• 한국간호교육학회지
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• 제13권1호
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• pp.74-81
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• 2007

Purpose: This study was to investigate the factors affecting health-related quality of life in Benign Prostatic Hypertrophy(BPH) Patients. Method: Data was collected on 259 outpatients who were receiving ambulatory treatment after having been diagnosed with BPH. The measurement tool for the quality of life was developed by Epstein and Deverka(1992) and adapted by Kim Yeong-hye(1997). Data was analyzed with the number, percentage, and the mean and multiple regression, by using the SPSS 12.0 program. Result: The mean quality of life in the sexual-life domain respectively. Factors affecting the quality of life in BPH patients were the symptom of BPH(51.4%), the perceived health state(3.6%), and self-efficacy (1.6%). These three factors described 56.6% of quality of life. Conclusion: It's necessary to have an intervention plan that can enhance the most influential disease-symptom management in a patient, and self-efficacy when planning a nursing education program aiming to promote quality of life in BPH patients.

• 대한화학회지
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• 제44권1호
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• pp.68-73
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• 2000

본 연구에서는 고등학교 학생들의 화학문제 해결력과 인지적 변인(논리적 사고력, 기억 용량,학습 전략) 및 정의적 변인(자아 효능감, 능력에 대한 자아 개념, 학습 목적, 과학에 대한 태도) 사이의 관계를조사하였다. 수리 문제와 개념 문제 해결력에 대한 변인들의 예언력을 중다 회귀 분석으로 조사하였다. 연구 결과, 인지적 변인 중 논리적 사고력이 수리 문제의 해결력을 유의미하게 설명하였고, 개념 문제의 해결력은 학습 전략이 가장 많이 설명하였으나 유의미하지는 않았다. 정의적 변인 중 능력에 대한 자아 개념은 수리 문제와 개념 문제 해결력 모두에 대해 유의미한 예언 변인이었으며, 자아 효능감은 개념 문제 해결력과 유의미한 상관이 있었으나 설명력은 없었다.

• Parasites, Hosts and Diseases
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• 제51권2호
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• pp.165-175
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• 2013

The fear that schistosomes will become resistant to praziquantel (PZQ) motivates the search for alternatives to treat schistosomiasis. The antimalarials quinine (QN) and halofantrine (HF) possess moderate antischistosomal properties. The major metabolic pathway of QN and HF is through cytochrome P450 (CYP) 3A4. Accordingly, this study investigates the effects of CYP3A4 inhibitor, ketoconazole (KTZ), on the antischistosomal potential of these quinolines against Schistosoma mansoni infection by evaluating parasitological, histopathological, and biochemical parameters. Mice were classified into 7 groups: uninfected untreated (I), infected untreated (II), infected treated orally with PZQ (1,000 mg/kg) (III), QN (400 mg/kg) (IV), KTZ (10 mg/kg)+QN as group IV (V), HF (400 mg/kg) (VI), and KTZ (as group V)+HF (as group VI) (VII). KTZ plus QN or HF produced more inhibition (P<0.05) in hepatic CYP450 (85.7% and 83.8%) and CYT b5 (75.5% and 73.5%) activities, respectively, than in groups treated with QN or HF alone. This was accompanied with more reduction in female (89.0% and 79.3%), total worms (81.4% and 70.3%), and eggs burden (hepatic; 83.8%, 66.0% and intestinal; 68%, 64.5%), respectively, and encountering the granulomatous reaction to parasite eggs trapped in the liver. QN and HF significantly (P<0.05) elevated malondialdehyde levels when used alone or with KTZ. Meanwhile, KTZ plus QN or HF restored serum levels of ALT, albumin, and reduced hepatic glutathione (KTZ+HF) to their control values. KTZ enhanced the therapeutic antischistosomal potential of QN and HF over each drug alone. Moreover, the effect of KTZ+QN was more evident than KTZ+HF.