• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제21권4호
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• pp.306-314
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• 2018

Purpose: The objective of this study was to describe the clinical phenotypes of children and adolescents with cystic fibrosis (CF); and to assess the role of pancreatic insufficiency and neonatal screening in diagnosis. Methods: A cross-sectional study was conducted, which included 77 patients attending a reference center of CF between 2014 and 2016. Epidemiological data, anthropometric measurements, and the presence of pulmonary, pancreatic, gastrointestinal and hepatobiliary manifestations were evaluated based on clinical data and complementary examinations. Results: Of the 77 patients, 51.9% were male, with a median age of 147 months (7.0-297.0 months), and the majority showed adequate nutritional status. The most common phenotype was pulmonary (92.2%), followed by pancreatic (87.0%), with pancreatic insufficiency in most cases. Gastrointestinal manifestation occurred in 46.8%, with constipation being the more common factor. Hepatobiliary disease occurred in 62.3% of patients. The group with pancreatic insufficiency was diagnosed earlier (5.0 months) when compared to the group with sufficiency (84.0 months) (p=0.01). The age of diagnosis was reduced following implementation of neonatal screening protocols for CF (6.0 months before vs. 3.0 months after, p=0.02). Conclusion: The pulmonary phenotype was the most common, although extrapulmonary manifestations were frequent and clinically relevant, and should mandate early detection and treatment. Neonatal screening for CF led to earlier diagnosis in patients with pancreatic failure, and therefore, should be adopted universally.

• 스트레스연구
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• 제26권4호
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• pp.277-289
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• 2018

본 연구는 일반인이 경험하는 일상우울 상태를 손쉽게 판단할 수 있는 개인선별용 검사를 제작하고 신뢰도와 타당도를 조사하는데 목적이 있다. 이를 위해 원척도인 일상우울 집단연구용 척도(17문항)를 바탕으로 5문항으로 된 단축형 척도를 개발하였다. 연구 결과, 집단연구용 척도와 단축형 척도 간 상관은 .94로 높았으며, 검사-재검사 신뢰도(60일 이내 .73) 또한 양호한 수준이었다. 검사의 내적 구조는 1요인으로 확인되었다. 끝으로 기준점수를 구하였는데, 단축형 5개 문항의 총점이 18점 이상이면 일상우울 수준을 넘어 역기능우울의 가능성이 있으므로 역기능우울척도를 실시하는 것을 권고한다.

• 약학회지
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• 제38권4호
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• pp.462-468
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• 1994

Hot aqueous extracts of 130 herbal medicines were screened for platelet activating factor (PAE) receptor binding antagonistic activity using rabbit platelet. The results suggested that 4 medicinal plants including Biota orientalis are potential sources of PAF antagonists.

• 대한불안의학회지
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• 제13권2호
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• pp.86-92
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• 2017

Objective : This study evaluated the factor structure of a Korean version of the Penn State Worry Questionnaire (K-PSWQ) with exploratory factor analysis in healthy adult subjects, and confirmatory factor analysis of subjects who have received psychiatric treatment. Methods : Exploratory principal component analysis was conducted with data from 318 non-psychiatric subjects, and 118 psychiatric patients were subjected to confirmatory factor analysis (maximum likelihood estimation). Participants were voluntary visitors at the booth who agreed to undergo screening for anxiety disorder at 2013 & 2014 Korea Mental Health Exhibitions. Results : Exploratory analysis revealed a two factor structure of the scale with total variance of 56.3%. Factor 1 was considered 'Worry engagement', and factor 2 was considered 'Absence of worry'. However, the results of the confirmatory factor analysis supported that both one factor model with method factor and two factor model are fit to structure of the scale considering fit indices. Internal consistency of total questions was good (Cronbach's ${\alpha}=0.899$). Conclusion : Our results supported the previously suggested factor structure of the PSWQ, and proved factorial validity of the K-PSWQ in both populations.

