• Title/Summary/Keyword: Selection of factors

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Different Potential of Hematopoietic Differentiation in Two Distinct Mouse Embryonic Stem Cells (두 개의 다른 마우스 배아줄기세포의 차별적인 조혈세포 분화능)

  • Kim, Jin-Sook;Kang, Ho-Bum;Song, Jee-Yeon;Oh, Goo-Taeg;Nam, Ki-Hoan;Lee, Young-Hee
    • Development and Reproduction
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    • v.9 no.2
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    • pp.105-114
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    • 2005
  • Embryonic stem(ES) cells have tremendous potential as a cell source for cell-based therapies. Realization of that potential will depend on our ability to understand and manipulate the factors that influence cell fate decision and to develop methods for getting enough cell numbers for clinical applications. Hematopoiesis has been widely studied, and hematopoietic differentiation from ES cells is a good model to study lineage commitment. In this study, we investigated stemness and compared the efficiency of hematopoietic differentiation using two different mouse embryonic stem cell lines TC-1 and B6-1. Although the two cell lines showed known stem cell properties with minor differences, the embryoid body formation efficiency in methylcellulose was much higher in TC-1 than B6-1. When measured potentials of hematopoietic differentiation using functional(colony-forming cell) and phenotypic(specific marker expression) assays, we found that TC-1 can differentiate into hematopoietic cells in methylcellulose culture but B6-1 cannot. These results imply that we can improve the efficiency of hematopoietic cell differentiation by selection of proper cell lines and this may be also applied in the differentiation of human embryonic stem cells.

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Mapping Species-Specific Optimal Plantation Sites Based on Environmental Variables in Namwon City, Korea (환경요인을 이용한 남원시의 적지적수도 제작)

  • Moon, Ga Hyun;Kim, Yong Suk;Lim, Joo Hoon;Shin, Man Yong
    • Korean Journal of Agricultural and Forest Meteorology
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    • v.17 no.2
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    • pp.126-135
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    • 2015
  • This study was conducted to develop a large scale map of species-specific plantation sites based on selected environmental variables such as topography, soil, and climatic factors in Namwon city. Site index equations by tree species were first regressed to 27 environmental variables that could influence the productivity of forest sites using digital forest site maps, digital climate maps, and the 5th National Forest Inventory data. Site index equations by tree species were all evaluated to estimate site productivity using 4-5 environmental variables, and the models' reliability was confirmed based on evaluation statistics. The determination coefficients of site index equations by species ranged from 0.42 to 0.76. With the site index equations, the site conditions appropriate for productive sites by species were considered to assess spatial distribution of productive areas for each species. The final map for optimal plantation in Namwon city was produced based on both site index equations and site conditions appropriate for productive sites by each species using GIS technique. Field survey was conducted to evaluate the suitability of selected species on the map of species-specific plantation sites. Results showed that the plantation map provides relatively reasonable spatial distribution of productive areas for selected species. It was revealed, however, that the sites evaluated as 'not suitable' for any tree species should be revised and complemented with additional information, especially with the site conditions appropriate for productive sites by species of interest. The outcomes of this study are expected to provide information for making customized species-specific plantation maps.

Intermediate and Long Term Results for Extracardiac Conduit Repair Between Right Ventricle and Pulmonary Artery in Congenital Cardiac Defect (선천성 심장기형의 우심실-폐동맥 인조혈관 연결 수술후 중장기 성적)

