• The Journal of Korean Academic Society of Nursing Education
• /
• v.13 no.1
• /
• pp.74-81
• /
• 2007

Purpose: This study was to investigate the factors affecting health-related quality of life in Benign Prostatic Hypertrophy(BPH) Patients. Method: Data was collected on 259 outpatients who were receiving ambulatory treatment after having been diagnosed with BPH. The measurement tool for the quality of life was developed by Epstein and Deverka(1992) and adapted by Kim Yeong-hye(1997). Data was analyzed with the number, percentage, and the mean and multiple regression, by using the SPSS 12.0 program. Result: The mean quality of life in the sexual-life domain respectively. Factors affecting the quality of life in BPH patients were the symptom of BPH(51.4%), the perceived health state(3.6%), and self-efficacy (1.6%). These three factors described 56.6% of quality of life. Conclusion: It's necessary to have an intervention plan that can enhance the most influential disease-symptom management in a patient, and self-efficacy when planning a nursing education program aiming to promote quality of life in BPH patients.

• Journal of the Korean Chemical Society
• /
• v.44 no.1
• /
• pp.68-73
• /
• 2000

In this study, tlhe relationships of high school students' abilities to solve chemistry problems with cognitive variables (logical thinking ability, mental capacity. and learning strategy) and affective variables(self-efficacy, self-concept of ability, learning goal, and attitude toward science) were investigated. The proportion of variance due to the variables for algorithmic and conceptual problem solving ability was studied by a multiple regression analysis. The results indicated that, among the cognitive variables, the logical thinking ability significantly predicted the algorithmic problem solving ability, and the learning strategy was the best predictor of conceptual problem solving ability although not significant. Among the affective variables studied, the self-concept of alility was the significant predictor of both algorithmic and conceptual problem solving abilities. The seif-efficacy was significantly correlated with conceptual problem solving ability, but it had no predictive power.

• Parasites, Hosts and Diseases
• /
• v.51 no.2
• /
• pp.165-175
• /
• 2013

The fear that schistosomes will become resistant to praziquantel (PZQ) motivates the search for alternatives to treat schistosomiasis. The antimalarials quinine (QN) and halofantrine (HF) possess moderate antischistosomal properties. The major metabolic pathway of QN and HF is through cytochrome P450 (CYP) 3A4. Accordingly, this study investigates the effects of CYP3A4 inhibitor, ketoconazole (KTZ), on the antischistosomal potential of these quinolines against Schistosoma mansoni infection by evaluating parasitological, histopathological, and biochemical parameters. Mice were classified into 7 groups: uninfected untreated (I), infected untreated (II), infected treated orally with PZQ (1,000 mg/kg) (III), QN (400 mg/kg) (IV), KTZ (10 mg/kg)+QN as group IV (V), HF (400 mg/kg) (VI), and KTZ (as group V)+HF (as group VI) (VII). KTZ plus QN or HF produced more inhibition (P<0.05) in hepatic CYP450 (85.7% and 83.8%) and CYT b5 (75.5% and 73.5%) activities, respectively, than in groups treated with QN or HF alone. This was accompanied with more reduction in female (89.0% and 79.3%), total worms (81.4% and 70.3%), and eggs burden (hepatic; 83.8%, 66.0% and intestinal; 68%, 64.5%), respectively, and encountering the granulomatous reaction to parasite eggs trapped in the liver. QN and HF significantly (P<0.05) elevated malondialdehyde levels when used alone or with KTZ. Meanwhile, KTZ plus QN or HF restored serum levels of ALT, albumin, and reduced hepatic glutathione (KTZ+HF) to their control values. KTZ enhanced the therapeutic antischistosomal potential of QN and HF over each drug alone. Moreover, the effect of KTZ+QN was more evident than KTZ+HF.