• 농약과학회지
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• 제16권1호
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• pp.62-68
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• 2012

본 연구에서는 내분비계 장애물질의 영향 및 생태계 건강성의 스크리닝 평가를 위해 미꾸리를 지표종으로 선정하여 대조지점(RA)과 농업지점(AS)에서 biomarker 4가지 항목과 bioindicator 4가지 항목을 포함하여 총 8가지 항목의 생물지표를 분석하였다. 생태계 건강성 평가를 위한 생물지표의 분석 결과 독성 화학물질의 영향을 나타내는 ethoxyresorufin-O-deethylase(EROD), acetylcholinesterase(AChE) 및 DNA damage 등의 생화학적 생물지표는 대조지점(RA)에 비해 유의한 차이가 있는 것으로 나타났다. 반면, 내분비계 장애물질의 영향을 반영하는 vitellogenin(VTG)는 농업지점(AS)에서 유의한 차이를 보이지 않았고, 개체수준의 생물지표(condition factor (CF), hepato-somatic index (HSI), gonado-somatic index (GSI)) 또한 유의한 차이를 보이지 않았다. 따라서 농업지점(AS)의 생태계 건강성은 내분비계 장애물질에 의한 영향은 미비한 것으로 판단되었으나, 농약, 중금속 등과 같은 독성을 보이는 화학물질이나 농업 지역의 특수성에 따른 서식지 환경 조건에 의해 일부 영향을 받은 것으로 사료되었다. 본 연구는 생화학적 생물지표와 개체수준의 생물지표를 이용한 스크리닝 평가로서 농업지역에 대한 종합적인 생태계 건강성 평가를 위해서는 생물지표 적용 항목을 확대하고, 개체군이나 군집 수준의 분석이 추가적으로 적용 되어야 하며 수생태계 내의 추정 오염물질에 대한 분석이 필요할 것으로 사료된다.

• 한국임상수의학회지
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• 제26권2호
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• pp.123-129
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• 2009

동맥관 개존증(PDA)은 동맥관의 불완전한 폐쇄로 인해 하행 대동맥과 폐동맥 사이에 비정상적인 단락이 형성된 것이다. 최근 인간의 유전자 연구에서 전사인자 AP-2 beta(TFAP2B)의 유전자 변이가 PDA 증후적 사례를 초래함을 발견하였다. TFAP2B 유전자의 변이는 사람의 PDA와 같은 특정 선천성 심장 기형과 관련되어 있다. 본 연구에서는 PDA에 이환된 개의 유전자 스크리닝을 하기 위해 개 TFAP2B유전자의 전체 exon 부위를 분리하였다. 개 TFAP2B유전자는 사람의 TFAP2B와 아미노산 서열이 매우 유사하였다. PDA에 이환된 말티즈견의 TFAP2B유전자 스크리닝에서 단일 c.936+203G>A 염기 변화가 발견되었다. 그러나 대조군의 유전자 스크리닝에서도 동일한 염기 변화가 발견되었다. 이 염기의 변화는 인트론 지역에 위치해 있었으며 이환되지 않은 대조군 개에서 발견된 것으로 보아 TFAP2B는 말티즈 견의 유전성 PDA와 다른 종의 PDA 환자를 초래하지 않을 것으로 보인다. 향후 더 많은 샘플을 모으고 PDA에 이환된 다양한 종과 다른 선천성 심장 기형을 가진 환축에서 TFAP2B를 스크리닝하는 연구가 필요하다.

• Archives of Plastic Surgery
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• 제34권4호
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• pp.516-519
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• 2007

Purpose: Hemophilia is one of the most common bleeding disorder, and circulating levels of factor VIII or IX are closely related to the severity and frequency of the bleeding. The severity of hemophilia is classified to be severe, moderate, and mild when the factor level is less than 1%, between 1% and 5%, and between 5% and 25%, respectively. Hemophilic pseudotumor is a rare complication occurring in 1 - 2% of patients with factor VIII or IX deficiency. If the treatment is delayed, it would cause disabling and life threatening results. Methods: We experienced hemophilic pseudotumor developed at the fracture site of the proximal phalanx of the hand in a hemophilic B patient. Hemophilic pseudotumor was successfully treated with perioperative factor replacement and surgical intervention included excision and autologous bone graft. Results: Hemophilic pseudotumor was healed with complete regression, and no specific complication was developed. Conclusion: When we accounter hematoma like lesion after surgery unpredictably, we must consider hemophilic pseudotumor and make a accurate diagnosis with preoperative hematologic screening and various imaging study. Subsequently, adequate perioperative supplement of concentrate and surgical intervention brings to the satisfactory result without recurrence.