  • 조범구
    • Journal of Chest Surgery
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    • v.28 no.6
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    • pp.571-578
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    • 1995
  • Rastelli operation in which right ventricle[RV and pulmonary artery[PA is connected with an artificial graft is effective in increasing the pulmonary blood flow in certain types of congenital heart disease but, in many, it requires a reoperation because of the relative stenosis of graft that develops as the patients become old. The purpose of this study is to evaluate the various factors which many influence the long term outcome of such patients following a Rastelli operation. A total of 47 patients underwent a Rastelli operation during a 15 year period between November, 1978 and October 1993. The mean follow-up period is 76.1 51.3 months.1 Among the 47 patients, a valved conduit was used in 30[63.8% , and non-valved conduit in 17[36.2% patients. In the 8 patients[17.0% who died postoperatively, a valved conduit was used in 5 [16.6% and a non-valved conduit in 3[17.6% . There was no statistical difference in mortality between the 2 groups. There was a good linear correlation between the body surface area[X and the conduit size[Y [Y=3.86X + 14.6, R=0.55, P=0.01 .2 Ten patients underwent replacement of the conduit during the follow-up period. The type of conduit used and the frequency of subsequent replacement were as follows: Ionescu-Shiley, valved-33.3%, Carpentier-Edwards, valved-30.8%, Hancock, valved-80% and non-valved conduit-9.1%. The median period free of reoperation was 110 months for the valved and 79 months for the non-valved group, there being no statistical difference between the 2 groups. 3 The patients who did not require reoperation are all doing well [New York Heart Association Functional Classification: Class I . Pressure gradient between the RV and the PA was 20 mmHg in 10 randomly selected patients who did not require reoperation and 92 9 mmHg in 10 patients who did require reoperation.4 In the 10 patients who underwent a conduit replacement procedure.5 Among patients undergoing reoperation, 2 died from endocarditis.The remaining 8 patients are doing well without limitation in physical activity at a mean follow-up period of 32.7 33.9 months [range 2 to 89 months . 6 At 5, 7, and 10 years, the reoperation-free rates among all patients were 96%, 91% and 29% and the survival rates were 82%, 82% and 71%. In conclusion, Rastelli operation is an effective procedure in ameliorating symptoms in a select group of patients with congenital heart disease. Because of the inherent nature of relative graft stenosis and degeneration, a long-term follow-up is required under the proper selection of the graft material.

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Optimization of Processing Conditions and Selection of Optimum Species for Sweet Potato Chips (품종별 고구마 칩의 제조 조건 최적화 및 최적 품종 선정)

  • Jang, Gwi-Yeong;Li, Meishan;Lee, Sang-Hoon;Woo, Koan-Sik;Sin, Hyun-Man;Kim, Hong-Sig;Lee, Jun-Soo;Jeong, Heon-Sang
    • The Korean Journal of Food And Nutrition
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    • v.26 no.3
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    • pp.565-572
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    • 2013
  • This study was performed to optimize the processing conditions and to select the optimum species for colored sweet potato chips (Shinjami, Juhwangmi and Hayanmi varieties) baked by far-infrared radiation. Sweet potato chips were prepared by different slicing thickness (1~3 mm), concentration of sucrose solution for soaking (15~30%), blanching time (15~60 sec), baking temperature ($110{\sim}140^{\circ}C$) and baking time (23~31 min) through sensory evaluation and failure stress measurement. Optimal processing condition of sweet potato chips using Shinjami was determined to 1 mm, 20%, 45 sec, $120^{\circ}C$ and 31 min, and those using Juhwangmi was determined as 1 mm, 25%, 45 sec, $130^{\circ}C$ and 29 min. Sweet potato chips using Hayanmi was determined as 1 mm, 20%, 45 sec, $120^{\circ}C$ and 31 min, respectively. Free sugar content of sweet potato chips was higher in chips than in raw materials. In the sensory evaluation, appearance, sweet taste, hardness, and overall acceptance were higher in Juhwangmi than in the Shinjami and Hayanmi varieties. Overall acceptance, sugar content, b-value and failure stress were highly correlated among factors affecting the sensory characteristics (p<0.01). From the results of this study, Juhwangmi variety was selected for production of sweet potato chips.

Conditions and Performance of Quality Improvement Activity in Korean Dental Hospitals (치과의료 질 향상활동 현황과 개선활동 만족도)

