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Synthesis of Protoberberine Derivatives and Studies on Their Biological Activities (Protoberberine 유도체합성 및 활성연구)

  • Lee, Ma-Sae;Chung, Sung-Hyun;Kim, Dong-Hyun;Choung, Se-Young;Kim, Sin-Kyu
    • YAKHAK HOEJI
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    • v.34 no.5
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    • pp.296-301
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    • 1990
  • Irradiation of the berberinephenolbetaine in a stream of argon produced the 8,14-cycloberberines [1]. On treatment with ethylchloroformate $C_8-N$ bond cleavage of the compound [1] occurred, accompanied with dehydrochlorination to give 7-ethylcarboxyisoquinoline [3], and the product [3] treated with strong alkali solution to give the 13-oxonorotensane [4] in 64% yield. Irradiation of the compound [4] converted easily to dihydro-8H-dibenzo[a, g] quinolizine-8-one [5]. and then the compound [5] was treated with methyliodide to give the 8-oxo-quinolizinium methiode. The intermediate colume chromatography on IRA-400 afforded the benzo[c, g]azecine-5-one[6] in 63% yield. The results of biological activities for these compounds are also presented.

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Lethal and Sublethal Toxicities of Bisphenol A and Ethynyl Estradiol Exposure on the 4th Instar Larvae of Chironomus riparius (Diptera, Chironomidae) (비스페놀 에이와 에티닐에스트라디올에 노출된 키로노무스 4기 유충의 치사, 아치사 독성연구)

  • Lee, Se-Bum;Choi, Jin-Hee
    • Environmental Analysis Health and Toxicology
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    • v.21 no.4 s.55
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    • pp.301-310
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    • 2006
  • 본 연구에서는 내분비계장애물질로 잘 알려진 Bisphenol A와 Ethynyl estradiol(이하 BPA, EE)이 Chironomus riparius에 미치는 영향을 알아보고자 하였다. 수생생태계에서 Chironomus의 생태학적 중요성을 고려하여 연구한 반수치사농도(LC50),효소 활성, 성장/발달 등의 생화학적, 생리학적 독성에 대한 연구는 이들 물질에 대한 잠재적인 생태학적 중요성을 이해하는데 있어 유용한 정보를 제공할 수 있을 것이다. 연구 결과 BPA와 EE에 노출된 후 C. riparius게서 CAT와 GST활성이 증가하였고, EE에 고농도로 노출된 후 성충까지 충분히 성장하지 못했음을 확인하였다 이러한 결과로부터 C. riparius에서 BPA, EE에 대한 중요한 독성정보를 얻을 수 있었다. 그러므로 앞으로 BPA와 EE의 생화학적 효과와 C. riparitis의 개체수준 이상에서의 생리학적 실험을 통한 검증이 필요할 것이다.

Robust Mobile-Robot Localization for Indoor SLAM (이동 로봇의 강인한 위치 추정을 통한 실내 SLAM)

  • Mo, Se-Hyun;Yu, Dong-Hyun;Park, Jong-Ho;Chong, Kil-To
    • Journal of Institute of Control, Robotics and Systems
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    • v.22 no.4
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    • pp.301-306
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    • 2016
  • This paper presents the results of a study for robust self-localization and indoor slam using external cameras (such as a CCTV) and odometry of mobile robot. First, a position of mobile robot was estimated by using maker and odometry. This data was then fused with camera data and odometry data using an extended kalman filter. Finally, indoor slam was realized by applying the proposed method. This was demonstrated in the actual experiment.

