• Molecules and Cells
• /
• 제26권4호
• /
• pp.323-328
• /
• 2008

Eukaryotic cells continuously integrate intrinsic and extrinsic signals to adapt to the environment. When exposed to stressful conditions, cells activate compartment-specific adaptive responses. If these are insufficient, apoptosis ensues as an organismal defense line. The mechanisms that sense stress and set the transition from adaptive to maladaptive responses, activating apoptotic programs, are the subject of intense studies, also for their potential impact in cancer and degenerative disorders. In the former case, one would aim at lowering the threshold, in the latter instead to increase it. Protein synthesis, consuming energy for anabolic processes as well as for byproducts disposal, can be a significant source of stress, particularly when difficult-to-fold proteins are produced. Recent work from our and other laboratories on the differentiation of antibody secreting cells, revealed a regulatory circuit that integrates protein synthesis, secretion and degradation (proteostasis), into cell lifespan determination. The apoptotic elimination - after an industrious, yet short lifetime - of terminal immune effectors is crucial to maintain immune homeostasis. Linking proteostasis to cell death, this paradigm might prove useful for biotechnological purposes, and the design of novel anti-cancer therapies.

• Journal of Information Science Theory and Practice
• /
• 제8권1호
• /
• pp.45-55
• /
• 2020

The purpose of this work was to study library website users' actions by tracking their behavior, determining popular content, and identifying browsing patterns and subsequent improvement of access to popular content. The study of behavior models and the use of web analytics has led to the emergence of solutions that improve the usability and functionality of the State Public Scientific-Technological Library of the Siberian Branch of the Russian Academy of Sciences (SPSTL SB RAS) website. These are: identifying user tasks as they are developed, conducting user testing to better understand the event. tracking data and collecting additional data to verify the effectiveness of the changes made. Examining data on the duration of the session and the number of visits will help determine the goals of user visits and develop new recommendations. Usability analysis and testing will make it possible to compare the data obtained using web analytics and the perception of the library site by the users themselves. Recommendations are offered to libraries on the use of data on the real behavior of the target audience of the library website to improve access to library resources and services, increase their relevance and improve information services.

• Journal of Information Science Theory and Practice
• /
• 제7권3호
• /
• pp.21-30
• /
• 2019

Information about the formation and filling (in 2014 to 2016) of a terminological dictionary on electronics and radioengineering and collective work (in 2017 to 2018) with a data bank "TERMIN" is presented in this article. In purpose of creating an instrument of navigating the modern scientific-technical space a net of terms with set semantic links is described. This set is based on the analysis of terms' definitions (each term is checked for inclusion in the definitions of all other terms; the definitions were borrowed from reputable reference editions: encyclopedias, dictionaries, reference books). The created model of a system that consists of different information sources, in which it (information) is indexed by the terminology of Russian State Rubricator of Scientific and Technical Information rubrics and/or keywords, is described. There is an access for the search in all these sources in the system. Searching inquiries are referred to in the language of these rubrics or formulated by arbitrary terms. The system is to refer to information sources and give out relevant information. In accordance with this model, semantic links of various types, which allow expanding a search at different modalities of query, should be set among data bank terms. Obtained links will have to increase semantic matching, i.e., they can provide actual understanding of the meaning of the information that is being sought.

• International Journal of Computer Science & Network Security
• /
• 제21권12호
• /
• pp.189-192
• /
• 2021

The article theoretically substantiated, developed and practically implemented a structural and functional model of the formation of ICT competence, taking into account interdisciplinary integration, defines the pedagogical conditions that contribute to the formation of ICT competence: interdisciplinary integration as a basis for building an interdisciplinary course, the content of which is aimed at the formation of ICT competence; the use of IEE, including information, didactic, technological components as a basis for the formation of ICT competence; integration of formal, non-formal and informal education for the implementation the integrity of the acquired knowledge, skills, experience as the basis for the formation of the ICT competence of teachers; creation and use of a set of tasks (educational (UZ), educational and methodological (UMP), educational and professional (UPZ)) as special tools for the formation of ICT competence.

• Journal of Information Science Theory and Practice
• /
• 제9권3호
• /
• pp.31-41
• /
• 2021

The growing number of threats to society through the uncontrolled distribution of information is forcing library communities in many countries to reconsider their views on free access to collections. Based on the content of numerous documents of international importance, it can be concluded that in any democratic country access to information is one of the most important human rights, along with the right to life, liberty, and security of person. However, the state has the right to restrict citizens' access to information within the framework of existing legislation. Constantly, restrictions on access to information are established in order to protect the ethical foundations of the constitutional order, morality, health, rights, and legitimate interests of others, to ensure the country's defense and state security. It goes without saying that each country has the right to independently decide where the boundaries lie between permitted and prohibited information, including printed information, contained in library collections. This article describes three levels of access restriction: foreign, state, and regional. The authors have analyzed the legal and regulatory documents that govern libraries, as well as the reasons and methods of limitation. A comparative analysis of the restriction of access to information in the countries of Europe and Asia is presented.