  • Kim, Han-Na;Kim, Ho;Kim, Hae-Young
    • Journal of dental hygiene science
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    • v.13 no.4
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    • pp.359-368
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    • 2013
  • This study aimed to evaluate conditions and performance of quality improvement (QI) activity in Korean dental hospitals. Twenty one representative dental hospitals in Korea were selected by the selection criteria. A questionnaire was implemented to measure awareness, perceived needs, educations, conferences, works, activating/obstructive factors and satisfaction related to QI activities. Satisfaction score range from 0 (lowest) to 5 (highest) among 329 dental hygienists who worked in the selected 21 dental hospitals. Implementation rate of programs on external customer satisfaction was the highest 59.9% in QI activities, and reduction of expenses (59.4%), Improvement in health care quality (58.7), risk management (52.8) were followed, while improvement in work efficiency (46.5) showed the lowest implementation rate. The most influencing factor accelerating QI activities was 'active participation of hospital workers' (54.7%), and 'effort to improve customer satisfaction' (44.7%) followed. The most influencing QI related obstructive factor was 'lack of QI-related manpower and support' (47.1%). A balanced development including QI programs with lower implementation rates is necessary. Encouraging participation of workers may be the most important in developing dental QI activities further.

A Study on Trust in U.S., Antinomic Acceptance toward U.S. Beef and Changes in the Amount of Beef Consumption (미국 신뢰 정도와 미국산 쇠고기에 대한 이율배반적 수용 태도 및 쇠고기 소비량 변화에 관한 연구)

  • Kim, Dong-Jin;Kim, Gi-Jin;Kwon, Yong-Ju
    • Culinary science and hospitality research
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    • v.15 no.1
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    • pp.254-270
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    • 2009
  • As consumers are becoming more conscious about food safety and high quality standards, they are getting more interested in influencing the food policy-making process. Triggered by FTA (Free Trade Agreement) ratification between the Republic of Korea and the U.S. in 2008, a sharp conflict was created in importing U.S. beef between the government of Republic of Korea and its people. Food selection is known as a complex mental process of consumers, which incorporates social and cultural values, personal tastes, and other psychological factors. This study utilized the concept of antinomy which was signified by Immanuel Kant in his thesis. The concept of antinomy indicates a contradiction between conclusions which seem equally logical, reasonable or necessary. This study is designed to investigate the changes in the amount of beef consumption among Korean consumers after the Republic of Korea resumed U.S. beef imports and the impact of a consumer's trust in the U.S. on his/her antinomic acceptance. Also, it examined the effects of antinomic acceptance and whether a consumer is a potential restaurateur or a general consumer on the changes in the amount of beef consumption.

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Cost Comparison of PWR and PHWR Nuclear Power Plants in Korea

  • Kim, Chang-Hyo;Chung, Chang-Hyun;So, Dong-Sub
    • Nuclear Engineering and Technology
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    • v.11 no.4
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    • pp.263-274
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    • 1979
  • A statistical approach is used to investigate the relative economic advantages of pressurized water reactor (PWR) and pressurized heavy water reactor (PHWR-CANDU) nuclear power plants for hypothetical 900Mwe systems with the throwaway fuel cycle to be built in the Republic of Korea. Power cost is decomposed into the cost components related to the plant capital, operation and maintenance, working capital requirements and fuel cycle operation. The calculation of construction cost is performed with the modified version of computer code ORCOST, and the modified POWERCO-50 is used to evaluate the cost components. Most of economic parameters are treated as statistical variables, each being given with a certain range. Through a random sampling procedures. the probability histograms on unit plant construction costs and power generating costs are obtained. The power cost probability histograms of the PWR and the PHWR plants overlap considerably, and the power costs of two systems appear to be almost same with the PHWR power cost being 0.4mil1/kwh lower compared with 39.4 mills/kwh for the PWR plant (July 1986 US-dollars). When a construction period of PHWR plant is longer by one year than that of PWR plant, there is no difference in the unit power cost of two plants. This comparison leads to no definite conclusion on the cost advantage of the PWR plant versus the PHWR plant. We conclude that the selection issue of nuclear power plants in Korea still remains an open question and that future effort to solve this question should be made toward economic quantification of those factors such as technology transfer and localization.