Optimized PWM switching method of DC-DC converter with the bipolar voltages for Redox Flow Battery (레독스 흐름 전지용 양극성 전압을 갖는 DC-DC 컨버터의 최적 PWM 스위칭 기법)

  • Jeong, Hyeon-Ju;Choi, Se-Wan
    • Proceedings of the KIPE Conference
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    • 2015.07a
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    • pp.301-302
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    • 2015
  • 본 논문은 레독스 흐름 전지(Redox Flow Battery : RFB)용 양극성을 갖는 DC-DC 컨버터의 기본 동작 원리 및 최적 스위칭 기법에 관한 것이다. 양극성을 갖는 DC-DC 컨버터는 매우 낮은 배터리 전압에서도 완전 방전을 위해 고승압이 필요하고, 완전 방전 후 극성 반전이 되어 매우 낮은 전압에서도 충전이 가능하여야 한다. 본 논문에서는 이러한 동작이 요구되는 RFB용 DC-DC 컨버터의 스위칭 손실을 최소화하기 위한 스위칭 방법을 제안한다. 최종 발표 시 실험 결과를 제시하고자 한다.

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Prediction of Influence Range in Saemangeum Reservoir by Floodgate Operation at Upstream (상류제수문 방류조건에 따른 새만금호의 영향범위 예측)

  • Kim, Se Min;Park, Young Ki
    • Proceedings of the Korea Water Resources Association Conference
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    • 2017.05a
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    • pp.297-301
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    • 2017
  • 본 연구에서는 새만금유역과 호 내의 복잡한 수체 형상, 유입 및 유출 구조를 반영하는데 적합한 모델을 적용하고 재현성이 검토된 모델 결과를 이용하여 호 내 수질을 모의하였다. 또한 구성한 모형의 결과를 바탕으로 만경강, 동진강의 상류에 위치하고 있는 제수문에서의 방류조건을 가정하여 모의를 수행하였다. 방류조건별 모의 결과, M3, D5지점에서 목표수질을 초과하는 것으로 나타났고 새만금호 상류부인 M3, D3지점은 방류조건에 따른 수질개선효과가 큰 것으로 예측되어 만경강과 동진강의 유입수의 영향이 지배적인 것으로 평가되었다. 전량방류시 영향범위를 거리로 살펴보면 만경강대교에서 새만금호 하류방향으로 약 22 km지점, 동진강대교에서 새만금호 하류방향으로 약 15 km지점까지로 나타났다. 농도변화와 방류조건별 영향범위를 살펴보면, 하류측으로 갈수록 수질개선에 영향을 적게 미치지만, 증가된 방류량에 의해 수질이 개선되어 제수문에서의 방류량 증가는 호 내 수질개선에 기여하는 것으로 판단된다.

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Rethinking of Research and Educational Trends in Foreign Studies Field in Korea (한국에서의 해외지역 연구와 교육에 대한 비판적 고찰)

  • Kwon, Se Eun
    • Cross-Cultural Studies
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    • v.22
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    • pp.279-301
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    • 2011
  • This paper is aimed to examine the current research and educational problems of foreign studies in Korean universities and review some alternative ways. Area studies as foreign studies have several characteristics which are different from those of the other research disciplines. It is a research and educational program that promotes comprehensive understanding about political, economic, social, and cultural phenomena of a specific area in the world. For better understand 'others', researchers in the field of area studies must explain the whole mechanism of the area, which could be revealed in terms of the very existence of its reality. Foreign studies are accomplished with joint-research method, collaborating two or more different research disciplines and based on the contemporary system of knowledge accumulation and educational program. Therefore, the critical issue can be gradually taken on a political and social characteristic. At this point, research and educational manner in foreign studies field in Korea should be changed to secure the academic reflections of temporality, sociality, placeness using a new paradigm such as complexity.

Prediction of the Shelter Dog Outcome using Machine Learning Models (머신러닝을 이용한 유기견 안락사 예측)

  • Lee, Ye-Seol;Lee, Se-Hoon;Keane, John
    • Proceedings of the Korean Society of Computer Information Conference
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    • 2020.07a
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    • pp.301-302
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    • 2020
  • The number of abandoned dogs were increasing every year in South Korea. However, many dogs are euthanized in the shelter because of the lack of budget. This project predicts euthanasia of abandoned dogs using machine learning algorithm. It collects data from the public data portal where Korea government provides a public dataset as a form of open API. This project uses recent three-year data 2017 to 2019 and 263371 cases were founded. This project implements random forest and logistic regression models. This project attained an average 72% of prediction accuracy.

