plate counting and most probable number (MPN) methods. The effects of NaCl (0.85 and 3%) and pH (from 6.6 to 7.4) in diluents based on distilled water or phosphate buffered saline (PBS) were evaluated with three V. parahaemolyticus strains. PBS-3% NaCl (pH 6.6), as opposed to PBS, was the most effective diluent at maintaining viable cell numbers up to 2 log CFU/g during dilution for direct plate counting using on thiosulfate citrate bile salts sucrose (TCBS) selective agar, as well as minimizing the difference in cell numbers between TCBS and non-selective nutrient agar. It also increased counts of V parahaemolyticus inoculated into oysters relative to PBS (p<0.01), suggesting that PBS-3% NaCl (PH 6.6) can reduce the problem of underestimating V. parhaemolyticus counts using PBS alone.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.65 no.3
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• pp.526-531
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• 2016

This paper presents an experimental study on the optimal settings for the selected DC fault relay (50F) to improve the operating performance for the high-speed circuit breaker on DC feeding system which ensure safety within rolling stock maintenance depot. In this study, current supplied to overhead contact wire was calculated on 1 ms interval to analyze the correction values of DC fault selective relay for the operation of current supply cutout. Particularly, standards for the accurate detection of accidents between an electric railway vehicle and the electric power facilities are shown by investigating the optimal correction values for detection of fault current, and the results indicated that it takes about 213 ms for the DC fault selective relay(50F) to fully open. In the future, the correction values of DC fault selective relay suggested in this paper will be used as the reference values of protective relay for the safe operation of DC electric railroad system such as urban railway.

• Journal of Korea Multimedia Society
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• v.19 no.8
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• pp.1453-1459
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• 2016

Recently, vector map has developed, used in many domains, and in most cases vector map data contains confidential information which must be kept away from unauthorized users. Moreover, the manufacturing process of a vector map is complex and the maintenance of a digital map requires substantial monetary and human resources. This paper presents the selective encryption scheme based on polyline simplification methods for GIS vector map data protection to store, transmit or distribute to authorized users. Main advantages of our algorithm are random vertices and transformation processes but it still meets requirements of security by random processes, and this algorithm can be implement to many types of vector map formats.

• Journal of Animal Reproduction and Biotechnology
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• v.34 no.4
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• pp.318-321
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• 2019

Recent studies showed that tight junctions (TJs) integrity and assembly are required for blastocyst development in mouse and pig models. However, the biological functions of TJs associated with embryo implantation and maintenance of pregnancy were not investigated yet. To examine whether disrupted TJs affect further embryo development, we employed RNAi approach and inhibitor treatment. The embryos were injected with Cxadr (Coxsackievirus and adenovirus receptor) siRNA for knock down (KD) and treated with Adam10 (A Disintegrin and Metalloproteinase specific inhibitor 10; GI254023X; SI). We compared blastocyst development and paracellular sealing assay using FITC dextran uptake between control and KD or SI embryos. Finally, we transferred control and Cxadr KD or Adam 10 SI treated blastocyst to uteri of recipients. Cxadr KD and Adam 10 SI showed lower blastocyst development and more permeable to FITC-dextran. Moreover, we observed that half of KD and inhibited embryos failed to maintain pregnancies after the second trimester. Our findings suggested that TJs integrity is required for the maintenance of pregnancy and can be used as a selective marker for the successful application of assisted reproduction technologies.

• Journal of the Korea institute for structural maintenance and inspection
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• v.19 no.2
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• pp.133-142
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• 2015

The budget for public buildings is expected to increase to their maintenance, and the systematic maintenance and sufficient budget are recognized as the important factors for building maintenance. In Korea, buildings are not systematically maintained due to the lack of manpower, expertise and basis of maintenance budget estimates. Compared with Australia where the facility maintenance is optimized through asset management, Korea has only passive maintenance systems that focus on regulations. The introduction of the systematic asset management is required to ensure the advanced building maintenance in Korea. In this study, the asset management processes for social infrastructure facilities in and out of Korea were analyzed, and the asset management framework for public buildings were established. The asset management procedure consisted of ordinary asset management procedure, selective asset value assessment. The framework in this study was developed focusing on the asset management task for public buildings and presented the detailed contents of each step. The application of this framework to the actual work will enable the systematic management of building's value and performance, and the efficient appropriation of the maintenance budget.