• Korean Journal of Biological Psychiatry
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• 제27권2호
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• pp.94-100
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• 2020

Objectives Amyloid β positron emission tomography (Aβ PET) is widely used as a diagnostic tool in patients who have symptoms of cognitive impairment, however, this diagnostic examination is too expensive. Thus, predicting the positivity of Aβ PET before patients undergo the examination is essential. We aimed to analyze clinical predictors of patients who underwent Aβ PET retrospectively, and to develop a predicting model of Aβ PET positivity. Methods 468 patients who underwent Aβ PET with cognitive impairment were recruited and their clinical indicators were analyzed retrospectively. We specified the primary outcome as Aβ PET positivity, and included variables such as age, sex, body mass index, diastolic blood pressure, systolic blood pressure, education, dementia family history, Mini Mental Status Examination (MMSE), Clinical Dementia Rating (CDR), Clinical Dementia Rating-Sum of Box (CDR-SB), hypertension (HTN), diabetes mellitus (DM) and presence of apolipoprotein E (ApoE) E4 as potential predictors. We developed three final models of amyloid positivity prediction for total subjects, mild cognitive impairment (MCI) and Alzheimer's disease (AD) dementia using a multivariate stepwise logistic regression analysis. Receiver operating characteristic (ROC) curve analysis was performed and the area under curve (AUC) value was calculated for the ROC curve. Results Aβ PET negative patients were 49.6% (n = 232), and Aβ PET positive patients were 50.4% (n = 236). In the final model of all subjects, older age, female sex, presence of ApoE E4 and lower MMSE are associated with Aβ PET positivity. The AUC value was 0.296. In the final model of MCI subjects (n = 244), older age and presence of ApoE E4 are associated with Aβ PET positivity. The AUC value was 0.725. In the final model of AD subjects (n = 173), lower MMSE scores, the presence of ApoE E4 and history of HTN are associated with Aβ PET positivity. The AUC value was 0.681. Conclusions The cerebral amyloid positivity model, which was based on commonly available clinical indicators, can be useful for prediction of amyloid PET positivity in MCI or AD patients.

• The Journal of the Korea Contents Association
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• 제21권10호
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• pp.48-58
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• 2021

For securing technology and business competences of companies that is the engine of domestic industrial growth, government-supported policy programs for the creation of commercialization results in various forms such as 『Technology Transaction Market Vitalization』 and 『Technology Finance-based R&D Commercialization Support』 have been carried out since 2014. So far, various studies on technology valuation theories and evaluation variables have been formalized by experts from various fields, and have been utilized in the field of technology commercialization. However, Their practicality has been questioned due to the existing constraint that valuation results are assessed lower than the expectation in the evaluation sector. Even considering that the evaluation results may differ depending on factors such as the corporate situation and investment environment, it is necessary to establish a reference infrastructure to secure the objectivity and reliability of the technology valuation results. In this study, we investigate the evaluation infrastructure built by each institution and examine whether the latest artificial neural networks and deep learning technologies are applicable for performing predictive simulation of technology values based on principal variables, and predicting sales estimates and qualitative evaluation scores in order to embed onto the technology valuation system.

• Journal of The Korean Society of Integrative Medicine
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• 제9권4호
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• pp.261-270
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• 2021

Purpose : The purpose of this study is to investigate the effects of sleep duration on stress and depression in college students. The results obtained will be used as a foundational framework for fostering a healthy sleep culture among college students and for formulating measures to improve the quality of their sleep. Ultimately, we intend to produce a publicity and educational material. Methods : For this study, a survey involving 100 college students was conducted, after which data based on a final total of 95 respondents were analyzed. The information on stress and depression were first analyzed in terms of general characteristics and then organized based on the data collected to investigate the effects of sleep duration on stress and depression. The participants were divided into the following groups: "less than 6 hours," "6 to 7 hours," and "7 to 8 hours." BEPSI-K (Brief encounter psychosocial instrument-Korean) was used for stress evaluation, while K-CESD-R (Korean version of center for epidemiologic studies depression scale-revised) was utilized for depression evaluation. Results : First, according to sleep duration, the BEPSI-K scores showed a statistically significant difference in each group (p<.01). In the post-hoc test, there was a difference among the "less than 6 hours" group, the "7 to 8 hours" group. A statistically significant difference was noted (p<.01). In addition, sleep duration had a statistically significant effect on the negative (-) direction of the BEPSI-K (p<.01). Second, the K-CESD-R score according to sleep duration showed a statistically significant difference in each group (p<.01). Notably, in the post-hoc test, the "less than 6 hours" group differed from the "6 to 7 hours" group, "7 to 8 hours" group. A statistically significant difference was noted (p<.01). In addition, sleep duration had a statistically significant effect on the negative (-) direction of the K-CESD-R (p<.01). Third, for the correlation between sleep duration and stress and depression, a negative (-) correlation was found between sleep duration and BEPSI-K and K-CESD-R. Meanwhile, a positive (+) correlation was found between BEPSI-K and K-CESD-R. Conclusion : Based on the findings of this study, the sleep duration of college students has an effect on stress and depression. The results of this study can be used as a foundational framework in formulating a plan for improving the quality of sleep of college students.

