• 공업화학
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• 제9권5호
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• pp.661-666
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• 1998

고시리카제올라이트 (HSZ), 거대망상수지입자(MR) 및 입상활성탄(GAC)에 의한 수용액중의 12가지 아민유도체의 평형흡착 실험 데이터와 Freundlich, Langmuir, Toth, Redlich-Peterson 식의 인자들을 각각 구하였다. 아민류의 흡착특징에 있어서는 고시리카제올라이트는 unfavourable, 입상활성탄은 favourable로 비선형이나, 거대망상수지흡착제는 선형관계의 특성을 나타내며, 변수가 2개인 Freundlich 식과 3개인 Redlich-Peterson 흡착등온식에 잘 일치하였다. HSZ, MR, GAC에 의한 아민류의 흡착능은 방향족>1급아민>2급아민 순이었으며, Freundlich상수 k와 n의 곱인 (k n)값은 HSZ와 MR 및 GAC에서 아민류의 끓는 점 $T_B$, 몰부피 $V_m$, 그리고 해리상수 $pK_a$에 비례하여 증가하였다.

• Bulletin of the Korean Chemical Society
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• 제11권1호
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• pp.45-49
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• 1990

${\alpha},{\omega}$-Diols react with secondary amines in the presence of a catalytic amount of ruthenium catalyst at $180^{\circ}C$ to give diamino compounds in good to excellent yields. The yield of diamino compound was affected by the molar ratio of ${\alpha},{\omega}$-diol to secondary amine. The reaction is affected by the nature of the phosphorus ligands employed and the effectiveness of the added ligand is completely different depending on the chain length of the ${\alpha},{\omega}$-diol. The reaction between ethylene glycol and primary amine in the presence of a catalytic amount of ruthenium catalyst gave 1,4-disubstituted piperazine.

• Bulletin of the Korean Chemical Society
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• 제20권8호
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• pp.973-976
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• 1999

• Bulletin of the Korean Chemical Society
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• 제6권6호
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• pp.379-380
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• 1985

• Bulletin of the Korean Chemical Society
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• 제26권7호
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• pp.1125-1128
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• 2005

• 한국산업보건학회지
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• 제11권3호
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• pp.249-253
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• 2001

The purpose of this study is the development of the simple and precise sampling and analysis method of methyl isocyanate(MIC) in the work place as their secondary aliphatic amine derivatives by gas chromatography with flame ionization detector. The urea derivatives are quantitatively and simultaneously derived from MIC with secondary aliphatic amines such as dipropylamine(DPA), dibutylamine(DBA), and dipentylamine (DAA) in methylene chloride. The method is based on sampling glass tube in XAD-2 resin which is coated with secondary aliphatic amines. The samples are desorbed by $2m{\ell}$ methylene chloride and analysed using gas chromatography with flame ionization detector(GC/FID). In the results, the detection limit of the overall procedure and reliable quantity are $0.020-0.027{\mu}g$($1.347-1.740{\mu}g/m^3$(0.529-0.684 ppb) based on a 15 L air volume) MIC per sample. The average desorption efficiencies are 97.96 - 101.23 %. The results of versus storage time are high and stable recovery rates.

• 대한화학회지
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• 제45권1호
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• pp.51-60
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• 2001

치환된 하이드록시 방향족 화합물과 이차아민, paraformaldehyde를 비 양성자성 용매하에서 one-pot으로 반응시켜 기질에 따른 상대적인 반응성을 비교하였으며, Mannich반응이 일어난 자리도 조사하였다. 치환된 하이드록시 방향족 고리의 Mannich반응의 반응성과 위치선댁성은 기질의 친핵성도와 아민의 입체장애에 의존함을 알 수 있었다.

• Environmental Analysis Health and Toxicology
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• 제15권1_2호
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• pp.53-59
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• 2000

The purpose of this study is the development of the simple and precise determination method of ethyl isocyanate (EIC) and propyl isocyanate (PIC) through derivatization using secondary aliphatic amines by gas chromatography with flame ionization detector. The urea derivatives are quantitatively and simultaneously derived from EIC and PIC with secondary aliphatic amines such as dipropylamine, dibutylamine. and dipentylamine in methylene chloride, and confirmed by thin layer chromatography and gas chromatography with mass selective detector. For GC/FID, according to the increasing carbon atom of the amines, the retention time and peak area of the urea derivatives are increased. The instrumental detection limits for EIC and PIC were about 23.3∼34.8 $\mu\textrm{g}$ and 21.6∼28.9 $\mu\textrm{g}$, respectively.

• Bulletin of the Korean Chemical Society
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• 제35권7호
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• pp.2130-2134
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• 2014

A kinetic study is reported on nucleophilic substitution reactions of 4-nitrophenyl isonicotinate (7) with a series of cyclic secondary amines in MeCN. The plots of $k_{obsd}$ vs. [amine] curve upward for the reactions with weakly basic amines (e.g., morpholine, 1-(2-hydroxyethyl)piperazine, and piperazine) but are linear for those with strongly basic amines (e.g., piperidine and 3-methylpiperidine). The curved plots for the reactions with the weakly basic amines are typical for reactions reported previously to proceed through uncatalyzed and catalyzed routes with two intermediates (e.g., a zwitterionic tetrahedral intermediate $T^{\pm}$ and its deprotonated form $T^-$). In contrast, the linear plots for the reactions with the strongly basic amines indicate that the catalytic route (i.e., the deprotonation process to yield $T^-$ from $T^{\pm}$ by a second amine molecule) is absent. The Br${\o}$nsted-type plots for $Kk_2$ and $Kk_3$ (i.e., the rate constants for the uncatalyzed and catalyzed routes, respectively) exhibit excellent linear correlations with ${\beta}_{nuc}$ = 0.99 and 0.69, respectively. The effect of amine basicity on the reaction mechanism is discussed in detail.

• 약학회지
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• 제30권4호
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• pp.163-168
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• 1986

Thirteen compounds were synthesized by condensing the N-heterocyclic amines (piperidine, pyrrolidine, morpholine) and secondary aliphatic amines (dimethylamine, diethylamine) with 3,4-methylenedioxyphenylalkenoic acid chlorides for developing CNS depressants. Among them, N, N-diethyl-3,4-methylenedioxycinnamamide (IX) and N, N-dimethyl-5-(3,4-methylenedioxyphenyl)-2, 4-pentadienoic acid amicle (XII) exhibited strong activity in antagonism against pentylenetetrazole-induced convulsion, strychnine-induced convulsion and maximal electroshock seizure. N, N-Dimethyl-3, 4-methylenedioxycinnamide (VIII) showed more potent activity in antagonism against strychnine-induced convulsion and maximal electroshock seizure and in the prolongation of hexobarbital sleeping time.