• International Journal of Computer Science & Network Security
• /
• 제21권3호
• /
• pp.94-102
• /
• 2021

The study aimed to define all the main determinants of writing a research paper in an integrated manner within the requirements of the science network journals, by introducing scientific research and the steps of writing a research paper, starting from choosing the title to writing the abstract, identifying the research problem, questions, importance and objectives of the study, how to choose previous studies, research methodology and tools, discussion and results In addition to determining the acceptable percentage of plagiarism for science network journals, recommendations, choosing appropriate references and choosing the appropriate references, in addition to determining the acceptable percentage of plagiarism for the journals of the Network of Science, the researcher used the method of analytical investigative research to find out the axes of the study and analyze different reference citation methods to deal with different sources of information (articles-books-theses-conference works-reviews), In addition to studying the most important international programs for measuring plagiarism ratios that are accredited within the journals of the Science Network, and the study concluded that the researcher must present original and innovative results, add an integrated and logical work, take into account all the scientific conditions in the design of the research, its steps and ethics, and take into account the international standards in citing Reference, taking into account the rates of plagiarism within Web of Science journals.

• 한국철도학회:학술대회논문집
• /
• 한국철도학회 2011년도 정기총회 및 추계학술대회 논문집
• /
• pp.2573-2580
• /
• 2011

SMRT(Seoul Metropolitan Rapid Transit Corporation) changed PC-oriented office system to Smart-Phone oriented mobile office system(STnF: SMRT Talk & Flash), and provided smart phone to all staffs. STnF make it possible not only voice communication between staff, but also to input and inquiry all kind of information related to work(ex: Facility maintenance, Rolling Stock management, office management, Finance, human resource etc.) based on smart phone. STnF conquers the limitation of time and space. All staffs can commute to the site directly to reduce moving time and to share information between staffs, so SMRT improve speed and reliability of work by making a quick decision and action on the spot. After introduction of STnF, within 1 year, the equipment failure ratio fell to 47%. Mobile office system reduced and level-off the step of approval. so enhanced civil customer service. Quantification and scientific movement of work make it fast evolution and development. These business improvement make it possible to put more outstanding manpower on new business and R&D project, and this contributes to company's management effectiveness.

• 한국진공학회:학술대회논문집
• /
• 한국진공학회 2013년도 제44회 동계 정기학술대회 초록집
• /
• pp.628-628
• /
• 2013

Graphene, a single layer of graphite, has raised extensive interest in a wide scientific community for its extraordinary thermal, mechanical, electrical and other properties [1,2]. However, because of zero-band gap of graphene, it is difficult to apply for electronic applications. To overcome this problem, chemical doping is one of way to opening grahene bandgap. According to experimental results, by changing doping concentration and doping time, it is possible to control work function of graphene. We can obtain results through raman spectroscopy, UPS, Sheet resistance. Moreover, electronic properties of doped graphene were studied by making field effect transistors. We were able to control the doping concentration, dirac point of graphene and work function of graphene by formng n-type, p-type doping materials. In this research, the chemicals of diazonium salts, viologen, etc. were used for extrinsic doping.

• 산업경영시스템학회지
• /
• 제11권18호
• /
• pp.41-57
• /
• 1988

This study was carried out to furnish information for the appropriate standard work time measure and applicate system development that help for korean manufacturers. As a research methodology of the study, the questionnaire survey by sampling nine hundreds registerd corporation, was conducted to find the scientific management technique level (for especially standard work time). By crossectionally analyzing the survey results, placed primary emphasis on the study to comparison with employee scale and types of industry classify. The contents of subjective study art as follows; (1) Establish state of standard time(S. T) (2) Mainly technique for establish S. T (3) Institute level and correctness of S. T (4) Practical use of S. T (5) Performance rating and Allowance rate (6) Advantage and disadvantage to application results.

• 한국과학교육학회지
• /
• 제33권7호
• /
• pp.1403-1417
• /
• 2013

본 연구에서는 과학자들의 상상력에 대한 인식과 과학 연구 과정에서 나타나는 과학적 상상력의 특성을 탐색하였다. 문헌 연구를 바탕으로 상상력의 개념과 특성을 도출한 뒤, 실제 과학자를 대상으로 상상력에 대한 인식과 연구 과정에서 강조되는 상상력의 특성을 알아보았다. 연구 참여자로는 스노우볼 표집을 통해 국내 과학자 8인을 선정하였으며, 개별 심층 면담을 통해 자료 수집이 이루어졌다. 면담은 주로 60-90분 동안 진행되었으며, 면담 내용은 모두 전사하여 분석 자료로 사용하였다. 면담 질문은 상상력에 대한 인식과 연구 과정에서 상상력이 발휘되었던 경험과, 상상력의 역할 등을 물어보는 반 구조화된 형식으로 구성하였다. 연구 결과, 과학자들은 상상력이 과학 연구 활동에서 중요한 역할을 한다고 인식하고 있었으며, 상상력에 대하여 긍정적인 관점을 지니고 있었다. 특히 과학자들은 상상력이 인간이 지니고 있는 특성으로 바라보았으며, 상상력의 개념을 폭넓게 이해하는 현대적 관점을 지니고 있었다. 연구 과정에서 강조되는 상상력의 특성은 문헌 연구에서 나타나는 상상력의 특성과 일치하였으며, 크게 세 가지로 분류하였다. 첫째, 과학자들의 상상력은 경험을 통한 지적 호기심과 궁금증이 원동력으로 작용한다는 것이다. 둘째, 과학적 상상력이 발휘되는 과정에서 창의적 특성이 나타난다. 셋째, 과학적 상상력은 과학 지식을 기반으로 현실 가능성을 고려하며, 새로운 것을 산출하는 특성을 지닌다. 연구 결과를 바탕으로 결론에서는 과학적 상상력의 특성을 도출하고, 그 의미와 함께 과학 학습에서의 상상력 활용 방안에 대하여 논의하였다.