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Classification and Selection of the Breeding Materials in the Silkworm, Bombyx mori, by Multivariate Analysis 2. Combining Ability and its Pre-estimate for the Top Cross Set made from the Silkworm Parental Lines Selected by Principal Component Analysis. (다변량 해석법에 의한 누에 육종소재의 탐색 2. 주성분 SCORE에 의하여 분류된 주요잠품종간의 TOP 교잡에 의한 조합능력 검정과 예측)

  • 정도섭;이인전;이상몽;김삼은
    • Journal of Sericultural and Entomological Science
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    • v.32 no.1
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    • pp.17-30
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    • 1990
  • A 6${\times}$4 top-cross set was made from the ten silkworm parental lines selected by the first principal component scores. They were also analysed for the relationship between the combining ability and the first principal component score. The highest general combining ability effects were detected in the parental lines of Japanese, N39 and chinese, C46, for the most quantitative characters in the study. The first principal component score of factors related to silk productivity in the parents was significantly and positively correlated to the general combining ability of the twelve characters such as cocoon yield, cocoon weight, cocoon shell weight, cocoon shell percentage, duration of the 5th instar larvae, total larval period, length of a bave, weight of a have, non-breaking length of a bave, non-breaking weight of a have, raw silk percentage, and neatness. Similarity distance (D$^2$) was related to the specific combining ability of the characters such as cocoon yield, non-breaking length of a bave, non-breaking weight of a have, non-breaking ratio of a bave, raw silk percentage, neatness. From the results, it is possible to predict the general combining ability effects by the principal component scores for the 12 characters of the parents related to silk productivity.

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Risk Analysis and Selection of the Main Factors in Fishing Vessel Accidents Through a Risk Matrix (위험도 매트릭스를 이용한 어선의 사고 위험도 분석과 사고 주요 요인 도출에 관한 연구)

  • WON, Yoo-Kyung;KIM, Dong-Jin
    • Journal of the Korean Society of Marine Environment & Safety
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    • v.25 no.2
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    • pp.139-150
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    • 2019
  • Though, fishing vessel accidents account for 70 % of all maritime accidents in Korean waters, most research has focused on identifying causes and developing mitigation policies in an attempt to reduce this rate. However, predicting and evaluating accident risk needs to be done before the implementation of such reduction measures. For this reasons, we havve performed a risk analysis to calculate the risk of accidents and propose a risk criteria matrix with 4 quadrants, within one of which forecasted risk is plotted for the relative comparison of risks. For this research, we considered 9 types of fishing vessel accidents as reported by Korea Maritime Safety Tribunal (KMST). Given that no risk evaluation criteria have been established in Korea, we established a two-dimensional frequency-consequence grid consisting of four quadrants into which paired frequency and consequence for each type of accident are presented. With the simple structure of the evaluation model, one can easily verify the effect of frequency and consequence on the resulting risk within each quadrant. Consequently, these risk evaluation results will help a decision maker employ more realistic risk mitigation measures for accident types situated in different quadrants. As an application of the risk evaluation matrix, accident types were further analyzed using accident causes including human error (factor) and appropriate risk reduction options may be established by comparing the relative frequency and consequence of each accident cause.

A Review on Measurement Techniques and Constitutive Models of Suction in Unsaturated Bentonite Buffer (불포화 벤토나이트 완충재의 수분흡입력 측정기술 및 구성모델 고찰)

  • Lee, Jae Owan;Yoon, Seok;Kim, Geon Young
    • Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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    • v.17 no.3
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    • pp.329-338
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    • 2019
  • Suction of unsaturated bentonite buffers is a very important input parameter for hydro-mechanical performance assessment and design of an engineered barrier system. This study analyzed suction measurement techniques and constitutive models of unsaturated porous media reported in the literature, and suggested suction measurement techniques and constitutive models suitable for bentonite buffer in an HLW repository. The literature review showed the suction of bentonite buffer to be much higher than that of soil, as measured by total suction including matric suction and osmotic suction. The measurement methods (RH-Cell, RH-Cell/Sensor) using a relative humidity sensor were suitable for suction measurement of the bentonite buffer; the RH-Cell /Sensor method was more preferred in consideration of the temperature change due to radioactive decay heat and measurement time. Various water retention models of bentonite buffers have been proposed through experiments, but the van Genuchten model is mainly used as a constitutive model of hydro-mechanical performance assessment of unsaturated buffers. The water characteristic curve of bentonite buffers showed different tendencies according to bentonite type, dry density, temperature, salinity, sample state and hysteresis. Selection of water retention models and determination of model input parameters should consider the effects of these controlling factors so as to improve overall reliability.