• Journal of Korean Traditional Oncology
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• v.24 no.2
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• pp.1-11
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• 2019

Objectives : We investigated whether a single center nutrition screening tool (Kyunghee Neo Nutrition Risk Screening, KNNRS) can predict survival in patients with metastatic cancer. Methods : We retrospectively reviewed data of inpatients with metastatic cancer from April 2016 to August 2019. Data on demographic and clinical parameters were collected from electronic medical records, and overall survival was estimated using the Kaplan-Meier method. Stepwise Cox regression analysis was used to determine factors associated with survival. Patients with a KNNRS score of 0 to 3 were classified as "no-risk", 4 to 10 as "low-risk", and 11 to 20 as "high-risk". Results : Total 105 patients were included in the study. According to nutritional screening at baseline, 25 patients (23.8%, median age 57.0) were classified as ""no risk"" group; 80 patients (76.2%, median age 68.5) as "low risk" group; No patients as "high risk" group. Predictors of survival were Eastern Cooperative Oncology Group Performance Status score of 3 or 4 (hazard ratio [HR] = 1.93; 95% confidence interval [CI] = 1.21-3.10), hemoglobin less than 10 g/dL (HR = 1.97; 95% CI = 1.25-3.10) and C-reactive protein more than 1.0 mg/dL (HR = 1.95; 95% CI = 1.21-3.13). Kaplan-Meier survival analysis showed significant differences in the survival between KNNRS groups: ""no risk"" group: 6.1 ± 1.4 months (95% CI = 3.37-8.83); ""low risk"" group: 3.4 ± 0.9 months (95% CI = 1.5-5.37). Conclusions : Nutritional status according to KNNRS wasn't significant predictor of survival for patients with metastatic cancer. Improvement of KNNRS score thresholds is needed.

• Journal of The Korea Institute of Healthcare Architecture
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• v.24 no.2
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• pp.15-25
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• 2018

Purpose: The important things in space plan of a screening center are improving the spatial awareness by space systemization and minimizing the examination time for customers, and reducing the required time of screening work and maximizing the capacity for the screening center. Therefore, we tried to solve the problem of improving spatial awareness and reducing the examination time by using the pedestrian based discrete event simulation at the minimum cost. Methods: We have analyzed the drawbacks and the supplement points by comparing the floor plan at the time of opening and the current floor plan. Based on the analysis, we propose an improved plan which changes the location of the examination rooms and the number of services, and we also verify the improved plan based on simulation analyses. Results: 1) Through the analyses, we derived the drawbacks of the floor plan at the time of opening, and we realized that the current floor plan reflects the drawbacks. 2) The major reasons of the long examination time are the human traffic jam and the occurrence of queues due to unreasonable allocation of services. 3) Through the discrete event simulation analyses, it was possible to specify the place of the queues manually so as to use the given space fairly. 4) Using the discrete event simulation, it was possible to reduce the examination time and to improve the spatial awareness effectively at the minimum cost. Implications: Although the proposed simulation methodology in this paper is an analysis of the existing screening center, we expect that the proposed methodology will be used to develop a more efficient architectural design process by pre-applying the method to the course of designing a screening center and finding the suitability of the proposed method with the matched number of services.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.15
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• pp.6605-6608
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• 2015

Background: Colorectal cancer is a major cause of morbidity and mortality throughout the world. Colorectal cancer screening is an optimal way for reducing of morbidity and mortality and a clinical decision support system (CDSS) plays an important role in predicting success of screening processes. DSS is a computer-based information system that improves the delivery of preventive care services. The aim of this article was to detail engineering of information requirements and work flow design of CDSS for a colorectal cancer screening program. Materials and Methods: In the first stage a screening minimum data set was determined. Developed and developing countries were analyzed for identifying this data set. Then information deficiencies and gaps were determined by check list. The second stage was a qualitative survey with a semi-structured interview as the study tool. A total of 15 users and stakeholders' perspectives about workflow of CDSS were studied. Finally workflow of DSS of control program was designed by standard clinical practice guidelines and perspectives. Results: Screening minimum data set of national colorectal cancer screening program was defined in five sections, including colonoscopy data set, surgery, pathology, genetics and pedigree data set. Deficiencies and information gaps were analyzed. Then we designed a work process standard of screening. Finally workflow of DSS and entry stage were determined. Conclusions: A CDSS facilitates complex decision making for screening and has key roles in designing optimal interactions between colonoscopy, pathology and laboratory departments. Also workflow analysis is useful to identify data reconciliation strategies to address documentation gaps. Following recommendations of CDSS should improve quality of colorectal cancer screening.

• Korean Journal of Radiology
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• v.21 no.9
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• pp.1027-1035
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• 2020

Objective: To assess the appropriate follow-up interval, and rate and timepoint of cancer detection in women with Breast Imaging Reporting and Data System (BI-RADS) 3 lesions on screening ultrasonography (US) according to the type of institution. Materials and Methods: A total of 1451 asymptomatic women who had negative or benign findings on screening mammogram, BI-RADS 3 assessment on screening US, and at least 6 months of follow-up were included. The median follow-up interval was 30.8 months (range, 6.8-52.9 months). The cancer detection rate, cancer detection timepoint, risk factors, and clinicopathological characteristics were compared between the screening and tertiary centers. Nominal variables were compared using the chi-square or Fisher's exact test and continuous variables were compared using the independent t test or Mann-Whitney U test. Results: In 1451 women, 19 cancers (1.3%) were detected; two (0.1%) were diagnosed at 6 months and 17 (1.2%) were diagnosed after 12.3 months. The malignancy rates were both 1.3% in the screening (9 of 699) and tertiary (10 of 752) centers. In the screening center, all nine cancers were invasive cancers and diagnosed after 12.3 months. In the tertiary center, two were ductal carcinomas in situ and eight were invasive cancers. Two of the invasive cancers were diagnosed at 6 months and the remaining eight cancers newly developed after 13.1 months. Conclusion: One-year follow-up rather than 6-month follow-up may be suitable for BI-RADS 3 lesions on screening US found in screening centers. However, more caution is needed regarding similar findings in tertiary centers where 6-month follow-up may be more appropriate.

• Bulletin of the Korean Chemical Society
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• v.32 no.11
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• pp.4086-4088
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• 2011

• Journal of Applied Biological Chemistry
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• v.48 no.3
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• pp.151-152
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• 2005

• 한국생물공학회:학술대회논문집
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• 2005.10a
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• pp.957-957
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• 2005

• 한국생물공학회:학술대회논문집
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• 2005.10a
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• pp.969-969
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• 2005

• 한국생물공학회:학술대회논문집
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• 2005.10a
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• pp.970-970
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• 2005

• 한국생물공학회:학술대회논문집
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• 2005.10a
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• pp.972-972
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• 2005