• Journal of Convergence for Information Technology
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• 제10권12호
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• pp.245-255
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• 2020

The purpose of this study was to investigate effects of 'activity program for effective storytelling' on the empathic ability and language teaching efficacy of a story grandmother. The subjects were 51 beautiful story grandmothers in Gangwon, Gyeongsangdo and Seoul. The research tools used the emotional empathy scale of Jeon(2003), and language teaching efficacy scale of Kim and Lee(2011). As for the research procedure, from March 06 to July 27, 2017, an 'activity program for effective storytelling' was conducted. For data analysis, a t-test of the corresponding sample was conducted to find the difference between the pre- and post-scores of the two variables. As a result of the study, first, the cognitive empathy ability between the story grandmother and the young children after applying the 'activity program for effective storytelling' was higher than that of the dictionary. Second, the language teaching efficacy between the story grandmother and the young children after applying the 'activity program for effective storytelling' was higher than that of the dictionary. Therefore, the 'activity program for effective storytelling' suggests that there is a positive effect on improving the cognitive empathic ability and language teaching efficacy of the story grandmothers.

• Journal of Korean Neurosurgical Society
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• 제64권1호
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• pp.125-135
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• 2021

Objective : This study aimed to validate the Korean version of the Repeatable Battery for the Assessment of Neuropsychological Status Update (K-RBANS). Methods : We performed a retrospective analysis of 283 psychiatric and neurosurgery patients. To investigate the convergent validity of the K-RBANS, correlation analyses were performed for other intelligence and neuropsychological test results. Confirmatory factor analysis was used to test a series of alternative plausible models of the K-RBANS. To analyze the various capabilities of the K-RBANS, we compared the area under the receiver operating characteristic (ROC) curves (AUC). Results : Significant correlations were observed, confirming the convergent validity of the K-RBANS among the Total Scale Index (TSI) and indices of the K-RBANS and indices of intelligence (r=0.47-0.81; p<0.001) and other neuropsychological tests at moderate and above significance (r=0.41-0.63; p<0.001). Additionally, the results testing the construct validity of the K-RBANS showed that the second-order factor structure model (model 2, similar to an original factor structure of RBANS), which includes a first-order factor comprising five index scores (immediate memory, visuospatial capacity, language, attention, delayed memory) and one higher-order factor (TSI), was statistically acceptable. The comparative fit index (CFI) (CFI, 0.949) values and the goodness of fit index (GFI) (GFI, 0.942) values higher than 0.90 indicated an excellent fit. The root mean squared error of approximation (RMSEA) (RMSEA, 0.082) was considered an acceptable fit. Additionally, the factor structure of model 2 was found to be better and more valid than the other model in χ2 values (Δχ2=7.69, p<0.05). In the ROC analysis, the AUCs of the TSI and five indices were 0.716-0.837, and the AUC of TSI (AUC, 0.837; 95% confidence interval, 0.760-0.896) was higher than the AUCs of the other indices. The sensitivity and specificity of TSI were 77.66% and 78.12%, respectively. Conclusion : The overall results of this study suggest that the K-RBANS may be used as a valid tool for the brief screening of neuropsychological patients in Korea.

• Journal of Life Science
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• 제30권12호
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• pp.1042-1053
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• 2020

The physicochemical properties, antioxidant activity, color value, sensory evaluation, and sinigrin content of chicken breast jerky supplemented with Dolsan leaf mustard powder (DLMP) were evaluated over a period of 120 days. The control groups contained no DLMP, and the product groups contained 0.04 g (S-1, S-3) and 0.3 g (S-2, S-4) of DLMP. These samples were stored at 25℃ and 60℃ and then compared. The pH changes decreased at 25℃ and 60℃ over the storage period, with S-1 maintaining the highest pH value over the course of the experiment. The acid and peroxide values increased at room temperature and 60℃ but were better controlled in the DLMP-containing groups. Overall, the antioxidant activity of these products decreased during storage; the most marked reduction was observed in the control group, and the greatest activity was retained in S-2 and S-4. Hardness and gumminess were higher in the S-2 and S-4 groups and thus correlated with increased DLMP concentration. Sinigrin content also increased with increasing DLMP concentration. Product color remained similar at days 0 and 120 but underwent daily fluctuations over the course of the 120-day storage period. Sensory evaluation scores for color, flavor, taste, texture, and overall acceptability were highest for the S-2 and S-4 groups stored at 25℃. This suggests that higher concentrations of DLMP were more effective at retaining good quality characteristics for fried chicken breast jerky. This was facilitated by its suppression, which decreased changes in textural and color properties while increasing the antioxidant activity of these products.