• Animal cells and systems
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• 제7권1호
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• pp.81-87
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• 2003

While screening proteins that interact with DnaA protein, the initiator protein for Escherichia coil chromosomal DNA replication, we found a 52-kD sized protein which bound to DnaA protein in a salt-dependent manner. This protein was identified as trigger factor, a ribosome-associated peptidyl-prolyl- cisltrans isomerase with chaperone activity. Trigger factor was overproduced and purified to near homogeneity, and its effect on the function of DnaA protein was examined, Enhanced binding of DnaA protein to DnaA box with no apparent supershift in the gel-shift experiments suggested that trigger factor, by virtue of its chaperone activity, exerts a change on DnaA protein thus increasing its binding affinity for DnaA box.

• 영재교육연구
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• 제25권2호
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• pp.237-259
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• 2015

이 연구는 음악(국악)영재 담당교사가 지녀야 할 자격 조건을 수렴하고, 수렴된 조건을 바탕으로 평가문항을 제작한 후, 그 문항에 대한 구인타당화를 도모함으로써 음악(국악)영재의 선발 및 교육과정 운영을 위한 토대를 마련하고 궁극적으로는 예술영재교육의 내실화 및 체계화를 도모하기 위하여 수행되었다. 음악(국악)영재 담당교사 평가문항의 문항분석을 위하여 탐색 및 확인적 요인분석을 실시하였고, 내적일관성 신뢰도를 추정하였다. 요인분석 결과 최종 41문항을 수렴하였고, 전통음악을 포함한 음악영재 담당교사가 지녀야 할 심리학적 구인을 확인할 수 있었다. 또한 평가문항에 대한 내적일관성 신뢰도 추정 결과 높은 신뢰도 수준(r=.974)을 확보할 수 있었다. 이 연구의 결과는 음악(국악)영재 담당교사 평가문항이 영재교육 현장에 즉시 투입 가능한 교사 평가도구임을 반영해준다.

• 대한조선학회논문집
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• 제54권6호
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• pp.476-484
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• 2017

The purpose of this paper is to verify the structural integrity of a region with numerous penetration-holes in offshore structures such as semi-submersible rig and FPSO. In order to effectively check the yielding and buckling strength of plate members with penetration-holes, a screening analysis program was developed with the FE analysis tool to generate fine meshed model using the theoretical and analysis methods. When a hole is appeared in the plate structure members, the flow of stress is altered such that concentrations of stress form near the hole. Stress concentrations are of concern during both preliminary and detail design and need to be addressed from the perspectives of strength. To configure the geometrical shape, very fine meshed FE analysis is needed as the most accurate method. However, this method is practically impossible to apply for the strength verifications for all perforated plates. In this paper, screening analysis method was introduced to reduce analysis tasks prior to detailed FE analysis. This method is applied to not only the peak stress calculation combined stress concentration factor with nominal stress but also nominal equivalent stress calculation considering cutout effects. The areas investigated by very fine meshed analysis were to be chosen through screening analysis without any reinforcements for penetration-holes. If screening analysis results did not satisfy the acceptance criteria, direct FE analysis method as the 2nd step approach were applied with one of the coarse meshed model considering hole or with the very fine meshed model considering the hole shape and size. In order to effectively perform the local fine meshed analysis, automatic model generating program was developed based on the MSC/PATRAN which is pre-post FE analysis program. Buckling strength was also evaluated by Common Structure Rule (CSR) adopted by IACS as the stress obtained from very fine meshed FE analysis. Due to development of the screening analysis program and automatic FE modeling program, it was able to reduce the design periods and structural analysis costs.