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Spectrum Feature Analysis of Crying Sounds of Infant Cold and Pneumonia (소아감기와 소아폐렴간의 울음소리 스펙트럼 특징 분석)

  • Kim, Bong-Hyun;Lee, Se-Hwan;Cho, Dong-Uk
    • The KIPS Transactions:PartB
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    • v.15B no.4
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    • pp.301-306
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    • 2008
  • Recently, various health care methods for infants have been suggested in the impending era of low birth rate society. We propose, in this context, an early diagnosis method for common infant respiratory diseases. Particularly, the method is regarding infant cold and infant pneumonia. Firstly, sounds of infant crying, only expressing means of infants, among the infant cold group and the infant pneumonia group are compared and examined to find the differences from those among the healthy infant group. For this, the link between infected organs and articulatory organs is investigated. Also, resulting wave forms and frequency bandwidths among each group are compared and analyzed, by using the spectrum for a component voice, to diagnose the infant cold and pneumonia. Finally, the effectiveness of this method is verified through the experiments.

Beach Sand Grain Size Analysis using Commercial Flat-bed Scanner (범용 평판 스캐너를 이용한 해빈 모래의 입도분석)

  • Cheon, Se-Hyeon;Ahn, Kyungmo;Suh, Kyung-Duck
    • Journal of Korean Society of Coastal and Ocean Engineers
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    • v.25 no.5
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    • pp.301-310
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    • 2013
  • For analyzing sand grain size, a specialized high-priced instrument has been used, such as sieve shaker, video camera, laser particle size analyzer, and microscope. Among these, the sieve shaker is commonly used because it is not only cheaper than others but also provides reasonable accuracy. However, it takes a long time and makes lots of dust and noise. In this study, a cheaper and easier method which can replace the sieve shaker is proposed. By using a commercial flat-bed scanner and a darkroom box, the sand size distribution can be analyzed. The darkroom box makes sand images clear and protects the glass of the scanner from being scratched. Comparison between the present method and sieve analysis shows that the present method not only has an accuracy comparable to the sieve analysis but also can save time and effort.

Metabolic Activities of Ginseng and Its Constituents, Ginsenoside Rb1 and Rg1, by Human Intestinal Microflora

  • Choi, Jong-Ryul;Hong, Sung-Woon;Kim, Yu-Ri;Jang, Se-Eun;Kim, Nam-Jae;Han, Myung-Joo;Kim, Dong-Hyun
    • Journal of Ginseng Research
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    • v.35 no.3
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    • pp.301-307
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    • 2011
  • To evaluate the difference in expressing pharmacological effects of ginseng by intestinal microflora between Koreans, metabolic activities of ginseng, ginsenoside $Rb_1$ and $Rg_1$ by 100 fecal specimens were measured. The ${\beta}$-glucosidase activity for p-nitrophenyl-${\beta}$-D-glucopyranoside was 0 to 0.42 mmol/min/mg and its average activity (mean${\pm}$SD) was $0.10{\pm}0.07$ mmol/min/mg. The metabolic activities of ginsenosides Rb1 and Rg1 were 0.01 to 0.42 and 0.01 to 0.38 pmol/min/mg, respectively. Their average activities were $0.25{\pm}0.08$ and $0.15{\pm}0.09$ pmol/min/mg, respectively. The compound K-forming activities from ginsenoside Rb1 and ginseng extract were 0 to 0.11 and 0 to 0.02 pmol/min/mg, respectively. Their average compound K-forming activities were $0.24{\pm}0.09$ pmol/min/ mg and $2.14{\pm}3.66$ fmol/min/mg, respectively. These activities all were not different between males and females, or between ages. Although compound K-forming activity from the aqueous extract of ginseng was low compared to that from ginenoside $Rb_1$, their profiles were similar to those of isolated compounds. Based on these findings, we believe that the intestinal bacterial metabolic activities of ginseng components are variable in individuals and may be used as selection markers for responders to ginseng.