• Journal of Gastric Cancer
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• 제20권4호
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• pp.408-420
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• 2020

Purpose: Isoform 2 of tight junction protein claudin-18 (CLDN18.2) is a potential target for gastric cancer treatment. A treatment targeting CLDN18.2 has shown promising results in gastric cancer. We investigated the clinical significance of CLDN18.2 and other cell-adherens junction molecules (Rho GTPase-activating protein [RhoGAP] and E-cadherin) in metastatic diffuse-type gastric cancer (mDGC). Materials and Methods: We evaluated CLDN18.2, RhoGAP, and E-cadherin expression using two-plex immunofluorescence and quantitative data analysis of H-scores of 77 consecutive mDGC patients who received first-line platinum-based chemotherapy between March 2015 and February 2017. Results: CLDN18.2 and E-cadherin expression was significantly lower in patients with peritoneal metastasis (PM) than those without PM at the time of diagnosis (P=0.010 and 0.013, respectively), whereas it was significantly higher in patients who never developed PM from diagnosis to death than in those who did (P=0.001 and 0.003, respectively). Meanwhile, CLDN18.2 and E-cadherin expression levels were significantly higher in patients with bone metastasis than in those without bone metastasis (P=0.010 and 0.001, respectively). Moreover, we identified a positive correlation between the expression of CLDN18.2 and E-cadherin (P<0.001), RhoGAP and CLDN18.2 (P=0.004), and RhoGAP and E-cadherin (P=0.001). Conversely, CLDN18.2, RhoGAP, and E-cadherin expression was not associated with chemotherapy response and survival. Conclusions: CLDN18.2 expression was reduced in patients with PM but significantly intact in those with bone metastasis. Furthermore, CLDN18.2 expression was positively correlated with other adherens junction molecules, which is clinically associated with mDGC and PM pathogenesis.

• Journal of the Korea Academia-Industrial cooperation Society
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• 제22권3호
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• pp.227-233
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• 2021

To obtain a fruitful outcome in intellectual property (IP) education in colleges, it is essential to identify the affecting factors. The relationships between the factors were to be analyzed as a structural equation model. The IP education achievement was measured by the IP total score. The students' characteristics (input factor) were measured by defining the characteristics, parents' expectations, and IP interest. The characteristics after highschool (process factor) were observed as college satisfaction and learning attitude. Students with excellent defining characteristics have not only high college satisfaction but also an excellent learning attitude, so they have a high IP total score. Using indirect effects analysis, the path through which the defining characteristics indirectly affects the IP total score through college satisfaction and learning attitude was identified. This is consistent with the prediction that self-directed students will have high participation in IP classes and achieve excellent results. The IP interest was found to have no significant effect on the IP total score. This contradicts the belief that students with high IP interest will actively participate in IP classes and earn high scores, which is because it overlooks the possibility that participation in IP activities in high school is semi-forced.

• Journal of Korean Society of Forest Science
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• 제109권4호
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• pp.532-543
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• 2020

This study was conducted with the aim of comparing and analyzing the relationship between visitors' characteristics and service satisfaction, overall satisfaction and loyalty (revisit intention, recommendation intention) of recreational forests and arboretums. The main results are as follows. First, the scores given for service satisfaction, overall satisfaction, and loyalty of the users of the recreational forests were all higher than those given by the visitors to arboretums, and the service satisfaction level was relatively different from that of the overall satisfaction level or loyalty of the users. Second, the service satisfaction level of the recreational forests did not affect the overall satisfaction level and visitor loyalty, whereas the service satisfaction level of the arboretum was found to be positively correlated with the overall satisfaction level and visitor loyalty. The results are meaningful given that the visitors to recreational forests and arboretums are distributed throughout the country; thus, we confirmed that there are differences in visitor characteristics between the two types of forest recreation areas. In order to differentiate operation strategies for each type of forest recreation areas, the development of common survey items covering the entire set of services provided by forest recreation areas is needed. In addition, it would be advantageous to further develop and modularize the relevant items and conduct surveys in parallel with common survey items, as the service contents are operated selectively to function in accordance with the purpose of creating each forest recreation area.

• The Journal of Internal Korean Medicine
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• 제41권6호
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• pp.1200-1209
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• 2020

Aphasia is a language disorder that results from brain damage and typically occurs after a stroke. The purpose of this case report was to describe the effects of Korean medical treatment on anomic aphasia after a putaminal hemorrhage. We used Korean medical treatment, including head acupuncture and herbal medicine (Hyungbangsabaek-san) therapy, on a patient who was admitted to the hospital for 19 days. The clinical symptoms were assessed with the Korean version of the Western Aphasia Battery (K-WAB), and quality of life was evaluated with Korean version of Stroke and Aphasia Quality of Life Scale-39 (K-SAQOL-39). After 19 days of treatment, the K-WAB scores were increased from 17 to 19 in the spontaneous speech score, from 7.55 to 9.85 in the comprehension score, from 9 to 9.4 in the speaking score, and from 5.8 to 9.7 in the naming score. The AQ score was increased from 78.7 to 95.9, and the K-SAQOL-3 score was increased from 2.64 to 3.26. In conclusion, the study findings suggested that Korean medical treatment could be an effective option for treating symptoms and improving quality of life in patients with aphasia after stroke.